CN111902428A - 一种双特异性抗体及其用途 - Google Patents
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Abstract
本发明提供了一种双特异性抗体及其用途。所述双特异性抗体包含第一蛋白功能区和第二蛋白功能区，其中，第一蛋白功能区靶向TIM‑3，其对应的靶向TIM‑3的TIM‑3全长抗体与猕猴(Macaca)TIM‑3有弱结合活性，与狨猴(Marmoset)和人TIM‑3有强结合活性并能够激活人NK细胞对肿瘤细胞的杀伤作用。所述的双特异性抗体保留单个TIM‑3抗体所具有的激活PBMC(NK)杀伤肿瘤细胞的活性，同时保持另一个蛋白功能区的原有活性，并能够达到和两个分子联用相当或者更好激活T淋巴细胞的活性。
Description
PCT国内申请，说明书已公开。
Claims (16)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
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| CN201810720048 | 2018-07-03 | ||
| PCT/CN2019/093548 WO2020007240A1 (zh) | 2018-07-03 | 2019-06-28 | 一种双特异性抗体及其用途 |
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| CN111902428A true CN111902428A (zh) | 2020-11-06 |
| CN111902428B CN111902428B (zh) | 2023-11-10 |
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| EP (1) | EP3819313A4 (zh) |
| JP (1) | JP7352973B2 (zh) |
| CN (2) | CN111902428B (zh) |
| WO (1) | WO2020007240A1 (zh) |
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| CN111518214B (zh) * | 2019-02-03 | 2023-09-22 | 上海健信生物医药科技有限公司 | 靶向cldn18.2的双特异性抗体及其制备方法和应用 |
| WO2021169948A1 (zh) * | 2020-02-24 | 2021-09-02 | 苏州恒康生命科学有限公司 | Tim3结合分子及其应用 |
| CN113698478A (zh) * | 2020-05-21 | 2021-11-26 | 迈威(上海)生物科技股份有限公司 | 抗α-溶血素的抗体及其稳定制剂 |
| TWI806087B (zh) * | 2020-06-30 | 2023-06-21 | 大陸商和鉑醫藥（上海）有限責任公司 | 免疫細胞銜接多特異性結合蛋白及其製備和應用 |
| CN111748040B (zh) * | 2020-07-31 | 2021-09-28 | 杭州皓阳生物技术有限公司 | 多价抗体及其制备方法 |
| CN113603779B (zh) * | 2021-08-18 | 2023-06-02 | 深圳市元谷生物科技有限公司 | 一种结合人淋巴细胞活化基因3(lag-3)的抗体及其用途 |
| CN115246885B (zh) * | 2022-06-30 | 2023-10-24 | 盛禾(中国)生物制药有限公司 | 一种双特异性抗体及其应用 |
| WO2024153115A1 (zh) * | 2023-01-18 | 2024-07-25 | 开拓药业(广东)有限公司 | 抗alk-1抗体及其用途 |
| CN118420712A (zh) * | 2023-02-01 | 2024-08-02 | 上海健信生物医药科技有限公司 | 一种三特异性抗体技术平台及其应用 |
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| WO2016015685A1 (zh) * | 2014-07-30 | 2016-02-04 | 珠海市丽珠单抗生物技术有限公司 | 抗pd-1抗体及其应用 |
| WO2016071448A1 (en) * | 2014-11-06 | 2016-05-12 | F. Hoffmann-La Roche Ag | Anti-tim3 antibodies and methods of use |
| WO2017055404A1 (en) * | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Bispecific antibodies specific for pd1 and tim3 |
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| JP2013532153A (ja) * | 2010-06-18 | 2013-08-15 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 慢性免疫病に対する免疫治療のためのｔｉｍ−３およびｐｄ−１に対する二重特異性抗体 |
| BR112014002353B1 (pt) | 2011-08-01 | 2022-09-27 | Genentech, Inc | Usos de antagonistas de ligação do eixo pd-1 e inibidores de mek, composições farmacêuticas, e kit |
| JOP20200096A1 (ar) * | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| CA2987118C (en) * | 2016-03-04 | 2020-03-24 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | A pdl-1 antibody, pharmaceutical composition thereof and use thereof |
| CN107459578B (zh) * | 2016-05-31 | 2021-11-26 | 泰州迈博太科药业有限公司 | 一种靶向cd47与pd-l1的双功能融合蛋白 |
| JOP20190133A1 (ar) * | 2016-12-08 | 2019-06-02 | Innovent Biologics Suzhou Co Ltd | أجسام مضادة لـ Tim-3 لمزجها بأجسام مضادة لـ PD-1 |
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| EP4036116A4 (en) * | 2019-09-27 | 2024-01-24 | Nanjing GenScript Biotech Co., Ltd. | ANTI-VHH DOMAIN ANTIBODIES AND USE THEREOF |
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- 2019-06-28 US US17/254,862 patent/US20210269521A1/en active Pending
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| WO2016071448A1 (en) * | 2014-11-06 | 2016-05-12 | F. Hoffmann-La Roche Ag | Anti-tim3 antibodies and methods of use |
| WO2017055404A1 (en) * | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Bispecific antibodies specific for pd1 and tim3 |
| WO2017087547A1 (en) * | 2015-11-17 | 2017-05-26 | Oncomed Pharmaceuticals, Inc. | Pd-l1-binding agents and uses thereof |
| CN108948193A (zh) * | 2017-05-18 | 2018-12-07 | 珠海市丽珠单抗生物技术有限公司 | 针对tim-3的抗体分子,抗原结合片段及其医药用途 |
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| EP3819313A4 (en) | 2021-09-01 |
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