CN111643399A - Antioxidant skin care composition containing levovitamin C and preparation method thereof - Google Patents

Abstract

The invention discloses an antioxidant skin care composition containing levovitamin C, which comprises the levovitamin C, dipotassium glycyrrhizinate, sodium hyaluronate, a polyalcohol humectant, a thickening agent and an antioxidant which are encapsulated by microcapsules, wherein the antioxidant adopts tocopherol, polylysine and the like under the action of the polyalcohol humectant, so that the irritation of the antioxidant permeating into skin can be reduced, the activity and the permeability of the antioxidant can be optimally exerted, and the antioxidant and the encapsulated levovitamin C play a synergistic role together, so that the effect of removing free radicals is better; also provides a preparation method of the antioxidant skin care composition containing the levorotatory vitamin C.

Description

Antioxidant skin care composition containing levovitamin C and preparation method thereof

Technical Field

The invention belongs to the technical field of skin care products, and particularly relates to an antioxidant skin care composition containing levorotatory vitamin C and a preparation method thereof.

Background

At present, antioxidant raw materials such as ascorbic acid, astaxanthin and coenzyme Q10 are used in skin antioxidant products, but most of the products for removing free radicals are ascorbic acid, which is also called vitamin C and is a strong antioxidant, can play a role in resisting oxidation and removing free radicals of skin, participate in the synthesis of collagen in the dermis layer of the skin and play a role in the expression of type I and type IV collagen. Meanwhile, the skin whitening cream can prevent the generation of melanin by inhibiting the activity of tyrosinase, has the effect of whitening, and is widely applied to the field of skin care products.

(1) A large number of researches show that the key of the antioxidation is to eliminate free radicals and avoid the problems of skin oxidation, aging acceleration and the like caused by the oxidative stress reaction of the free radicals to the skin. Clinically approved ascorbic acid as a common antioxidant is easily oxidized by itself, is very unstable after being dissolved in water, is easily oxidized and is accelerated, and the solution turns yellow. The clinical use modes are three, one is that the powder is mixed into liquid before use and is used immediately; another way is to use derivatives of ascorbic acid. The former is inconvenient to use and has certain risks; the latter can be used in aqueous preparations, but studies have shown that ascorbic acid derivatives are less effective than ascorbic acid. The third is prepared by adopting a formula system of anhydrous or oil-in-silanol, but the experience feeling is poor and the consumer acceptance is low.

(2) Meanwhile, the effective concentration of the ascorbic acid is irritating to most of the clinically problematic skins, tolerance needs to be gradually established for normal skins, and similar antioxidant products cannot be selected for sub-healthy skins with damaged sensitive muscles or skin barriers to perform antioxidant management on the skins.

The reasons for the above problems are analyzed: (1) reducibility of ascorbic acid: ascorbic acid has strong reducibility, has unstable chemical property, and can be easily oxidized and converted into hexose derivatives under certain conditions (such as heat, alkalinity, illumination, oxygen and the like) to lose the original reducibility.

(2) Anhydrous systems cause poor skin feel: in order to solve the stability problem of ascorbic acid, a formula of a silicone oil-in-alcohol or anhydrous system is generally adopted to prepare an antioxidant product, so that the formula is more oily and has poorer experience.

(3) Irritation to the skin: the ascorbic acid has certain irritation to the skin when permeating into the skin, the skin barrier is damaged for sensitive skin, the pricking feeling is stronger, and besides the irritation to the skin caused by the ascorbic acid, a relieving and antiseptic system of the whole formula system is also very critical.

Through search, in the patent of application No. CN202010375322.X, disclose a whitening composition and its preparation method, adopt ancient method + modern whitening complex composition and its preparation method, adopt phenylethyl resorcinol + radix Notoginseng extract, rhizoma Chuanxiong extract, folium Ginkgo extract, radix Angelicae sinensis extract, through inhibiting the activity of tyrosinase, removing active oxygen, reducing already synthetic melanin, blocking the transportation of melanin and accelerating the epidermal cell metabolism speed, achieve the effect of whitening, its formulation includes, dipotassium glycyrrhizinate 0.05-0.5;

in patent application No. CN201910389647.0, a whitening anti-aging essence is disclosed, which comprises levo-vitamin C, astaxanthin, methyl hesperidin, ferulic acid and phloretin. The skin care product is added with a plurality of components of astaxanthin, levorotatory VC and methyl hesperidin which can eliminate excessive free radicals in the skin and inhibit the tyrosinase, and is added with two components of ferulic acid and phloretin which have the effects of activating the skin, promoting permeation and absorption, and compared with a common water aqua, the skin care product has stronger whitening and anti-aging effects and can restore the skin to the optimal state in a short time.

In the field of skin antioxidation whitening, the compounding of different skin care components is selected, which is a common method for skin antioxidation whitening, the compounding of different skin care components is carried out, according to the actual application effect, except that the skin care product has no harm to human bodies, different groups of people and the use effect of different skin types are mainly seen, the compounding of different skin care components is an additive effect under general conditions, so that the skin care product really has little synergistic effect, especially has obvious synergistic effect, and the research of the inventor finds that the microencapsulated levorotatory vitamin and the antioxidant have the following effects: the tocopherol, the polylysine glycerol, the polyalcohol humectant and the dipotassium oxalate are compounded according to a specific proportion to generate a good synergistic effect, so that oxygen radicals in various forms can be effectively eliminated, and how to effectively eliminate the oxygen radicals is not reported in the publication.

Disclosure of Invention

The invention aims to provide an antioxidant skin care composition containing levorotatory vitamin C and having a synergistic effect and a preparation method thereof.

In order to achieve the aim, the invention provides an antioxidant skin care composition containing levorotatory vitamin C, which comprises the following components in parts by weight: microencapsulated levovitamin C: 10-20 parts of dipotassium glycyrrhizinate: 0.1-0.9 parts of sodium hyaluronate: 0.05-0.5 part of polyhydric alcohol humectant: 2-20 parts of a thickening agent: 0.2-2 parts of antioxidant: 0 to 0.8 portion and the balance of water.

Wherein the polyalcohol humectant is one or more selected from glycerol, polyethylene glycol, propylene glycol, butanediol and pentanediol.

Wherein the thickener is one or more of xanthan gum, hydroxyethyl cellulose and carboxymethyl cellulose.

Wherein the antioxidant is selected from one or more of tocopherol and polylysine.

The invention also provides a preparation method of the antioxidant skin care composition containing the levorotatory vitamin C, which comprises the following steps:

(1) adding the polyalcohol humectant, the sodium hyaluronate and the thickener into a reaction kettle, uniformly stirring, adding water, stirring and heating to 80 ℃;

(2) after the polyhydric alcohol humectant, the sodium hyaluronate and the thickening agent are completely dissolved, adding the levovitamin C, the dipotassium glycyrrhizinate and the antioxidant, and continuously stirring for about 30 min;

(3) after stirring uniformly, starting the reaction kettle to cool water, discharging when the temperature is reduced to be less than or equal to 40 ℃, and filling;

(4) and after filling, performing irradiation sterilization on 8-25Kgy Co60 to obtain the skin care composition.

The invention has the beneficial effects that:

in the invention, the irritation of large dose of levorotatory VC to skin is considered, the encapsulated levorotatory vitamin C is adopted, the sustained-release effect can be realized while the stability is realized, the irritation to the skin is reduced, the irritation of the whole formula system is directly relieved by adding the allergy-relieving component, in addition, the irritation of the antioxidant penetrating into the skin can be reduced by adding the polyalcohol humectant, and the optimal activity and permeability of the antioxidant can be brought into play.

Sodium hyaluronate is an acidic mucopolysaccharide, naturally exists in corneal skin, and can absorb 1000 times of water of the corneal skin so as to achieve the purpose of retaining skin water and preventing water from losing through epidermis. When the skin is damaged, the sodium hyaluronate is used as a barrier to repair, so that the skin does not feel dry, the skin luster is increased, the skin nutrition metabolism can be improved, the skin is soft and smooth, the wrinkles are removed, the elasticity is increased, the skin aging is prevented, and the sodium hyaluronate is a good transdermal absorption enhancer while keeping moisture. Can be used in combination with other nutritional ingredients to promote nutrient absorption.

The thickener contained in the nourishing and repairing emulsion can ensure that the nourishing and repairing emulsion has good physical stability, and can also ensure that effective moisturizing and whitening components in the nourishing and repairing emulsion are uniformly dispersed.

Under the action of the polyalcohol humectant, the antioxidant substances such as tocopherol, polylysine and the like can reduce the stimulation of the penetration of the antioxidant into the skin, simultaneously contribute to the optimal activity and permeability of the antioxidant, and play a role in synergy with the microencapsulated levorotatory vitamin C, particularly the microencapsulated levorotatory vitamin C can be used in a large dose of 10-20 parts, so that the effect of scavenging free radicals is better.

Detailed Description

To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.

Example 1:

the embodiment provides an antioxidant skin care composition containing levorotatory vitamin C, which sequentially comprises the following components in parts by mass: 10 parts of microsphere-coated levo-vitamin C, 0.1 part of dipotassium glycyrrhizinate, 0.05 part of sodium hyaluronate, 2 parts of glycerol, 5 parts of polyethylene glycol, 0.1 part of xanthan gum, 0.2 part of hydroxyethyl cellulose, 0.2 part of tocopherol, 0.1 part of polylysine and the balance of water.

Step 1, weighing raw materials in parts by weight in sequence;

step 2: adding glycerol, polyethylene glycol, sodium hyaluronate, xanthan gum and hydroxyethyl cellulose into a reaction kettle, uniformly stirring, adding water, stirring and heating to 80 ℃;

and step 3: after the glycerin, the polyethylene glycol, the sodium hyaluronate and the thickening agent are completely dissolved, adding the levorotatory vitamin C microspheres, the dipotassium glycyrrhizinate, the tocopherol and the polylysine, and continuously stirring for about 30 min;

and step 3: after stirring uniformly, starting cooling water, discharging when the temperature is reduced to be less than or equal to 40 ℃, and filling;

and 4, step 4: after filling, 8-25Kgy Co60 is irradiated for sterilization to obtain the composition.

Example 2:

the embodiment provides an antioxidant skin care composition containing levorotatory vitamin C, which sequentially comprises the following components in parts by mass: 12.5 parts of L-vitamin C wrapped by microspheres, 0.2 part of dipotassium glycyrrhizinate, 0.02 part of sodium hyaluronate, 5 parts of glycerol, 2 parts of polyethylene glycol, 0.2 part of xanthan gum, 0.1 part of polylysine and the balance of water.

Step 1, weighing raw materials in parts by weight in sequence;

step 2: adding glycerol, polyethylene glycol, sodium hyaluronate and xanthan gum into a reaction kettle, uniformly stirring, adding water, stirring and heating to 80 ℃;

and step 3: after the glycerin, the polyethylene glycol, the sodium hyaluronate and the xanthan gum are completely dissolved, adding the levorotatory vitamin C microspheres, the dipotassium glycyrrhizinate and the polylysine, and continuously stirring for about 30 min;

and step 3: after stirring uniformly, starting cooling water, discharging when the temperature is reduced to be less than or equal to 40 ℃, and filling;

and 4, step 4: after filling, 8-25Kgy Co60 is irradiated for sterilization to obtain the composition.

Example 3:

the embodiment provides an antioxidant skin care composition containing levorotatory vitamin C, which sequentially comprises the following components in parts by mass: 15 parts of microsphere-coated levovitamin C, 0.4 part of dipotassium glycyrrhizinate, 0.05 part of sodium hyaluronate, 5 parts of glycerol, 2 parts of polyethylene glycol, 0.2 part of sodium carboxymethylcellulose, 0.2 part of tocopherol and the balance of water.

Step 1, weighing raw materials in parts by weight in sequence;

step 2: adding glycerol, polyethylene glycol, sodium hyaluronate and sodium carboxymethylcellulose into a reaction kettle, uniformly stirring, adding water, stirring and heating to 80 ℃;

and step 3: after the glycerin, the polyethylene glycol, the sodium hyaluronate and the sodium carboxymethylcellulose are completely dissolved, adding the levorotatory vitamin C microspheres, the dipotassium glycyrrhizinate and the tocopherol, and continuously stirring for about 30 min;

and step 3: after stirring uniformly, starting cooling water, discharging when the temperature is reduced to be less than or equal to 40 ℃, and filling;

and 4, step 4: after filling, 8-25Kgy Co60 is irradiated for sterilization to obtain the composition.

Example 4:

the embodiment provides an antioxidant skin care composition containing levorotatory vitamin C, which sequentially comprises the following components in parts by mass: 8 parts of microsphere-coated levovitamin C, 0.1 part of dipotassium glycyrrhizinate, 0.05 part of sodium hyaluronate, 5 parts of glycerol, 2 parts of polyethylene glycol, 0.2 part of xanthan gum, 0.1 part of tocopherol and the balance of water.

Step 1, weighing raw materials in parts by weight in sequence;

step 2: adding glycerol, polyethylene glycol, sodium hyaluronate and xanthan gum into a reaction kettle, uniformly stirring, adding water, stirring and heating to 80 ℃;

and step 3: after the glycerin, the polyethylene glycol, the sodium hyaluronate and the xanthan gum are completely dissolved, adding the levovitamin C microspheres, the dipotassium glycyrrhizinate and the tocopherol and continuing stirring for about 30 min;

and step 3: after stirring uniformly, starting cooling water, discharging when the temperature is reduced to be less than or equal to 40 ℃, and filling;

and 4, step 4: after filling, 8-25Kgy Co60 is irradiated for sterilization to obtain the composition.

Example 5:

the embodiment provides an antioxidant skin care composition containing levorotatory vitamin C, which sequentially comprises the following components in parts by mass: 12 parts of microsphere-coated levorotatory vitamin C, 0.3 part of dipotassium glycyrrhizinate, 0.25 part of sodium hyaluronate, 2 parts of glycerol, 5 parts of polyethylene glycol, 0.1 part of xanthan gum, 0.1 part of polylysine and the balance of water.

Step 1, weighing raw materials in parts by weight in sequence;

step 2: adding glycerol, polyethylene glycol, sodium hyaluronate and xanthan gum into a reaction kettle, uniformly stirring, adding water, stirring and heating to 80 ℃;

and step 3: after the glycerin, the polyethylene glycol, the sodium hyaluronate and the xanthan gum are completely dissolved, adding the levorotatory vitamin C microspheres, the dipotassium glycyrrhizinate and the polylysine, and continuously stirring for about 30 min;

and step 3: after stirring uniformly, starting cooling water, discharging when the temperature is reduced to be less than or equal to 40 ℃, and filling;

and 4, step 4: after filling, 8-25Kgy Co60 is irradiated for sterilization to obtain the composition.

Comparative example 1 experimental conditions were as follows: (containing no antioxidant ingredient):

the comparative example provides an antioxidant-free composition which sequentially comprises the following components in parts by mass: 0.02 part of sodium hyaluronate, 0.3 part of dipotassium glycyrrhizinate, 5 parts of glycerol, 2 parts of polyethylene glycol, 0.2 part of xanthan gum and the balance of water.

Step 1, weighing raw materials in parts by weight in sequence;

step 2: adding glycerol, polyethylene glycol, sodium hyaluronate and xanthan gum into a reaction kettle, uniformly stirring, adding water, stirring and heating to 80 ℃;

and step 3: after the glycerin, the polyethylene glycol, the sodium hyaluronate and the xanthan gum are completely dissolved, adding the ascorbic acid, the dipotassium glycyrrhizinate and the polylysine, and continuously stirring for about 30 min;

and step 3: after stirring uniformly, starting cooling water, discharging when the temperature is reduced to be less than or equal to 40 ℃, and filling;

and 4, step 4: after filling, 8-25Kgy Co60 is irradiated for sterilization to obtain the composition.

The skin care compositions prepared in examples 1 to 5 were tested for irritation and safety, and the following results were obtained.

Stability test

By adopting a high-temperature acceleration experiment, a sample of the formula is placed in an oven for carrying out a 50 ℃ stability test for 4 weeks, samples are taken every week or every other week, and the content of VC in the sample is mainly measured. The vc content is determined by referring to the method in Chinese pharmacopoeia 2000 edition, about 0.5ml of sample is taken and precisely weighed, 50ml of newly boiled cold water and 10ml of dilute acetic acid are added for dissolution and dispersion, 1ml of starch indicator is added, and the solution is immediately titrated by using iodine standard titration solution (0.1 mol/L) until the solution shows blue and does not fade within 30s to be the titration end point.

The mass fraction in the sample was calculated according to equation (1).

W=VI × CI × 8．806／(m×0.1×1000) ×100％ (1)

Wherein w is the mass fraction,%, of VC; VI is the consumption of standard iodine solution, mL; CI is the concentration of standard iodine solution, mol/L; m is the sample mass, g. The VC retention was calculated by the following equation (2).

VC Retention ratio = Wi/W0X 100% (2)

Wherein W0 is the mass fraction of the initial sample VC; wi is the mass fraction of sample VC after t weeks of accelerated experiment. The security verification results are obtained as in table 1.

Table 1: stability test of the compositions

Safety test

Selecting 50 volunteers aged 20-50 years, marking 5 × 5cm area on inner side of left forearm of volunteer, sterilizing with 75% alcohol, introducing composition into tested area with 36-needle micro needle for 30s, gently wiping residual liquid with medical cotton ball soaked with physiological saline, and keeping tested area dry; the spot tester cells are numbered from 1 to 6, and test samples (the compositions prepared in examples 1 to 1) are respectively put into the spot tester cells with the corresponding numbers, wherein the dosage is 0.02g per cell; the spot tester is pasted on the part marked with the wound, after 24h of waterproof pasting, the spot tester is removed, the skin condition of the wound part is observed, and the safety verification result is obtained, as shown in table 2:

table 2: composition safety test

According to the safety verification result, the formula and the raw materials adopted by the technical scheme of the invention have no irritation to human skin and do not cause anaphylactic reaction.

Oxidation resistance test

Scavenging ability for DPPH radicals: adding 2ml of DDPH solution and different volumes of the sample solutions of the example 1 to the comparative example 1 into a test tube, supplementing absolute ethyl alcohol to the total volume of 3ml, uniformly mixing, standing for 30min, measuring the absorbance A at 519nm, and calculating the DPPH free radical clearance rate of the sample according to the formula (3)

DPPH free radical clearance = A0-A/A0 × 100% (3)

DPPH free radical clearance results are shown in table 3:

TABLE 3 DPPH radical scavenging Rate

From the oxidation resistance verification result, the formula and the preparation method adopted by the technical scheme of the invention are effective in resisting oxidation (free radical scavenging capacity).

Under the action of the polyalcohol humectant, the antioxidant substances such as tocopherol, polylysine and the like can reduce the stimulation of the penetration of the antioxidant into the skin, simultaneously contribute to the optimal activity and permeability of the antioxidant, and play a role in synergy with the microencapsulated levorotatory vitamin C, particularly the microencapsulated levorotatory vitamin C can be used in a large dose of 10-20 parts, so that the effect of scavenging free radicals is better.

Claims (5)

1. An antioxidant skin care composition containing levovitamin C is characterized by comprising the following components in parts by weight: microencapsulated levovitamin C: 10-20 parts of dipotassium glycyrrhizinate: 0.1-0.9 parts of sodium hyaluronate: 0.05-0.5 part of polyhydric alcohol humectant: 2-20 parts of a thickening agent: 0.2-2 parts of antioxidant: 0 to 0.8 portion and the balance of water.

2. The antioxidant skin care composition containing levovitamin C as claimed in claim 1, wherein the polyhydric alcohol humectant is one or more selected from glycerin, polyethylene glycol, propylene glycol, butylene glycol and pentylene glycol.

3. The antioxidant skin care composition containing levovitamin C as claimed in claim 1, wherein said thickener is one or more selected from xanthan gum, hydroxyethyl cellulose, carboxymethyl cellulose.

4. The antioxidant skin care composition containing levovitamin C according to claim 1, wherein the antioxidant is selected from one or more of tocopherol and polylysine.

5. The method for preparing the antioxidant skin care composition containing levovitamin C according to claim 1, comprising the steps of:

(1) adding the polyalcohol humectant, the sodium hyaluronate and the thickener into a reaction kettle, uniformly stirring, adding water, stirring and heating to 80 ℃;

(2) after the polyhydric alcohol humectant, the sodium hyaluronate and the thickening agent are completely dissolved, adding the levovitamin C, the dipotassium glycyrrhizinate and the antioxidant, and continuously stirring for about 30 min;

(3) after stirring uniformly, starting the reaction kettle to cool water, discharging when the temperature is reduced to be less than or equal to 40 ℃, and filling;

(4) and after filling, performing irradiation sterilization on 8-25Kgy Co60 to obtain the skin care composition.