CN110237233B - 一种含有环孢素的眼用药物组合物、其制备方法及用途 - Google Patents
一种含有环孢素的眼用药物组合物、其制备方法及用途 Download PDFInfo
- Publication number
- CN110237233B CN110237233B CN201910692970.5A CN201910692970A CN110237233B CN 110237233 B CN110237233 B CN 110237233B CN 201910692970 A CN201910692970 A CN 201910692970A CN 110237233 B CN110237233 B CN 110237233B
- Authority
- CN
- China
- Prior art keywords
- product
- pharmaceutical composition
- ophthalmic pharmaceutical
- preparation
- cyclosporine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title claims abstract description 78
- 108010036949 Cyclosporine Proteins 0.000 title claims abstract description 78
- 229960001265 ciclosporin Drugs 0.000 title claims abstract description 77
- 229930182912 cyclosporin Natural products 0.000 title claims abstract description 77
- 238000002360 preparation method Methods 0.000 title claims abstract description 44
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 27
- 239000004094 surface-active agent Substances 0.000 claims abstract description 25
- 239000003814 drug Substances 0.000 claims abstract description 17
- 239000000203 mixture Substances 0.000 claims abstract description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 47
- 238000002156 mixing Methods 0.000 claims description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
- 229930105110 Cyclosporin A Natural products 0.000 claims description 26
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 17
- 239000003921 oil Substances 0.000 claims description 16
- -1 polyoxyethylene Polymers 0.000 claims description 15
- 230000001502 supplementing effect Effects 0.000 claims description 15
- 239000004359 castor oil Substances 0.000 claims description 14
- 239000002202 Polyethylene glycol Substances 0.000 claims description 13
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 10
- 239000003889 eye drop Substances 0.000 claims description 10
- 239000000600 sorbitol Substances 0.000 claims description 10
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims description 8
- 206010013774 Dry eye Diseases 0.000 claims description 8
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 7
- 229930195725 Mannitol Natural products 0.000 claims description 7
- 239000000594 mannitol Substances 0.000 claims description 7
- 235000010355 mannitol Nutrition 0.000 claims description 7
- 230000003204 osmotic effect Effects 0.000 claims description 7
- 239000002562 thickening agent Substances 0.000 claims description 7
- 206010061218 Inflammation Diseases 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- 230000000843 anti-fungal effect Effects 0.000 claims description 3
- 230000002141 anti-parasite Effects 0.000 claims description 3
- 230000004054 inflammatory process Effects 0.000 claims description 3
- 206010062016 Immunosuppression Diseases 0.000 claims description 2
- 229940121375 antifungal agent Drugs 0.000 claims description 2
- 239000003096 antiparasitic agent Substances 0.000 claims description 2
- 230000001506 immunosuppresive effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000002997 ophthalmic solution Substances 0.000 abstract description 17
- 229940054534 ophthalmic solution Drugs 0.000 abstract description 17
- 229940079593 drug Drugs 0.000 abstract description 11
- 239000012535 impurity Substances 0.000 abstract description 10
- 229940023490 ophthalmic product Drugs 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 87
- 235000011187 glycerol Nutrition 0.000 description 15
- 235000019198 oils Nutrition 0.000 description 14
- 239000008215 water for injection Substances 0.000 description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
- 238000012360 testing method Methods 0.000 description 11
- 241000283973 Oryctolagus cuniculus Species 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 8
- 229940012356 eye drops Drugs 0.000 description 8
- 230000007794 irritation Effects 0.000 description 8
- 229940057917 medium chain triglycerides Drugs 0.000 description 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 5
- 230000000638 stimulation Effects 0.000 description 5
- 229920002385 Sodium hyaluronate Polymers 0.000 description 4
- 230000033228 biological regulation Effects 0.000 description 4
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 4
- 229940010747 sodium hyaluronate Drugs 0.000 description 4
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 4
- 238000013112 stability test Methods 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 206010015946 Eye irritation Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 3
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 235000019438 castor oil Nutrition 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
- 239000003018 immunosuppressive agent Substances 0.000 description 3
- 150000004667 medium chain fatty acids Chemical class 0.000 description 3
- 231100000286 mucous membrane, eye irritation or corrosion testing Toxicity 0.000 description 3
- 229960000502 poloxamer Drugs 0.000 description 3
- 229920001983 poloxamer Polymers 0.000 description 3
- 229940051841 polyoxyethylene ether Drugs 0.000 description 3
- 229920000056 polyoxyethylene ether Polymers 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 239000012085 test solution Substances 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 2
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 2
- 244000060011 Cocos nucifera Species 0.000 description 2
- 235000013162 Cocos nucifera Nutrition 0.000 description 2
- 235000001950 Elaeis guineensis Nutrition 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 206010024769 Local reaction Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 230000002924 anti-infective effect Effects 0.000 description 2
- 229960001631 carbomer Drugs 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 210000000795 conjunctiva Anatomy 0.000 description 2
- 210000004087 cornea Anatomy 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 231100000013 eye irritation Toxicity 0.000 description 2
- 210000000744 eyelid Anatomy 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 229940125721 immunosuppressive agent Drugs 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 210000000554 iris Anatomy 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000004530 micro-emulsion Substances 0.000 description 2
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 2
- 229960002446 octanoic acid Drugs 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- ZEMPKEQAKRGZGQ-AAKVHIHISA-N 2,3-bis[[(z)-12-hydroxyoctadec-9-enoyl]oxy]propyl (z)-12-hydroxyoctadec-9-enoate Chemical compound CCCCCCC(O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(O)CCCCCC)COC(=O)CCCCCCC\C=C/CC(O)CCCCCC ZEMPKEQAKRGZGQ-AAKVHIHISA-N 0.000 description 1
- 241000512897 Elaeis Species 0.000 description 1
- 240000003133 Elaeis guineensis Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- PBCJIPOGFJYBJE-UHFFFAOYSA-N acetonitrile;hydrate Chemical compound O.CC#N PBCJIPOGFJYBJE-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 206010023332 keratitis Diseases 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
刺激等级 | 总分 | 判定标准 |
1 | 0-3分 | 无刺激性 |
2 | 4-8分 | 轻度刺激 |
3 | 9-12分 | 中度刺激 |
4 | 13-16分 | 强度刺激 |
Claims (14)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910692970.5A CN110237233B (zh) | 2019-07-30 | 2019-07-30 | 一种含有环孢素的眼用药物组合物、其制备方法及用途 |
PCT/CN2020/078805 WO2021017475A1 (zh) | 2019-07-30 | 2020-03-11 | 一种含有环孢素的眼用药物组合物、其制备方法及用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910692970.5A CN110237233B (zh) | 2019-07-30 | 2019-07-30 | 一种含有环孢素的眼用药物组合物、其制备方法及用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110237233A CN110237233A (zh) | 2019-09-17 |
CN110237233B true CN110237233B (zh) | 2021-01-15 |
Family
ID=67893765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910692970.5A Active CN110237233B (zh) | 2019-07-30 | 2019-07-30 | 一种含有环孢素的眼用药物组合物、其制备方法及用途 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN110237233B (zh) |
WO (1) | WO2021017475A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110237233B (zh) * | 2019-07-30 | 2021-01-15 | 沈阳兴齐眼药股份有限公司 | 一种含有环孢素的眼用药物组合物、其制备方法及用途 |
CN111905094B (zh) * | 2020-06-15 | 2022-08-09 | 华熙生物科技股份有限公司 | 一种眼用组合物及其在制备用于干眼症的药物中的用途 |
CN114246935B (zh) * | 2020-09-23 | 2023-12-26 | 上海现代药物制剂工程研究中心有限公司 | 含有环孢素的组合物及其在制备治疗干眼症药物中的应用 |
WO2022156373A1 (zh) * | 2021-01-22 | 2022-07-28 | 成都瑞沐生物医药科技有限公司 | 一种滴眼给药治疗黄斑水肿、视神经炎和非感染性眼内炎的眼用制剂 |
CN113577024B (zh) * | 2021-08-20 | 2023-05-05 | 山西利普达医药科技有限公司 | 一种眼用组合物及其制备方法和应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE412400T1 (de) * | 2004-11-09 | 2008-11-15 | Novagali Pharma Sa | Öl-in-wasser-emulsion mit niedriger konzentration des kationischen mittels und positivem zetapotential |
CN100478025C (zh) * | 2005-03-25 | 2009-04-15 | 中国科学院上海药物研究所 | 一种环孢菌素a眼用微乳制剂及其制备方法 |
CN101130058B (zh) * | 2006-08-23 | 2011-10-05 | 华北制药集团新药研究开发有限责任公司 | 一种环孢菌素a眼用乳剂及其制备方法 |
KR20090105396A (ko) * | 2008-04-02 | 2009-10-07 | 박은석 | 면역억제제를 함유한 안과용 유제 |
IT1404931B1 (it) * | 2010-06-11 | 2013-12-09 | Medivis S R L | Composizioni oftalmiche per la somministrazione di principi attivi liposolubili . |
EP2659903B1 (en) * | 2010-12-28 | 2016-09-14 | Hanlim Pharmaceutical Co., Ltd. | Nanoemulsion-type ophthalmic composition |
CN103656617A (zh) * | 2012-09-26 | 2014-03-26 | 沈阳兴齐眼药股份有限公司 | 一种环孢素眼用溶液的制备方法 |
KR101492447B1 (ko) * | 2013-05-20 | 2015-02-23 | 주식회사태준제약 | 사이클로스포린을 함유하는 나노에멀젼 점안 조성물 및 그의 제조 방법 |
CN107929235B (zh) * | 2016-10-13 | 2021-08-17 | 沈阳兴齐眼药股份有限公司 | 一种他克莫司眼用制剂及其制备方法 |
CN110237233B (zh) * | 2019-07-30 | 2021-01-15 | 沈阳兴齐眼药股份有限公司 | 一种含有环孢素的眼用药物组合物、其制备方法及用途 |
-
2019
- 2019-07-30 CN CN201910692970.5A patent/CN110237233B/zh active Active
-
2020
- 2020-03-11 WO PCT/CN2020/078805 patent/WO2021017475A1/zh active Application Filing
Also Published As
Publication number | Publication date |
---|---|
CN110237233A (zh) | 2019-09-17 |
WO2021017475A1 (zh) | 2021-02-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN110237233B (zh) | 一种含有环孢素的眼用药物组合物、其制备方法及用途 | |
JP2019108380A (ja) | シクロスポリン組成物 | |
KR20190060787A (ko) | 카나비노이드 수용체 결합 리간드를 포함하는 조성물 | |
CN107929235B (zh) | 一种他克莫司眼用制剂及其制备方法 | |
EP2968139B1 (en) | Microemulsion topical delivery platform | |
US20230355594A1 (en) | Topical ophthalmological compositions | |
CN103656617A (zh) | 一种环孢素眼用溶液的制备方法 | |
CN103919718B (zh) | 一种维生素a棕榈酸酯滴眼剂及其制备方法和用途 | |
KR20230142548A (ko) | 국소 안과용 조성물 | |
CN102716074A (zh) | 一种贝美前列素滴眼剂及其制备方法 | |
CN111905094B (zh) | 一种眼用组合物及其在制备用于干眼症的药物中的用途 | |
TWI768056B (zh) | 倍氯松的水包油奈米乳液組成物 | |
US8969305B2 (en) | Aqueous ophthalmic solution based on cyclosporin | |
EP4282401A1 (en) | Ophthalmic preparation administered by eye drops and used for preventing and treating dry macular degeneration and retinal light damage | |
CN117503702A (zh) | 一种含环孢素的组合物、纳米胶束、其制备方法及其应用 | |
CN111437252A (zh) | 一种含有灯盏细辛提取物的眼用制剂、制备方法及应用 | |
CN118903006A (zh) | 一种眼用环孢素纳米胶束药物及其制备方法和应用 | |
CN118903005A (zh) | 一种负载环孢素的眼用纳米药物递送系统及其制备方法和应用 | |
KR20130038512A (ko) | 사이클로스포린 함유 안약 조성물 및 그 제조방법 | |
CN102716185A (zh) | 一种水包油塞利洛尔、桂皮油纳米乳抗高血压药物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP02 | Change in the address of a patent holder |
Address after: No. 25 Xinyunhe Road, Shenyang Area, China (Liaoning) Pilot Free Trade Zone, Shenyang City, Liaoning Province, 110167 Patentee after: SHENYANG XINGQI PHARMACEUTICAL Co.,Ltd. Address before: 110163 Surabaya street, Dongling District, Shenyang, Liaoning Province, No. 68 Patentee before: SHENYANG XINGQI PHARMACEUTICAL Co.,Ltd. |
|
CP02 | Change in the address of a patent holder | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: An ophthalmic drug composition containing cyclosporine, its preparation method, and use Effective date of registration: 20231008 Granted publication date: 20210115 Pledgee: Pudong Development Bank of Shanghai Limited by Share Ltd. Shenyang branch Pledgor: SHENYANG XINGQI PHARMACEUTICAL Co.,Ltd. Registration number: Y2023210000251 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20210115 Pledgee: Pudong Development Bank of Shanghai Limited by Share Ltd. Shenyang branch Pledgor: SHENYANG XINGQI PHARMACEUTICAL Co.,Ltd. Registration number: Y2023210000251 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right |