CN107050147B - Composition for bidirectionally improving gastrointestinal tract function and losing weight and beautifying and preparation thereof - Google Patents
Composition for bidirectionally improving gastrointestinal tract function and losing weight and beautifying and preparation thereof Download PDFInfo
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- CN107050147B CN107050147B CN201710070499.7A CN201710070499A CN107050147B CN 107050147 B CN107050147 B CN 107050147B CN 201710070499 A CN201710070499 A CN 201710070499A CN 107050147 B CN107050147 B CN 107050147B
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Abstract
The invention provides a composition for bidirectionally improving gastrointestinal tract functions, losing weight and beautifying and a preparation thereof, and particularly relates to a compound composition of Plantago ovata forsk husk, hawthorn and lactein and a preparation thereof. Wherein, the Plantago ovata forsk shells are subjected to low-temperature airflow crushing to obtain ultramicro wall-broken powder, the content of dietary fiber is more than or equal to 85 percent, and the content of polysaccharide is more than or equal to 9 percent; extracting fructus crataegi with 50% ethanol under reflux to obtain extract with organic acid content (calculated by citric acid) not less than 15%; the lactobacillus defatted milk is prepared by fermenting lactobacillus acidophilus, the total acid content (counted by lactic acid) is 10-20 percent, and the protein content is more than or equal to 30 percent. The composition can also be added with a flavoring agent with the ratio of 1: 0.1-0.6, and can be prepared into various oral solid preparations with or without pharmaceutically acceptable auxiliary materials. Experiments prove that: the composition disclosed by the invention can be used for improving gastrointestinal tract functions in a two-way manner, has a weight-reducing effect obviously superior to that of each component substance before combination, and has important significance for developing and utilizing new resources such as Plantago ovata forsk, hawthorn, lactein and the like or traditional medicine and food dual-purpose substances.
Description
Technical Field
The invention relates to a composition for bidirectionally improving gastrointestinal tract function, losing weight and beautifying and a preparation thereof. Belongs to the field of biological medicine and health.
Technical Field
The problems of gastrointestinal dysfunction, constipation, diarrhea and obesity become important concerns of sub-health and organic disease people by integrating the influences of factors such as social development, accelerated life rhythm, increased working pressure, changed dietary structure, food safety, environmental deterioration and the like, and the health and the life quality of people are seriously influenced. Currently, the clinical treatments for obesity, constipation, diarrhea are mainly to change dietary structure, increase exercise and are supplemented with osmotic, unidirectional regulation, irritancy and antibiotic drugs. It is a rare health product which can remarkably improve constipation and diarrhea, reduce weight and beautify the face by bidirectionally regulating gastrointestinal functions and has no any harmful damage to human body.
Plantago ovata forsk is dry mature seed shell of Plantago ovata forsk of Plantaginaceae, is batched by national Weijiu (No. 10 bulletin 2014) as a new food raw material in 2014, and is prepared by grinding Plantago ovata forsk according to a production process specified in the bulletin, wherein the content of dietary fiber is more than or equal to 80%. Modern researches have considered that Plantago ovata husk also contains polysaccharide, trace elements, protein and vitamin B1And choline and other nutrient components needed by human bodies are paid attention due to the super-large expansion coefficient and the high content of insoluble dietary fibers. The fructus crataegi is dried mature fruit of Crataegus pinnatifida or Crataegus pinnatifida of Rosaceae. As a traditional medicine and food dual-purpose medicinal material, the functional main indications in the pharmacopoeia of the people's republic of China are as follows: invigorating stomach, promoting digestion, promoting qi circulation, removing blood stasis, eliminating turbid pathogen, and reducing blood lipid. Modern researches show that the hawthorn contains various nutritional and functional components such as flavone, triterpene, fatty acid, amino acid, vitamin, polysaccharide and the like. The lactobacillus series skim milk is prepared by fermenting acidophilic lactobacillus, the content of lactic acid is more than or equal to 10 percent and the content of protein is more than or equal to 28 percent which are specified by standards issued by the ministry of health, and the lactobacillus series skim milk is a natural antibacterial peptide which is widely applied to the fields of medicines, foods, fermentation, livestock raising, feeds, cosmetics and the like, is completely nontoxic and can not cause the drug resistance of bacteria.
A liquid dairy product and a preparation method thereof (patent application publication No. CN201610045234.7) disclose that the liquid dairy product comprises 200-750 parts by weight of raw milk or reconstituted milk, 10-20 parts by weight of Plantago ovata forsk husk, 1-100 parts by weight of fruit and vegetable juice (at least one selected from banana juice, hawthorn juice, pineapple juice, celery juice, watermelon juice and carrot juice), 1-20 parts by weight of stabilizer, 10-80 parts by weight of white granulated sugar, 0-10 parts by weight of at least one selected from stevioside and mogroside, and 5-80 parts by weight of whey protein powder. A weight-reducing yogurt and its preparation method (patent application publication No. CN201210361849.2) disclose a weight-reducing yogurt prepared by mixing and fermenting semen Cassiae powder, mume fructus powder, semen plantaginis powder, folium Nelumbinis powder, fructus crataegi powder and skimmed milk.
The invention aims to prepare a composition for remarkably improving gastrointestinal tract bidirectional regulation, losing weight and beautifying and a preparation thereof by adopting a new food raw material Plantago ovata seed husk, traditional medicinal and edible hawthorn and lactein formula and adopting a specific proportion, a special process and a quality control technical scheme. Experiments prove that unexpected technical effects are obtained.
Disclosure of Invention
The invention aims to provide a composition for remarkably improving the function of bidirectionally regulating gastrointestinal tract and losing weight and beautifying and a preparation method thereof; the other purpose is to provide the composition preparation and the application thereof.
One of the objects of the present invention is achieved by the following means.
Firstly, the invention provides a composition for remarkably improving the function of bidirectionally regulating gastrointestinal tract and losing weight and beautifying, which consists of 13.7 to 60.2 weight percent of Plantago ovata forsk, 30.8 to 72.3 weight percent of hawthorn and 12.3 to 43.4 weight percent of lactein.
Preferably, the composition is characterized in that: the composition consists of 18.9 to 46.4 weight percent of plantain seed husk, 37.9 to 56.7 weight percent of hawthorn and 16.7 to 33.0 weight percent of lactein.
Further preferably, the composition is characterized by comprising 24.6-37.4% by weight of Plantago ovata forsk, 42.2-50.0% by weight of hawthorn and 20.9-26.6% by weight of lactein.
Secondly, the psyllium husk is pulverized into 800-1200 mesh ultramicro wall-breaking powder by adopting a low-temperature airflow pulverization technology at the temperature of-20 ℃ under the condition of liquid nitrogen. Wherein, the content of dietary fiber is more than or equal to 85 percent, and the content of polysaccharide is more than or equal to 9 percent.
The hawthorn is crushed into 20-40 mesh coarse powder, 10 times of 50% ethanol is added to soak the coarse powder for 0.5-1 hour, the mixture is subjected to hot reflux extraction for 1.5-2 hours at 65-70 ℃, the extraction solution is continuously extracted for 2 times, and the extraction solution is collected, concentrated and dried to obtain the hawthorn extract. Wherein the content of organic acid is more than or equal to 15 percent calculated by citric acid.
The lactobacillus series skim milk is prepared by fermenting lactobacillus acidophilus. Wherein, the protein content is more than or equal to 30 percent, and the total acid content (calculated by lactic acid) is 10 to 20 percent, preferably 12 to 18 percent, and more preferably 14 to 16 percent.
And finally, crushing the hawthorn extract and the lactein, sieving the crushed hawthorn extract and the lactein by a 80-mesh sieve, and fully and uniformly mixing the crushed hawthorn extract and the lactein with the Plantago ovata forsk ultramicro wall-broken powder to obtain the composition for remarkably improving the function of bidirectionally regulating the gastrointestinal tract and losing weight and beautifying.
Preferably, the composition can also be added with one or more of sucrose, glucose, xylitol, sucralose, stevioside and aspartame, and the addition ratio is 1:0.1 to 0.6, preferably 1: 0.2 to 0.5, more preferably 1:0.3 to 0.4.
The second purpose of the invention is realized by the following technical scheme.
Firstly, the composition is applied to the preparation of medicines, health-care foods, functional common foods, special medical foods and special dietary foods with the functions of bidirectionally improving the gastrointestinal function and losing weight and beautifying.
Secondly, the composition is added with acceptable auxiliary materials of medicines, health-care food, functional common food, special medical food and special dietary food and prepared into powder, granules, tablets and capsules.
Detailed description of the preferred embodiments
The present invention is further illustrated but not limited in any way by the following description, and any alterations or substitutions based on the teachings of the present invention are intended to fall within the scope of the present invention.
The invention provides a composition of Plantago ovata forsk husk, hawthorn and lactein and a preparation method thereof, and the composition is suitable for modern high-rhythm life, is convenient to carry and use, has obvious effect of bidirectionally regulating gastrointestinal tract functions, and has the effects of losing weight and beautifying. Has obvious beneficial effect on improving the health condition of human body.
Example 1: preparation method of Plantago ovata forsk shell ultramicro wall-breaking powder
The method comprises the following steps of breaking wall of Plantago ovata forsk shells by adopting a low-temperature jet milling technology to obtain the ultramicro wall-broken Plantago ovata forsk shells, and comprises the following specific steps:
crushing equipment: a liquid nitrogen low temperature jet mill (Gaoqiao/M-250 type) manufactured by Pudong Gaoqiao testing machine, Inc. of Shanghai.
The preparation process comprises the following steps: starting a liquid nitrogen jet cryogenic pulverizer, precooling to-20 ℃, adding Plantago ovata forsk shells with the water content less than or equal to 10%, and obtaining 1000-mesh wall-broken powder through jet milling.
Quality control: taking Plantago ovata forsk shell powder under the preparation process item, and detecting: the content of dietary fiber is 88.4%; the polysaccharide content was 9.47%.
Example 2: preparation of hawthorn extract
1. Screening of Process conditions
Selection of extraction method
Water extraction method: weighing 30g of hawthorn, adding 200ml of water, soaking for 30min, decocting for 60min, filtering, adding 150ml of water into the medicine residues, decocting for 1h, filtering, combining the two filtrates, evaporating in a water bath to dryness, and determining the content of organic acid (calculated by citric acid) to be 9.4%.
An ethanol extraction method: weighing 30g of hawthorn, adding 200ml of ethanol, soaking for 30min, refluxing in water bath for 1h, filtering, adding 150ml of ethanol into the residue, refluxing in water bath for 1h, filtering, combining the two filtrates, recovering ethanol, and evaporating in water bath to dryness. The organic acid content (calculated as citric acid) was determined to be 15.8%.
Experiments prove that the content of organic acid in the hawthorn extracted by ethanol is far higher than that of the organic acid extracted by water. Therefore, ethanol extraction is superior to water extraction.
Optimization of extraction process
1) Extraction method 1
Crushing dried hawthorn, sieving with a 20-mesh sieve, weighing 100g of hawthorn powder, placing into a round-bottom flask, adding 30% ethanol solution according to the material-liquid ratio of 1:10, heating to 60 ℃, standing for 1h, starting a reflux device, heating to 65 ℃, refluxing for 2h, and filtering to obtain filtrate; then adding 30% ethanol solution according to the feed-liquid ratio of 1:4, heating to 65 ℃, refluxing for 1h, and filtering to obtain filtrate. Mixing the two filtrates, concentrating, drying to obtain dry extract, pulverizing, and sieving with 80 mesh sieve.
2) Extraction method II
Pulverizing dried fructus crataegi, sieving with 20 mesh sieve, weighing 100g fructus crataegi powder, placing in round bottom flask, adding 50% ethanol solution at a material-to-liquid ratio of 1:10, heating to 60 deg.C, standing for 1 hr, starting reflux device, heating to 70 deg.C, and refluxing for 1.5 hr. Filtering to obtain filtrate, adding 50% ethanol solution according to the material-liquid ratio of 1:8, heating to 70 deg.C, refluxing for 1h, and filtering to obtain filtrate. Mixing the two filtrates, concentrating, drying to obtain dry extract, pulverizing, and sieving with 80 mesh sieve.
3) Extraction method III
Pulverizing dried fructus crataegi, sieving with 20 mesh sieve, weighing 100g fructus crataegi powder, placing in round bottom flask, adding 75% ethanol solution at a material-to-liquid ratio of 1:10, heating to 60 deg.C, standing for 0.5 hr, starting reflux device, heating to 65 deg.C, and refluxing for 1.5 hr. Filtering to obtain filtrate, adding 75% ethanol solution according to the material-liquid ratio of 1:7, heating to 65 deg.C, refluxing for 1h, and filtering to obtain filtrate. Mixing the two filtrates, concentrating, drying to obtain dry extract, pulverizing, and sieving with 80 mesh sieve.
4) Extraction method four
Pulverizing dried fructus crataegi, sieving with 20 mesh sieve, weighing 100g fructus crataegi powder, placing in round bottom flask, adding 95% ethanol solution at a material-to-liquid ratio of 1:10, heating to 60 deg.C, standing for 0.5 hr, starting reflux device, and refluxing at 70 deg.C for 1.5 hr. Filtering to obtain filtrate, adding 95% ethanol solution according to the material-liquid ratio of 1:10, heating to 70 deg.C, refluxing for 1h, and filtering to obtain filtrate. Mixing the two filtrates, concentrating, drying to obtain dry extract, pulverizing, and sieving with 80 mesh sieve.
Evaluation of the Process
Modern research suggests that: the hawthorn mainly contains total flavonoids, organic acids and hawthorn polysaccharides. According to the needs of the invention, the extraction method I-IV is evaluated by selecting the extract rate and the organic acid content of the extract as evaluation indexes.
The method for measuring the content of the organic acid comprises the following steps: refer to the method for measuring the content of organic acid in hawthorn in the 'Chinese pharmacopoeia' 2015 edition. The method specifically comprises the following steps: taking about 1g of extract powder, precisely weighing, precisely adding 100ml of water, shaking for dissolving, and filtering. Precisely taking 25ml of subsequent filtrate, adding 50ml of water, adding 2 drops of phenolphthalein indicator solution, titrating with sodium hydroxide titration solution (0.1mol/L), recording the volume of the titration solution consumed by the sample, and corresponding to 6.404mg of citric acid (C) per 1ml of sodium hydroxide titration solution (0.1mol/L)6H8O7) And calculating the content of the organic acid in each sample.
The method for measuring the extractum rate comprises the following steps: weighing the dry extract obtained by each extraction method, and calculating the extract rate of the hawthorn obtained by different extraction methods compared with the feeding amount of the hawthorn.
The results of the organic acid content and the extractum rate of the dry extractum obtained by the first extraction method to the fourth extraction method are shown in the table 1.
TABLE 1 different extraction methods of the dry extract organic acid content and extract rate
As seen in table 1: the second to fourth extraction methods have better extraction effect. Comprehensively considering the yield of the hawthorn extract, the content of organic acid and the convenience, safety and cost of industrialized extraction, the second extraction method is selected as the preferred extraction method of the invention.
Example 3: preparation of Lactobacilli
The composition of the invention is prepared by directly purchasing lactobacillus acidophilus, inoculating the lactobacillus acidophilus into fermentation liquor containing skim milk, fermenting and drying to obtain food-grade or medicine-grade lactein. Through detection: the protein content was 35.07%, and the total acid content (as lactic acid) was 15.03%.
Example 4: preparation of the composition 1
Weighing 95g of Plantago ovata forsk husk, and preparing ultramicro wall-broken powder according to example 1; weighing 115g of hawthorn, and preparing hawthorn extract according to example 2; 68g of the lactein powder prepared in example 3 was weighed. Placing the three into a clean stainless steel mixing container, and stirring and mixing uniformly to obtain the final product.
Example 5: preparation of the composition 2
85g of plantain seed husk is weighed, and ultramicro wall-broken powder is prepared according to example 1; weighing 110g of hawthorn, and preparing the hawthorn extract according to the example 2; 60g of the lactein powder prepared in example 3 was weighed. Placing the three into a clean stainless steel mixing container, and stirring and mixing uniformly to obtain the final product.
Example 6: preparation of the composition 3
350g of Plantago ovata forsk husk is weighed, and ultramicro wall-broken powder is prepared according to example 1; weighing 525g of hawthorn, and preparing the hawthorn extract according to the example 2; 270g of the lactein powder prepared in example 3 was weighed. Placing the three into a clean stainless steel mixing container, and stirring and mixing uniformly to obtain the final product.
Example 7: preparation of the composition 4
Weighing 300g of the composition prepared in the embodiment 6, adding 105g of mixed powder of xylitol and sucralose, and fully stirring and uniformly mixing to obtain the composition.
Example 8: preparation of the formulation 1
100g of the composition prepared in example 6 was weighed, and a small amount of pregelatinized starch, microcrystalline cellulose and magnesium stearate was added, followed by granulation and tableting to prepare tablets.
Example 9: preparation of the formulation 2
100g of the composition prepared in example 7 was weighed and prepared into powder or granules by wet/dry methods.
To further illustrate the technical effects of the compositions of the present invention, the compositions prepared in examples 6 and 7 were used as test samples and numbered as (r) and (v). The plantain seed husk superfine powder, the hawthorn extract, the lactein and a composition prepared from the plantain seed husk superfine powder, the hawthorn extract and the lactein in the weight ratio of 3:5.3:8 (note: the composition is outside the composition) are selected as reference samples and are numbered as (I), (II), (III) and (III) in sequence. Meanwhile, a negative control group and a model control group are arranged to eliminate molding interference and errors, and a comparison test for constipation, diarrhea and weight-reducing improvement is carried out, and the result is as follows:
constipation improving function test
Experimental animals: healthy male Kunming mouse (weight: 18 ~ 22g)
Constipation-causing agents: compound diphenoxylate tablet (2.5 mg/tablet)
Experimental methods and results:
1. dosage given: the daily sample dose of the composition (test samples (iv), (v)) of the present invention for 60kg adults was determined to be 10g, and the sample dose was 26.0 mg/mouse based on the weight of 20g mice. The sample dosage of the control sample is determined to be 26.0 mg/sample according to the principle of equal dosage sample comparison. According to the principle of equal-dose sample feeding comparability, the highest daily recommended dose of plantain seed husk powder, hawthorn and lactobacillus specified by the state is combined to determine that the sample feeding amount of a control sample is 26.0 mg/sample; control sample 2 gives 10.6 mg/sample; control sample (18.7 mg/sample).
2. Test protocol and data: 80 healthy Kunming male mice are selected and divided into a blank control group, a model control group, a sample control group (I, II, III, IV) and a test group (IV, V) according to weight balance, and each group contains 10 mice. The animals are fed normally for 10 days and fasted for 16h before the experiment. The mice of the model control group and the experimental groups I to II are both administrated with 10mg/kg compound diphenoxylate constipation model in a gastric lavage mode, and the blank control group is administrated with water in equal amount to replace a molding medicament for molding for 30 min. And (3) feeding blank ink of a blank control group and a model control group according to the gastric lavage quantity of 2ml/100g, and feeding ink suspension containing corresponding samples of the experimental groups. In the experiment, mice are normally raised in a single cage, water is normally drunk, the black defecation time of the first mouse and the number and weight of the first mouse in 5 hours are recorded, and the results are shown in table 2.
TABLE 2 Constipation modeling and defecation statistics for mice
As seen in table 2: the time of first defecation, the number of defecation granules within 5h and the weight of defecation within 5h of the model control group and the blank control group all meet P <0.01, and the model control group and the blank control group have high statistical difference, which indicates that the constipation model of the mice manufactured by orally administering 10mg/kg of compound diphenoxylate is established. Compared with a model control group and a sample control group (I, II, III, IV), the test group (IV) and the sample control group (IV, II, III, IV) have statistical differences that the first defecation time, the number of the defecation granules within 5h and the defecation weight within 5h all meet P < 0.05; compared with the test group IV, the first defecation time, the number of the defecation particles within 5h and the defecation weight within 5h all meet P & gt 0.05, and no statistical difference exists.
3. And (4) test conclusion: the first defecation time of the test group (the fourth and the fifth) is shortened by 1.5 to 5.7 times compared with the first defecation time of the sample control group (the fourth, the third and the sixth); the number of the defecation grains is increased by 1.4 to 3.2 times within 5 hours; the weight of the excrement in 5 hours is increased by 1.2 to 1.6 times. The composition provided by the invention is proved to be remarkably improved in the improvement of the constipation of the mice.
Experiment for relieving diarrhea by using waste rocks
Experimental animals: healthy Kunming seed rat (180 to 220g)
Laxative, senna leaf decoction
Experimental methods and results:
1. dosage given: the daily dosage of the composition (test samples (iv), (v)) of the present invention for 60kg adult was determined to be 10g, and the daily dosage of the composition for 200g rat was 180.0 mg/rat based on the weight. The sample dosage of the control sample is determined to be 180.0 mg/sample according to the principle of equal dosage sample comparison. According to the principle of equal-dose sample feeding comparability, the highest daily recommended dose of plantain seed husk powder, hawthorn and lactobacillus specified by the state is combined to determine that the sample feeding amount of a control sample is 180.0 mg/sample; control sample ② the sample dosage is 74.0 mg/sample; control sample (c) the amount of sample given was 129.6 mg/sample.
2. Preparation of a laxative: soaking folium sennae in cold water for 30min, boiling, decocting for 5min, removing residue, and concentrating to 1 g/ml.
3. Test protocol and data: 80 healthy Kunming rats with half of male and female are selected and divided into blank control groups, model control groups, sample control groups (i, ii, iii and iv) and test groups (i and v) according to weight balance, wherein each group comprises 10 rats. The animals are fed normally for 10 days and fasted for 16h before the experiment. The rats of the model control group and the first to sixth experimental groups are respectively fed with 1ml/100g of senna decoction in a gastric lavage mode, 1 time/day of the senna decoction is used for making a diarrhea model, and the blank control group is fed with water with the same amount to replace a model making medicine. And (3) according to the gastric lavage amount of 2ml/100g, adding distilled water to a blank control group and a model control group, and adding distilled water suspension containing corresponding samples to the experimental groups. The time interval between the water decoction of the gastric lavage senna and the gastric lavage sample material is 3h, and the time interval is 3d continuously. In the test, the rats are normally fed in a single cage, water and food are normally drunk, the defecation condition of each rat is recorded for 0-72 h, and the stool dilution rate is calculated according to the following formula, and the result is shown in table 3.
TABLE 3 rat diarrhea modeling and stool dilution rate statistics
As seen in table 3: the stool dilution rate of the model control group and the blank control group meets the requirement that P is less than 0.01, and the model has high statistical difference, which indicates that the diarrhea model of the rat is established by feeding 1ml/100g senna water decoction through the gavage. Compared with a model control group and a sample control group (I, II, III, IV), the test group (IV) and the sample control group (IV) have statistical differences, and the stool dilution rate of the test group (IV) and the sample control group (IV, III, IV) meets P < 0.05; and the stool dilution rate of the test group IV and the test group V meets P & gt 0.05, and no statistical difference exists.
4. And (4) test conclusion: the stool dilution rate of the test groups (i) and (v) is reduced by 1.8 to 3.7 times within 3d compared with the stool dilution rate of the sample control groups (i), ii, iii and (v). The composition of the invention is proved to significantly relieve the diarrhea of rats.
First weight loss experiment
Experimental animals: fat rat (body weight 240 ~ 270g)
Experimental methods and results:
1. dosage given: the daily dosage of the composition (test samples (iv), (v)) of the present invention for 60kg adult was determined to be 10g, and the daily dosage of the composition for 255g rat was 180.0mg based on this. The sample dosage of the control sample is determined to be 180.0 mg/sample according to the principle of equal dosage sample comparison. According to the principle of equal-dose sample feeding comparability, the highest daily recommended dose of plantain seed husk powder, hawthorn and lactobacillus specified by the state is combined to determine that the sample feeding amount of a control sample is 180.0 mg/sample; control sample ② the sample dosage is 74.0 mg/sample; control sample (c) the amount of sample given was 129.6 mg/sample.
2. Test protocol and data: selecting 60 obese rats (each half of male and female), and dividing the rats into sample control groups (i, ii, iii and iv) and test groups (i, iv) according to weight balance and gender balance, wherein each group comprises 10 rats. 168g/d of feed containing corresponding samples (i) - (sixth) is respectively fed in the morning and afternoon according to the number, water is freely drunk, the feed is continuously fed for two weeks, and the weight of the rat before the experiment and the weight of the rat after the two weeks are recorded, and the results are shown in a table 4.
TABLE 4 weight change test data for obese rats
As seen in table 4: the weight differences of the test groups (the fourth and the fifth) compared with the sample control groups (the first, the second, the third and the sixth) all meet P <0.05, and the test groups have statistical differences; the weight differences compared in the test group IV and the test group V both meet that P is larger than 0.05, and no statistical difference exists.
3. And (4) test conclusion: compared with the sample control groups (I, II, III, IV), the test groups (I, IV) significantly reduce the weight of the obese rat, and the difference of the weight-reducing effect is significant.
Claims (5)
1. A composition for bidirectionally regulating gastrointestinal function and losing weight and beautifying comprises 24.6-37.4 wt% of Plantago ovata forsk, and is prepared by pulverizing Plantago ovata forsk at-20 deg.C and liquid nitrogen to 800-1200 meshes to obtain Plantago ovata forsk ultramicro wall-breaking powder with dietary fiber content not less than 85% and polysaccharide content not less than 9%; 42.2 to 50.0 weight percent of hawthorn is extracted by 50 percent ethanol in a reflux way, the material-liquid ratio is 1:10, the temperature is controlled to be 65 to 70 ℃, the extraction time is 1.5 to 2 hours, the hawthorn is continuously extracted for 2 times, the extracting solution is collected, concentrated and dried to obtain the hawthorn extract, and the organic acid content of the hawthorn extract is more than or equal to 15 percent based on citric acid; 20.9-26.6 wt%, protein content not less than 30 wt% and lactic acid content 10-20 wt%; the sum of the contents of all the components is 100%, and 1: 0.1-0.6 of a sweetener.
2. The composition of claim 1, wherein: the content of lactic acid in the lactein is 14-16%.
3. The composition of claim 1, wherein: the composition is prepared without adding or adding 1: 0.3-0.4 of sweetening agents.
4. The composition of claim 1, wherein: the sweetener is one or more of sucrose, glucose, xylitol, sucralose, stevioside and aspartame.
5. The composition of claim 1, wherein: the composition is applied to the preparation of medicines, health-care foods, functional common foods, special medical foods and special dietary foods with the functions of bidirectionally improving gastrointestinal functions and losing weight and beautifying, and auxiliary materials acceptable for the medicines, the health-care foods, the functional common foods, the special medical foods and the special dietary foods are added to further prepare powder, granules, tablets and capsules.
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| Title |
|---|
| 回回药方中药物八子里哈土纳本草考证研究;杨丽娟等;《中国民族医药杂志》;20141231(第12期);第49-52页，尤其是第49页右栏第1-2段，第50页右栏第4段 * |
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| CN107050147A (en) | 2017-08-18 |
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