CN106362658B - A kind of microballoon molding reactor - Google Patents

A kind of microballoon molding reactor Download PDF

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Publication number
CN106362658B
CN106362658B CN201611058499.7A CN201611058499A CN106362658B CN 106362658 B CN106362658 B CN 106362658B CN 201611058499 A CN201611058499 A CN 201611058499A CN 106362658 B CN106362658 B CN 106362658B
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China
Prior art keywords
capillary
reaction tube
shaped pipe
round
short
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CN201611058499.7A
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Chinese (zh)
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CN106362658A (en
Inventor
徐文峰
廖晓玲
肖文谦
刘雪
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Zhejiang Chaosheng Technology Co ltd
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Chongqing University of Science and Technology
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093Microreactors, e.g. miniaturised or microfabricated reactors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40Mixing liquids with liquids; Emulsifying
    • B01F23/41Emulsifying
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00788Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • B01J2219/00792One or more tube-shaped elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00889Mixing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00891Feeding or evacuation
    • B01J2219/00894More than two inlets

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

The present invention provides a kind of microballoons to form reactor.It is characterized by: being made of capillary and Y-shaped pipe.Y-shaped pipe includes round reaction tube and the passing away being connected, and is connected between the two in " Y " font cylinder funnel-form.Short capillary one, long capillary, short capillary two, the vertical parallel of totally 3 capillaries, closed to be mounted on inside the round reaction tube of Y-shaped pipe.Fluid is injected from 3 capillaries, is finally discharged by the reaction Mixed Zone of Y-shaped pipe circle reaction tube into passing away.It is an advantage of the current invention that microballoon molding reactor round reaction tube be microballoon form space is provided, water oil phase reaction is concentrated in microreactor, can be realized it is simple, quickly prepare microballoon.

Description

A kind of microballoon molding reactor
Technical field
The present invention relates to a kind of microballoons to form reactor, the principle of microballoon is prepared according to emulsion process, by water oil phase reaction collection In in microreactor.
Background technique
Conventional medicine microballoon is a kind of bead of partial size in the micron-scale, as crystal gap object, pharmaceutical carrier, zymophore Deng it is very widely used.It is cumbersome that traditional emulsion process prepares the step of micron microballoon, is finally cut using mixing speed It cuts to form microballoon, is related to concentration, temperature, the multiple parameters such as speed, mixing speed is added, technique controlling difficulty is big, microballoon size It is difficult to control.
To solve this problem, a kind of microballoon molding reactor is invented, has been designed on the basis of traditional emulsion process new Type reactor, realization concentrate on water oil phase reaction in microreactor.
Summary of the invention
Technology of the invention is that a kind of microballoon molding reactor is made of Y-shaped pipe and capillary, it is characterised in that: Y-shaped pipe includes round reaction tube and the passing away that is connected.The internal diameter D of round reaction tube is passing away internal diameter d13 Times or more, it is connected between the two in " Y " font cylinder funnel-form.Short capillary one, long capillary, short capillary two, totally 3 Capillary is parallel vertically, and tube wall is arranged by tube wall, is mounted on inside the round reaction tube of Y-shaped pipe, and closed circle reaction tube The opening at this end guarantees to be sealed without water leakage.Inside round reaction tube, from round reaction tube inside 3 capillaries opening, Reaction Mixed Zone is formed at the connector of the passing away of Y-shaped pipe.Fluid is injected from 3 capillaries, passes through Y-shaped pipe The reaction Mixed Zone of round reaction tube is finally discharged into passing away.
Preferably, the long capillary is arranged in parallel within vertically among short capillary one and short capillary two, to meet reality It is identical with liquid in the pipeline of short capillary two to test short capillary one, it is different from liquid in the pipeline of long capillary.Undercoat is thin Pipe one is concordant with two aperture lines of short capillary, and the aperture lines with long capillary are jointly at a distance of H1Distance.The long capillary energy The length of enough adjustment insertion Y-shaped pipes, can adjust H1Size.In this way design can experimental raw material it is dense The parameters such as degree, viscosity, flow velocity, are adjusted flexibly H1Size.The reaction Mixed Zone of the circle reaction tube is from long capillary The length H for the junction that tube opening is started zooming out to diameter2, H2≥20H1.Design guarantees that reaction Mixed Zone has sufficient sky Between.
Preferably, the internal diameter d of the short capillary one, long capillary, short capillary two2Size is identical;The circle of Y-shaped pipe Internal diameter D≤50d of shaped reaction pipe2.Design mainly guarantees the experiment molding necessary shearing force of microballoon.
Preferably, the inside of the round reaction tube of the Y-shaped pipe can process the funnel shaped drainage of installation one and accelerate Structure, the inner wall closing for draining the outer wall and round reaction tube of the bucket type drainage tube of accelerating structure connect, and funnel taper angle α≤ 45°;Drain the length H of the acceleration straight trip pipe of accelerating structure3≥20H1, and aperture lines are less than the reaction mixed zone of round reaction tube The region that domain diameter starts zooming out avoids diameter from reducing the function of influencing drainage accelerating structure.Drain accelerating structure purpose of design And function, it is to increase shearing force of the fluid to center, guarantees the realization that drainage accelerates.
The advantages of above scheme, is that the round reaction tube of microballoon molding reactor provides space for microballoon molding, by water Oily phase reaction concentrates in microreactor, can be realized it is simple, quickly prepare microballoon.
Detailed description of the invention
Fig. 1 is a kind of schematic cross-sectional view of conventional structure of the invention.
Fig. 2 is that the major parameter of Fig. 1 structure of the invention marks schematic diagram.
Fig. 3 is a kind of schematic front view with drainage accelerating structure of the invention.
Fig. 4 is that the major parameter of Fig. 3 structure of the invention marks schematic diagram.
Fig. 5 is overlooking structure diagram of the invention.
Wherein: 1. Y-shaped pipes;2. round reaction tube;3. short capillary one;4. long capillary;5. short capillary two;6. React Mixed Zone;7. passing away;8. bucket type drainage tube;9. accelerating straight trip pipe.
Specific embodiment
1- attached drawing 5 and specific embodiment with reference to the accompanying drawing, are further illustrated the present invention.
Specific embodiment one
A kind of conventional structure does not drain the microballoon molding reactor of accelerating structure.Short capillary 1, long capillary 4, Short capillary 25 is vertical arranged in parallel, and the internal diameter of three pipelines is 0.4mm, outer diameter 0.75mm.The internal diameter of round reaction tube 2 For 4mm, 7 internal diameter d of passing away1=0.6mm。H1=1mm, H2=25mm.Inject the 20 μ L/S of flow rate of liquid of long capillary 4, injection The 40 μ L/S of flow rate of liquid of short capillary 1, short capillary 25.
Specific embodiment two
A kind of microballoon molding reactor having drainage accelerating structure.Short capillary 1, long capillary 4, short capillary 25 Vertical arranged in parallel, the internal diameter of three pipelines is d1=0.75mm, outer diameter 1.5mm.The internal diameter of round reaction tube 2 is 20mm, 7 internal diameter d of passing away1=1mm。H1=2mm, H2=55mm.Funnel taper angle α=45 ° of the bucket type drainage tube 8 of accelerating structure are drained, Accelerate the length H of straight trip pipe 93=45mm.The 40 μ L/S of flow rate of liquid of long capillary 4 is injected, injection short capillary 1, undercoat are thin The 60 μ L/S of flow rate of liquid of pipe 25.

Claims (1)

1. a kind of microballoon forms reactor, it is made of Y-shaped pipe and capillary, it is characterised in that: Y-shaped pipe (1) includes circle Reaction tube (2) and the passing away (7) being connected, the internal diameter D of round reaction tube (2) be 3 times of passing away (7) internal diameter d1 with On, it is connected between the two in " Y " font cylinder funnel-form;Short capillary one (3), long capillary (4), short capillary two (5), Totally 3 capillaries are parallel vertically, and tube wall is arranged by tube wall, and the round reaction tube (2) for being mounted on Y-shaped pipe (1) is internal, and closes The opening at round this end of reaction tube (2);The long capillary (4) is arranged in parallel within short capillary one (3) and short capillary vertically Two (5) are intermediate;Short capillary one (3) is concordant with short capillary two (5) aperture lines, the common phase of aperture lines with long capillary (4) Distance away from H1;The long capillary (4) can adjust the length in insertion Y-shaped pipe (1), can adjust the size of H1; Length of the reaction Mixed Zone (6) of the circle reaction tube (2) from the junction that long capillary (4) opening is started zooming out to diameter Spend H2, H2 >=20H1;The short capillary one (3), long capillary (4), the internal diameter d2 size of short capillary two (5) are identical;"Y" Internal diameter D≤50d2 of the round reaction tube (2) of type pipe (1);The inside energy of the round reaction tube (2) of the Y-shaped pipe (1) One funnel shaped drainage accelerating structure of enough processing installations, outer wall and the circle for draining the bucket type drainage tube (8) of accelerating structure are anti- The inner wall closing connection of (2), funnel taper angle α≤45 ° should be managed;The length H3 of the acceleration straight trip pipe (9) of drainage accelerating structure >= 20H1, and aperture lines are less than the region that reaction Mixed Zone (6) diameter of round reaction tube (2) starts zooming out;It is reacted in circle (2) inside is managed, from the opening of internal 3 capillaries of round reaction tube (2), to the company of the passing away (7) of Y-shaped pipe (1) Interface forms reaction Mixed Zone (6);Fluid is injected from 3 capillaries, passes through the anti-of the round reaction tube (2) of Y-shaped pipe (1) Mixed Zone (6) are answered, into passing away (7), are finally discharged.
CN201611058499.7A 2016-11-27 2016-11-27 A kind of microballoon molding reactor Active CN106362658B (en)

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Application Number Priority Date Filing Date Title
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CN106362658B true CN106362658B (en) 2019-02-01

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN215277246U (en) * 2021-07-02 2021-12-24 苏州姆比特生物科技有限公司 Phase change microcapsule equipment

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101376093A (en) * 2008-09-24 2009-03-04 东华大学 Method for preparing coaxial microchannel reactor
CN101624364A (en) * 2009-08-06 2010-01-13 王传华 CTP synthesis technology of rubber scorch retarder and device thereof
CN206262516U (en) * 2016-11-27 2017-06-20 重庆科技学院 A kind of microballoon synthesis reactor
CN206262515U (en) * 2016-11-27 2017-06-20 重庆科技学院 A kind of microballoon for having accelerating structure is molded reactor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10250406B4 (en) * 2001-10-30 2007-10-25 Hitachi, Ltd. Reaction device and mixing system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101376093A (en) * 2008-09-24 2009-03-04 东华大学 Method for preparing coaxial microchannel reactor
CN101624364A (en) * 2009-08-06 2010-01-13 王传华 CTP synthesis technology of rubber scorch retarder and device thereof
CN206262516U (en) * 2016-11-27 2017-06-20 重庆科技学院 A kind of microballoon synthesis reactor
CN206262515U (en) * 2016-11-27 2017-06-20 重庆科技学院 A kind of microballoon for having accelerating structure is molded reactor

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Effective date of registration: 20230328

Address after: 324400 No. 3 Workshop of Zhejiang Huijin Machinery Manufacturing Co., Ltd., No.1 Fengshan Road, Longyou Economic Development Zone, Muhuan Township, Longyou County, Quzhou City, Zhejiang Province

Patentee after: Zhejiang Chaosheng Technology Co.,Ltd.

Address before: No. 20, East Road, University City, Chongqing, Shapingba District, Chongqing

Patentee before: Chongqing University of Science & Technology