CN1052636C - Application of alcohol extract of xanthoceras sorbifolia bunge in preparation of medicine for treating mental retardation - Google Patents
Application of alcohol extract of xanthoceras sorbifolia bunge in preparation of medicine for treating mental retardation Download PDFInfo
- Publication number
- CN1052636C CN1052636C CN93111010A CN93111010A CN1052636C CN 1052636 C CN1052636 C CN 1052636C CN 93111010 A CN93111010 A CN 93111010A CN 93111010 A CN93111010 A CN 93111010A CN 1052636 C CN1052636 C CN 1052636C
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- Prior art keywords
- medicine
- mental retardation
- alcohol extract
- application
- preparation
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000003814 drug Substances 0.000 title claims abstract description 14
- 208000036626 Mental retardation Diseases 0.000 title claims abstract description 11
- 244000248162 Xanthoceras sorbifolium Species 0.000 title claims abstract description 9
- 235000009240 Xanthoceras sorbifolium Nutrition 0.000 title claims abstract description 9
- 238000002360 preparation method Methods 0.000 title claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title abstract description 14
- 239000000284 extract Substances 0.000 title abstract description 10
- 241000612118 Samolus valerandi Species 0.000 title 1
- 206010012289 Dementia Diseases 0.000 claims abstract description 9
- 235000020183 skimmed milk Nutrition 0.000 claims description 12
- 235000013399 edible fruits Nutrition 0.000 claims description 8
- 239000000469 ethanolic extract Substances 0.000 claims 1
- 150000007949 saponins Chemical class 0.000 abstract description 11
- 239000001397 quillaja saponaria molina bark Substances 0.000 abstract description 10
- 229930182490 saponin Natural products 0.000 abstract description 10
- 235000019750 Crude protein Nutrition 0.000 abstract description 8
- 230000003925 brain function Effects 0.000 abstract description 8
- 235000019784 crude fat Nutrition 0.000 abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 8
- 230000006870 function Effects 0.000 abstract description 3
- 210000004556 brain Anatomy 0.000 abstract description 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 230000002888 effect on disease Effects 0.000 abstract 1
- 208000008967 Enuresis Diseases 0.000 description 7
- 239000002775 capsule Substances 0.000 description 7
- 238000001035 drying Methods 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000008187 granular material Substances 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 235000014593 oils and fats Nutrition 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000008157 edible vegetable oil Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002481 ethanol extraction Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000000401 methanolic extract Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229960004793 sucrose Drugs 0.000 description 2
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical compound CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 241001529246 Platymiscium Species 0.000 description 1
- 241001093760 Sapindaceae Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000003495 polar organic solvent Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A brain function improving medicine for treating mental retardation and dementia is an alcohol extract of shinyleaf yellowhorn seeds, and comprises the following specific contents:
crude fat crude protein saponin
1～10 15～20 10～2
Carbohydrate water and others
20 to 3010 to 15
The medicine for improving brain function can comprehensively improve the function of a brain nervous system, and has obvious curative effect on diseases such as children's mental retardation, senile dementia and the like.
Description
The present invention relates to Chinese medicine, particularly a kind of medicine of the raising brain function that is used for the treatment of mental retardation and dementia that makes with the shinyleaf yellowhorn fruit extract.
Lignum Xanthoceratis is a Sapindaceae Lignum Xanthoceratis platymiscium, have another name called the precipice Fructus Chaenomelis, belong to machaka or dungarunga, imparipinnate leaf, raceme, floral white, capsule three lobe types, the seed majority, through bright to the sub-Chemical Analysis of Wire Rod of Lignum Xanthoceratis, it contains 60% the oils and fats of having an appointment, about 26% protein, about 1.2% thick Saponin, 2.4% moisture content and other composition of 4.9%, the past is wild plant, there is the training of carrying recent northern some areas, its adaptability is strong, and is cold-resistant, drought-enduring, impoverishment tolerant, generally the utilization to Lignum Xanthoceratis mostly is two aspects, the first is checked winds and fixed drifting sand, it two is to squeeze edible oil with its seed, and through consulting relevant document both at home and abroad, finding " does not all have medicinal record to Lignum Xanthoceratis in the medicinal book on Chinese herbal medicine of Chinese pharmacopoeia and successive dynasties.
The object of the present invention is to provide a kind of medicine that improves brain function.
The medicine of raising brain function provided by the present invention can be treated enuresis, mental retardation and dementia etc. because the low caused disease of brain function is characterized in that described medicine is the extract of shinyleaf yellowhorn fruit.
One of them is the skimmed milk of Lignum Xanthoceratis kernel, contains crude fat, and by crude protein, Saponin, water, candy, trace element that 17 seed amino acids (as glutamic acid, lysine, arginine, cruel propylhomoserin etc.) are formed, the Saponin structure is:
Concrete content is: other 1～10 55～65 2～4 7～10 remaining years product processes of crude fat crude protein Saponin water are carried out according to following step:
-press kernel cake powder in advance;
-extraction defat;
-drying is pulverized, and sieves, sterilize skimmed milk.
Wherein extract defat and can adopt following manner:
-with weakly polar organic solvent such as petroleum ether, benzene, n-hexane equal under the room temperature or＜90 ℃ of situations of heating under, extraction;
-collect extract, remove desolvate the defat coarse powder.
Perhaps adopt supercritical CO
2
Can make the capsule or the granule of treatment enuresis with Lignum Xanthoceratis kernel skimmed milk.
Shinyleaf yellowhorn fruit and YINIAOTING capsule and granule be to the cure rate evident in efficacy 75% of enuresis, improvement rate 18%, and total effective rate reaches 93%, is ideal a kind of in this type of medicine at present.Simultaneously, YINIAOTING capsule or granule can also be treated mental retardation and dementia.
The present invention also provides a kind of curable substance mental retardation and dementia and enuresis that improves brain function, and described medicine is the alcohol extract of shinyleaf yellowhorn fruit, and concrete content is:
Crude fat crude protein Saponin candy water other
Surplus in the of 1～10 15～20 10～20 20～30 10～15
Technical process is as follows:
Lixiviates such as shinyleaf yellowhorn fruit the after-squeezing or Lignum Xanthoceratis skimmed milk usefulness alcohol organic solvent such as ethanol, methanol, n-butyl alcohol;
-collect lixiviating solution, remove and desolvate, sterilize the alcohol extract clear paste.Can make electuary or tablet with described extract clear paste.Improve the brain function medicine and can improve the cerebral nervous system function comprehensively, diseases such as mental retardation of children and person in middle and old age's dementia are had obvious curative effects.The present invention is that raw material extracts medicine with the shinyleaf yellowhorn fruit, show through various pharmacological testings, without any side effects, preparation technology is simple for Lignum Xanthoceratis kernel skimmed milk, Saponin yield height, cost are low, contain 60% oils and fats in the fruit, contain 17 seed amino acids, the oils and fats of taking off can be used as edible oil and senior paint etc.Be described in detail the present invention below by embodiment.
Embodiment 1
The 1kg Lignum Xanthoceratis seed of gathering, clean, drying is peelled off kind of a skin and is got the 440g kernel, presses kernel in advance and gets the cake powder, at room temperature press n-hexane with n-hexane: cake powder=lixiviate in 1: 14 to 5 times, each 24～48 hours, collect lixiviating solution, remove with distillation under vacuum and desolvate, drying and crushing sieve sterilize the 176g skimmed milk, composition is:
Crude fat crude protein Saponin water other
5.4 61 3.3 7.5 22.8 embodiment 2
Example 1 described skimmed milk 76g is added an amount of ethanol become soft material, the granulation of sieving, the heat drying granulate that sieves is adorned 380 of No. 2 capsules.This capsule is the YINIAOTING capsule of treatment enuresis.
Embodiment 3
With example 1 described skimmed milk 100g, add the 400g cane sugar powder and be mixed, granulate, drying, sterilization, 50 in dress 10g bag is a kind of YINIAOTING granule.
Embodiment 4
The 1Kg Lignum Xanthoceratis seed of gathering gets the 170g skimmed milk by example 1 described step, and composition is:
Crude fat crude protein Saponin water other
6.2 59 3.5 8.2 23.1
Embodiment 5
With example 4 gained skimmed milk, press ethanol: skimmed milk=lixiviate in 2: 1 3～4 times, each 16 to 32 hours, collect lixiviating solution, remove and desolvate, sterilization gets ethanol extraction 25.5g, and composition is:
Crude fat crude protein Saponin candy water other
8.0 15.6 19.2 23.5 14.1 19.6
Embodiment 6
The Lignum Xanthoceratis seed 1Kg identical in quality with embodiment 4 that gather cleans drying, the squeezing oil removing, the 750g cake, with 2 times methanol lixiviates 3～4 times, each 20～40 hours, collect lixiviating solution except that desolvating, sterilize methanolic extract 80g, composition:
Crude fat crude protein Saponin candy water other
6.1 17.1 12.3 20.5 12.6 31.4
Embodiment 7
With example 5 gained ethanol extraction clear paste 10g, add 0.2g dried starch, 0.06g50% ethanol and 0.1g Pulvis Talci, mixing, tabletting, sterilization gets 60 tablets of 200mg sheet.Can treat enuresis, mental retardation and dementia.
Embodiment 8
6 gained methanolic extract clear paste 10g add the 32g cane sugar powder with example, the mixed pelletization drying, and sterilization, 4 in dress 10g bag can be treated enuresis, mental retardation and dementia.
Claims (1)
1. the application of shinyleaf yellowhorn fruit skimmed milk ethanol extract in preparation treatment mental retardation and dementia medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93111010A CN1052636C (en) | 1993-03-29 | 1993-03-29 | Application of alcohol extract of xanthoceras sorbifolia bunge in preparation of medicine for treating mental retardation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93111010A CN1052636C (en) | 1993-03-29 | 1993-03-29 | Application of alcohol extract of xanthoceras sorbifolia bunge in preparation of medicine for treating mental retardation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1092991A CN1092991A (en) | 1994-10-05 |
| CN1052636C true CN1052636C (en) | 2000-05-24 |
Family
ID=4988820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93111010A Expired - Lifetime CN1052636C (en) | 1993-03-29 | 1993-03-29 | Application of alcohol extract of xanthoceras sorbifolia bunge in preparation of medicine for treating mental retardation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1052636C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012006865A1 (en) * | 2010-07-16 | 2012-01-19 | 哈尔滨三乐生物工程有限公司 | Use of xanthoceras sorbifolia and xanthoceras sorbifolia extract in preparing medicaments for curing urinary incontinence or overactive bladder |
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|---|---|---|---|---|
| US6391310B1 (en) * | 1996-03-13 | 2002-05-21 | Archer Daniels Midland Company | Method of preparing and using isoflavones for the treatment of neurological symptoms |
| DK1066042T3 (en) * | 1998-03-26 | 2006-12-18 | Phytopharm Plc | Steroidal saponins for the treatment of Alzheimer's disease |
| GB9923076D0 (en) | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
| US6616943B2 (en) | 2001-08-31 | 2003-09-09 | Fountain Silver Limited | Composition comprising Wenguanguo extracts and methods for preparing same |
| US7727561B2 (en) | 2001-08-31 | 2010-06-01 | Pacific Arrow Limited | Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof |
| CN100346805C (en) * | 2001-10-31 | 2007-11-07 | 杨柏珍 | Xanthoceras sorbifolia bunge shell extract for treating cerebral hypofunction and anti-diabetic activity |
| US8614197B2 (en) | 2003-10-09 | 2013-12-24 | Pacific Arrow Limited | Anti-tumor compounds with angeloyl groups |
| US7488753B2 (en) | 2003-10-09 | 2009-02-10 | Pacific Arrow Limited | Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof |
| US7514412B2 (en) | 2003-10-09 | 2009-04-07 | Pacific Arrow Limited | Anticancer biangeloyl saponins |
| US7262285B2 (en) | 2003-10-09 | 2007-08-28 | Pacific Arrow Limited | Anticancer biangeloyl saponins |
| US9884884B2 (en) | 2004-07-07 | 2018-02-06 | Baizhen Yang | Compound extracted from husk and fruit stem of xanthoceras sobifolia and its extracting method and use thereof |
| US9382285B2 (en) | 2004-09-07 | 2016-07-05 | Pacific Arrow Limited | Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells |
| US8735558B2 (en) | 2005-02-14 | 2014-05-27 | Pacific Arrow Limited | Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof |
| US8586719B2 (en) | 2005-04-27 | 2013-11-19 | Pacific Arrow Limited | Triterpenes for modulating gene expression and cell membrane, and as antiprotozoal agents |
| CN100482254C (en) | 2006-01-12 | 2009-04-29 | 哈尔滨三乐生物工程有限公司 | Method for extracting effective site of Xanthoceras sorbifolia hulled seed |
| US20120277308A1 (en) | 2010-07-16 | 2012-11-01 | Pacific Arrow Limited | compounds for treating cancer and other diseases |
-
1993
- 1993-03-29 CN CN93111010A patent/CN1052636C/en not_active Expired - Lifetime
Non-Patent Citations (1)
| Title |
|---|
| 自然资源研究1985(1) 1985.1.1 我国特有植物文冠果的化学成分生物活性及综合利用的研究，王红斗等 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012006865A1 (en) * | 2010-07-16 | 2012-01-19 | 哈尔滨三乐生物工程有限公司 | Use of xanthoceras sorbifolia and xanthoceras sorbifolia extract in preparing medicaments for curing urinary incontinence or overactive bladder |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1092991A (en) | 1994-10-05 |
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