CN104922051A

CN104922051A - Traditional Chinese medicine eye cream capable of relieving canthus wrinkles and eye pouches and preparation method thereof

Info

Publication number: CN104922051A
Application number: CN201510409979.2A
Authority: CN
Inventors: 孙霞
Original assignee: Qingdao Hengbo Instrument Co Ltd
Current assignee: Qingdao Hengbo Instrument Co Ltd
Priority date: 2015-07-14
Filing date: 2015-07-14
Publication date: 2015-09-23

Abstract

The invention provides a traditional Chinese medicine eye cream capable of relieving canthus wrinkles and eye pouches and a preparation method thereof. The ingredient medicine of the traditional Chinese medicine eye cream comprises, by weight, 10-20 parts of white poria, 10-20 parts of horsetail, 10-20 parts of astragalus membranaceus, 10-20 parts of leonurus, 10-20 parts of myrrh, 10-20 parts of salvia miltiorrhiza, 10-20 parts of peach kernel, 10-20 parts of fried sanguisorba, 10-20 parts of flowers carthami, 10-20 parts of radix paeoniae alba, 10-20 parts of bletilla striata, 10-20 parts of mint, 10-20 parts of pyracantha, 10-20 parts of ampelopsis japonica, 10-20 parts of radix angelicae, 10-20 parts of rhizoma cyperi, 10-20 parts of calendula, 10-20 parts of felwort, 10-20 parts of geranium and 10-20 parts of roses. According to the eye cream, the pharmacological research achievements of traditional and modern traditional Chinese medicine are referred, the natural traditional Chinese medicine capable of nourishing liver, tonifying kidney, removing nebula, calming liver, suppressing yang, clearing away heat and toxic materials and eliminating edema is selected, the traditional Chinese medicine is capable of strengthening the body resistance to eliminate pathogenic factors, clearing hollow viscera, discharging poison, invigorating the circulation of scattered stasis, regulating metabolism function of a human body and improving blood circulation of the skin around eyes of the human body, and therefore the purposes of subsiding swelling, resolving stagnation and relieving fatigue are achieved.

Description

A kind of Chinese medicine eye cream alleviating canthus wrinkle eye pouch and preparation method thereof

Technical field

The present invention relates to the beauty treatment preparation containing deriving from plant, animal or mineral component, particularly a kind of Chinese medicine eye cream and preparation method thereof alleviating canthus wrinkle, eye pouch.

Background technology

Agerasia is the dream of each woman, have the eyes that a pair of is bright, the glamour value of woman can be allowed to increase, the eyes are the windows of the mind, eyes also can expose the age of woman, if your eyes have grown microgroove black eye, the microgroove that how to disappear has become a very urgent problem of going to solve.Skin is near the eyes especially tender and lovely, and the skin of eyes surrounding is only containing a small amount of fat, and eyelid is the skin that human body is the thinnest, and very fragile, easy edema, is easy to grow wrinkle, and deepens with advancing age and constantly.Occur that canthus wrinkle is not difficult to remove, because horny layer is weaker, recovery fast.So, how to remove canthus wrinkle?

First daily misconduct custom must be given up.Such as: do not narrow one's eyes and see thing, answer wearing spectacles if any myopia, astigmatism, correct defects of vision; Often deliberately do not blink; Very important eyelid edema, look into the cause of disease, suit the remedy to the case; As fruit fat-reducing is gradual, because body weight declines suddenly, skin does not have enough time to adapt to the minimizing of body fat, can cause wrinkle yet; Make up when removing ornaments and formal dress and do not pull at skin of disputing over trifles; Should keep the skin wet in time in dry environment, otherwise wrinkle also can increase.

Secondly must supply enough nutrients and supplement the moisture lost, selecting suitable moisturizing eye cream to be also an important link.Must guard against when being coated with eye cream and carelessly smear, correct method is: be first stained with a little eye cream with the third finger, and open even for eye cream with the third finger of another hands, " printing " is in eyelid surrounding lightly, finally massages five to six times in the mode of looping.

It is too fat to move that eye pouch refers to that lower eyelid portion organizes, and hangs from above in bag-shaped.In frame, fat content and the supportive structure of lower eyelid maintain poised state under normal circumstances, when due to capsula adiposa bulbi overheap or lower eyelid, this balance is supported that structure thin is weak and is changed, the restriction that capsula adiposa bulbi breaks through lower eyelid protrudes from outside socket of the eye, namely forms the bag-shaped deformity of lower eyelid.Clinical manifestation is that skin of lower eyelid is lax, accumulation, capsula adiposa bulbi is deviate to hang from above in bag-shaped, outer canthus position moves down, lower margo palpebrae and eyeball are fitted not tight, lower margo palpebrae radian increases, move excessive tear outside lower lacrimal point, the aging absorption of facial skeleton causes lower eyelid supporting structure secondary to relax, and is the main cause that person in middle and old age's eye pouch is formed.

Eye pouch caused due to cutis laxa.This understanding has very large representativeness.Through demonstration, it is also the main cause that eye pouch produces.So promoting skin tightness is main Ways to improve.More satisfactory mode is oral collagen.But do not extravagantly hope and thoroughly improve at short notice, because the reparation of eye pouch needs certain process.

Increasing the weight of of eye pouch is because hyperliposis causes.This is also have representational understanding, and Orbital septum fat has its normal physiological function, and its major function is protection eyeball.Also be one of reason forming eye pouch simultaneously.Why forming " pouch sample " outward appearance, is caused by the hypotonia due to socket of the eye barrier film completely.The minimizing technology of this eye pouch carries out operation liposuction exactly.If after operation liposuction, and do not carry out the reparation of socket of the eye barrier film, consequence will inevitably cause eye pouch to recur.If take out fat in a large number, that must cause the depression of lower eyelid, increases the weight of aged appearance.

Cosmetics can rescue eye pouch.This will analyze from two aspects, if " functional " eye pouch, that is during eye pouch obviously, time and not obvious.Suitable applied nutrition frost class cosmetics for prevent eye pouch increase the weight of can play a role.And once eye pouch is " pathologic ", namely organizational structure there occurs change, and eye pouch manifests for a long time, and increases the weight of gradually.If want to be corrected by cosmetics, that is futile completely.Must carry out in advance eyes maintenance, eye pouch physiologic factor except few pathologic factor accounts for the overwhelming majority, a large amount of women ignores the demand to eyes maintenance when health, cause starting occurring old and feeble after speed very fast, it is conscious before aging that to carry out maintenance extremely important.

The appearance of eye pouch with increase the weight of to be one of the mark of skin of face aging.Wanting the generation avoiding eye pouch completely, be unrealistic is also impossible.Because aging is the natural law, be overpowering.As long as but note a little, be the generation completely likely delaying and prevent eye pouch.

Theory of Chinese medical science thinks that the generation of most of eye problems is relevant with Liver and kidney void, and after Liver and kidney void, kidney essense can not nourishing the liver blood, and " liver opening at eye ", finally because of essence and blood loss, shows and eyes just form black eye, eye pouch, canthus wrinkle, ocular edema.And modern study also confirms that eye pouch, canthus wrinkle, eye edema are owing to often staying up late, emotional instability, eye strain, aging, cause vein blood vessel blood flow rate too slow, eye part skin red blood cell is for hypoxgia, and in vein blood vessel, carbon dioxide and metabolic waste accumulation too much, form chronic hypoxia, blood is comparatively dark and formed and be detained and cause eye pigmentation, and eye edema and eye pouch.This and theory of Chinese medical science match.Eye pouch can pass through operative correction.Laser also can improve eye pouch, promotes the metabolism of skin, and promote the circulation of blood, lymph circulation, make the desalination slowly of deep eye pouch, about course for the treatment of will see that obvious laser beautifying goes the effect of eye pouch later.Laser goes eye pouch to belong to noinvasive beauty treatment, does not need anesthesia, but expensive, and has certain risk, is not everyone rising of can bearing.

Summary of the invention

Technical problem to be solved by this invention is, skin is near the eyes especially tender and lovely, and the skin of eyes surrounding is only containing a small amount of fat, and eyelid is the skin that human body is the thinnest, very fragile, easy edema, be easy to grow wrinkle, and deepen with advancing age and constantly.And along with the growth at age, spleen and stomach function weakens, and can cause body internal water accumulation, cause palpebra inferior to relax, form eye pouch; Liver opening at eye, the problem of liver shows eyes place entirely, if liver cannot clear toxin, will form eye pouch.Suffer from a deficiency of the kidney and body fluid dysbolismus can occur, deficiency of kidney-QI, with the passing of time cause QI and blood not smooth, occur eye pouch.Though clinical laser has certain curative effect, expensive, there is side effect in various degree or cause some complication; Chinese medicine product then because of its draw materials natural, safety good, low side effect, documents and materials are abundant, clinical efficacy is good and enjoy favor.But existing prescription specific aim is poor, effectively can not alleviate canthus wrinkle, the appearance of eye pouch, and also has certain side effect.Therefore, the Chinese medicine eye cream finding a kind of highly effective and safe becomes the urgent needs of people.

For solving these technical barriers, the invention provides a kind of alleviation canthus wrinkle, eye pouch Chinese medicine eye cream, in Chinese medicine eye cream described in it, the parts by weight of various crude drug are: Poria 10 ~ 20 parts, Herba Equiseti Hiemalis 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Myrrha 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, 10 ~ 20 parts, Semen Persicae, Radix Sanguisorbae preparata 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, the Radix Paeoniae Alba 10 ~ 20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Herba Menthae 10 ~ 20 parts, pyracantha fortuneana 10 ~ 20 parts, Radix Ampelopsis 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Flos Inulae 10 ~ 20 parts, Radix Gentianae 10 ~ 20 parts, Flos Pelargonii 10 ~ 20 parts, Flos Rosae Rugosae 10 ~ 20 parts.

Described alleviation canthus wrinkle, eye pouch Chinese medicine eye cream, in Chinese medicine eye cream described in it, the parts by weight of various crude drug can be: Poria 10 ~ 15 parts, Herba Equiseti Hiemalis 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Myrrha 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, 10 ~ 15 parts, Semen Persicae, Radix Sanguisorbae preparata 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami, the Radix Paeoniae Alba 10 ~ 15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 15 parts, Herba Menthae 10 ~ 20 parts, pyracantha fortuneana 10 ~ 20 parts, Radix Ampelopsis 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Flos Inulae 10 ~ 20 parts, Radix Gentianae 10 ~ 20 parts, Flos Pelargonii 10 ~ 20 parts, Flos Rosae Rugosae 10 ~ 20 parts.

Described alleviation canthus wrinkle, eye pouch Chinese medicine eye cream, in Chinese medicine eye cream described in it, the parts by weight of various crude drug can also be: Poria 10 ~ 20 parts, Herba Equiseti Hiemalis 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Myrrha 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, 10 ~ 20 parts, Semen Persicae, Radix Sanguisorbae preparata 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, the Radix Paeoniae Alba 10 ~ 20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Herba Menthae 10 ~ 15 parts, pyracantha fortuneana 10 ~ 15 parts, Radix Ampelopsis 10 ~ 15 parts, the Radix Angelicae Dahuricae 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, Flos Inulae 10 ~ 15 parts, Radix Gentianae 10 ~ 15 parts, Flos Pelargonii 10 ~ 15 parts, Flos Rosae Rugosae 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine eye cream alleviating canthus wrinkle, eye pouch, and described in it, preparation method comprises the following steps:

A. get Herba Menthae, Myrrha, Rhizoma Cyperi and the Pseudobulbus Bletillae (Rhizoma Bletillae) way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as component 1;

B. pyracantha fortuneana, Flos Inulae, Radix Gentianae, Flos Pelargonii and Flos Rosae Rugosae ethanol heat is extracted 2 times, merge concentrated extracting solution;

C. by all the other crude drug water extraction 2 times, concentrated extracting solution is merged;

D. two kinds of extracting solution above-mentioned steps obtained are condensed into extractum, as component 2;

E. add substrate after component 1 being mixed with component 2 to be in harmonious proportion, sterilization tinning.

In described step a, first crude drug Herba Menthae, Myrrha, Rhizoma Cyperi and Pseudobulbus Bletillae (Rhizoma Bletillae) steam method can be distilled, obtain crystal, then pulverize, cross 120-150 mesh sieve, for subsequent use as component 1.

In described step b, pyracantha fortuneana, Flos Inulae, Radix Gentianae, Flos Pelargonii and Flos Rosae Rugosae can be added the soak with ethanol 4-6 hour accounting for its quality 5-10 times amount, heating extraction 2 times, each 1-2 hour, merge extractive liquid, removes supernatant after leaving standstill, then 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.25 filtrate, stand for standby use.

In described step c, surplus stock medicine can be added the water accounting for its quality 5-10 times amount, heating extraction 2 times, each 1-2 hour, merge extractive liquid, removes supernatant after leaving standstill, then 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.25 filtrate, stand for standby use.

In described steps d, two kinds of filtrates above-mentioned steps can extracted, put into economic benefits and social benefits vacuum concentrator and mix, and when first filtrate being concentrated into 80 DEG C, relative density is the concentrated solution of 1.32, then inserts 0 ~ 5 DEG C of deepfreeze 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g extractum, becomes component 2.

In described step e, component 1 can be dropped in component 2, stir, heating, mediation substrate, becomes gel; Described substrate is selected from: Tween-80, triethanolamine, propylene glycol, one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline.

The Chinese medicine eye cream of described alleviation canthus wrinkle, eye pouch, the using method of its Chinese medicine eye cream is, at every turn just before going to bed after clean, by eye cream uniform application near the eyes, and massaging 15-20 minute near the eyes by middle finger finger belly, after fully absorbing to it, getting up early in second day washes away.

The present invention's reference is Chinese medicine pharmacological research achievement at all times, the natural Chinese medicine that screening Glycerin, inrigorating qi and promoting blood circulation, liver heat removing and eyesight improving, nourishing liver and kidney, improving acuity of vision and removing nebula, suppressing the hyperactive liver and subsiding YANG, detumescence dewater, strengthening vital QI to eliminate pathogenic factors, purging FU-organs lets out poison, promoting blood circulation to remove blood stasis, regulates the metabolism function of human body, improves human body periocualr skin blood circulation, thus reach detumescence blood stasis dispelling, fatigue alleviating, the skin around the eyes that compacts, desalination eye pouch, reduce wrinkle, beautify the object of appearance.The present invention is according to Traditional Chinese medical theory and modern pharmacological research result, and repeated screening medicine for external use, is mixed with Chinese medicine eye cream, has effect of blood circulation promoting and blood stasis dispelling, Glycerin, improving acuity of vision and removing nebula, warm promoting blood circulation, skin-active detumescence, blood-nourishing and freckle-removing, the skin that compacts.The present invention effectively can expand peripheral vessel, improves face microcirculation near the eyes, and detumescence blood stasis dispelling, has certain inhibitory action to the generation of wrinkle.Therapeutic effect of the present invention is more satisfactory, and non-toxic and safe, preparation method is simple and easy to do, can create good social benefit and economic benefit.

Detailed description of the invention

Cosmetics can rescue eye pouch.This will analyze from two aspects, if " functional " eye pouch, that is during eye pouch obviously, time and not obvious.Suitable applied nutrition frost class cosmetics for prevent eye pouch increase the weight of can play a role.And once eye pouch is " pathologic ", namely organizational structure there occurs change, and eye pouch manifests for a long time, and increases the weight of gradually.If want to be corrected by cosmetics, that is futile completely.Must carry out in advance eyes maintenance, eye pouch physiologic factor except few pathologic factor accounts for the overwhelming majority, a large amount of women ignores the demand to eyes maintenance when health, cause starting occurring old and feeble after speed very fast, it is conscious before aging that to carry out maintenance extremely important.Its outstanding maintenance energy usefulness forms the frivolous moistening sebum film as yarn at skin surface, produces remarkable moistening effect, keeps skin youth moistening.

Theory of Chinese medical science thinks most of eye pouch, eye edema, and the generation of edema is relevant with Liver and kidney void, and after Liver and kidney void, kidney essense can not nourishing the liver blood, and " liver opening at eye ", finally because of essence and blood loss, show and eyes just form eye pouch and eye edema.And modern study also confirms eye pouch, eye edema is owing to often staying up late, emotional instability, eye strain, aging, cause vein blood vessel blood flow rate too slow, eye part skin red blood cell is for hypoxgia, in vein blood vessel, carbon dioxide and metabolic waste accumulation are too much, form chronic hypoxia, comparatively dark also formation is detained and causes eye pouch blood, and this and theory of Chinese medical science match.

Motherland's medical science is thought, this pathogenetic endogenous cause of ill with liver,spleen,kidney three is dirty and QI-blood circulation not normal in close relations, therefore treatment by oral administration of medicines internal organs many from liver spleen kidney by controlling, but be also the external reflection of body interior dysequilibrium.So will from entirety in treatment, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.Liver spleen essence and blood is full, punching appoints tune smooth, then the money of medicine carrying had by oneself by blood network.Liver controlling conveyance and dispersion, can adjust and reach QI and blood, happy feelings will.If depression of liver-QI, qi-blood disharmony. qi depression to blood stasis.Stop up stagnant channels, on tie and then cause speckle in face.Liver storing blood.Liver blood fill and, then body be good for face profit.If deficiency of the liver and kindey, blood and essence asthenia, can not go up Rong Ze easily raw speckle.

Traditional Chinese medical science QI and blood theory is thought, qi-blood circulating process is the material base that all histoorgans of human body carry out work, QI-blood circulating regularly freely balances as expensive, if QI and blood is not smooth will produce blood stasis, blood stasis hinders in body, will cause the deterioration of qi-blood circulating further, cause more serious stasis of blood plug, therefore the traditional Chinese medical science take QI and blood as guiding principle, make it smooth balance by regulating qi and activating blood, can disease-relieving and physique enhancing, beauty treatment of nourishing blood.Skin speckle basic in the stasis of blood, move back speckle must first blood stasis dispelling, blood stasis dispelling when invigorating blood circulation, invigorate blood circulation more must QI invigorating, regulate the flow of vital energy, qi being the governor of blood, blood runs thereupon; Blood is keeping of gas, be so incensed that and quiet, depressed then blood clotting, the deficiency of vital energy then blood prostration, gas compel then blood walk.QI and blood and then all and.And regulate the flow of vital energy liver, QI invigorating at lung kidney, lung governing skin and hair.Because of qi depression to blood stasis, have influence on the QI-blood circulation function of lung spleen Liver and kidney, and cause face and occur even occurring alopecia, alopecia areata by the mottles such as chloasma, black eye, eye pouch, eye edema, freckle.The present invention mainly identifies and corrects the principle treated according to Chinese medicine, collect many doctor chiefs, extensively adopts the strange medicine wonderful recipe in rich receipts area, skims the cream off milk; Choose inrigorating qi and promoting blood circulation, natural Chinese medicine that liver heat removing and eyesight improving, nourishing liver and kidney, improving acuity of vision and removing nebula, suppressing the hyperactive liver and subsiding YANG, heat-clearing and toxic substances removing, detumescence dewater, strengthening vital QI to eliminate pathogenic factors, purging FU-organs lets out poison, promoting blood circulation to remove blood stasis, regulate the metabolism function of human body, improve human body periocualr skin blood circulation, thus reach detumescence blood stasis dispelling, fatigue alleviating, eye skin of compacting.Desalination eye pouch, beautifies the object of appearance.

The Radix Astragali, can invigorating QI to consolidate the body surface resistance based on tonify deficiency, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Cave in for insufficiency of vital energy and blood, skin infection, difficulty in discharging of pus or burst for a long time and do not hold back person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and the immunologic function of energy enhancing body, therefore can also be used for the generation preventing some infectious disease." book on Chinese herbal medicine meets former " carries: " all void of Radix Astragali energy tonifying five ZANG-organs, controls stringy pulse spontaneous perspiration, rush down YIN-fire, remove lung-heat, lossless, sends out, and has antiperspirant then to stop." be the good medicine promoting resistance and defence disease.

Poria: Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Poria slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, is reached by strong activating the spleen pulmonary function, different from the Chinese medicine of other direct diuretic.For diarrhea due to hypofunction of the spleen, leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy

Flos Pelargonii stops blooding, vasoconstrictive, asthma, liver and expelling toxin, cholelithiasis, kidney toxin expelling, renal calculus, diuresis, muscular soreness, oily skin, aging skin activates, herpes, palor, and fat-reducing, promotes to scab, eczema, sunburn of burning, tinea, menstruation has some setbacks, engorgement of breasts inflammation, alleviates melancholy uneasy, drives demon, mend body, deodorization, antibacterial, sterilization, smoking cessation (wine).The major function of Flos Pelargonii is to adjust skin, and the effective ingredient in Flos Pelargonii extracting solution and natural alicyclic organic have very strong affinity, and therefore, the normal combination with alicyclic organic of Flos Pelargonii makes lipoid product.General cleaning supplies are after cleaned, the functional components major part of skin protection can be rinsed by water and be run off, the scientific research personnel of Switzerland is on the basis of three-hypers fresh extractor technology, select to hands sections such as organized enzymes by adding, the effective ingredient of Flos Pelargonii is made also to produce affinity with skin epidermal area while affine with lipoid, this affinity has surmounted the affinity with water, therefore, in the process of cleaning, most of effective ingredient of Flos Pelargonii still can be absorbed by the skin, play the effect adjusting skin, Flos Pelargonii is almost applicable to various skin, because it can balance sebum secretion and make turgor.May to eczema, burn, herpes zoster, herpes, tinea and chilblain be useful.Slack and undisciplined, pore is blocked and oily skin also fine, because Flos Pelargonii can pore refining, blood circulation promoting, can allow after using pale skin is comparatively ruddy vigor, makes the glossy exquisiteness of skin.

The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, pain relieving in slow, and yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, and spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, repercussive blood, can lose pus, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, brings down a fever, relieving restlessness, QI invigorating, the capable hot disease in sky, pestilence miasma, mania and irritation, and married woman's blood is transported, and hemorrhoidal hamorrhage, rushes down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion exerts meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.

Pseudobulbus Bletillae (Rhizoma Bletillae) property is bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Shennong's Herbal: " main carbuncle, malignant boil, lose cellulitis, the dead flesh of impairment of YIN, pathogen in stomach "; Compendium of Material Medica: " abnormal smells from the patient (root) is bitter, flat, nontoxic.

Radix Angelicae Dahuricae meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping." Japan hanako materia medica ": control conjunctival congestion bulbar conjunctiva polyp, and tire patching leaks landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, desolation, scabies, pain relieving granulation promoting, goes face Shao-defect scar.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

Flos Inulae, latin name (Calendula officinalis), has another name called Calendula officinalis, asphodel.Calendula officinalis is rich in multivitamin, especially vitamin A and vitamin C, can prevent pigementation, promote skin gloss and elasticity, delaying senility, avoid the lax life of skin to wrinkle.Also can prevent ciril disease, as vascular lesion and cancer, more can regulate the flow of vital energy cough-relieving, stomach invigorating, reduce phlegm, prevention of asthma and bronchitis.Almost each position can eat; Its petal has the function of beauty treatment, and flower is containing carotenoid, lycopene, violaxanthin, rubixanthin, volatile oil, resin, lymphatic temperament, malic acid etc.Root contains amaroid, mountain gold east glycol; Seed is containing glyceride, ceryl alcohol and alkaloid.Putting in shampoo to make hair color thin out.

Herba Menthae, popular name, " lunar caustic grass ", is labiate, namely belongs to other dry herbs together, be born in by hill wetland river more, and rhizome grows wild underground, is a kind of fragrant crop having extraordinary economic worth.The blue or green gas fragrance of Herb.Leaf, to life, spends little lavender, lip, spends the dark violet brown granule fruit of rear knot.Herba Menthae is one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache.Place uses can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.Herba Menthae is Chinese conventional Chinese medicine, and young tender stem point can make vegetable edible, and herb can be used as medicine again, and cure cold heating laryngalgia, and headache, conjunctival congestion with ophthalmalgia, myalgia, skin rubella is scratched where it itches, the diseases such as measles without adequate eruption, also effective to carbuncle, cellulitis, scabies, tinea, dermatitis rhus in addition.Herba Menthae contains menthol, and this material can fresh breath have the multiple property of medicine, can alleviate stomachache, gallbladder problem as spasm, also have antisepsis and sterilization, diuresis, reduces phlegm, stomach invigorating and the effect such as aid digestion.A large amount of edible Herba Menthae can cause insomnia, but low dose of eating conduces to sleep.

Myrrha (Commiphora myrrha Engl.), has another name called myrrh, is olive subject plant Herba Violae tree or the dry resin of Ha Didingshu.Main product is in African Somalia, Ethiopia and India and other places.Gather the white oleo-gum-resin of being oozed out by bark crack, in air, become rufous and hard nahlock.After smashing, fry to coke black and apply.Cure mainly breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.There is the effect such as promoting blood circulation and stopping pain, detumescence and promoting granulation.Be in the Orient a kind ofly to invigorate blood circulation, blood stasis dispelling, pain relieving, stomach invigorating Chinese medicine, raw property or lymphatic temperament disease, as raw property arthralgia, sciatica, oral cavity pain, has sore throat, cold cough, moist abundant expectoration, bronchiectasis, eczema abscess, menoxenia, dysuria." note doctor allusion quotation ": " hair growing, speckle dispelling disappears trace, and softening the hard mass is except tumor, and except tinea more wound, teeth consolidating is good for gum, removing toxic substances etc.Control alopecia capillary, black spot bruise, verruca plana, various eczema, gingiva is rotten to the corn, and poisonous insect stings wound etc." Myrrha compatibility Flos Carthami, Myrrha promoting blood circulation and stopping pain, Flos Carthami activating blood and removing stasis stimulates the menstrual flow.Papillary, have invigorate blood circulation, silt of dispelling, stimulate the menstrual flow, effect of pain relieving, by the stasis pain of resistance stomachache and traumatic injury of becoming silted up in the trusted subordinate's pain caused by what treatment blood stasis, dysmenorrhea, puerperal.

Herba Equiseti Hiemalis is medicinal is the herb of Equisetaceae plant Herba Equiseti Hiemalis, and Herba Equiseti Hiemalis's (Classification system: Equisetum hyemaleL.) has another name called: thousand peaks grass, file grass, nib grass, Herba equiseti ramosissimi, Rhizoma seu Herba Elatostematis stewardii, horse Radix Ginseng etc.Herba Equiseti Hiemalis's sweet in the mouth, hardship, property is put down.Return lung, Liver Channel, there is effect of dispelling wind and heat pathogens, improving acuity of vision and removing nebula, hemostasis.Herba Equiseti Hiemalis gathers summer, and removing impurity, dries or storage of drying in the shade, the medicinal process of preparing Chinese medicine: remove withered stem and undesirable root, and spray clear water, slightly moistens, cutting, dry.Cut off section.Wind-dispelling heat-dissipating, expelling pathogenic factors from muscles, nebula removing.Control the raw nebula of order, epiphora induced by wind, discharging fresh blood stool, dysentery, de-liver, malaria, laryngalgia, carbuncle." good blessing book on Chinese herbal medicine ": argument disease, nebula removing film.Removing food stagnancy block again, the liver benefiting gallbladder, improving eyesight, treats hemorrhoidal hamorrhage, dysentery relieving and married woman's metrorrhagia." detailed outline ": expelling pathogenic factors from muscles, arresting lacrimation, hemostasis, curing rheumatism, colic, large intestine proctoptosis.

Flos Carthami (Classification system: Carthamus tinctorius L.), another name: red indigo plant flower, thorn Flos Carthami, Compositae, Flos Carthami platymiscium, dry tubular flower, orange red, floral tube is carefully narrow, and tip 5 splits, and sliver is narrow linear, flower pesticide is yellow, be unified into pipe, exceed outside sliver, its central authorities have stigma to expose.The special fragrance of tool, mildly bitter flavor.To spend, length of a film, color are scarlet, the soft person of matter is good.Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, contributes to controlling amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the twinge of the breast side of body, traumatic injury, skin infection swells and ache curative effect.Have blood circulation promoting and blood stasis dispelling, wet dissipation goes the effect swollen.

Semen Persicae (Semen Persicae), can refer to the core youngster in Semen Persicae; When using as Chinese herbal medicine Semen Persicae, refer in particular to the seed of rosaceous plant Fructus Persicae or Prunus davidiana, another name Radix Fici Hirtae core, almond core, large Semen Persicae, pluck during fruit maturation in 6 ~ July, removing sarcocarp and nucleocapsid, take out seed, dry, there is effect of blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, can be used for amenorrhea, dysmenorrhea, WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation etc.Anemia of pregnant woman is cautious use of.Clinical observation proves, Semen Persicae is improved effect to blood flow retardance, blood obstacle, and each internal organs can be made respectively to organize functional recovery normal.

The pungent micro-hardship of Rhizoma Cyperi is sweet, flat.To regulate the flow of vital energy resolving depression; Menstruction regulating and pain relieving; Antiabortive.Main distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.

Pyracantha fortuneana, fire sour jujube (Pyracantha fortuneana (Maxim.) Li), be used as medicine with fruit, root, leaf, property is put down, sweet in the mouth, acid, leaf energy heat-clearing and toxic substances removing, sore swollen toxin is controlled in external application, firethorn fruit contains abundant organic acid, protein, aminoacid, vitamin and multiple mineral element, can eat raw, also can be processed into various beverage.Its fruit is ripe for autumn, and seemingly torch, can do shade tree or garden is planted.Its root bark, peel of stem, fruit, containing abundant tannin, can be used to extract tanning material.Fire sour jujube root can be used as medicine, and its nature and flavor are pained, the effect such as have antidiarrheal, dissipating blood stasis, help digestion, and fruit, leaf, peel of stem be the similar drug effect of tool also.Fire sour jujube leaves can tea making, has heat-clearing and toxic substances removing, the effect of promoting the production of body fluid to quench thirst, astringing to arrest diarrhea.Containing the active substance suppressing dental caries in Fructus Pyracanthae, having positive effect to human teeth control, is again the quality raw materials making toothpaste.Bright exquisite in pearl during Taiwan Fructus Pyracanthae is red, because taste is otherwise known as " pocket Fructus Mali pumilae ", " king of micro-fruit " like Fructus Mali pumilae.Its ascorbic content of Fructus Pyracanthae as pearl is equivalent to a Big Apple, is the high health fruit of nutrition.Scientific research finds, containing biological whitening substance in Fructus Pyracanthae, effectively can suppress the vigor of various pigment enzyme in human body, make skin not chromogenesis.Fructus Pyracanthae extracting solution is widely used in cosmetics, is rich in natural fiery sour jujube elite, can reaches skin bottom, deep layer whitening from inside to outside, moisturizing, effectively improves obscure dry-out phenomenon.

Radix Gentianae heat clearing and damp drying; Eliminating pathogen in the liver is calmed the frightened.Jaundice due to damp-heat; Urine leaching pain; Swelling of the vulva pudendal pruritus; Damp-heat vaginal discharge; The feeling of fullness in the head headache of liver and gall excess-fire; Conjunctival congestion and swelling pain; Deaf ear swells; Hypochondriac pain bitter taste; Calentura convulsion with spasms." detailed outline ": treat throat pain, wind heat night sweat.Fire is posted in liver and gall mutually, have rush down of no help, therefore the gas of the liver benefiting gallbladder of Radix Gentianae, just with its can eliminating pathogen in the liver gallbladder pathogenic heat also.But in large bitter Great Cold, cross clothes and probably to injure one's stomach the gas of middle hair growth promoting, instead help pathogenic fire, also take Rhizoma Coptidis for a long time instead from the justice of cremate." Bencao Jingshu ": careless Radix Gentianae taste both large hardships, property is Great Cold again, and also, though can remove excess-heat, the people of insufficiency of stomach insufficiency of blood can not gently try the medicine of pure the moon.On an empty stomach the making us excessive and can't help of bait, with its too hardship then to let out too far down therefore also.

Radix Sanguisorbae preparata bitter in the mouth, acid, cold nature; Return liver, stomach, large intestine channel; Enter blood to hold back and fall; There is cooling blood for hemostasis, effect of eliminating fire and detoxication; Cure mainly hematemesis and epistaxis, hematuria is had blood in stool, metrorrhagia, hemorrhoidal hamorrhage dysentery, anal fistula, leucorrhea with red and white discharge, and carbuncle skin ulcer swells and ache, eczema pudendal pruritus, burn due to hot liquid or fire, worm venom." herbal classic ": housewife people's seven kinds of impairments, leukorrheal diseases, pain relieving, except disliking meat, hidroschesis, treats incised wound." not Lu ": only pus and blood, all flaccidity, malignant boil, disappear wine, and except quenching one's thirst, mending and hindering absolutely, in puerperal, plug, can make incised wound cream.Main internal hemorrhage due to trauma is more than, insufficiency of blood." property of medicine opinion ": hemostasis dysentery erosion pus.

Containing 300 various chemical components in Flos Rosae Rugosae, as the alcohol of fragrance, aldehyde, fatty acid, phenol and containing the oil of essence and fat, to wake up stomach with easing the affected liver in normal food Flos Rosae Rugosae goods, have a respite and invigorate blood circulation, looks improving and the skin nourishing, make us refreshing refreshing.The flower opened at the beginning of Flos Rosae Rugosae and root can be used as medicine, and regulate the flow of vital energy, invigorate blood circulation, Thyme Extract, cure mainly menoxenia, and traumatic injury, irritability are had a stomachache, the diseases such as newborn too fat to move pain.The sarcocarp of Rosehips, can be made into fruit jam, has flavour, and fruit contains abundant vitamin C and Citrin, and acute and chronic infectious disease, coronary heart disease, hepatopathy and prevention can be prevented to produce carcinogen etc.With the Flos Rosae Rugosae quintessence oil (title Liquor Rosae Rugosae Distillata) that roseleaf obtains with way of distillation refinement, androgen and sperm can be activated.Liquor Rosae Rugosae Distillata can also improve skin texture, blood circulation promoting and metabolism.

Herba Leonuri acrid in the mouth is bitter, cool, invigorates blood circulation, silts of dispelling, regulating menstruation, disappear water, treatment menoxenia, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Herba Leonuri has inducing diuresis to remove edema, shrinks the effect of uterus effect, is that ancient Chinese medicine doctor is used for treating gynopathic key medicine.Herba Leonuri can all herbal medicine, and effective ingredient is Herba Leonuri element, and Herba Leonuri is containing multiple alkaloid and benzoic acid, potassium chloride etc. such as leonurine, stachydrine, leonuridine, leonurinines.Motherwort formulation has the effect of excited animal uterus, similar to pituitrin, and Herba Leonuri extractum and decoct have strong and lasting excitation to uterus, not only can strengthen its contractility, can improve its tensity and shrinkage factor simultaneously.

Radix Ampelopsis is the root of vitaceae Radix Ampelopsis, and annual spring, autumn excavate, and removing stem and thin fibrous root, after cleaning, many rip cuttings become two lobes, pintongs or inclined tab, dry and can be used as medicine.It is cool in nature, and bitter but sweet flavor is pungent, has effect of heat clearing away, removing toxic substances, eliminating stagnation, granulation promoting, pain relieving, is used for the treatment of the diseases such as carbuncle, furuncle, scrofula, scald, pyrexial malaria, infantile convulsion, dysentery, hemorrhoidal hamorrhage, anal fistula.

Specific embodiment 1

Herba Menthae 1000g, Myrrha 1000g, Rhizoma Cyperi 1000g and the Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g way of distillation being vaporized into crystallization, pulverizing stand-by, is component 1; Again other raw material pyracantha fortuneana 1000g, Flos Inulae 1000g, Radix Gentianae 1000g, Flos Pelargonii 1000g and Flos Rosae Rugosae 1000g are added the soak with ethanol 4-6 hour accounting for its quality 5-10 times amount, heating extraction 2 times, each 1-2 hour, merge extractive liquid, remove supernatant after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.25 filtrate, stand for standby use.By surplus stock medicine Poria 1000g, Herba Equiseti Hiemalis 1000g, Radix Astragali 1000g, Herba Leonuri 1000g, Radix Salviae Miltiorrhizae 1000g, Semen Persicae 1000g, Radix Sanguisorbae preparata 1000g, Flos Carthami 1000g, Radix Paeoniae Alba 1000g, Radix Ampelopsis 1000g, Radix Angelicae Dahuricae 1000g, add the water accounting for its quality 5-10 times amount, heating extraction 2 times, each 1-2 hour, merge extractive liquid, removes supernatant after leaving standstill, then 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.25 filtrate, stand for standby use.By two kinds of filtrates that above-mentioned steps is extracted, put into economic benefits and social benefits vacuum concentrator and mix, when first filtrate being concentrated into 80 DEG C, relative density is the concentrated solution of 1.32, then inserts 0 ~ 5 DEG C of deepfreeze 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g extractum, becomes component 2.Component 1 dropped in component 2, stir, heating, mediation substrate, becomes gel; Described substrate is selected from: Tween-80, triethanolamine, propylene glycol, one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline.

Specific embodiment 2

Herba Menthae 1100g, Myrrha 1200g, Rhizoma Cyperi 1100g and the Pseudobulbus Bletillae (Rhizoma Bletillae) 1200g way of distillation are vaporized into crystallization, pulverize, stand-by as component 1, then get pyracantha fortuneana 1100g, Flos Inulae 1200g, Radix Gentianae 1200g, Flos Pelargonii 1300g, Flos Rosae Rugosae 1200g, Poria 1200g, Herba Equiseti Hiemalis 1200g, Radix Astragali 1200g, Herba Leonuri 1200g, Radix Salviae Miltiorrhizae 1200g, Semen Persicae 1100g, Radix Sanguisorbae preparata 1100g, Flos Carthami 1100g, Radix Paeoniae Alba 1200g, Radix Ampelopsis 1200g, Radix Angelicae Dahuricae 1200g, be soaked in water, heated and boiled 3 times, each 1-2 hour, filter, filtrate is for subsequent use; To merge in the filtrate suction concentrating under reduced pressure tank of latter 3 times, being evaporated to relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C; Become component 2, blending ingredients 1 and component 2, mediation substrate, becomes gel; Described substrate is selected from: Tween-80, triethanolamine, propylene glycol, one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline, and furnishing eye cream ultraviolet disinfection is bottled.

Specific embodiment 3

By Herba Menthae 1100g, Myrrha 1100g, Rhizoma Cyperi 1200g and Pseudobulbus Bletillae (Rhizoma Bletillae) 1100g, being vaporized into crystallization by the way of distillation, pulverizing stand-by, is component 1, other raw material pyracantha fortuneana 1200g, Flos Inulae 1300g, Radix Gentianae 1200g, Flos Pelargonii 1100g, Flos Rosae Rugosae 1200g, Poria 1200g, Herba Equiseti Hiemalis 1200g, Radix Astragali 1200g, Herba Leonuri 1200g, Radix Salviae Miltiorrhizae 1200g, Semen Persicae 1100g, Radix Sanguisorbae preparata 1200g, Flos Carthami 1200g, Radix Paeoniae Alba 1200g, Radix Ampelopsis 1200g, Radix Angelicae Dahuricae 1100g, add and account for its quality 7-10 soak with ethanol 2-3 hour doubly, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.25 filtrate.The medicinal residues of the crude drug crossed by above-mentioned ethanol extraction again add 10 times of water gagings, heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.25 filtrate, mix two kinds to extract filtrates and insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount, becomes component 2.By the merging of component 1 and component 2, add Pearl 1300g, be in harmonious proportion substrate, become gel; Described substrate is selected from: Tween-80, triethanolamine, propylene glycol, one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline, and furnishing eye cream ultraviolet disinfection is bottled.

Specific embodiment 4

Herba Menthae 1100g, Myrrha 1100g, Rhizoma Cyperi 1200g and the Pseudobulbus Bletillae (Rhizoma Bletillae) 1100g way of distillation being vaporized into crystallization, pulverizing stand-by, is component 1; Get other raw material pyracantha fortuneana 1200g, Flos Inulae 1300g, Radix Gentianae 1200g, Flos Pelargonii 1100g, Flos Rosae Rugosae 1200g, Poria 1200g, Herba Equiseti Hiemalis 1200g, Radix Astragali 1200g, Herba Leonuri 1200g, Radix Salviae Miltiorrhizae 1200g, Semen Persicae 1100g, Radix Sanguisorbae preparata 1200g, Flos Carthami 1200g, Radix Paeoniae Alba 1200g, Radix Ampelopsis 1200g, Radix Angelicae Dahuricae 1100g, roguing, dries, be ground into granule, soak 1 hour; Soaked raw material is put in multi-function extractor and decocts with water secondary; Add up the water of medical material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of total amount 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters; The filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, and being concentrated into every 1ml containing 0.1g crude drug amount, is component 2.By the merging of component 1 and component 2, add Pearl 1300g, be in harmonious proportion substrate, become gel; Described substrate is selected from: Tween-80, triethanolamine, propylene glycol, one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline, and furnishing eye cream ultraviolet disinfection is bottled.

Pharmacological toxicity is tested

Toxicology test:

Test example 1: acute toxicity test of the present invention

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.

Medicine: eye cream of the present invention.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, often organize 10, male and female half and half, dissolve lotion, are made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mice 20, each 10 of male and female.Tablet adding distil water is dissolved, is made into maximum concentration, by the maximum tolerated dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Test example 2: acute skin irritation test report of the present invention

1, experiment purpose: detect the present invention to the stimulation/corrosiveness of laboratory animal skin and intensity

2, materials and methods:

2.1. tested material title: eye cream of the present invention (embodiment method 1 obtains)

2.2. laboratory animal: one grade of large ear white race rabbit, 10, female, body weight 2.1-2.3kg; Thered is provided by Affiliated Hospital of Qingdao University biology department Experimental Animal Center;

2.3. test method:

Its spinal column both sides, back are cut by hair in test by the healthy rabbits selecting skin intact 10 for first 24 hours, the left and right each about 4cm × 4cm of unhairing area.Get tested material 0.2ml during test to be applied on two layers of gauze of 2.5cm × 2.5cm, be applied to skin of unhairing surface, side, oilpaper covers, immobilization with adhesive tape.Opposite side skin is as blank.Close after 4 hours, dismantle, and go residual tested material with warm water cleaning, within 1,24 and 48 hour after removing tested material, observe and smear position dermoreaction, and mark.

3, experimental result: any erythema does not appear in laboratory animal skin, red and swollen, inflammation phenomenon.

4, brief summary: according to " (disinfection technology standard " (1999) middle skin wound repair standards of grading judgement, ointment of the present invention belongs to nonirritant to animal skin stimulus intensity.

Embodiment 3: vaginal mucomembranous irritant test result

1. test method:

After laboratory animal is quarantined 3 days, select 18 above-mentioned healthy rabbits, be divided into three groups at random, often organize each 6, be respectively: blank, excipient control, eye cream of the present invention.Be placed in excipient control group and the intravaginal of tested material treated animal with the sterilizing cotton sliver leaching of suitable size with sterile saline and tested material respectively, contact 6 hours with vaginal mucosa, after 24 hours, put to death animal.Taking-up topical vaginal tissue, observes pathological changes situation.

2, result of the test: vaginal mucomembranous irritant test result

Embodiment 4: skin anaphylactic test result

Use eye cream of the present invention, carry out inducing and exciting contact test, viewing test mice after 24 hours and 48 hours, all loseing skin has the phenomenon such as erythema and edema, with negative control group zero difference.Result shows, this unguentum is bordering on zero, namely without skin allergic reaction to dermoreaction intensity.

Embodiment 5: long term toxicity test data

1, experimental technique

Random for Cavia porcellus part is become 4 groups, often organizes 15.In guinea pig back spinal column both sides, depilatory is evenly coated, make its scope about 40 square centimeters of losing hair or feathers.Clean depilatory, observe and often organize Cavia porcellus after 24 hours and be coated with eye cream 0.2,0.4 of the present invention and 0.8ml respectively, respectively containing crude drug 92,184 and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observe the ordinary circumstance of Cavia porcellus, experiment terminates rear execution animal and carries out hematology, blood biochemical and pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunk unhairing districts, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity are movable, blood biochemistry checking, medication group and matched group are all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathological changes.Prompting, Chinese medicine eye cream long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.

Pharmacological experiment

One, microcirculation experimental technique of the present invention:

1, materials and methods: get 50 mices, be divided into 5 groups at random, often organizes 10 (male and female half and half), and it is a little that matched group every Mus auris dextra is coated with normal saline; Positive controls every Mus auris dextra gives the new permanent U.S. Firm eye cream 15ml of commercially available herborist (Shanghai herborist cosmetics company limited product), and tested group is external eye cream 15ml of the present invention.15min pneumoretroperitoneum injects 0.1% pentobarbital sodium 0.1ml/10g anesthetized animal, tail vein injection 0.1% epinephrine 0.1mL/10g subsequently, observes mouse right ear fine motion vein bore (μm) immediately and 0.2mm2 blood capillary net number .t checks process experimental data.

2 results and discussion

2.1. on microcirculatory impact

Compared with matched group, tested group 1 pair mice capillary open number has showed increased (P < 0.01); Tested group of 2 pairs of venule bores and capillary open number have remarkable increase (P < 0.01); Tested group of 3 pairs of mice fine motions, vein bore and capillary open number all have increase (P < 0.01); Illustrate and be subject to reagent to improve microcirculation, have function of promoting blood circulation to disperse blood clots (table 1).

Table 1, eye mask of the present invention are on the impact of mice fine motion, vein bore and capillary open number

Two, on the impact of Oleum Tiglii induced mice auricle edema

Get healthy mice 30, be divided into 3 groups at random, i.e. blank group, the new permanent U.S. Firm eye cream positive controls of herborist, eye cream group of the present invention, often organize 10, male and female half and half, positive controls and instant component are not smeared, blank group smears isodose normal saline, successive administration 7 days, after last administration 0.5 hour, survey outward at the left in ear of mice and be coated with Oleum Tiglii proinflammatory agent (2% Oleum Tiglii, 20% dehydrated alcohol, 5% distilled water, 73% ether) 0.1ml causes inflammation, cause inflammation and lay a left side with card punch (aperture 6mm) in latter 4 hours, auris dextra sheet, weigh, using left and right auricle weight difference as swelling degree, the results are shown in Table 2.

Table 2 is on the impact (X ± SD) of Oleum Tiglii induced mice auricle edema

Group	Number of animals (only)	Swelling (mg)
			Blank group	10	8.51±1.72
The new permanent U.S. Firm eye cream of herborist	10	5.32±1.57**

Eye cream group of the present invention

10

4.26±1.39#

Note: compare with matched group: * * P < 0.01; Compare with positive controls: #P < 0.05; As can be seen from upper table experimental result, eye cream of the present invention has pharmacological action of better subsiding a swelling.

Three. the impact of rat paw edema caused by Carrageenan

Get healthy rat 30, body weight 180-220g, be divided into blank group, the new permanent U.S. Firm eye cream positive controls of herborist, eye cream group of the present invention at random.Often organize 10, male and female half and half, sub-cage rearing.Positive controls and drug component of the present invention smear 0.2g other every day, the normal saline that blank group gives same dosage is smeared, successive administration 7 days, after last administration 30 minutes, only inflammation is caused respectively at Rat Right metapedes plantar subcutaneous injection 1% carrageenin suspension 0.1ml/, respectively at cause scorching before and cause scorching after within 15,30,60,120,240 minutes, survey the girth of the Rat Right metapedes sole of the foot, and calculate swelling rate [swelling rate=(cause scorching metapedes sole of the foot girth-cause scorching front foot sole of the foot girth)/cause scorching front foot sole of the foot girth × 100%]; The results are shown in Table 3.

The impact (X ± SD) of rat paw edema caused by table 3 on Carrageenan

Note: compare with matched group: * * P < 0.01; Compare with positive controls: #P < 0.05; As can be seen from upper table experimental result, medicine group of the present invention has the pharmacological action of better detumescence blood stasis dispelling.

3 discuss

Theory of Chinese medical science thinks most of eye pouch, and the generation of eye edema is relevant with Liver and kidney void, and after Liver and kidney void, kidney essense can not nourishing the liver blood, and " liver opening at eye ", finally because of essence and blood loss, show and eyes just form upper lower eyelid edema, eye pouch is very large.And modern study also confirms that eye pouch is owing to often staying up late, emotional instability, eye strain, aging, cause vein blood vessel blood flow rate too slow, eye part skin red blood cell is for hypoxgia, and in vein blood vessel, carbon dioxide and metabolic waste accumulation too much, form chronic hypoxia, blood is comparatively dark also forms the appearance being detained and causing eye eye pouch, eye edema, and this and theory of Chinese medical science match.

Skin is near the eyes especially tender and lovely, and the skin of eyes surrounding is only containing a small amount of fat, and eyelid is the skin that human body is the thinnest, and very fragile, easy edema, is easy to grow wrinkle, and deepens with advancing age and constantly.Occur that canthus wrinkle is not difficult to remove, because horny layer is weaker, recovery fast.So, how canthus wrinkle is removed.

Should suit the remedy to the case after eye pouch is formed, consult a physician, find out the cause of disease, treat in time; Keep in high spirits, reduce mental burden, live a regular life, restraining tobacco and wine, ensure sufficient sleep, impel QI and blood vigorous, appearance is shone; Strengthen the massage of eye, improve local blood circulation state, reduce congestion and be detained; As be coated with containing oil content, moisture abundance eye cream, make eye part skin and subcutaneous tissue dynamic, desalination eye pouch, ocular edema.

Clinical trial

Illustrate: my institute is in June ,-2014 in June, 2013, and use the treatment of self-control eye cream eye pouch, canthus wrinkle, evident in efficacy, existing report is as follows.

Clinical data: clinically choose eye pouch, obvious person 100 example of canthus wrinkle.Be all women.Age 25-55 year, average 34.2 years old; Unmarried 35 example, the married 65 example, does not educate person 45 example; The course of disease 6 months-20 years, average 8.28 years; Educational level University Culture 86 people, white collar, teacher, cadre, office staff 78 example, other staff 22 example.Readme often stay up late overtime work 45 example, heredity 35 fall, insomnia 20 example, daily maintenance is person 56 people near the eyes, and laser therapy eye pouch recurs 12 people.The clinical treatment group 50 that is divided into is routine, matched group 50 example.

Therapeutic Method: treatment group adopts homemade traditional Chinese drug eye cream, Fang Yong: Poria 12g, Herba Equiseti Hiemalis 13g, Radix Astragali 11g, Herba Leonuri 12g, Myrrha 13g, Radix Salviae Miltiorrhizae 12g, Semen Persicae 13g, Radix Sanguisorbae preparata 13g, Flos Carthami 12g, Radix Paeoniae Alba 13g, Pseudobulbus Bletillae (Rhizoma Bletillae) 12g, Herba Menthae 12g, pyracantha fortuneana 13g, Radix Ampelopsis 12g, Radix Angelicae Dahuricae 12g, Rhizoma Cyperi 11g, Flos Inulae 11g, Radix Gentianae 13g, Flos Pelargonii 12g, Flos Rosae Rugosae 12g, be prepared into eye cream by the method for embodiment 1.

Get eye cream matched group, often organize 50 examples, use the new permanent U.S. Firm eye cream of commercially available herborist respectively.

Operating process: when carrying out in the flat bed of personnel, with the clean face of 3% hydrogen peroxide, with negative ion atomizer spraying face, coordinate meridian point massage 12 methods to carry out facial massage simultaneously, near the eyes local do emphasis massage, the time be about 10m in. after get eye cream, be evenly applied to eyelid surrounding, note not doing into eyes, suitably can massage 10-15 minute.Once a day, 15 days courses for the treatment of.After terminating the course for the treatment of, monthly follow up a case by regular visits to 1 time, follow up a case by regular visits to 3 months continuously.It is pungent that treatments period advises patient to eat less, takes a good rest, and other eye cream of stopping using, eye-care product.

Criterion of therapeutical effect

Recovery from illness: after treating for 2 courses for the treatment of, eye pouch, canthus wrinkle are obviously desalinated, and curative effect maintains more than 1 month, eyestrain is alleviated; Effective: eye pouch, canthus wrinkle are obviously thin out, disappear more than 50%, the conscious satisfaction of patient, sleep quality is good; Or treatments period eye pouch disappears, but it is bad to follow up a case by regular visits to middle sleep, and overtime work has recurrence again; Invalid: eye pouch, canthus wrinkle change not obvious or unchanged; Or once disappeared more than 50%, but obviously increase the weight of in following up a case by regular visits to, testing crew is unsatisfied with.

Therapeutic outcome: treatment group total effective rate compares with each matched group, difference all has significance (P < 0.01), illustrates that self-control eye cream curative effect is obviously better than commercially available eye cream.Refer to table 1

Table 13 groups of Comparison of therapeutic tables (%)

Note: compare * P < 0.01 with other each group

Follow-up results follows up a case by regular visits to discovery, and massage person is better than the personage do not massaged.After recurrence, use still effective if continue.

Claims

1. alleviate canthus wrinkle eye pouch Chinese medicine eye cream for one kind, it is characterized in that, in described Chinese medicine eye cream, the parts by weight of various crude drug comprise: Poria 10 ~ 20 parts, Herba Equiseti Hiemalis 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Myrrha 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, 10 ~ 20 parts, Semen Persicae, Radix Sanguisorbae preparata 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, the Radix Paeoniae Alba 10 ~ 20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Herba Menthae 10 ~ 20 parts, pyracantha fortuneana 10 ~ 20 parts, Radix Ampelopsis 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Flos Inulae 10 ~ 20 parts, Radix Gentianae 10 ~ 20 parts, Flos Pelargonii 10 ~ 20 parts, Flos Rosae Rugosae 10 ~ 20 parts.

2. alleviate canthus wrinkle eye pouch Chinese medicine eye cream according to claim 1, it is characterized in that, in described Chinese medicine eye cream, the parts by weight of various crude drug comprise: Poria 10 ~ 15 parts, Herba Equiseti Hiemalis 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Myrrha 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, 10 ~ 15 parts, Semen Persicae, Radix Sanguisorbae preparata 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami, the Radix Paeoniae Alba 10 ~ 15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 15 parts, Herba Menthae 10 ~ 20 parts, pyracantha fortuneana 10 ~ 20 parts, Radix Ampelopsis 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Flos Inulae 10 ~ 20 parts, Radix Gentianae 10 ~ 20 parts, Flos Pelargonii 10 ~ 20 parts, Flos Rosae Rugosae 10 ~ 20 parts.

3. alleviate canthus wrinkle eye pouch Chinese medicine eye cream according to claim 1, it is characterized in that, in described Chinese medicine eye cream, the parts by weight of various crude drug comprise: Poria 10 ~ 20 parts, Herba Equiseti Hiemalis 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Myrrha 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, 10 ~ 20 parts, Semen Persicae, Radix Sanguisorbae preparata 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, the Radix Paeoniae Alba 10 ~ 20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Herba Menthae 10 ~ 15 parts, pyracantha fortuneana 10 ~ 15 parts, Radix Ampelopsis 10 ~ 15 parts, the Radix Angelicae Dahuricae 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, Flos Inulae 10 ~ 15 parts, Radix Gentianae 10 ~ 15 parts, Flos Pelargonii 10 ~ 15 parts, Flos Rosae Rugosae 10 ~ 15 parts.

4. according to any one of claims 1 to 3, alleviate a preparation method for the Chinese medicine eye cream of canthus wrinkle eye pouch, it is characterized in that, described preparation method comprises the following steps:

5. alleviate the preparation method of the Chinese medicine eye cream of canthus wrinkle eye pouch according to claim 4, it is characterized in that, in described step a, first crude drug Herba Menthae, Myrrha, Rhizoma Cyperi and Pseudobulbus Bletillae (Rhizoma Bletillae) steam method are distilled, obtain crystal, then pulverize, cross 120-150 mesh sieve, for subsequent use as component 1.

6. alleviate the preparation method of the Chinese medicine eye cream of canthus wrinkle eye pouch according to claim 4, it is characterized in that, in described step b, pyracantha fortuneana, Flos Inulae, Radix Gentianae, Flos Pelargonii and Flos Rosae Rugosae are added the soak with ethanol 4-6 hour accounting for its quality 5-10 times amount, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.25 filtrate, stand for standby use.

7. alleviate the Chinese medicine eye cream preparation method of canthus wrinkle eye pouch according to claim 4, it is characterized in that, in described step c, surplus stock medicine is added the water accounting for its quality 5-10 times amount, heating extraction 2 times, each 1-2 hour, merge extractive liquid, removes supernatant after leaving standstill, then 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.25 filtrate, stand for standby use.

8. alleviate the Chinese medicine eye cream preparation method of canthus wrinkle eye pouch according to claim 4, it is characterized in that, in described steps d, by two kinds of filtrates that above-mentioned steps is extracted, put into economic benefits and social benefits vacuum concentrator to mix, when first filtrate being concentrated into 80 DEG C, relative density is the concentrated solution of 1.32, then inserts 0 ~ 5 DEG C of deepfreeze 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g extractum, becomes component 2.

9. alleviate the Chinese medicine eye cream preparation method of canthus wrinkle eye pouch according to claim 4, it is characterized in that, in described step e, component 1 dropped in component 2, stir, heating, mediation substrate, becomes gel; Described substrate is selected from: Tween-80, triethanolamine, propylene glycol, one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline.

10. according to any one of claim 1 ~ 9, alleviate the Chinese medicine eye cream of canthus wrinkle eye pouch, it is characterized in that, the using method of Chinese medicine eye cream is, each just before going to bed after clean, by eye cream uniform application near the eyes, and massaging 15-20 minute near the eyes by middle finger finger belly, after fully absorbing to it, getting up early in second day washes away.