CN102988264A

CN102988264A - Ginkgo leaf freckle removing whitening cream and preparation method thereof

Info

Publication number: CN102988264A
Application number: CN2012105832170A
Authority: CN
Inventors: 杨高林
Original assignee: Qingdao Huaren Information Technology Development Co Ltd
Current assignee: Guangdong Junda Biological Polytron Technologies Inc
Priority date: 2012-12-28
Filing date: 2012-12-28
Publication date: 2013-03-27
Anticipated expiration: 2032-12-28
Also published as: CN102988264B

Abstract

The invention provides ginkgo leaf freckle removing whitening cream. Raw materials of the ginkgo leaf freckle removing whitening cream comprise, by weight, 10-30 parts of ginkgo leaf, 10-20 parts of leonurus, 10-20 parts of radix angelicae, 10-20 parts of angelica sinensis, 10-20 parts of rhizoma bletillae, 10-20 parts of salvia miltiorrhiza, 10-20 parts of peach blossom, 10-20 parts of rhizome atractylodis, 10-20 parts of myrrh, 10-20 parts of calendula, 10-20 parts of Chinese trumpet creeper, 10-20 parts of scutellaria baicalensis, 10-20 parts of radix paeoniae alba, 10-20 parts of honey suckle, 10-20 parts of albizia flower, 10-20 parts of propollis, 10-20 parts of caulis spatholobi, 10-20 parts of mint and 10-20 parts of pearl. Ginkgol biloba extract has a good effect of removing radical and an antioxidation effect. Yellow glycoside, amino acid and amino acid synthesis collagen in ginkgo leaves have a large effect on beautifying, restraining melanin and maintaining skin gloss and elasticity, and the cream is suitable for long-term use and suitable for use at night.

Description

Folium Ginkgo freckle removing and whitening frost and preparation method thereof

Technical field

The present invention relates to contain the freckle whitening makeup that derives from plant composition, particularly a kind of Folium Ginkgo freckle removing and whitening frost and preparation method thereof.

Background technology

Folium Ginkgo is a kind of plant with very high medical value, and ginkgo is one of ancient seeds of China, and it is the tree of the medical treatment of mystery, Jurassic Period dinosaur control terrestrial time before more than 200,000,000 5 thousand year, and Semen Ginkgo is one of the most flouring plant.Life on earth is gone through the change in 100000000000 years, especially after the glacier covering of the 4th century, only has Semen Ginkgo still to keep its most original looks, is called as " living fossil " in the organic evolution history.Its leaf, fruit, seed have higher medical value, and its pharmacological action constantly is familiar with, and clinical application range progressively enlarges.Ginkgo has another name called maidenhair tree, is the rarity of China, and is rare valuable, is described as " hollywood lignumvitae ", " living fossil " of the earth.

Modern people's living and diet is too meticulous, and quantity of motion reduces, or eating and drinking too much at one meal, or overstrain, so that the body metabolism function fails gradually, causes visceral dysfunction, causes easily the pigmented lesions such as chloasma faciei, freckle.The traditional Chinese medical science thinks that facial colour spot is uncomfortable because of the internal organs meridian qi and blood, and blood deficiency is not dissolved in face; Or because of internal injury caused by excess of seven emotions, stagnation of QI due to depression of the liver, incoordination between the liver and spleen; Or because of improper diet and overtiredness, menoxenia; Or because of the blood system of fire stagnation meridians, ailment said due to cold or exposure is rich and due to sending out outward.Adopt this class disease of western medicine, be mostly outer wiping or vitamins for oral administration, flavonols medicine.Because pathogenesis is more, adopt the western medicine effect to differ, also be difficult for radical cure, some medicine side effect is larger.

Women's lusterless complexion, face has speckle, and its pathomechanism is complicated, and endocrine disturbance, ultraviolet radiation, D﹠C, Nervous and Mental Factors etc. all can cause the generation of primary disease.Chloasma and liver, kidney is relevant and the imbalance day after tomorrow, dysfunction of the spleen in transportation, and QI-blood failing to nourish upward is also given birth to brown patch in face.In a word, primary disease and liver,spleen,kidney three are dirty, and be especially in close relations with liver.Chloasma has another name called chloasma, shows as the symptoms such as dark complexion, dark, dusty face, face Shao-, chloasma hepaticum, the black speck of looking unfamiliar, and for a kind of how sick because of the property pigmentation, affects patient's appearance, causes serious mental pressure to it.

Contain the multiple components useful with health such as natural activity flavone and amarolide in the Folium Ginkgo, has dissolving cholesterol, the effect of blood vessel dilating has positive effect to improving disordered brain function, arteriosclerosis, hypertension, dizzy, tinnitus, headache, senile dementia, hypomnesis etc.Its diseases prevention, cure the disease, the value of body-building is early on the books in the Compendium of Material Medica of Ming Dynasty's Li Shizhen (1518-1593 A.D.).Detect proof through national health department: drink Folium Ginkgo tea and can obviously reduce serum cholesterol, triglyceride and low-density blood lipoprotein, reduce the effect of depot lipid in the body.For fat-reducing of the complementary controls of diseases of cardiovascular and cerebrovascular systems patient such as adjusting, hypertension and the coronary heart disease of hyperlipidemia and obese type crowd etc. good effect being arranged, is the desirable beverage of prophylactic treatment senile dementia.It is the optimal pharmaceutical compositions of cardiovascular and cerebrovascular disease of controlling, prevent recognized in the world.Astringe the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving.Be used for cough and asthma due to lung deficiency; Coronary heart disease, angina pectoris, hyperlipidemia, anticoagulant is solid, has certain probability to improve memory.Though Folium Ginkgo energy blood circulation promoting, the prevention cardiovascular diseases, but can not take simultaneously other and control cardiovascular drugs (for example aspirin), Semen Ginkgo extrac has very strong removing free radical and antioxidation, the synthetic collagen Proteins of yellow glycoside, aminoacid and aminoacid in the Folium Ginkgo is improved looks to human body, the check melanin growth keeps skin gloss and elasticity to play no small effect.

Although the ginkgo Leaves health care effect is very strong, Folium Ginkgo contains poisonous composition, and brewing up with it to cause clonospasm, neural paralysis, platycoria, allergy and other side effect.Anemia of pregnant woman and child, old man are careful.A kind of composition is arranged ginkgoic acid in the Folium Ginkgo, if the dosage of usefulness is excessive, perhaps Time of Administration is long, can damage heart.Semen Ginkgo contains a large amount of ginkgoic acids, ginkgoic acid be contain virose, the leaf of generally buying does not pass through deep processing and extraction, the ginkgoic acid content of the inside is up to 3000-4000ppm, special ginkgoic acid is water miscible, one soaked Semen Ginkgo pyrite and the active substance such as Semen Ginkgo lactone of not only not having the inside, effect is opposite on the contrary, the inside is poison entirely.Ginkgoic acid, improper use or dosage are too large, are easy to cause poisoning.So at present in the urgent need to a kind of technique, health-care effect that can the application Folium Ginkgo makes again its poisonous material drop to minimum.Anemia of pregnant woman and child, old man are careful.

At present, most researchs are thought, mottle lesions of patients position melanocyte increased activity, and melanocyte and melanosome all increase, and then show mottle.Under the pathological state, the intradermal macrophage can be engulfed the melanosome that is dropped into corium, or calm in the corium upper strata, or degrades in cell, and a part is through lymph metastasis.The generation of pigment with drain disequilibrium, and superfluous the part that is gathered in the epidermis cell just forms pigmentation.Melanic drainage has two approach: the one, in kidney, to drain, and another is to discharge through skin, namely melanin is transferred in the keratoprotein, with the epidermal growth horny layer of dividing a word with a hyphen at the end of a line, renews with the horny layer cycle at last and comes off.The method for the treatment of mottle comprise acupuncture and tuina-massage (as local acupuncture, body acupuncture, acupoint injection therapy, cup, scrape therapy, massage, SHENQUE acupoint stick, sunken cord, imbedding needle, the ear acupoint etc.), external treatment (such as cream, facial film, lotion, stifling side) and decoction for the treatment etc.Existing square medicated bag is drawn together QUBAN SHUANG, is added flavor QUBAN SHUANG, LIUWEI DIHUANG TANG, TAOHONG SIWU TANG, decoction for removing blood stasis, ERZHI WAN, GUIPI TANG etc.; The most frequently used Chinese medicine is followed successively by Radix Angelicae Sinensis, Poria, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Bupleuri, Flos Carthami, Radix Glycyrrhizae, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Semen Persicae, Cortex Moutan, the Radix Rehmanniae, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, the Radix Angelicae Dahuricae, Fructus Corni, Herba Leonuri, Rhizoma Dioscoreae, Fructus Ligustri Lucidi, Rhizoma Atractylodis etc.But the effect of these Therapeutic Method is not very desirable, can not fundamentally treat mottle, and also has certain side effect.Therefore, improve a kind of control mottle of highly effective and safe, the Chinese medicine health care product of freckle removing and whitening frost skin has become people's urgent needs.

Summary of the invention

Technical problem to be solved by this invention is, has a lot of defectives for prior art, contains poisonous composition such as Folium Ginkgo, a kind of composition is arranged ginkgoic acid in the Folium Ginkgo, if the dosage of usefulness is excessive, perhaps Time of Administration is long, can damage heart.But Semen Ginkgo extrac has very strong removing free radical and antioxidation, the synthetic collagen Proteins of yellow glycoside, aminoacid and aminoacid in the Folium Ginkgo is improved looks to human body, the check melanin growth keeps skin gloss and elasticity to play no small effect, and difficulty is quite large but refinement is got up.The invention solves the virose shortcoming of Folium Ginkgo; And the beneficiating ingredient that has kept greatly Folium Ginkgo makes it not have work in-process to run off, and has on the make avoided secondary pollution, is the health product of green health environmental protection fully.Add some blood circulation promoting and blood stasis dispelling, the natural Chinese medicine of inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, heat-clearing and toxic substances removing, check melanin growth, the energy strengthening vital QI to eliminate pathogenic factors, purging FU-organs is let out poison, promoting blood circulation to remove blood stasis, the metabolism function of regulation of skin reaches and improves blood circulation of human body and skin detoxification ability, reach and beautify skin, the effect of whitening and speckle dispelling.

For solving the problems of the technologies described above, the invention provides a kind of Folium Ginkgo freckle removing and whitening frost, the parts by weight of the various raw materials of its described Folium Ginkgo freckle removing and whitening frost are: 10～30 parts of Folium Ginkgos, 10～20 parts of Herba Leonuris, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts in Flos persicae, 10～20 parts of Rhizoma Atractylodis, 10～20 parts of Myrrhas, 10～20 parts of Flos Inulaes, 10～20 parts of Flos Campsiss, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Flos Loniceraes, 10～20 parts of Flos Albiziaes, 10～20 parts of propolis, 10～20 parts of Caulis Spatholobis, 10～20 parts of Herba Menthaes, 10～20 parts of Margaritas.

Described Folium Ginkgo freckle removing and whitening frost, the parts by weight of the various raw materials of its described Folium Ginkgo freckle removing and whitening frost can be preferably: 10～30 parts of Folium Ginkgos, 10～15 parts of Herba Leonuris, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts in Flos persicae, 10～15 parts of Rhizoma Atractylodis, 10～15 parts of Myrrhas, 10～15 parts of Flos Inulaes, 10～20 parts of Flos Campsiss, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Flos Loniceraes, 10～20 parts of Flos Albiziaes, 10～20 parts of propolis, 10～20 parts of Caulis Spatholobis, 10～20 parts of Herba Menthaes, 10～20 parts of Margaritas.

Described Folium Ginkgo freckle removing and whitening frost is characterized in that, the parts by weight of the various raw materials of described Folium Ginkgo freckle removing and whitening frost can also be preferably: 10～30 parts of Folium Ginkgos, 10～20 parts of Herba Leonuris, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts in Flos persicae, 10～20 parts of Rhizoma Atractylodis, 10～20 parts of Myrrhas, 10～20 parts of Flos Inulaes, 10～15 parts of Flos Campsiss, 10～15 parts of Radix Scutellariaes, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Flos Loniceraes, 10～15 parts of Flos Albiziaes, 10～15 parts of propolis, 10～15 parts of Caulis Spatholobis, 10～15 parts of Herba Menthaes, 10～15 parts of Margaritas.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Folium Ginkgo freckle removing and whitening frost, and the preparation process of described freckle removing and whitening frost frost comprises:

A. the Folium Ginkgo preparation is pulverized;

B. Folium Ginkgo extracts;

C. Folium Ginkgo extract sucking filtration;

D. Folium Ginkgo extract is condensed into unguentum;

E. the surplus stock component is made unguentum;

F. canned after adding glycerol, the antiseptic after unguentum obtained above being mixed with the Folium Ginkgo extract unguentum of making.

Among the described step a, can get fresh Folium Ginkgo, clean, dry, in 70 ℃ of baking ovens, baking 8-12h takes out and places cooling in the drying baker, pulverizes 100 mesh sieves with pulverizer, and powder places brown wide mouthed bottle to store.

Among the described step b, can get 60% alcoholic solution; Then get ginkgo leaf powder in 60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, use filtered through gauze, add 60% ethanol in the residue again, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.

Among the described step c, ginkgo biloba succi can be used first the gauze coarse filtration, remove the bulky grain precipitation, to improve sucking filtration speed; The sucking filtration instrument is installed, and adding a small amount of lixiviating solution in the buchner funnel carries out sucking filtration, after the sucking filtration end, gets filtrate and abandons filtering residue.

In the described steps d, distillation, concentrating appts can be installed, contain a large amount of alcoholic solution in the sucking filtration liquid, carry out ethanol with distilling apparatus and concentrate, become the paste object.

Among the described step e, can first Rhizoma Atractylodis, Herba Menthae and the Myrrha way of distillation be vaporized into crystal, the surplus stock component be put into 10 times of amount ethanol again, heating and refluxing extraction 2 times each 1～2 hour, leaves standstill 2 extracting solution merging; The medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution merging are left standstill; Above-mentioned two kinds of extracting solution are merged, 1.36 o'clock filtrate when the concentrating under reduced pressure relative density is 80 ℃, Recycled ethanol is adjusted proportion to 1.06 with gained filtrate, and extractum reduces pressure to get.

Among the described step f, add the crystal after the vaporization after the extractum that makes the Folium Ginkgo extract that extractum and above-mentioned steps make in the step 9 can being mixed, it is canned after being in harmonious proportion to add glycerol and antiseptic.

The present invention is adapted at using during the 21-23 point at night.Evenly be applied in face during use, the rear cleaning of getting up morning gets final product.Be fit to life-time service every day.Be the skin self-regeneration night, and the best opportunity of the functional cosmetics produce effects such as whitening skin and preserving moisture, the present invention uses during this period, can reach the check melanin growth, keeps skin gloss and elastic reaction.

Semen Ginkgo extrac has very strong removing free radical and antioxidation, the synthetic collagen Proteins of yellow glycoside, aminoacid and aminoacid in the Folium Ginkgo is improved looks to human body, the check melanin growth, keep skin gloss and elasticity to play no small effect, be fit to life-time service, can not damage health.The invention solves the virose shortcoming of Folium Ginkgo; And the beneficiating ingredient that has kept greatly Folium Ginkgo makes it not have work in-process to run off, and has on the make avoided secondary pollution, is the cosmetics of green health environmental protection fully.Add some blood circulation promoting and blood stasis dispelling, inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, heat-clearing and toxic substances removing, Cucumber Extract cell, the natural Chinese medicine of whitening and speckle dispelling, the check melanin growth, purging FU-organs is let out poison, promoting blood circulation to remove blood stasis, the metabolism function of balance the body, improve blood circulation of human body and skin detoxification ability, reach and beautify skin, the effect of freckle removing and whitening.

The specific embodiment

The modern medicine whitening and speckle dispelling principle mainly be check melanin cytoactive, check melanin synthetic, remove the melanin that generated, destroy the opacifier etc. that melanin granule and utilization have anti-photo effect.Mainly contain at present following several method: (1) takes orally or vein gives vitamin C, cooperates simultaneously vitamin E to use, and can stop the oxidizing process of melanin metabolism, and check melanin forms.(2) local topical Hydrochinone Cream can suppress tyrosine and be converted into melanin and stop melanic biosynthesis, suppresses the formation of black rope granule and increases its degraded, suppresses synthesizing according to pigment cell DNA and RNA.Or with being coated with outside 20% the Azelex part, Azelex is the competitive inhibitor of tryrosinase, but direct interference biosynthesis.Do not affect normal melanocyte, in conjunction with wide spectrum opacifier treatment epidermis type and mixed type mottle certain curative effect is arranged.Or the local topical retinoid cream, can suppress the melanoma cells tyrosinase activity of In vitro culture, stop melanin to the transhipment of keratinocyte, reduce simultaneously cutin and form, increase drug osmotic.Or the treatments such as external 3% Arbutin cream or lotion.The external treatment medicine of relevant mottle, Western medicine mainly are cracking-off agent (such as retinoic acid, salicylic acid), Donisolone, plumbous mercurial, oxidant or Reducing agent (such as hydroquinone, hydrogen peroxide), side effect is in various degree arranged or cause some complication.Chinese medicine product then because of its draw materials natural, safety good, low side effect, documents and materials are abundant, clinical efficacy is good enjoys favor.Chinese medicine facial cream therapy, is widely used in the treatment of skin whitening in recent years at mottle, and most clinical report Chinese medicine facial cream whitening and speckle dispelling are obtained comparatively significantly effect.

Traditional Chinese medical science QI and blood theory is thought, the qi-blood circulating process is the material base that all histoorgans of human body carry out work, the smooth balance of QI-blood circulating regularly is expensive, will not produce blood stasis if QI and blood is smooth, blood stasis hinders in body, will further cause the deterioration of qi-blood circulating, cause more serious stasis of blood plug, so the traditional Chinese medical science take QI and blood as guiding principle, makes it smooth balance by regulating qi and activating blood, but disease-relieving and physique enhancing, the beauty treatment of nourishing blood.Skin speckle at all in the stasis of blood, moving back speckle must first blood stasis dispelling, blood stasis dispelling be when invigorating blood circulation, invigorating blood circulation more must QI invigorating, regulate the flow of vital energy, qi being the governor of blood, blood moves thereupon; Blood is keeping of gas, be so incensed that and quiet, depressed then blood clotting, the deficiency of vital energy is blood prostration then, gas is compeled then blood and is walked.QI and blood and then all and.And regulate the flow of vital energy liver, QI invigorating is at the lung kidney, lung governing skin and hair.Because of qi depression to blood stasis, have influence on the QI-blood circulation function of lung spleen Liver and kidney, the mottles such as chloasma, freckle occur and cause face, even alopecia, alopecia areata occur.The present invention mainly identifies and corrects according to Chinese medicine and executes the principle of controlling, and the many doctor chiefs of family of collection skim the cream off milk; Based on pathogenetic understanding and the Therapeutic Principle of Chinese medicine to facial colour spot, reference is Chinese medicine pharmacological research achievement at all times, the natural Chinese medicine of screening inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, heat-clearing and toxic substances removing, clearing away heat-fire, strengthening vital QI to eliminate pathogenic factors, purging FU-organs is let out poison, promoting blood circulation to remove blood stasis, the metabolism function of balance the body, improve blood circulation of human body and liver detoxification ability, reach the effect that beautifies skin.Semen Ginkgo extrac has very strong removing free radical and antioxidation, and the synthetic collagen Proteins of yellow glycoside, aminoacid and the aminoacid in the Folium Ginkgo is improved looks to human body, and the check melanin growth keeps skin gloss and elasticity to play no small effect.

The Mineral Concentrations such as VC, VE, carotene and calcium, phosphorus, boron, selenium are also very abundant in the Folium Ginkgo, surpass general fruit and vegetable and edible plant raw material.Biological anti-oxidant is a class material that directly and indirectly has anti-oxidation function in the body.In Folium Ginkgo, contain two class antioxidants--nutrient antioxidant and non-nutritive antioxidant.The former mainly contains carotene, VC, VE, selenium, zinc, copper etc.; the latter mainly contains ginkgetin, terpene lactones, catechin, Polyphenols etc.; content is also very abundant, and they are not subjected to have ten important effects aspect the oxidative damage due to the free radical at the protection body.Therefore, Folium Ginkgo integrates nutrition, health care, treatment function, and Folium Ginkgo is developed as the resource that high nutrition, health care are worth, and this is significant for improving the Folium Ginkgo comprehensive utilization ratio.The development and use of Folium Ginkgo are from the thirties in 20th century, and Japan and West Germany have namely begun the research of Folium Ginkgo.Along with deepening continuously of modern pharmacological research, to find not only to contain Flavonoid substances in the Folium Ginkgo, and also have the chemical compounds such as terpene lactones, phenols, the pharmacological action of their brilliances is familiar with gradually by people.Clinical observation proves that Folium Ginkgo has following several effect: 1, reduce cholesterol levels in the blood of human body, prevent arteriosclerosis.To be short of physical strength behind the middle-aged and elderly people light activity, palpitating speed, chest pain, the effect of being significantly improved such as feel dizzy.2, reduce blood pressure by increasing the saturating property of blood vessel and elasticity, preferably antihypertensive effect is arranged.3, the deposition composition on the elimination blood vessel wall improves blood flow and changes, and promotes erythrocyte deformability, and blood viscosity lowering makes blood flow unobstructed, can prevent and treat cerebral hemorrhage and cerebral infarction.The senile dementia that arteriosclerosis is caused also has certain curative effect.Gingko leaf preparation and antidiabetic drug share the treatment diabetes good therapeutic effect, can be used for the adjuvant of diabetes.5, can obviously alleviate the symptoms such as abdominal pain in menstruation and sore waist and aching in the waist and the back.6, be used for the treatment of bronchial asthma, good therapeutic effect is also arranged.7, reduce level of lipid, reduce freckle, moist skin, beautiful appearance.8, relieving constipation, diuresis, toxin expelling, detoxifcation.9, climacteric syndrome is improved significantly.

Anemia of pregnant woman of the present invention and child, old man are careful.A kind of composition is arranged ginkgoic acid in the Folium Ginkgo, if the dosage of usefulness is excessive, perhaps Time of Administration is long, can damage heart.

The present invention overcomes the poisonous defective that should not extract of Folium Ginkgo, has kept greatly the beneficiating ingredient of Folium Ginkgo, makes it not have work in-process to run off, and has on the make avoided secondary pollution, is the cosmetics of green health environmental protection fully.Semen Ginkgo extrac has very strong removing free radical and antioxidation, the synthetic collagen Proteins of yellow glycoside, aminoacid and aminoacid in the Folium Ginkgo is improved looks to human body, the check melanin growth, keep skin gloss and elasticity to play no small effect, be fit to life-time service, can not damage health.And add some blood circulation promoting and blood stasis dispelling, inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, heat-clearing and toxic substances removing, Cucumber Extract cell, the natural Chinese medicine of whitening and speckle dispelling, the check melanin growth, purging FU-organs is let out poison, promoting blood circulation to remove blood stasis, the metabolism function of balance the body, improve blood circulation of human body and skin detoxification ability, reach and beautify skin, the effect of freckle removing and whitening.

The Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, dispel silt, regulating menstruation, water disappears.The treatment menoxenia, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, rushes down blood, the carbuncle skin infection at hematuria.Herba Leonuri contains the materials such as leonurine, Fumaric acid, and the effects such as promoting blood flow to regulate menstruation, blood pressure lowering, inducing diuresis to remove edema are arranged.

Pseudobulbus Bletillae (Rhizoma Bletillae) is bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.Be used for hemoptysis and spit blood traumatic hemorrhage, sore swollen toxin, chapped skin; The pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Shennong's Herbal: " main carbuncle, malignant boil, lose cellulitis, the dead flesh of impairment of YIN, pathogen in the stomach "; Compendium of Material Medica: " abnormal smells from the patient (root) is bitter, flat, nontoxic.

Radix Angelicae Dahuricae meridian distribution of property and flavor: suffering, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping." Japan hanako materia medica ": control the conjunctival congestion bulbar conjunctiva polyp, and tire patching leakage landing, broken stagnated blood is mended fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, and evacuation of pus, desolation, scabies, the pain relieving granulation promoting is gone face Shao-defect scar.

Flos Inulae is for being the dry flower of Compositae Calendula officinalis platymiscium Calendula officinalis (latin name Cymbopogon citrat).The Flos Inulae nature and flavor are light flat, and flower, leaf have antiinflammatory, antibacterial action.Root energy promoting flow of QI and blood, but removing heat from blood, hemostasis spent.Superpower healing ability, sterilization convergence wound is administered inflammation, skin sore, corse sweat pore prevents the generation of cicatrix.The calm skin of energy improves the sensitivity skin quality.Effect with maintenance cicatrix.Can promote the metabolism of skin.Especially for the skin of drying, the moisturizing effect of height is arranged.Radix Curcumae is hot, bitter, and is cold.Return liver, the heart, lung meridian.Function cures mainly regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.Be used for the amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, the calentura coma, epilepsy is gone mad, the jaundice dark coloured urine.Promoting QI circulation for relieving depression, the removing heat from blood removing blood stasis with potent drugs.Control all pains of breast abdomen side of body rib, it is demented to lose the heart, and the calentura coma is spitted blood epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice." property of medicine opinion " carries it: control woman's stagnated blood epigastric pain caused by emotional factors, the cold air knot is poly-, and warm vinegar rubs and takes it.Tang Materia Medica carries it: main accumulation of blood, the therapeutic method to keep the adverse QI flowing downwards, granulation promoting, hemostasis, broken stagnant blood, stranguria with blood, hematuria, incised wound.

A kind of Chinese medicine material of Flos Campsis has promoting the circulation of blood blood stasis removing, cooling blood, expelling wind dampness removing, heat-clearing and toxic substances removing, and acrid in the mouth acid, cold nature is returned liver, pericardium channel, function promoting blood circulation to remove blood stasis, cooling blood, expelling wind.Cure mainly menoxenia, amenorrhea lump in the abdomen, puerperal swelling of the breast, skin pruritus. " Amplification on Materia Medica addendum ": Flos Campsis, control the key medicine of pain in the blood also, and the nourishing YIN victory very, be stamped and keep and walk alone, in the married woman side multiplex what." Nanning City's medicine will ": the merit of eliminating inflammation and expelling toxin, hemostasis and pain-relieving, evacuation of pus granulation promoting is arranged, control red Hakuri.

Flos Albiziae contains the Herba Albiziae glycoside, tannin, and resolving stagnation for tranquilization, the appetizing of regulating the flow of vital energy, activating collaterals to relieve pain is used for irritability, melancholy insomnia.It is uncomfortable in chest to control pent-up, and insomnia is forgetful, and acute conjunctivitis can settling five organs, and will, improving healthy complexion, have preferably keep fit, calm, the effect of calming the nerves, improve looks, also be to treat neurasthenic good merchantable brand.Also has clearing away summer-heat, the face-beautifying and spot-removing effect such as relieve the effect of alcohol." book on Chinese herbal medicine warp " said: " Flos Albiziae energy settling five organs, and will, improving healthy complexion." especially to the anemia of pregnant woman, have preferably keep fit, calm, the effect of calming the nerves, improve looks, also be to treat neurasthenic good merchantable brand.

Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, collateral dredging.Be used for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carry it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Flos Campsis, Caulis Spatholobi is for oral administration to be that the treatment blood stasis is not loose, the good medicine that nourishing blood silt is invigorated blood circulation.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibiotic not worse than Rhizoma Coptidis, and does not develop immunity to drugs.Hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, the lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, by " the sensible opinion of married woman " cloud, SIWU TANG is controlled the gynecopathy, pays no attention to antenatal puerperal, through water what, all can be general, only flavor Radix Salviae Miltiorrhizae is loose, cures mainly identical with it.The lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls ends the metrorrhagia dysentery, the regulating menstruation arteries and veins.The Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves effects such as circulating, remove intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote the liver blood circulation to be beneficial to liver cell regeneration.

Propolis (bee glue) have the good reputation of " blood vessel street cleaner ", what the recent domestic scholar did studies show that in a large number, flavonoid in the propolis (flavonoid) composition and various active composition, can improve elasticity and the permeability of blood vessel, vasodilator is removed the overstocked thing of depositing of blood vessel, purify the blood, blood fat reducing, blood viscosity lowering improves and organizes microcirculating state, and the effect that has stronger antioxidation, removes free radical.The toxicological experiment result shows that propolis is actual innocuous substance, is safe and feasible by the prevention of long-term taking propolis and treatment hyperlipemia therefore.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, really the gas medicine in the blood, the also panacea in the blood.About mending to mend then of assistant, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the pain relieving constipation of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so want its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, and repercussive blood can lose pus, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui brings down a fever, relieving restlessness, QI invigorating, day hot disease of row, the pestilence miasma, mania and irritation, married woman's blood fortune, and hemorrhoidal hamorrhage are rushed down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, the skin ulcer scabies, headache makes eye bright, and conjunctival congestion is exerted meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.

Flos Lonicerae is the general designation of Chinese crude drug and plant.The plant Flos Lonicerae has another name called Radix Ophiopogonis, is the perennial half evergreen winding bejuco of Caprifoliaceae." Flos Lonicerae " one come from Compendium of Material Medica because Flos Lonicerae just opens and is white, after transfer yellow to, Flos Lonicerae hence obtains one's name.The medical material Flos Lonicerae is Caprifoliaceae woodbine Radix Ophiopogonis and congener dry flower or the first flower of opening of band.Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.The sweet cold of its property fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, and also kind removing summer-heat blood poison is used for various febrile diseases, and such as fever of the body, dermexanthesis, send out the cards such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, all effect is remarkable.The effect that Flos Lonicerae also has skin whitening, detumescence to make eye bright.

It is hot cold sweating antipyretic medicine for Herba Menthae, controls influenza, headache, conjunctival congestion, fever of the body, throat, the dental bed disease such as swell and ache.But external training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.The quintessence oil that extract from Herba Menthae can be used for aromatotherapy and makes perfume and cosmetics, protection skin.Herba Menthae contains the materials such as volatile oil, peppermint essence and tannin, helps to smooth indignation, the negative emotions such as dejected, is allaying tiredness, relieving stress, dispassionate quick-witted tonic.

Flos persicae is rosaceous plant Flos persicae (latin name: dry flower Prunus persica).Flos persicae can be made into the food such as Flos persicae ball, Flos persicae tea.It has very high ornamental value, is the material commonly used of literary creation.In addition, first medical value that have dredging the meridian, skin care in the Flos persicae.Contain multivitamin and trace element in the Flos persicae, these substance dredging the meridian, expansion tip hair and blood pipe improves blood circulation, promotes skin-nourishing and oxygen supply, skin care.Prevent pigment chronic precipitation in skin, effectively remove the chloasma, freckle, the black speck that hinder beauty treatment in the body surface." a thousand pieces of gold prescription " carries: " Flos persicae three strains are drunk the eel-like figure body on an empty stomach." " Mingyi Bielu " carry: " peachization bitter in the mouth, flat, main except aqueous vapor, sharp defecation, lower three worms." the Flos persicae nature and flavor are sweet, flat nontoxic, it is pleasant to help digestion, and phlegm retention is stagnant, dysuria, amenorrhea.The skin protection of we's single reducing weight and beautifying features is fabulous cosmetics.The beautification function of Flos persicae, mainly be come from contain that kaempferol, perfume (or spice), bean are smart in spending, trifolin and vitamin A, the nutrient substance such as B, C.These substance blood vessel dilating, promotion of blood circulation, moist skin, improve blood circulation, promote skin-nourishing and oxygen supply, make the lipofuscin element that promotes human senility accelerate to drain, prevent melanin chronic deposition in skin, thereby can effectively prevent chloasma, freckle, black speck, also be rich in vegetable protein and the aminoacid that is free state in the flowering peach, be absorbed by the skin easily, to preventing and treating xerosis cutis, coarse and wrinkles etc. effectively also can strengthen the resistance against diseases of skin, thereby prevent and treat dermatosis, seborrheic dermatitis, suppurative dermatitis, vitamin C deficiency etc., of great advantage to skin

Rhizoma Atractylodis have drying damp and strengthening spleen, the effect of wind-damp dispelling.Cure mainly retention of dampness in middle-JIAO, anemofrigid-damp arthralgia, the foot swelling and pain in knee, flaccidity is soft unable, nyctalopia nyctalopia." pearl sac " day: " can stomach invigorating pacify spleen, non-this of all damp-edema can not remove." Compendium of Material Medica says: " control the damp-phlegm prolonged fluid-retention ... and spleen is wet dirty, turbid drop leukorrhagia, the sliding hemorrhoidal hamorrhage that rushes down.". Compendium of Material Medica: control the damp-phlegm prolonged fluid-retention, or hold blood stasis under the arm and become the nest capsule, and spleen is wet dirty, turbid drop leukorrhagia, the sliding hemorrhoidal hamorrhage that rushes down.

Myrrha cures mainly breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.The effects such as promoting blood circulation and stopping pain, detumescence and promoting granulation are arranged.Antibiotic, antimicrobial, antiinflammatory, convergence, tool balosam speciality, deodorization, the flatulence of dispelling, sterilization, diuresis, stimulate the menstrual flow, reduce phlegm, antifungal, excitation, sharp stomach, urge antiperspirant, mend body, sharp uterus, control wound, to dry and cracked, to take off coarse skin helpful.Amplification on Canon of Materia Medica: Myrrha, the general logical blood that stagnates is beaten and is pounced on damage pain, all takes with alcoholizing.Stasis then gas is stopped up solidifyingly, and gas stops up that solidifying then meridians are completely anxious, and meridians are completely anxious, so pain and swollen.All beating pounced on muscle palpus struttuer, meridian trauma, and QI and blood is not all right, stops up and coagulates, so in this way.

Margarita: tranquilizing mind, yin nourishing relieves dizziness, high fever, infantile convulsions, epilepsy, etc., heat clearing away pendant expectorant, removing nebula makes eye bright, removing toxic substances and promoting granulation.Control palpitation with fear, palpitation with a distress feeling, epilepsy, infantile convulsion is twitched, and dysphoria with smothery sensation is quenched one's thirst, the sore throat aphtha, order is given birth to cataracta, and skin infection does not close up for a long time.Ming Dynasty Li Shizhen (1518-1593 A.D.) is paid attention to the pharmacological action of Margarita, and think the drug effect of Margarita at skin Caring, thereby write especially in Compendium of Material Medica: " the Margarita salty in the mouth is sweet cold nontoxic, relieving palpitation point order; Margarita is coated with face, makes us moist good color.Be coated with brothers, peeling skin hangnail; Pendant expectorant, except speckle, antidiarrheal; Except children's's fever (of children) accompanied by fear, the peace soul; The nebulousurine of only passing out semen is separated pox and is treated poison.Make the gloss pure white " etc.Simultaneously, it has also put down in writing the medicinal several different methods of Margarita.The effect that suppresses lipofuscin and remove free radical: mouse peritoneal injection Margarita powder suspension 200mg/(kg. days) * 25 days, the lipofuscin content in cardiac muscle and the cerebral tissue is obviously reduced, liver organization is had no significant effect.Product after the PFC that extracts from the Hyriopsis cumingii Margarita powder and the separation thereof is with its effect to the free radical of O of chemiluminescence determination.The result shows that both all have the inhibition luminous function, and the monomer component PCM-1 effect after PFC purifies is stronger, can suppress the interior free yl reaction.

Specific embodiment 1:

Preparation: get fresh Folium Ginkgo, clean, dry, in 70 ℃ of baking ovens, baking 9h (it is fixed that the time is looked the sample moisture, can 8～12h), and take out and place cooling in the drying baker, pulverized 80 mesh sieves with pulverizer, powder places brown wide mouthed bottle to store.

Lixiviate: prepare 60% alcoholic solution (get 640mL95% ethanol, the 360mL pure water is made into 60% alcoholic solution).Get the 100g ginkgo leaf powder in 700mL60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, use filtered through gauze, add 60% ethanol 700mL in the residue, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.Do simultaneously parallel laboratory test.

Sucking filtration: use first the gauze coarse filtration, remove the bulky grain precipitation, to improve sucking filtration speed.The sucking filtration instrument is installed, and adding a small amount of lixiviating solution in the buchner funnel carries out sucking filtration, owing to contain gelatinous precipitate in the Folium Ginkgo, filter paper easily results in blockage, and causes the decline of sucking filtration speed, so should often change filter paper.Sucking filtration is got filtrate and is abandoned filtering residue after finishing.

Distillation, concentrated: distillation, concentrating appts are installed, are contained a large amount of alcoholic solution in the sucking filtration liquid, carry out ethanol with distilling apparatus and concentrate.A certain amount of ethanol also has bactericidal action, when measuring the extract bacteriostasis, should get rid of the interference of alcohol solvent as far as possible, and ethanol is volatilized totally fully.In order not destroy effective ingredient in the extract, bath temperature is controlled at 60 ℃～70 ℃, and the boiling point of 95% ethanol is about 75 ℃, so distillation speed is slow, the time is long.Can take simple method, direct heating in water bath, the ethanol that in air, volatilizees, this method shortcoming: can not Recycled ethanol.The extract that finally obtains is part precipitation extractum, and color is the dark-brown dope.

Dry: owing to still contain part ethanol and moisture in the concentrated lixiviating solution, adopt boulton process, temperature is controlled between 60 ℃～70 ℃, and utilization increases vacuum and reduces boiling point, removes last ethanol and residual part moisture.If conditions permit can also adopt freezing and drying lyophilization dry.Except containing flavonoid and lactone, also contain a certain amount of impurity in the extract of this moment.

All the other raw materials are granulated: with all the other raw material Herba Leonuris, and the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Salviae Miltiorrhizae, Flos persicae, Rhizoma Atractylodis, Myrrha, Flos Inulae, Flos Campsis, Radix Scutellariae, the Radix Paeoniae Alba, Flos Lonicerae, Flos Albiziae, propolis, Caulis Spatholobi, Herba Menthae, the concentrated extractum of making of Margarita.

Packing: with the above-mentioned extractum that makes, mix with aforementioned Folium Ginkgo extract, add an amount of glycerol and be in harmonious proportion, canned.

Specific embodiment 2:

Pluck the fresh and tender Folium Ginkgo of 1000g, clean, dry, in 70 ℃ of baking ovens, baking 10h takes out and places cooling in the drying baker, pulverizes 60 mesh sieves with pulverizer, and powder places brown wide mouthed bottle storage preparation 60% alcoholic solution.Get the 1000g ginkgo leaf powder in 7000mL60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, use filtered through gauze, add 60% ethanol 7000mL in the residue, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.Do simultaneously parallel laboratory test.Use first the gauze coarse filtration, remove the bulky grain precipitation, to improve sucking filtration speed.The sucking filtration instrument is installed, and adding a small amount of lixiviating solution in the buchner funnel carries out sucking filtration, owing to contain gelatinous precipitate in the Folium Ginkgo, filter paper easily results in blockage, and causes the decline of sucking filtration speed, so should often change filter paper.Sucking filtration is got filtrate and is abandoned filtering residue after finishing, and contains a large amount of alcoholic solution in the sucking filtration liquid, carries out ethanol with distilling apparatus and concentrates.A certain amount of ethanol also has bactericidal action, when measuring the extract bacteriostasis, should get rid of the interference of alcohol solvent as far as possible, and ethanol is volatilized totally fully.In order not destroy effective ingredient in the extract, bath temperature is controlled at 60 ℃～70 ℃, and the boiling point of 95% ethanol is about 75 ℃, so distillation speed is slow, the time is long.Can take simple method, direct heating in water bath, the ethanol that in air, volatilizees, this method shortcoming: can not Recycled ethanol.The extract that finally obtains is part precipitation extractum, and color is the dark-brown dope.Owing to still contain part ethanol and moisture in the concentrated lixiviating solution, adopt boulton process, temperature is controlled between 60 ℃～70 ℃, utilizes increase vacuum to reduce boiling point, removes last ethanol and residual part moisture.First with Rhizoma Atractylodis 500g, Myrrha 500g, the vaporization of the Herba Menthae 500g way of distillation is distilled into crystalline solid, with all the other Herba Leonuri 500g, Radix Angelicae Dahuricae 500g, Radix Angelicae Sinensis 500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 500g, Radix Salviae Miltiorrhizae 500g, Flos persicae 500g, Flos Inulae 500g, Flos Campsis 500g, Radix Scutellariae 500g, Radix Paeoniae Alba 500g, Flos Lonicerae 500g, Flos Albiziae 500g, propolis 500g, Caulis Spatholobi 500g, Margarita 500g put it in 10 times of amount ethanol, heating and refluxing extraction 2 times each 1～2 hour, leaves standstill 2 extracting solution merging; The medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution merging are left standstill; Above-mentioned two kinds of extracting solution are merged, and the concentrating under reduced pressure relative density is the filtrate of 1.36 (80 ℃), and Recycled ethanol is adjusted proportion to 1.06 with gained filtrate, and extractum reduces pressure to get; Then the Folium Ginkgo extract extractum that obtains with above-mentioned steps, and the crystal that obtains after the vaporization use emulsifying agent, for example Tween-80, do not have that sour Pyrusussuriensis is smooth, pluronic restrains F-68, lecithin, fabaceous lecithin; Antioxidant, such as sodium sulfite, sodium pyrosulfite, dibutyl benzoic acid etc.; Solubilizing agent, mediations such as tween 80, bile, glycerol, canned.

Specific embodiment 3:

Pluck the 500g Folium Ginkgo, clean, dry, in 70 ℃ of baking ovens, baking 9h takes out and places cooling in the drying baker, pulverized 60 mesh sieves with pulverizer, powder places brown wide mouthed bottle storage preparation 60% alcoholic solution (get 640mL95% ethanol, the 360mL pure water is made into 60% alcoholic solution).Get the 500g ginkgo leaf powder in 3500mL60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, use filtered through gauze, add 60% ethanol 35000mL in the residue, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.Do simultaneously parallel laboratory test.Use first the gauze coarse filtration, remove the bulky grain precipitation, to improve sucking filtration speed.The sucking filtration instrument is installed, and adding a small amount of lixiviating solution in the buchner funnel carries out sucking filtration, owing to contain gelatinous precipitate in the Folium Ginkgo, filter paper easily results in blockage, and causes the decline of sucking filtration speed, so should often change filter paper.Sucking filtration is got filtrate and is abandoned filtering residue after finishing.Distillation, concentrating appts are installed, are contained a large amount of alcoholic solution in the sucking filtration liquid, carry out ethanol with distilling apparatus and concentrate.In order not destroy effective ingredient in the extract, bath temperature is controlled at 60 ℃～70 ℃, and the boiling point of 95% ethanol is about 75 ℃, so distillation speed is slow, the time is long.The extract that finally obtains is part precipitation extractum, and color is the dark-brown dope.Owing to still contain part ethanol and moisture in the concentrated lixiviating solution, adopt boulton process, temperature is controlled between 60 ℃～70 ℃, utilizes increase vacuum to reduce boiling point, removes last ethanol and residual part moisture.First with Rhizoma Atractylodis 230g, Myrrha 220g, the vaporization of the Herba Menthae 210g way of distillation is distilled into crystalline solid, with all the other Herba Leonuri 220g, Radix Angelicae Dahuricae 240g, Radix Angelicae Sinensis 250g, Pseudobulbus Bletillae (Rhizoma Bletillae) 230g, Radix Salviae Miltiorrhizae 230g, Flos persicae 210g, Flos Inulae 220g, Flos Campsis 210g, Radix Scutellariae 210g, Radix Paeoniae Alba 220g, Flos Lonicerae 220g, Flos Albiziae 230g, propolis 240g, Caulis Spatholobi 230g, Margarita 240g puts it in 10 times of water gagings and soaks.Drop into multi-function extractor and extract twice, add 8-10 times of water gaging for the first time and decocted 1-2 hour, add 4-8 times of water gaging for the second time and decocted 1-2 hour, merge decocting liquid twice, filter to get filtrate; Heating is concentrated into pasty state, and the Folium Ginkgo extract extractum that then obtains with above-mentioned steps, and the crystal that obtains after the vaporization use emulsifying agent, for example Tween-80, do not have that sour Pyrusussuriensis is smooth, pluronic restrains F-68, lecithin, fabaceous lecithin; Antioxidant, such as sodium sulfite, sodium pyrosulfite, dibutyl benzoic acid etc.; Solubilizing agent, mediations such as tween 80, bile, glycerol, canned.

Pharmacology's toxicity test

Folium Ginkgo freckle removing and whitening frost of the present invention acute toxicity test

The acute toxicity testing data

1, experimental technique

Depilatory is evenly coated in guinea pig back spinal column both sides, make about 40 square centimeters of unhairing scope.Clean depilatory returns cage to observe 24 hours, every group of Cavia porcellus is coated with respectively the present invention 0.2,0.4 and 0.8g, contain respectively crude drug 92mg, 184mg and 368mg), another group is coated with solvent (normal saline) 0.8ml every day three times, and a continuous week is after experiment finishes, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin are done pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity activity, histopathologic examination, the administration group heart, liver, kidney and depilation skin and contrast word more also no significant difference.

The long term toxicity test data

1, experimental technique

Cavia porcellus at random part is become 4 groups, 15 every group.In guinea pig back spinal column both sides depilatory is evenly coated, made about 40 square centimeters of its depilation scope.Clean depilatory, observe after 24 hours every group of Cavia porcellus and be coated with respectively the present invention 0.2,0.4 and 0.8ml, contain respectively crude drug 92,184 and 368mg), another group is coated with the every twice-daily of solvent 0.8ml, continuous 60 days, observe the ordinary circumstance of Cavia porcellus, put to death animal after experiment finishes and carry out hematology, blood biochemical and pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunk unhairing districts, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity activity, blood biochemistry checking, medication group and matched group are all in normal range.Histopathologic examination, experiment is respectively organized the heart, liver, kidney and local skin and is showed no obvious pathological changes.Prompting, long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.Result of the test shows: experiment safety of the present invention is reliable.

The test of pesticide effectiveness:

1.HMB45 the PATHOMORPHOLOGICAL OBSERVATION OF PULLORUM of the dermal melanin cell of labelling

1) routine paraffin wax embedded section (5um) dewaxes to water.Distilled water flushing, PBS soaked 5 minutes.

2) 3%H2O2 incubated at room 5-10 minute, to eliminate the activity of endogenous peroxydase, PBS washed, and * was 3 times in 2 minutes.

3) 10% normal goats serum sealing, incubated at room 10 minutes drips primary antibodie HMB45, and 4 ℃ are spent the night.

4) PBS flushing, * was 3 times in 2 minutes.Drip the biotin labeling two anti-(1%BSA-PBS dilution) of proper proportion dilution, 37 degree were hatched 10-30 minute;

5) PBS flushing, * was 3 times in 2 minutes.Drip the Radix Cochleariae officinalis enzyme labelling strepto-avidin (PBS dilution) of proper proportion dilution, 37 degree were hatched 10-30 minute;

6) PBS flushing, * was 3 times in 2 minutes.Chromogenic reagent (DAB) 5-10 minute.

7) tap water fully washes, and haematoxylin is redyed, and transparent, mounting dewaters.

Adopt Image-Pro Plus5.0 image analysis system software analysis, calculate area and the optical density of respectively organizing melanocyte and melanin granule positive expression position.

The expression of 2 dermal melanin cell NOS

1) routine paraffin wax embedded section (5um) dewaxes to water.Distilled water flushing, PBS soaked 5 minutes

3) 10% normal goats serum sealing, incubated at room 10 minutes drips primary antibodie NOS, and 4 ℃ are spent the night.

Adopt Image-Pro Plus5.0 image analysis system software analysis, calculate area and the optical density of respectively organizing NOS positive expression position.

4.5 the mrna expression of skin tryrosinase

1) frozen section (5um) is put room temperature 10 minutes in the punching liquid, and punching changes histiocytic permeability and makes fast permeates cell membranes smoothly of probe to cell.0.1M PBS flushing 3 times.

2) put H2O2 confining liquid room temperature 20 minutes, with sealing endogenous H2O2 enzyme.0.1MPBS wash 3 times.

3) drip compound digestion working solution, cover tissue surface, room temperature 20 minutes, 0.1M PBS flushing 3 times.0.2Xssc flushing is (room temperature 3 minutes) once.

4) drip the prehybridization working solution, cover in situ hybridization specialty coverslip, cover 42 ℃ of wet boxes of tissue and hatched 4 hours.

5) throw off coverslip, with 0.2Xssc flushing three times, washed 5 minutes at every turn.

6) drip crossing work liquid, cover 37 ℃ of wet boxes of tissue and hatched 5 hours.

7) throw off coverslip, with 2Xssc37 ℃ of flushing three times, washed 5 minutes at every turn.0.2Xssc37 ℃ flushing three times was washed 5 minutes at every turn.0.1M TBS37 ℃ is washed 3-5 time, washed 5 minutes at every turn.

8) drip the biotin labeled antibody working solution of the anti-digoxin of mice, cover 37 ℃ of wet boxes of tissue and hatched 45-60 minute.0.1M PBS flushing 3 times was washed 5 minutes at every turn.

9) drip high quick catalase streptavidin complex working solution, cover 37 ℃ of wet boxes of tissue and hatched 50 minutes, 0.1M PBS flushing 3 times was washed 5 minutes at every turn.

10) DAB colour developing, optical microphotograph Microscopic observation to the positive color of cell endoplasm and extracellular background color contrast contrast and use distilled water flushing, cessation reaction when obvious.

11) haematoxylin is redyed, and transparent, mounting dewaters.

Primer sequence is as follows: the Mus tryrosinase: 5 '-GGTCC CTCAG GTGTT CCATCGCATA AA concentration and probe concentration: the 8ug/ml hybridization solution, probe is applicable to mice.

3, data statistics and graphical analysis

3.1 statistical analysis was carried out in the pairing T check of monofactorial variance analysis and treatment cross-reference between data statistics employing SPSS11.0 software carried out organizing more.

3.2 the graphical analysis image carries out graphical analysis at Imagepro Plus5.0 image analysis system.Every group of 8-10 opens section, and 3 visuals field of every slice analysis are carried out image and processed.Carry out space and optical density correction with the micrometer image of taking under the equal conditions and blank first before the processing, measure respectively each subregion arbitrary area average optical (mean optical density, MOD), integrated absorbance (intergral optical density, IOD) and positive object plane long-pending (area, μ m).Data result is by as follows

Formula calculates: positive area=positive object plane amasss/measures the gross area, the IOD=integrated absorbance measured value/measurement gross area.

The variation of the total SOD activity of table 1 skin (x ± s ,/mg albumen)

Annotate: dead 2 of QUBAN SHUANG treatment group, sample size is 8.Compare * P＜0.05, * * P＜0.01 with the blank group; Compare ★ P＜0.05, ★ ★ P＜0.01 with model group.Liver F=4.624, skin F=5.010

3.3 mensuration and the statistics of skin MDA activity

With the contrast of blank group, of the present invention group skin MDA activity value raises, and has extremely significant difference.With the model group contrast, QUBAN SHUANG, the present invention's height, middle dosage group have extremely significant difference, and there were significant differences for low dose group, sees Table 3.As seen obviously active rising of the chloasma mouse model skin MDA of chronic constraint+ultraviolet+Progesterone method foundation, it is active that QUBAN SHUANG, the high, medium and low dosage of the present invention all can reduce skin MDA, wherein high, the middle dosage of QUBAN SHUANG, the present invention has extremely significantly effect, with the blank group without significant difference.

The variation (x ± s ,/mg albumen) of table 2MDA activity

Annotate: dead 2 of QUBAN SHUANG treatment group, sample size is 8.Compare * P＜0.05, * * P＜0.01 with the blank group; Compare ★ P＜0.05, ★ ★ P＜0.01 with model group.Liver F=9.572, skin F=4.867.

4.1HMB45 the dermal melanin cell pathology morphological observation of labelling

4.2HMB45 the whole observation of the dermal melanin cell of labelling

Normal group: squamous epithelial cancer is more poor, formed by basal cell and the spine cell of marshalling, and layer 2-3 altogether, there is a small amount of cutin on the surface.See hair follicle in the corium, sebaceous gland links to each other with epidermis, has no sweat gland.It is special that subcutaneus adipose tissue has no.Almost have no melanocyte in the HMB45 labelling epidermis, see a small amount of melanocyte in hair follicle, the sebaceous gland basal cell.

Model group: the melanin positive cell showed increased of HMB45 labelling, with the blank group utmost point significant difference is arranged, cluster is distributed in the hair follicle basal cell group, is strong positive reaction, also see the single melanocyte that is dispersed in distribution in epidermal basal cell and the prickle cell layer, companion cell nuclear increases and examines and move.The epidermis cell number increases, and the part is verrucous hyperplasia.Treatment group: show substantially same model group, the melanin positive cell reduces, there were significant differences with model group, and the liver energy stagnation type chloasma mouse model dermal melanin cell compared with normal mice of pointing out chronic constraint+ultraviolet+Progesterone method to set up is significantly increased, and QUBAN SHUANG and of the present invention group have therapeutical effect.

The variation of melanin granule positive area in the mouse skin melanocyte of table 3HMB45 labelling

Annotate: dead 2 of QUBAN SHUANG treatment group, sample size is 24.Compare * P＜0.05, * * P＜0.01 with the blank group; Compare ★ P＜0.05, ★ ★ P＜0.01 with model group.The F=61.170 of positive area, the F=14.096 of IOD, the F=11.896 of MOD.

As seen from Table 3:

(1) the positive area compared with normal group of melanin granule significantly raise (P＜0.01) in the mouse skin melanocyte of model group HMB45 labelling, QUBAN SHUANG, each dosage treatment group of the present invention have downward trend, wherein QUBAN SHUANG treatment group and low dose group decline highly significant of the present invention (P＜0.01), the present invention is high, the downward trend of middle dosage group is not obvious.

(2) the IOD compared with normal group of melanin granule significantly raise (P＜0.01) in the mouse skin melanocyte of model group HMB45 labelling, QUBAN SHUANG, each dosage treatment group of the present invention have downward trend, wherein QUBAN SHUANG treatment group and low dose group decline highly significant of the present invention (P＜0.01).The downward trend of the middle and high dosage group of the present invention is not obvious.

(3) the MOD compared with normal group of melanin granule significantly raise (P＜0.01) in the mouse skin melanocyte of model group HMB45 labelling, QUBAN SHUANG, each dosage treatment group of the present invention have downward trend, QUBAN SHUANG treatment group decline highly significant (P＜0.01) wherein, dosage group descend obviously (P＜0.05) among the present invention.High and low dose group of the present invention downward trend is not obvious.

In sum, positive area, IOD, the MOD of melanin granule all have significant rising in the mouse skin melanocyte of model group HMB45 labelling, QUBAN SHUANG, each dosage treatment group of the present invention have downward trend, but in general, the effect of high dose group of the present invention is the most remarkable, positive area, IOD, MOD are all had significant reducing effect, secondly are dosage groups among the present invention.

Clinical trial data:

1, because of visceral dysfunction, the pigmented lesions such as the chloasma faciei that causes, mottle, freckle adopt facial cream of the present invention, follow the tracks for the treatment of because of visceral dysfunction, pigmented lesion 100 examples such as the chloasma faciei that causes, freckle, in age 16-52 year, the patient is take person between twenty and fifty as main.

Clinical symptoms: facial simple and unadorned, face is partially dark, and facial long-term length has the pigmented lesions such as chloasma, freckle, and some is also with pox, skin sore, acne etc.Eye pouch, black eye are obvious.

Tcm diagnosis thinks, this disease is stagnant in internal organs, zang-fu disharmony, and qi depression to blood stasis has influence on the QI-blood circulation function of internal organs.Its inherent zang-fu disharmony is freely not to be fruit because, deficiency of both QI and blood, the stasis of blood stagnate, and depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, inrigorating qi and promoting blood circulation are answered in treatment.

Using method: facial cream of the present invention every night between the 21-23 point, after clean, evenly is applied in face.The rear cleaning of getting up morning gets final product.

Semen Ginkgo extrac has very strong removing free radical and antioxidation, and the synthetic collagen Proteins of yellow glycoside, aminoacid and the aminoacid in the Folium Ginkgo is improved looks to human body, and the check melanin growth keeps skin gloss and elasticity to play no small effect.10 days is a course for the treatment of, and common 1-3 course for the treatment of is effective, and pertinacious disease needs 4-5 the course for the treatment of.

Therapeutic effect: after smearing 1-3 the course for the treatment of, the perusal facial colour spot from depth to shallow, eliminate the sixth of the twelve Earthly Branches gradually, the healing patient of clinical symptoms complete obiteration is 43 people, cure rate 43%; The perusal facial colour spot is obviously desalinated the sixth of the twelve Earthly Branches, but does not eliminate fully, and the produce effects patient that clinical symptoms disappears substantially is 37 examples, obvious effective rate 37%, and this part patient continues to use; The perusal facial colour spot is slightly desalinated, patient's 8 examples that clinical symptoms has part to reduce, and effective percentage 8%, this part patient continues to use; After 5 courses for the treatment of, symptom still unalterable patient is 12 examples, inefficiency 12%.Follow up a case by regular visits to the healing patient and had no recurrence in 2 years.

2, because of menoxenia, the pigmented lesions such as the chloasma faciei that causes, freckle

Adopt facial cream of the present invention, women patient's 100 examples, age 22-50 year, suffer from history 2-30, clinical symptoms: face is partially dark, the facial long-term long pigmented lesions such as chloasma, freckle that have, with menoxenia, pass through smooth, piece, dysmenorrhea arranged through color is dark red.The patient has Deficiency and coldness of spleen and stomach, lustreless complexion and dark and gloomy, and face has the pigmented lesions such as chloasma, freckle, butterfly spot, and most of patients has the constipation phenomenon.The patient used the dermopathic medicine of existing multiple treatment more, DeGrain, or invalid.Tcm diagnosis thinks, this disease is stagnant in internal organs, zang-fu disharmony, and qi depression to blood stasis has influence on the QI-blood circulation function of internal organs.Its inherent zang-fu disharmony is freely not to be fruit because, deficiency of both QI and blood, the stasis of blood stagnate, and depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, inrigorating qi and promoting blood circulation, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver dive bright, consumer product dredge stasis, loosening bowel to relieve constipation, promoting the circulation of QI to relieve pain are answered in treatment.

Therapeutic Method: smear facial cream of the present invention.Semen Ginkgo extrac is ointment, have very strong removing free radical and antioxidation, the synthetic collagen Proteins of yellow glycoside, aminoacid and aminoacid in the Folium Ginkgo is improved looks to human body, and the check melanin growth keeps skin gloss and elasticity to play no small effect.Every night between the 21-23 point, after clean, evenly be applied in face.The rear cleaning of getting up morning gets final product.General 10 days is a course for the treatment of, and common 1-3 course for the treatment of is effective, and pertinacious disease needs 4-5 the course for the treatment of, also can various dosage forms can be used alternatingly.

Therapeutic effect: after using 1-3 the course for the treatment of, facial colour spot is eliminated from depth to shallow gradually, and the healing patient of clinical symptoms complete obiteration is 45 people, cure rate 45%; Facial colour spot is shallow by being deep to, and does not eliminate fully, and the produce effects patient that clinical symptoms disappears substantially is 38 examples, obvious effective rate 38%, and this part patient continues to use; Facial colour spot slightly shoals, effective patient 12 examples that clinical symptoms has part to reduce, and effective percentage 12%, this part patient continues to use; After 5 courses for the treatment of, symptom still unalterable patient is 5 examples, inefficiency 5%.In following the tracks for the treatment of healing patient, have no obvious adverse effect and toxic and side effects.Follow up a case by regular visits to the healing patient and had no recurrence in 2 years.

Discuss: Semen Ginkgo extrac has very strong removing free radical and antioxidation, the synthetic collagen Proteins of yellow glycoside, aminoacid and aminoacid in the Folium Ginkgo is improved looks to human body, the check melanin growth, keep skin gloss and elasticity to play no small effect, be fit to life-time service, can not damage health.The present invention has kept the beneficiating ingredient of Folium Ginkgo greatly, makes it not have work in-process to run off, and has on the make avoided secondary pollution, is the cosmetics of green health environmental protection fully.Add some blood circulation promoting and blood stasis dispelling, inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, heat-clearing and toxic substances removing, Cucumber Extract cell, the natural Chinese medicine of whitening and speckle dispelling, the check melanin growth, purging FU-organs is let out poison, promoting blood circulation to remove blood stasis, the metabolism function of balance the body, improve blood circulation of human body and skin detoxification ability, reach and beautify skin, the effect of freckle removing and whitening.Be fit to vast personage's life-time service of liking to be beautiful.

Claims

1. a Folium Ginkgo freckle removing and whitening frost is characterized in that, comprises the crude drug of following parts by weight: 10～30 parts of Folium Ginkgos, 10～20 parts of Herba Leonuris, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts in Flos persicae, 10～20 parts of Rhizoma Atractylodis, 10～20 parts of Myrrhas, 10～20 parts of Flos Inulaes, 10～20 parts of Flos Campsiss, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Flos Loniceraes, 10～20 parts of Flos Albiziaes, 10～20 parts of propolis, 10～20 parts of Caulis Spatholobis, 10～20 parts of Herba Menthaes, 10～20 parts of Margaritas.

2. described Folium Ginkgo freckle removing and whitening is white according to claim 1, it is characterized in that the parts by weight of described crude drug are: 10～30 parts of Folium Ginkgos, 10～15 parts of Herba Leonuris, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts in Flos persicae, 10～15 parts of Rhizoma Atractylodis, 10～15 parts of Myrrhas, 10～15 parts of Flos Inulaes, 10～20 parts of Flos Campsiss, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Flos Loniceraes, 10～20 parts of Flos Albiziaes, 10～20 parts of propolis, 10～20 parts of Caulis Spatholobis, 10～20 parts of Herba Menthaes, 10～20 parts of Margaritas.

3. described Folium Ginkgo freckle removing and whitening is white according to claim 1, it is characterized in that the parts by weight of described crude drug are: 10～30 parts of Folium Ginkgos, 10～20 parts of Herba Leonuris, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts in Flos persicae, 10～20 parts of Rhizoma Atractylodis, 10～20 parts of Myrrhas, 10～20 parts of Flos Inulaes, 10～15 parts of Flos Campsiss, 10～15 parts of Radix Scutellariaes, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Flos Loniceraes, 10～15 parts of Flos Albiziaes, 10～15 parts of propolis, 10～15 parts of Caulis Spatholobis, 10～15 parts of Herba Menthaes, 10～15 parts of Margaritas.

4. one kind such as the preparation method of Folium Ginkgo freckle removing and whitening frost as described in each in the claim 1～3, it is characterized in that preparation process comprises:

A. the Folium Ginkgo preparation is pulverized;

B. Folium Ginkgo extracts;

C. Folium Ginkgo extract sucking filtration;

D. Folium Ginkgo extract is condensed into unguentum;

E. surplus stock is made unguentum;

F. add glycerol after unguentum obtained above being mixed with the Folium Ginkgo extract unguentum of making, antiseptic is canned.

5. the preparation method of described Folium Ginkgo freckle removing and whitening frost according to claim 4, it is characterized in that: among the described step a, get fresh Folium Ginkgo, clean, dry, in 70 ℃ of baking ovens, baking 8-12h, taking-up places cooling in the drying baker, pulverizes 100 mesh sieves with pulverizer, and powder places brown wide mouthed bottle to store.

6. the preparation method of described Folium Ginkgo freckle removing and whitening frost according to claim 4 is characterized in that: among the described step b, get 60% alcoholic solution; Then get ginkgo leaf powder in 60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, use filtered through gauze, add 60% ethanol 700mL in the residue, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.

7. the preparation method of described Folium Ginkgo freckle removing and whitening frost according to claim 4 is characterized in that: among the described step c, ginkgo biloba succi is used first the gauze coarse filtration, remove the bulky grain precipitation, to improve sucking filtration speed; The sucking filtration instrument is installed, and adding a small amount of lixiviating solution in the buchner funnel carries out sucking filtration, after the sucking filtration end, gets filtrate and abandons filtering residue.

8. the preparation method of described Folium Ginkgo freckle removing and whitening frost according to claim 4 is characterized in that: in the described steps d, distillation, concentrating appts are installed, are contained a large amount of alcoholic solution in the sucking filtration liquid, it is concentrated to carry out ethanol with distilling apparatus, becomes the paste object.

9. the preparation method of described Folium Ginkgo freckle removing and whitening frost according to claim 4 is characterized in that: among the described step e, first Rhizoma Atractylodis, Herba Menthae and the Myrrha way of distillation are vaporized into crystal; The surplus stock component is put into 10 times of amount ethanol, heating and refluxing extraction 2 times each 1～2 hour, leaves standstill 2 extracting solution merging again; The medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution merging are left standstill; Above-mentioned two kinds of extracting solution are merged, 1.36 o'clock filtrate when the concentrating under reduced pressure relative density is 80 ℃, Recycled ethanol is adjusted proportion to 1.06 with gained filtrate, and extractum reduces pressure to get.

10. the preparation method of described Folium Ginkgo freckle removing and whitening frost according to claim 4, it is characterized in that: among the described step f, add Rhizoma Atractylodis, Herba Menthae and the Myrrha way of distillation after the extractum that makes the Folium Ginkgo extract that extractum and above-mentioned steps make among the step e mixed and be vaporized into crystal, it is canned after being in harmonious proportion to add glycerol and antiseptic again.