CN102796156B - Adenosine cyclophosphate double-molecule meglumine compound and preparation method thereof - Google Patents
Adenosine cyclophosphate double-molecule meglumine compound and preparation method thereof Download PDFInfo
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- CN102796156B CN102796156B CN201210314213.2A CN201210314213A CN102796156B CN 102796156 B CN102796156 B CN 102796156B CN 201210314213 A CN201210314213 A CN 201210314213A CN 102796156 B CN102796156 B CN 102796156B
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- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229940071138 stearyl fumarate Drugs 0.000 description 1
- 238000012859 sterile filling Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Compound | Water-soluble (mg/ml water) |
CAMP two meglumines | Be less than 1 |
CAMP one meglumine | Be greater than 8 |
CAMP | Be greater than 20 |
CAMP two meglumines | 30g |
N.F,USP MANNITOL | 120g |
Buffer reagent | In right amount |
Water for injection | Add to 2500ml |
Claims (6)
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CN201210314213.2A CN102796156B (en) | 2012-08-24 | 2012-08-24 | Adenosine cyclophosphate double-molecule meglumine compound and preparation method thereof |
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CN201210314213.2A CN102796156B (en) | 2012-08-24 | 2012-08-24 | Adenosine cyclophosphate double-molecule meglumine compound and preparation method thereof |
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CN102796156B true CN102796156B (en) | 2014-07-30 |
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CN103613626B (en) * | 2013-11-29 | 2015-10-14 | 湖北美林药业有限公司 | A kind of adenosine cyclophosphate compound and meglumine adenosine cyclophosphate medicine composition thereof |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS49116096A (en) * | 1972-07-25 | 1974-11-06 | ||
US3872082A (en) * | 1971-05-19 | 1975-03-18 | Boehringer Mannheim Gmbh | Substituted purineribofuranoside-3,5-cyclophosphate compounds and process for their preparation |
CN1459288A (en) * | 2003-06-18 | 2003-12-03 | 赵琛 | Cyclophosphadenosine glucosamine infusion prepn., and its prepn. process, and method for testing contents thereof |
CN1579413A (en) * | 2004-02-11 | 2005-02-16 | 江卫世 | Meglumine adenosine cyclophosphate for injection and its preparing method |
CN1923180A (en) * | 2006-09-22 | 2007-03-07 | 江苏万邦生化医药股份有限公司 | Meglumine cyclic adenosine for injecta and its preparing process |
CN101455631A (en) * | 2009-01-06 | 2009-06-17 | 湖北德康药业有限公司 | Meglumine cyclic adenosine injection and preparation technique thereof |
CN102258531A (en) * | 2011-04-12 | 2011-11-30 | 宁辉 | Medicinal composition containing adenosine cyclophosphate and meglumine and preparation method thereof |
CN102488650A (en) * | 2011-12-19 | 2012-06-13 | 王保明 | Adenosine cyclophosphate pharmaceutical composition and preparation method thereof |
-
2012
- 2012-08-24 CN CN201210314213.2A patent/CN102796156B/en active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3872082A (en) * | 1971-05-19 | 1975-03-18 | Boehringer Mannheim Gmbh | Substituted purineribofuranoside-3,5-cyclophosphate compounds and process for their preparation |
JPS49116096A (en) * | 1972-07-25 | 1974-11-06 | ||
CN1459288A (en) * | 2003-06-18 | 2003-12-03 | 赵琛 | Cyclophosphadenosine glucosamine infusion prepn., and its prepn. process, and method for testing contents thereof |
CN1579413A (en) * | 2004-02-11 | 2005-02-16 | 江卫世 | Meglumine adenosine cyclophosphate for injection and its preparing method |
CN1923180A (en) * | 2006-09-22 | 2007-03-07 | 江苏万邦生化医药股份有限公司 | Meglumine cyclic adenosine for injecta and its preparing process |
CN101455631A (en) * | 2009-01-06 | 2009-06-17 | 湖北德康药业有限公司 | Meglumine cyclic adenosine injection and preparation technique thereof |
CN102258531A (en) * | 2011-04-12 | 2011-11-30 | 宁辉 | Medicinal composition containing adenosine cyclophosphate and meglumine and preparation method thereof |
CN102488650A (en) * | 2011-12-19 | 2012-06-13 | 王保明 | Adenosine cyclophosphate pharmaceutical composition and preparation method thereof |
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Application publication date: 20121128 Assignee: SHANDONG LUYE PHARMACEUTICAL Co.,Ltd. Assignor: Ning Hui Contract record no.: 2014370000117 Denomination of invention: Adenosine cyclophosphate double-molecule meglumine compound and preparation method thereof License type: Common License Record date: 20140711 |
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TR01 | Transfer of patent right |
Effective date of registration: 20240418 Address after: Room 202, East Building C, Headquarters Center, No. 23 Guangfu East Street, Houtang Community, Jiangbei Street, Dongyang City, Jinhua City, Zhejiang Province, 322100 Patentee after: Zhejiang Zhongyan Pharmaceutical Technology Co.,Ltd. Country or region after: China Address before: Room 202, Study Abroad Building, No. 129 Fuzhou North Road, Shibei District, Qingdao City, Shandong Province, 266034 Patentee before: Ning Hui Country or region before: China |