CN102093234B - Tromethamine salt compound of dibasic ester acid, preparation method and medicinal application thereof - Google Patents
Tromethamine salt compound of dibasic ester acid, preparation method and medicinal application thereof Download PDFInfo
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- CN102093234B CN102093234B CN201010571246.6A CN201010571246A CN102093234B CN 102093234 B CN102093234 B CN 102093234B CN 201010571246 A CN201010571246 A CN 201010571246A CN 102093234 B CN102093234 B CN 102093234B
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- trometamol
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- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
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- 229910052739 hydrogen Inorganic materials 0.000 description 1
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- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
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- 210000004969 inflammatory cell Anatomy 0.000 description 1
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- 210000000936 intestine Anatomy 0.000 description 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
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- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
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- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 239000012982 microporous membrane Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000000324 neuroprotective effect Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052755 nonmetal Inorganic materials 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 229940096978 oral tablet Drugs 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- NDLPOXTZKUMGOV-UHFFFAOYSA-N oxo(oxoferriooxy)iron hydrate Chemical compound O.O=[Fe]O[Fe]=O NDLPOXTZKUMGOV-UHFFFAOYSA-N 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 230000001769 paralizing effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 229940023488 pill Drugs 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- XTUSEBKMEQERQV-UHFFFAOYSA-N propan-2-ol;hydrate Chemical compound O.CC(C)O XTUSEBKMEQERQV-UHFFFAOYSA-N 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 159000000000 sodium salts Chemical group 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007962 solid dispersion Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
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- 239000008107 starch Substances 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229940071138 stearyl fumarate Drugs 0.000 description 1
- 238000012859 sterile filling Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Images
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Operation | Temperature rise rate | Temperature (DEG C) | |
1 | Pre-freeze | Be refrigerated to-40 DEG C by room temperature | |
2 | Insulation | -35℃ | |
3 | Vacuumize | -35℃ | |
4 | Heat up | 6 DEG C/h | Be warming up to-5 DEG C |
5 | Heat up | -5 DEG C are warming up to 0 DEG C | |
6 | Heat up | 0 DEG C is warming up to 10 DEG C | |
7 | Heat up | 10 DEG C are warming up to 25 DEG C | |
8 | Insulation | 25℃ |
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201010571246.6A CN102093234B (en) | 2009-11-26 | 2010-11-24 | Tromethamine salt compound of dibasic ester acid, preparation method and medicinal application thereof |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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CN200910224894.1 | 2009-11-26 | ||
CN200910224894 | 2009-11-26 | ||
CN201010571246.6A CN102093234B (en) | 2009-11-26 | 2010-11-24 | Tromethamine salt compound of dibasic ester acid, preparation method and medicinal application thereof |
Publications (2)
Publication Number | Publication Date |
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CN102093234A CN102093234A (en) | 2011-06-15 |
CN102093234B true CN102093234B (en) | 2014-06-18 |
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Application Number | Title | Priority Date | Filing Date |
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CN201010570080.6A Expired - Fee Related CN102079715B (en) | 2009-11-26 | 2010-11-24 | Lysine salt compound of binary ester acid, preparation method and medicinal application |
CN201010571246.6A Expired - Fee Related CN102093234B (en) | 2009-11-26 | 2010-11-24 | Tromethamine salt compound of dibasic ester acid, preparation method and medicinal application thereof |
CN201010571076.1A Expired - Fee Related CN102079717B (en) | 2009-11-26 | 2010-11-24 | Arginine salt compound of dibasic ester acids and preparation method and medicinal application thereof |
CN2010105709656A Pending CN102126973A (en) | 2009-11-26 | 2010-11-24 | Meglumine compound of dibasic ester acid and preparation method and medicinal application thereof |
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CN201010570080.6A Expired - Fee Related CN102079715B (en) | 2009-11-26 | 2010-11-24 | Lysine salt compound of binary ester acid, preparation method and medicinal application |
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CN201010571076.1A Expired - Fee Related CN102079717B (en) | 2009-11-26 | 2010-11-24 | Arginine salt compound of dibasic ester acids and preparation method and medicinal application thereof |
CN2010105709656A Pending CN102126973A (en) | 2009-11-26 | 2010-11-24 | Meglumine compound of dibasic ester acid and preparation method and medicinal application thereof |
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CN103373957A (en) * | 2012-04-12 | 2013-10-30 | 成都苑东药业有限公司 | Chelate with functions of protecting nerve cells |
KR102200892B1 (en) * | 2019-05-13 | 2021-01-12 | 대원제약주식회사 | Novel salts of pelubiprofen, preparation method thereof and pharmaceutical compositions comprising thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999016741A2 (en) * | 1997-09-28 | 1999-04-08 | D-Pharm Limited | Lipophilic diesters of chelating agents |
CN1944378A (en) * | 2006-10-23 | 2007-04-11 | 广东中科药物研究有限公司 | Biphenyl ammonia acetate butantriol salt and its preparing method |
CN101514189A (en) * | 2008-02-18 | 2009-08-26 | 杨喜鸿 | Glycin diazole tromethamine compound as well as preparation method and medicament application thereof |
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CN1899275B (en) * | 2005-07-11 | 2013-11-27 | 南京中敬医药科技研究所 | Use of composition of rheinic acid or rheinic acid compounds in preparing medicine for treating osteoarthritis |
CN1923798A (en) * | 2005-08-30 | 2007-03-07 | 陈亦林 | Preparation method of dexibuprofen amino acid salt and application |
CN101486644B (en) * | 2009-02-24 | 2012-07-25 | 合肥工业大学 | Preparation of arginine acetylsalicylate |
-
2010
- 2010-11-24 CN CN201010570080.6A patent/CN102079715B/en not_active Expired - Fee Related
- 2010-11-24 CN CN201010571246.6A patent/CN102093234B/en not_active Expired - Fee Related
- 2010-11-24 CN CN201010571076.1A patent/CN102079717B/en not_active Expired - Fee Related
- 2010-11-24 CN CN2010105709656A patent/CN102126973A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999016741A2 (en) * | 1997-09-28 | 1999-04-08 | D-Pharm Limited | Lipophilic diesters of chelating agents |
CN1944378A (en) * | 2006-10-23 | 2007-04-11 | 广东中科药物研究有限公司 | Biphenyl ammonia acetate butantriol salt and its preparing method |
CN101514189A (en) * | 2008-02-18 | 2009-08-26 | 杨喜鸿 | Glycin diazole tromethamine compound as well as preparation method and medicament application thereof |
Also Published As
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CN102079717A (en) | 2011-06-01 |
CN102093234A (en) | 2011-06-15 |
CN102079715A (en) | 2011-06-01 |
CN102079717B (en) | 2014-01-22 |
CN102126973A (en) | 2011-07-20 |
CN102079715B (en) | 2014-07-23 |
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