CN101338327B - Process for extracting resveratrol with purity higher than 98 0.000000rom giant knotweed - Google Patents
Process for extracting resveratrol with purity higher than 98 0.000000rom giant knotweed Download PDFInfo
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- CN101338327B CN101338327B CN2008100320678A CN200810032067A CN101338327B CN 101338327 B CN101338327 B CN 101338327B CN 2008100320678 A CN2008100320678 A CN 2008100320678A CN 200810032067 A CN200810032067 A CN 200810032067A CN 101338327 B CN101338327 B CN 101338327B
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- resveratrol
- giant knotweed
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- ethanol
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- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 title claims abstract description 54
- 244000153955 Reynoutria sachalinensis Species 0.000 title claims abstract description 49
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 title claims abstract description 49
- 238000000034 method Methods 0.000 title abstract description 17
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 title abstract description 6
- 229940016667 resveratrol Drugs 0.000 title abstract description 6
- 235000021283 resveratrol Nutrition 0.000 title abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 49
- 108090000790 Enzymes Proteins 0.000 claims abstract description 19
- 102000004190 Enzymes Human genes 0.000 claims abstract description 19
- 238000002425 crystallisation Methods 0.000 claims abstract description 15
- 230000008025 crystallization Effects 0.000 claims abstract description 15
- 239000007788 liquid Substances 0.000 claims abstract description 15
- 238000001953 recrystallisation Methods 0.000 claims abstract description 12
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000004587 chromatography analysis Methods 0.000 claims abstract description 5
- 238000007670 refining Methods 0.000 claims abstract description 4
- 238000001291 vacuum drying Methods 0.000 claims abstract description 4
- 235000018991 trans-resveratrol Nutrition 0.000 claims description 46
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 18
- 229940088598 enzyme Drugs 0.000 claims description 17
- 239000000047 product Substances 0.000 claims description 17
- 238000005516 engineering process Methods 0.000 claims description 16
- 238000005189 flocculation Methods 0.000 claims description 15
- 230000016615 flocculation Effects 0.000 claims description 15
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 10
- 239000012043 crude product Substances 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- 230000009849 deactivation Effects 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 6
- 238000001556 precipitation Methods 0.000 claims description 6
- 239000000741 silica gel Substances 0.000 claims description 6
- 229910002027 silica gel Inorganic materials 0.000 claims description 6
- 108010059892 Cellulase Proteins 0.000 claims description 5
- 229940106157 cellulase Drugs 0.000 claims description 5
- 229940059442 hemicellulase Drugs 0.000 claims description 5
- 108010002430 hemicellulase Proteins 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 239000013049 sediment Substances 0.000 claims description 4
- 108010047754 beta-Glucosidase Proteins 0.000 claims description 3
- 102000006995 beta-Glucosidase Human genes 0.000 claims description 3
- 238000010828 elution Methods 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 238000011084 recovery Methods 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 230000011218 segmentation Effects 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000006228 supernatant Substances 0.000 claims description 3
- 230000001131 transforming effect Effects 0.000 claims description 3
- 238000010792 warming Methods 0.000 claims description 3
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 2
- 229920002498 Beta-glucan Polymers 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 22
- 238000009776 industrial production Methods 0.000 abstract description 3
- 238000001914 filtration Methods 0.000 abstract description 2
- 239000003086 colorant Substances 0.000 abstract 1
- 238000005336 cracking Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003480 eluent Substances 0.000 abstract 1
- 239000008213 purified water Substances 0.000 abstract 1
- 238000004064 recycling Methods 0.000 abstract 1
- 230000000630 rising effect Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 description 5
- 230000004151 fermentation Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 4
- 101710130006 Beta-glucanase Proteins 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 230000009466 transformation Effects 0.000 description 3
- OEGPRYNGFWGMMV-UHFFFAOYSA-N (3,4-dimethoxyphenyl)methanol Chemical compound COC1=CC=C(CO)C=C1OC OEGPRYNGFWGMMV-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 101710081598 Beta-glucosidase 30 Proteins 0.000 description 1
- 101710081293 Beta-glucosidase 40 Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 238000012262 fermentative production Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN2008100320678A CN101338327B (en) | 2008-08-13 | 2008-08-13 | Process for extracting resveratrol with purity higher than 98 0.000000rom giant knotweed |
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CN2008100320678A CN101338327B (en) | 2008-08-13 | 2008-08-13 | Process for extracting resveratrol with purity higher than 98 0.000000rom giant knotweed |
Publications (2)
Publication Number | Publication Date |
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CN101338327A CN101338327A (en) | 2009-01-07 |
CN101338327B true CN101338327B (en) | 2011-03-23 |
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CN2008100320678A Active CN101338327B (en) | 2008-08-13 | 2008-08-13 | Process for extracting resveratrol with purity higher than 98 0.000000rom giant knotweed |
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Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101698634B (en) * | 2009-06-30 | 2013-03-27 | 三原润禾植化有限公司 | Method for extracting and separating resveratrol from giant knotweed rhizome |
CN101628859A (en) * | 2009-08-11 | 2010-01-20 | 张守力 | Extraction method of resveratrol |
CN101628858A (en) * | 2009-08-11 | 2010-01-20 | 张守力 | Preparation process of resveratrol |
CN101805755B (en) * | 2010-04-14 | 2012-01-25 | 卢昶年 | Process for extracting and purifying resveratrol from giant knot weed |
CN102060397B (en) * | 2010-11-18 | 2013-01-02 | 湘西自治州兴湘科技开发有限责任公司 | Method for treating waste water generated in extraction process of active ingredient of polygonum cuspidatum |
CN102304028B (en) * | 2011-07-01 | 2013-10-30 | 中山大学 | Method for separating and purifying resveratrol in polygonum cuspidatum |
CN102627677A (en) * | 2012-03-22 | 2012-08-08 | 聊城大学 | Method for separating and purifying monomer compounds from Rhizoma Polygoni Cuspidati |
CN102838455A (en) * | 2012-09-17 | 2012-12-26 | 湖南希尔天然药业有限公司 | Method for extracting high-content resveratrol from polygonum cuspidatum |
CN103396295B (en) * | 2013-07-31 | 2015-12-02 | 王喜军 | A kind of method extracting resveratrol ingredient from giant knotweed |
CN103571891B (en) * | 2013-11-01 | 2015-07-08 | 湖南科源生物制品有限公司 | Method for extracting resveratrol from polygonum cuspidatum |
CN103695478A (en) * | 2013-12-24 | 2014-04-02 | 湖南科源生物制品有限公司 | Method for converting polydatin to resveratrol |
CN103695479B (en) * | 2013-12-25 | 2015-05-13 | 吉首大学 | High-purity resveratrol preparation method |
CN104800299B (en) * | 2015-04-10 | 2018-03-06 | 辽宁中医药大学 | A kind of concocting method of giant knotweed |
CN105039426A (en) * | 2015-06-24 | 2015-11-11 | 江南大学 | Method for ultrasound-assisted two-aqueous-phase extraction of resveratrol |
CN107660559A (en) * | 2016-07-27 | 2018-02-06 | 四川利尔作物科学有限公司 | Composition pesticide and its application |
CN106397166A (en) * | 2016-08-31 | 2017-02-15 | 防城港市防城区那梭香料厂 | Method for extracting cinnamaldehyde from cinnamomum cassia presl |
CN108048495B (en) * | 2017-12-17 | 2021-04-16 | 安徽济人药业有限公司 | Biological extraction method of resveratrol |
KR101951649B1 (en) * | 2018-05-28 | 2019-02-25 | 주식회사 제이투케이바이오 | Method for manufacturing extract of polygonum cuspidatum having increased resveratrol and anti-fungal composition containing same |
CN109432243A (en) * | 2018-12-18 | 2019-03-08 | 广东冠龙生物科技有限公司 | A kind of resveratrol process for preparing buccal lozenge |
CN116115672B (en) * | 2022-12-27 | 2024-01-26 | 宁波杰顺生物科技有限公司 | Polygonum cuspidatum extract and preparation method thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1546503A (en) * | 2003-12-12 | 2004-11-17 | 深圳海王药业有限公司 | Method for preparing polygonin and resveratrol |
CN1621401A (en) * | 2003-11-28 | 2005-06-01 | 张�浩 | Method for extracting high purity resveratrol from giant knotweed rhizome |
-
2008
- 2008-08-13 CN CN2008100320678A patent/CN101338327B/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1621401A (en) * | 2003-11-28 | 2005-06-01 | 张�浩 | Method for extracting high purity resveratrol from giant knotweed rhizome |
CN1546503A (en) * | 2003-12-12 | 2004-11-17 | 深圳海王药业有限公司 | Method for preparing polygonin and resveratrol |
Non-Patent Citations (6)
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向海艳 等.酶法提取虎杖中白蔡芦醇的研究.《分析试验室》.2007,第26卷375-376. |
向海艳等.酶法提取虎杖中白蔡芦醇的研究.《分析试验室》.2007,第26卷375-376. * |
李梦青 等.酶解法提取虎杖中白藜芦醇、白藜芦醇苷、大黄素.《精细化工》.2008,第25卷(第5期),467-470. |
李梦青等.酶解法提取虎杖中白藜芦醇、白藜芦醇苷、大黄素.《精细化工》.2008,第25卷(第5期),467-470. * |
瞿卫林 等.酶解法提高虎杖中白藜芦醇含量的研究.《中国野生植物资源》.2005,第24卷(第4期),52-55. |
瞿卫林等.酶解法提高虎杖中白藜芦醇含量的研究.《中国野生植物资源》.2005,第24卷(第4期),52-55. * |
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CN101338327A (en) | 2009-01-07 |
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