CN100998572A - Hard medicine capsule - Google Patents
Hard medicine capsule Download PDFInfo
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- CN100998572A CN100998572A CN 200610022606 CN200610022606A CN100998572A CN 100998572 A CN100998572 A CN 100998572A CN 200610022606 CN200610022606 CN 200610022606 CN 200610022606 A CN200610022606 A CN 200610022606A CN 100998572 A CN100998572 A CN 100998572A
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- aqueous solution
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Abstract
An empty capsule for medicines is proportionally prepared from hydroxypropyl methylcellulose, hydroxypropyl starch and chitin through preparing aqueous solution, immersing die in it, baking, removing die and trimming. It has bactericiding action.
Description
Technical field
The present invention relates to a kind of Capsules, specifically relating to a kind of is hard medicine capsule and the preparation method that primary raw material is made with the pure plant fiber element.
Background technology
Traditional Capsules raw materials for production are pharmagel, and pharmagel belongs to animal proteinum, but there is potential safety hazard in animal proteinum; In addition, gelatine capsule is to the variation sensitivity of temperature, humidity, and temperature, humidity were grasped not at that time, were easy to fragmentation, is not easy to transportation and storage.At present, useful starch, Rhizoma amorphophalli glucomannan are produced Capsules, and are the record of the hollow cellulose capsule made of primary raw material with the plant cellulose class.
Summary of the invention
The purpose of this invention is to provide a kind of is the hard medicine capsule of primary raw material preparation with the pure plant fiber element.
Plant capsule of the present invention is achieved by following technical proposals: hard medicine capsule of the present invention is made raw materials of effective components and is consisted of by weight percentage: hydroxypropyl methylcellulose 35～45%; Hydroxypropyl starch 40～55%; Chitin 10～15%; Each constituent content percent sum should equal 100% in the described compositions; Capsule processing technology flow process is: obtained aqueous solution, and the axonometer immersion, oven dry, the demoulding, finishing promptly makes the plant capsule housing; Its process conditions are: described concentration of aqueous solution is 10～50%; Solution viscosity is 1000～10000 centipoises; Be preheated to before the axonometer immersion in 40～100 ℃, it is 2 minutes that axonometer immerses the aqueous solution time; The aqueous solution heating-up temperature is 40～60 ℃; Bake out temperature is 30～70 ℃.
The existing prior art of plant capsule of the present invention has been compared following beneficial effect: because plant capsule of the present invention adopts the pure natural plant fiber element to make for primary raw material, good product performance, stable in properties, pliability is good, anti-impact force is strong, is difficult for broken, safe, good reliability does not contain the pathogenic bacterium of animal proteinum and causes a disease and infects gene.Plant capsule of the present invention and not with medicine generation chemical reaction, take safety, take human body favourable for a long time.And suitable crowd is extensive.Also contain chitin in the plant capsule of the present invention, can kill the intravital hepatovirus of people, improve immunity of human body itself.Plant capsule cost of the present invention is low, and preparation technology is simple, strong operability, and formed product is good, is convenient to transportation and storage.
The specific embodiment
Below in conjunction with embodiment the present invention is further described.
Hard medicine capsule of the present invention is made raw materials of effective components and is consisted of by weight percentage: hydroxypropyl methylcellulose 35～45%; Hydroxypropyl starch 40～55%; Chitin 10～15%; Each constituent content percent sum should equal 100% in the described compositions; Described cellulose is any cellulose in hydroxypropyl emthylcellulose in the plant cellulose (HPMC), ethyl cellulose (EC), hydroxyethyl-cellulose (HEC), the hydroxypropylmethyl cellulose phthalate (HPMCP); Gel is any and the metal ion compatibility in alginate jelly, carrageenan, the xanthan gum.
Capsule processing technology flow process is: obtained aqueous solution, and the axonometer immersion, oven dry, the demoulding, finishing promptly makes the plant capsule housing; Its process conditions are: described concentration of aqueous solution is 10～50%; Solution viscosity is 1000～10000 centipoises; Be preheated to before the axonometer immersion in 40～100 ℃, it is 2 minutes that axonometer immerses the aqueous solution time; The aqueous solution heating-up temperature is 40～60 ℃; Bake out temperature is 30～70 ℃.
Described axonometer preheat temperature is 70～80 ℃.
Described capsule set adopt diameter greater than the axonometer of capsule housing through immersion, oven dry, the demoulding, finishing makes capsule set, promptly makes plant capsule with the capsule housing fit.
Embodiment 1.
Hard medicine capsule of the present invention is made raw materials of effective components and is consisted of by weight percentage: hydroxypropyl methylcellulose 35%; Hydroxypropyl starch 55%; Chitin 10%; Capsule processing technology flow process is: obtained aqueous solution, described concentration of aqueous solution are 10%; Solution viscosity is 1000 centipoises; Aqueous solution immerses heating-up temperature after leaving standstill or be decompressed to the degassing fully, being preheated to 70 ℃ before the axonometer immersion in the glue jar be 40 ℃ of aqueous solutions, placed 2 minutes; Take out axonometer, with the oven dry of sealing drying baker, bake out temperature is 30 ℃; Form one deck duricrust shape polymer blend film on axonometer, axonometer is promptly extracted in the demoulding, just makes the hard medicine capsule housing through finishing;
Described capsule set adopt diameter greater than the axonometer of capsule housing through above-mentioned technological process obtained aqueous solution, immersion, oven dry, the demoulding, finishing makes capsule set, promptly makes plant capsule with the capsule housing fit.
Described capsule is made in the raw materials of effective components based on the capsule of blend can also arbitrarily be mixed with known additives, as plasticizer: glycerol, sorbitol, mannitol, sucrose, Polyethylene Glycol etc., as opacifier: titanium dioxide, barium sulfate, winnofil etc., as coloring agent: water solublity colorant, mordant pigment etc.Gel: sodium alginate, carrageenan, pectin, ethylene copolymer, alginic acid etc. account for the 0.1-3% of above-mentioned main overall component content, the 0.001-0.02% of the total body burden of the above-mentioned main component of surfactant comprise.
Through the test time to rupture is 6.5 minutes.
Embodiment 2.
Hard medicine capsule of the present invention is made raw materials of effective components and is consisted of by weight percentage: hydroxypropyl methylcellulose 40%; Hydroxypropyl starch 47%; Chitin 13%; Capsule processing technology flow process is: obtained aqueous solution, described concentration of aqueous solution are 20%; Solution viscosity is 5000 centipoises; Aqueous solution immerses heating-up temperature after leaving standstill or be decompressed to the degassing fully, being preheated to 75 ℃ before the axonometer immersion in the glue jar be 50 ℃ of aqueous solutions, placed 2 minutes; Take out axonometer, with the oven dry of sealing drying baker, bake out temperature is 35 ℃; Form one deck duricrust shape polymer blend film on axonometer, axonometer is promptly extracted in the demoulding, just makes the hard medicine capsule housing through finishing;
Described capsule set adopt diameter greater than the axonometer of capsule housing through above-mentioned technological process obtained aqueous solution, immersion, oven dry, the demoulding, finishing makes capsule set, promptly makes plant capsule with the capsule housing fit.
Described capsule is made in the raw materials of effective components based on the capsule of blend can also arbitrarily be mixed with known additives, as plasticizers such as glycerol, sorbitol, mannitol, sucrose, Polyethylene Glycol, as opacifiers such as titanium dioxide, barium sulfate, winnofils, as coloring agent such as water solublity colorant, mordant pigments.Gel: sodium alginate, carrageenan, pectin, ethylene copolymer, alginic acid etc. account for the 0.1-3% of above-mentioned main overall component content, the 0.001-0.02% of the total body burden of the above-mentioned main component of surfactant comprise.
Through the test time to rupture is 6.8 minutes.
Embodiment 3.
Hard medicine capsule of the present invention is made raw materials of effective components and is consisted of by weight percentage: hydroxypropyl methylcellulose 45%; Hydroxypropyl starch 40%; Chitin 15%; Capsule processing technology flow process is: obtained aqueous solution, described concentration of aqueous solution are 30%; Solution viscosity is 10000 centipoises; Aqueous solution immerses heating-up temperature after leaving standstill or be decompressed to the degassing fully, being preheated to 80 ℃ before the axonometer immersion in the glue jar be 60 ℃ of aqueous solutions, placed 2 minutes; Take out axonometer, with the oven dry of sealing drying baker, bake out temperature is 55 ℃; Form one deck duricrust shape polymer blend film on axonometer, axonometer is promptly extracted in the demoulding, just makes the hard medicine capsule housing through finishing;
Described capsule set adopt diameter greater than the axonometer of capsule housing through above-mentioned technological process obtained aqueous solution, immersion, oven dry, the demoulding, finishing makes capsule set, promptly makes plant capsule with the capsule housing fit.
Described capsule is made in the raw materials of effective components based on the capsule of blend can also arbitrarily be mixed with known additives, as plasticizers such as glycerol, sorbitol, mannitol, sucrose, Polyethylene Glycol, as opacifiers such as titanium dioxide, barium sulfate, winnofils, as coloring agent such as water solublity colorant, mordant pigments.Gel: sodium alginate, carrageenan, pectin, ethylene copolymer, alginic acid etc. account for the 0.1-3% of above-mentioned main overall component content, the 0.001-0.02% of the total body burden of the above-mentioned main component of surfactant comprise.
Through the test time to rupture is 7.3 minutes.
Embodiment 4.
Hard medicine capsule of the present invention is made raw materials of effective components and is consisted of by weight percentage: hydroxypropyl methylcellulose 45%; Hydroxypropyl starch 40%; Chitin 15%; Capsule processing technology flow process is: obtained aqueous solution, described concentration of aqueous solution are 50%; Solution viscosity is 10000 centipoises; Aqueous solution immerses heating-up temperature after leaving standstill or be decompressed to the degassing fully, being preheated to 80 ℃ before the axonometer immersion in the glue jar be 60 ℃ of aqueous solutions, placed 2 minutes; Take out axonometer, with the oven dry of sealing drying baker, bake out temperature is 55 ℃; Form one deck duricrust shape polymer blend film on axonometer, axonometer is promptly extracted in the demoulding, just makes the hard medicine capsule housing through finishing;
Described capsule set adopt diameter greater than the axonometer of capsule housing through above-mentioned technological process obtained aqueous solution, immersion, oven dry, the demoulding, finishing makes capsule set, promptly makes plant capsule with the capsule housing fit.
Described capsule is made in the raw materials of effective components based on the capsule of blend can also arbitrarily be mixed with known additives, as plasticizers such as glycerol, sorbitol, mannitol, sucrose, Polyethylene Glycol, as opacifiers such as titanium dioxide, barium sulfate, winnofils, as coloring agent such as water solublity colorant, mordant pigments.Gel: sodium alginate, carrageenan, pectin, ethylene copolymer, alginic acid etc. account for the 0.1-3% of above-mentioned main overall component content, the 0.001-0.02% of the total body burden of the above-mentioned main component of surfactant comprise.
Through the test time to rupture is 7.3 minutes.
Claims (3)
1, a kind of hard medicine capsule is characterized in that: described capsule is made raw materials of effective components and is consisted of by weight percentage: hydroxypropyl methylcellulose 35～45%; Hydroxypropyl starch 40～55%; Chitin 10～15%; Each constituent content percent sum should equal 100% in the described compositions; Capsule processing technology flow process is: obtained aqueous solution, and the axonometer immersion, oven dry, the demoulding, finishing promptly makes the plant capsule housing; Its process conditions are: described concentration of aqueous solution is 10～50%; Solution viscosity is 1000～10000 centipoises; Be preheated to before the axonometer immersion in 40～100 ℃, it is 2 minutes that axonometer immerses the aqueous solution time; The aqueous solution heating-up temperature is 40～60 ℃; Bake out temperature is 30～70 ℃.
2, hard medicine capsule according to claim 1 is characterized in that: described axonometer preheat temperature is 70～80 ℃.
3, hard medicine capsule according to claim 1 is characterized in that: described capsule set adopt diameter greater than the axonometer of capsule housing through immersion, oven dry, the demoulding, finishing makes capsule set, promptly makes plant capsule with the capsule housing fit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610022606A CN100577155C (en) | 2006-12-20 | 2006-12-20 | Hard medicine capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610022606A CN100577155C (en) | 2006-12-20 | 2006-12-20 | Hard medicine capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN100998572A true CN100998572A (en) | 2007-07-18 |
| CN100577155C CN100577155C (en) | 2010-01-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200610022606A Expired - Fee Related CN100577155C (en) | 2006-12-20 | 2006-12-20 | Hard medicine capsule |
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| Country | Link |
|---|---|
| CN (1) | CN100577155C (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103937037A (en) * | 2014-04-28 | 2014-07-23 | 中国科学院化学研究所 | Modified starch adhesive for preparing hollow capsule and starch-base hollow capsule thereof |
| CN103937038A (en) * | 2014-04-28 | 2014-07-23 | 中国科学院化学研究所 | Composition for preparing hollow capsule and starch-base hollow capsule thereof |
| CN103933009A (en) * | 2014-04-01 | 2014-07-23 | 吉林文辉胶囊有限公司 | Composition used for preparing cellulose hard capsule and application thereof |
| CN103933011A (en) * | 2014-04-28 | 2014-07-23 | 中国科学院化学研究所 | Plant mass cement for preparing hollow capsule, as well as hollow capsule of plant mass cement |
| CN105055364A (en) * | 2015-07-31 | 2015-11-18 | 刘百平 | Preparation technology of oxidized hydroxypropyl starch hollow capsule |
| CN105832551A (en) * | 2016-03-22 | 2016-08-10 | 浙江睿码科技有限公司 | Process for preparing hard hollow capsules from material having thermal gel performance |
| CN105878209A (en) * | 2016-05-13 | 2016-08-24 | 西宁鑫沃化工有限公司 | Plant protein empty capsule and preparation method thereof |
| CN106727413A (en) * | 2016-12-26 | 2017-05-31 | 浙江睿码科技有限公司 | A kind of preparation technology of Hydroxypropyl methylcellulose hollow and hard capsule preparation solution |
| CN107126424A (en) * | 2017-04-21 | 2017-09-05 | 陈建峰 | A kind of preparation method of enteric solubility Capsules |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5183860B2 (en) * | 2005-04-19 | 2013-04-17 | 凸版印刷株式会社 | COMPOSITE MOLDED ARTICLE AND METHOD FOR IMMOBILIZING ACTIVE SUBSTANCES |
-
2006
- 2006-12-20 CN CN200610022606A patent/CN100577155C/en not_active Expired - Fee Related
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103933009A (en) * | 2014-04-01 | 2014-07-23 | 吉林文辉胶囊有限公司 | Composition used for preparing cellulose hard capsule and application thereof |
| CN103937038B (en) * | 2014-04-28 | 2016-08-17 | 中国科学院化学研究所 | For preparing composition and the starch matrix Capsules thereof of Capsules |
| CN103937038A (en) * | 2014-04-28 | 2014-07-23 | 中国科学院化学研究所 | Composition for preparing hollow capsule and starch-base hollow capsule thereof |
| CN103933011A (en) * | 2014-04-28 | 2014-07-23 | 中国科学院化学研究所 | Plant mass cement for preparing hollow capsule, as well as hollow capsule of plant mass cement |
| CN103937037A (en) * | 2014-04-28 | 2014-07-23 | 中国科学院化学研究所 | Modified starch adhesive for preparing hollow capsule and starch-base hollow capsule thereof |
| CN103933011B (en) * | 2014-04-28 | 2016-09-21 | 北京崇尚科技开发有限公司 | For preparing phyteral glue and the Capsules thereof of Capsules |
| CN103937037B (en) * | 2014-04-28 | 2016-09-21 | 北京崇尚科技开发有限公司 | For preparing modified starch glue and the starch matrix Capsules thereof of Capsules |
| CN105055364A (en) * | 2015-07-31 | 2015-11-18 | 刘百平 | Preparation technology of oxidized hydroxypropyl starch hollow capsule |
| CN105055364B (en) * | 2015-07-31 | 2018-02-27 | 陕西嘉元生物工程有限公司 | A kind of manufacture craft for aoxidizing hydroxypropul starch Capsules |
| CN105832551A (en) * | 2016-03-22 | 2016-08-10 | 浙江睿码科技有限公司 | Process for preparing hard hollow capsules from material having thermal gel performance |
| CN105878209A (en) * | 2016-05-13 | 2016-08-24 | 西宁鑫沃化工有限公司 | Plant protein empty capsule and preparation method thereof |
| CN106727413A (en) * | 2016-12-26 | 2017-05-31 | 浙江睿码科技有限公司 | A kind of preparation technology of Hydroxypropyl methylcellulose hollow and hard capsule preparation solution |
| CN107126424A (en) * | 2017-04-21 | 2017-09-05 | 陈建峰 | A kind of preparation method of enteric solubility Capsules |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100577155C (en) | 2010-01-06 |
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Granted publication date: 20100106 Termination date: 20101220 |