CN106727413A - A kind of preparation technology of Hydroxypropyl methylcellulose hollow and hard capsule preparation solution - Google Patents
A kind of preparation technology of Hydroxypropyl methylcellulose hollow and hard capsule preparation solution Download PDFInfo
- Publication number
- CN106727413A CN106727413A CN201611217537.9A CN201611217537A CN106727413A CN 106727413 A CN106727413 A CN 106727413A CN 201611217537 A CN201611217537 A CN 201611217537A CN 106727413 A CN106727413 A CN 106727413A
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- China
- Prior art keywords
- hydroxypropyl methylcellulose
- rises
- remaining
- thin liquid
- hard capsule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of preparation technology of Hydroxypropyl methylcellulose hollow and hard capsule preparation solution, comprise the following steps:A) stir；B) the pre- material that rises is prepared；C) it is dilute molten；D) remaining material thin liquid is prepared；E) mix；F) auxiliary material is added.The present invention carries out Depth Study to Hydroxypropyl methylcellulose, and precision is excavated, change of the subdivision optimization to each phase temperature of Hydroxypropyl methylcellulose and performance is kept away from deficiency.Utilized along its road.Supporting special equipment and technology carries out high speed dispersion, pre- the rising of dehydration and reaches the requirement of invention again, Hydroxypropyl methylcellulose carried out at high temperature also during process above once cleaning, make Hydroxypropyl methylcellulose in organic residue, oxide is removed, and is that the later stage generation of operation bubble is effectively controlled.
Description
【Technical field】
The present invention relates to the technology neck of the technical field of capsule, particularly Hydroxypropyl methylcellulose hollow and hard capsule preparation solution
Domain.
【Background technology】
Plant cellulose Hydroxypropyl methylcellulose is in the application existing several years of hollow and hard field of capsules, its security, stabilization
Property, universality obtained consumers in general's accreditation, but due to conventional capsules manufacturing process equipment and material and auxiliary material performance etc.
Reason, in Hydroxypropyl methylcellulose Capsules manufacturing process, utilization rate of raw materials is very low, and disposable yield rate is not also high, structure
Into waste of material is big, high cost, so as to influence marketing and need to use.The present invention will thoroughly solve this problem, make raw material profit
More than 98% is reached with rate.Correlation residual is thoroughly removed, it is ensured that the lifting of yield rate.
【The content of the invention】
The purpose of the present invention is exactly to solve the problems of the prior art, proposes a kind of Hydroxypropyl methylcellulose hollow and hard capsule system
The preparation technology of standby liquid, can be effectively improved the utilization rate of Hydroxypropyl methylcellulose.
To achieve the above object, the present invention proposes a kind of preparation work of Hydroxypropyl methylcellulose hollow and hard capsule preparation solution
Skill, comprises the following steps：
A) stir：Purified water is inserted in the agitator with function of temperature control, purified water is heated to 60-100 DEG C, by hydroxyl
Third methylcellulose adds agitator, stirs 5-10 minutes；
B) the pre- material that rises is prepared：Taken off dewatering system is imported with the mixed liquor of water by the Hydroxypropyl methylcellulose after stirring
Water, obtains the pre- material that rises after the completion of dehydration, remainder is remaining material, the pre- material that rises is imported stand-by in heat-preserving container；
C) it is dilute molten：Purified water is added in the container with function of temperature control, by purified water temperature rise in container to 25-55 DEG C,
Remaining material is added, hydrotropy is stirred, remaining material is 1 with the ratio of purified water:8-20, temperature control is at 25-55 DEG C, stirring
Between 30-60 minutes, treat residue dissolve entirely, standing 30-60 minutes, obtain dilution；
D) remaining material thin liquid is prepared：The dilute molten dilutions for obtaining of step c) are filtered by 200-250 mesh filter membranes,
Remaining material thin liquid is obtained, remaining material thin liquid importing deposit bucket inside holding is stand-by, 30-50 DEG C of holding temperature；
E) mix：Remaining thin liquid is poured into and is had in the heat-preserving container of the pre- material that rises, the volume accounting of the material that rises in advance is 20-40%,
The volume accounting of remaining thin liquid is 80-60%.Mixed liquor is heated to 30-80 DEG C and is incubated, 2-3 is stood after stirring small
When, it is stirred for 10-15 minutes, until the pre- material that rises is well mixed with remaining thin liquid, standing removes bubble, and the time is 1-24 hours；
F) auxiliary material is added：According to Production requirement, additive and auxiliary material are added in the mixed liquor being mixed to get toward step e),
Insulation stands the upper production line of waiting.
Preferably, in the step a) stirring Hydroxypropyl methylcellulose and water ratio 1:5-8.
Preferably, speed of agitator is 60-120 revs/min in the step e) mixing.
Beneficial effects of the present invention：The present invention carries out Depth Study to Hydroxypropyl methylcellulose, and precision is excavated, subdivision optimization is right
Each phase temperature of Hydroxypropyl methylcellulose is kept away from deficiency with the change of performance.Utilized along its road.Supporting special equipment and work again
Skill carries out high speed dispersion, pre- the rising of dehydration and reaches the requirement of invention, to Hydroxypropyl methylcellulose in high temperature also during process above
Under once clean, the organic residue made in Hydroxypropyl methylcellulose, oxide are removed, and are the product of later stage operation bubble
Life is effectively controlled.The present invention is to manufacturing process remaining material using low temperature, the dilute molten technique of stirring.Using filter membrane to residue
Liquid is filtered, and removes the pollutant in raffinate, preparation solution is returned to stoste state this species diversity and is prepared, and is maximized favourable factors and minimized unfavourable ones, two
The Particular craft of person's mixing, is finally made into Hydroxypropyl methylcellulose hollow and hard capsule preparation solution.
Feature of the invention and advantage will be described in detail by embodiment.
【Specific embodiment】
A kind of preparation technology of Hydroxypropyl methylcellulose hollow and hard capsule preparation solution of the present invention, comprises the following steps：
A) stir：Purified water is inserted in the agitator with function of temperature control, purified water is heated to 60-100 DEG C, by hydroxyl
Third methylcellulose adds agitator, stirs 5-10 minutes；
B) the pre- material that rises is prepared：Taken off dewatering system is imported with the mixed liquor of water by the Hydroxypropyl methylcellulose after stirring
Water, obtains the pre- material that rises after the completion of dehydration, the pre- material that rises is imported stand-by in heat-preserving container；
C) it is dilute molten：Container with function of temperature control is added into purified water, treats that purified water temperature rise is to 25-55 DEG C in container, plus
Enter remaining material, be stirred hydrotropy.The ratio 1 of remaining material and water:8-20, water temperature is advisable with 25-55 DEG C, mixing time 30-60
Minute, treat that residue is dissolved entirely, 30-60 minutes is stood, obtain dilution；
D) remaining material thin liquid is prepared：The dilute molten dilutions for obtaining of step c) are filtered by 200-250 mesh filter membranes,
Remaining material thin liquid is obtained, remaining material thin liquid importing deposit bucket inside holding is stand-by, 30-50 DEG C of holding temperature；
E) mix：Remaining thin liquid will be prepared and poured into and had in the heat-preserving container of the pre- material that rises, the volume accounting of the material that rises in advance is 20-
40%, prepare remaining thin liquid 80-60%.Mixed liquor is heated to 30-80 DEG C and is incubated, 2-3 hours is stood after stirring, then
Stirring 10-15 minutes, until the pre- material that rises is well mixed with remaining thin liquid, standing removes bubble, and the time is 1-24 hours；
F) auxiliary material is added：According to Production requirement, additive and auxiliary material are added in the mixed liquor being mixed to get toward step e),
Insulation stands the upper production line of waiting.
The ratio 1 of Hydroxypropyl methylcellulose and water in the step a) stirrings:5-8, the step d) prepares mistake in raffinate
Filter membrane is the filter membrane of 200-250 mesh, and speed of agitator is 60-120 revs/min in the step e) mixing.
The course of work of the present invention：
A kind of preparation technology of Hydroxypropyl methylcellulose hollow and hard capsule preparation solution of the present invention, depth is carried out to Hydroxypropyl methylcellulose
Degree research, precision is excavated, change of the subdivision optimization to each phase temperature of Hydroxypropyl methylcellulose and performance is kept away from deficiency.Along its road
Utilize.Supporting special equipment and technology carries out high speed dispersion, pre- the rising of dehydration and reaches the requirement of invention again, also in process above mistake
Hydroxypropyl methylcellulose carried out at high temperature in journey once cleaning, the organic residue made in Hydroxypropyl methylcellulose, oxide are obtained
It is that the later stage generation of operation bubble is effectively controlled to removing.The present invention is dilute using low temperature, stirring to manufacturing process remaining material
Molten technique.Raffinate is filtered using filter membrane, removes the pollutant in raffinate, preparation solution is returned to stoste state
This species diversity prepare, maximize favourable factors and minimize unfavourable ones, the two mixing Particular craft, be finally made into Hydroxypropyl methylcellulose hollow and hard capsule preparation
Liquid.
Above-described embodiment is the description of the invention, is not limitation of the invention, it is any to simple transformation of the present invention after
Scheme belong to protection scope of the present invention.
Claims (3)
1. a kind of preparation technology of Hydroxypropyl methylcellulose hollow and hard capsule preparation solution, it is characterised in that：Comprise the following steps：
A) stir：Purified water is inserted in the agitator with function of temperature control, purified water is heated to 60-100 DEG C, by hydroxypropyl first
Cellulose adds agitator, stirs 5-10 minutes；
B) the pre- material that rises is prepared：It is dehydrated dewatering system is imported with the mixed liquor of water by the Hydroxypropyl methylcellulose after stirring,
The pre- material that rises is obtained after the completion of dehydration, remainder is remaining material, the pre- material that rises is imported stand-by in heat-preserving container；
C) it is dilute molten：Purified water is added in the container with function of temperature control, by purified water temperature rise in container to 25-55 DEG C, is added
Remaining material, is stirred hydrotropy, and the ratio of remaining material and purified water is 1:8-20, temperature control is in 25-55 DEG C, mixing time
30-60 minutes, treat that residue is dissolved entirely, stand 30-60 minutes, obtain dilution；
D) remaining material thin liquid is prepared：The dilute molten dilutions for obtaining of step c) are filtered by 200-250 mesh filter membranes, is obtained
Remaining material thin liquid, remaining material thin liquid importing deposit bucket inside holding is stand-by, 30-50 DEG C of holding temperature；
E) mix：Remaining thin liquid is poured into and is had in the heat-preserving container of the pre- material that rises, the volume accounting of the material that rises in advance is 20-40%, remaining
The volume accounting of thin liquid is 80-60%.Mixed liquor is heated to 30-80 DEG C and is incubated, 2-3 hours is stood after stirring, then
Stirring 10-15 minutes, until the pre- material that rises is well mixed with remaining thin liquid, standing removes bubble, and the time is 1-24 hours；
F) auxiliary material is added：According to Production requirement, additive and auxiliary material, insulation are added in the mixed liquor being mixed to get toward step e)
Stand the upper production line of waiting.
2. a kind of preparation technology of Hydroxypropyl methylcellulose hollow and hard capsule preparation solution as claimed in claim 1, it is characterised in that：
The ratio 1 of Hydroxypropyl methylcellulose and water in the step a) stirrings:5-8.
3. a kind of preparation technology of Hydroxypropyl methylcellulose hollow and hard capsule preparation solution as claimed in claim 1, it is characterised in that：
Speed of agitator is 60-120 revs/min in the step e) mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611217537.9A CN106727413A (en) | 2016-12-26 | 2016-12-26 | A kind of preparation technology of Hydroxypropyl methylcellulose hollow and hard capsule preparation solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611217537.9A CN106727413A (en) | 2016-12-26 | 2016-12-26 | A kind of preparation technology of Hydroxypropyl methylcellulose hollow and hard capsule preparation solution |
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| Publication Number | Publication Date |
|---|---|
| CN106727413A true CN106727413A (en) | 2017-05-31 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611217537.9A Pending CN106727413A (en) | 2016-12-26 | 2016-12-26 | A kind of preparation technology of Hydroxypropyl methylcellulose hollow and hard capsule preparation solution |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100998572A (en) * | 2006-12-20 | 2007-07-18 | 刘杰 | Hard medicine capsule |
| CN102743359A (en) * | 2012-07-12 | 2012-10-24 | 青岛益青药用胶囊有限公司 | Cellulose or polysaccharide plant pearly-luster hollow capsule and method for preparing same |
| CN103301086A (en) * | 2013-06-05 | 2013-09-18 | 绍兴康可胶囊有限公司 | Plant cellulose hard empty capsule preparation method |
| CN104873476A (en) * | 2014-02-27 | 2015-09-02 | 江苏长禾胶囊有限公司 | Processing process and manufacturing equipment of plant hollow capsules |
| CN105832551A (en) * | 2016-03-22 | 2016-08-10 | 浙江睿码科技有限公司 | Process for preparing hard hollow capsules from material having thermal gel performance |
-
2016
- 2016-12-26 CN CN201611217537.9A patent/CN106727413A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100998572A (en) * | 2006-12-20 | 2007-07-18 | 刘杰 | Hard medicine capsule |
| CN102743359A (en) * | 2012-07-12 | 2012-10-24 | 青岛益青药用胶囊有限公司 | Cellulose or polysaccharide plant pearly-luster hollow capsule and method for preparing same |
| CN103301086A (en) * | 2013-06-05 | 2013-09-18 | 绍兴康可胶囊有限公司 | Plant cellulose hard empty capsule preparation method |
| CN104873476A (en) * | 2014-02-27 | 2015-09-02 | 江苏长禾胶囊有限公司 | Processing process and manufacturing equipment of plant hollow capsules |
| CN105832551A (en) * | 2016-03-22 | 2016-08-10 | 浙江睿码科技有限公司 | Process for preparing hard hollow capsules from material having thermal gel performance |
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Application publication date: 20170531 |
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