CH608784A5 - Process for the preparation of new benzylaminoalkanoic acids - Google Patents
Process for the preparation of new benzylaminoalkanoic acidsInfo
- Publication number
- CH608784A5 CH608784A5 CH7511709A CH1170975A CH608784A5 CH 608784 A5 CH608784 A5 CH 608784A5 CH 7511709 A CH7511709 A CH 7511709A CH 1170975 A CH1170975 A CH 1170975A CH 608784 A5 CH608784 A5 CH 608784A5
- Authority
- CH
- Switzerland
- Prior art keywords
- acids
- benzylaminoalkanoic
- preparation
- new
- represent hydrogen
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 150000007513 acids Chemical class 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
- C07C49/395—Saturated compounds containing a keto group being part of a ring of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
- C07C49/403—Saturated compounds containing a keto group being part of a ring of a six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
- C07C51/295—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with inorganic bases, e.g. by alkali fusion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Adhesives Or Adhesive Processes (AREA)
Abstract
omega -Benzylaminoalkylcarboxylic acids of formula: <IMAGE> in which R1 represents a C3-C6 alkyl, R2 and R4 represent hydrogen or a lower alkyl, R3 represents hydrogen, a halogen, a lower alkoxy or the CF3 group, A and B represent hydrogen or a methyl or ethyl group and n represents an integer from 4 to 10, are prepared by condensation of an acid R1CO-(CAB)n-COOH with a benzylamine R3C6H4-CHR4-NHR2 under reducing conditions. These compounds, their salts and their optical isomers are novel and are distinguished by antiagressive properties; they can be used for the treatment of depressive states or of anxiety.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3944374A GB1472627A (en) | 1974-09-10 | 1974-09-10 | Benzylaminoalkanoic acids process for their preparation and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH608784A5 true CH608784A5 (en) | 1979-01-31 |
Family
ID=10409574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH7511709A CH608784A5 (en) | 1974-09-10 | 1975-09-10 | Process for the preparation of new benzylaminoalkanoic acids |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5645905B2 (en) |
| BE (1) | BE833238A (en) |
| CA (1) | CA1063619A (en) |
| CH (1) | CH608784A5 (en) |
| DE (1) | DE2540334C2 (en) |
| DK (1) | DK145080C (en) |
| ES (1) | ES440831A1 (en) |
| FR (1) | FR2284322A1 (en) |
| GB (1) | GB1472627A (en) |
| NL (1) | NL166253C (en) |
| PH (1) | PH16279A (en) |
| SE (1) | SE420917B (en) |
| SU (1) | SU660588A3 (en) |
| ZA (1) | ZA755777B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1545291A (en) * | 1976-03-11 | 1979-05-10 | Science Union & Cie | Benzylamino-alkanamides process for their preparation and pharmaceutical compositions containing them |
| FR2434797A1 (en) * | 1978-09-01 | 1980-03-28 | Biochemical Res Corp | PREPARATION OF ALCOHOLS AND LONG-DHAINE CARBOXYLIC ACIDS |
| CN112920042A (en) * | 2021-01-27 | 2021-06-08 | 北京岳达生物科技有限公司 | Method for preparing alkane carboxylic acid by increasing alkane carbon chain |
-
1974
- 1974-09-10 GB GB3944374A patent/GB1472627A/en not_active Expired
-
1975
- 1975-09-01 SU SU752167228A patent/SU660588A3/en active
- 1975-09-04 DK DK396175A patent/DK145080C/en active
- 1975-09-09 BE BE159885A patent/BE833238A/en not_active IP Right Cessation
- 1975-09-09 CA CA235,367A patent/CA1063619A/en not_active Expired
- 1975-09-09 FR FR7527536A patent/FR2284322A1/en active Granted
- 1975-09-09 NL NL7510588.A patent/NL166253C/en not_active IP Right Cessation
- 1975-09-09 JP JP10942475A patent/JPS5645905B2/ja not_active Expired
- 1975-09-09 ES ES440831A patent/ES440831A1/en not_active Expired
- 1975-09-09 SE SE7510024A patent/SE420917B/en not_active IP Right Cessation
- 1975-09-10 ZA ZA00755777A patent/ZA755777B/en unknown
- 1975-09-10 CH CH7511709A patent/CH608784A5/en not_active IP Right Cessation
- 1975-09-10 DE DE2540334A patent/DE2540334C2/en not_active Expired
-
1980
- 1980-06-11 PH PH24126A patent/PH16279A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2284322A1 (en) | 1976-04-09 |
| DE2540334A1 (en) | 1976-03-25 |
| PH16279A (en) | 1983-08-26 |
| NL166253C (en) | 1981-07-15 |
| BE833238A (en) | 1976-03-09 |
| JPS5159826A (en) | 1976-05-25 |
| SE7510024L (en) | 1976-03-11 |
| ES440831A1 (en) | 1977-03-01 |
| DK145080B (en) | 1982-08-23 |
| NL166253B (en) | 1981-02-16 |
| AU8464875A (en) | 1977-03-17 |
| GB1472627A (en) | 1977-05-04 |
| JPS5645905B2 (en) | 1981-10-29 |
| NL7510588A (en) | 1976-03-12 |
| ZA755777B (en) | 1976-08-25 |
| DE2540334C2 (en) | 1983-03-10 |
| SU660588A3 (en) | 1979-04-30 |
| SE420917B (en) | 1981-11-09 |
| CA1063619A (en) | 1979-10-02 |
| DK145080C (en) | 1983-01-24 |
| FR2284322B1 (en) | 1978-07-28 |
| DK396175A (en) | 1976-03-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |