GB1457086A - Alkanolamine derivatives - Google Patents

Alkanolamine derivatives

Info

Publication number
GB1457086A
GB1457086A GB705075A GB705075A GB1457086A GB 1457086 A GB1457086 A GB 1457086A GB 705075 A GB705075 A GB 705075A GB 705075 A GB705075 A GB 705075A GB 1457086 A GB1457086 A GB 1457086A
Authority
GB
United Kingdom
Prior art keywords
compounds
general formula
image
iii
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB705075A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of GB1457086A publication Critical patent/GB1457086A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel aryloxyaminobutanols of the general formula (I) <IMAGE> in which R represents an optionally substituted aryl group and R<1> represents an alkyl, cycloalkyl or aralkyl group, it being possible for the aryl group to be substituted, and also the stereoisomers and the non-toxic acid addition salts of these compounds, are beta-receptor blockers and have antiarrhythmic action. The compounds are prepared by reacting compounds of the general formula (III) <IMAGE> and compounds of the general formula (IV> X-R<1> (IV> in which X represents a leaving group, or reacting compounds of the general formula (III) with compounds of the general formula (V) <IMAGE> and simultaneously or subsequently reducing, and if desired reacting the resulting compounds of the general formula (I) to give their non-toxic acid addition salts or liberating them from their salts. The stereoisomers of the formula III can be used as starting materials.
GB705075A 1974-02-20 1975-02-19 Alkanolamine derivatives Expired GB1457086A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUCI1449A HU169464B (en) 1974-02-20 1974-02-20

Publications (1)

Publication Number Publication Date
GB1457086A true GB1457086A (en) 1976-12-01

Family

ID=10994508

Family Applications (1)

Application Number Title Priority Date Filing Date
GB705075A Expired GB1457086A (en) 1974-02-20 1975-02-19 Alkanolamine derivatives

Country Status (22)

Country Link
JP (1) JPS5929063B2 (en)
AT (1) AT339281B (en)
BE (1) BE825745A (en)
BG (2) BG26367A4 (en)
CA (1) CA1074338A (en)
CH (1) CH619684A5 (en)
CS (1) CS199578B2 (en)
DD (1) DD119414A5 (en)
DE (1) DE2506355C2 (en)
DK (1) DK141935B (en)
ES (2) ES434784A1 (en)
FI (1) FI61304C (en)
FR (1) FR2261001B1 (en)
GB (1) GB1457086A (en)
HU (1) HU169464B (en)
IL (1) IL46634A (en)
NL (1) NL182698C (en)
NO (1) NO141754C (en)
PL (2) PL99023B1 (en)
SE (1) SE433935B (en)
SU (1) SU1025327A3 (en)
YU (2) YU36916B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603138A (en) * 1982-06-10 1986-07-29 Beecham Wuelfing Gmbh & Co. Kg Amine derivatives

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48309A (en) * 1974-10-25 1980-01-31 Robins Co Inc A H 1-aryloxy-4-amino-2-butanols and pharmaceutical compositions containing them

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1245148A (en) * 1968-11-18 1971-09-08 Pfizer Ltd Propanolamine derivatives
DE1957706C3 (en) * 1968-11-18 1978-06-29 Pfizer Corp., Colon (Panama) Nuclear-substituted 3-phenoxy-1-phenoxyalkylamino-propan-2-ols and drugs based on them
SE384853B (en) * 1972-04-04 1976-05-24 Haessle Ab PROCEDURE FOR THE PREPARATION OF NEW AMINES
AT305246B (en) * 1969-09-24 1973-02-12 Ici Ltd Process for the preparation of new substituted 1-phenoxy-2-hydroxy-3-aminopropanes and their acid addition salts

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603138A (en) * 1982-06-10 1986-07-29 Beecham Wuelfing Gmbh & Co. Kg Amine derivatives

Also Published As

Publication number Publication date
ATA114075A (en) 1977-02-15
IL46634A (en) 1979-01-31
SU1025327A3 (en) 1983-06-23
BG26366A3 (en) 1979-03-15
FI61304C (en) 1982-07-12
NO141754B (en) 1980-01-28
BE825745A (en) 1975-06-16
FI750443A (en) 1975-08-21
SE433935B (en) 1984-06-25
YU37375A (en) 1982-06-18
NL7501951A (en) 1975-08-22
ES453326A1 (en) 1977-11-16
NO141754C (en) 1980-05-07
CA1074338A (en) 1980-03-25
JPS5929063B2 (en) 1984-07-18
JPS50117728A (en) 1975-09-16
YU37116B (en) 1984-08-31
SE7501801L (en) 1975-08-21
AT339281B (en) 1977-10-10
IL46634A0 (en) 1975-04-25
BG26367A4 (en) 1979-03-15
PL99023B1 (en) 1978-06-30
FI61304B (en) 1982-03-31
YU36916B (en) 1984-08-31
NL182698C (en) 1988-05-02
DE2506355A1 (en) 1975-08-21
FR2261001B1 (en) 1978-07-21
DK141935C (en) 1980-12-08
DK60875A (en) 1975-10-20
CS199578B2 (en) 1980-07-31
CH619684A5 (en) 1980-10-15
ES434784A1 (en) 1977-03-16
YU167681A (en) 1983-04-27
DD119414A5 (en) 1976-04-20
HU169464B (en) 1976-11-28
DK141935B (en) 1980-07-21
PL99025B1 (en) 1978-06-30
FR2261001A1 (en) 1975-09-12
NO750566L (en) 1975-08-21
DE2506355C2 (en) 1983-10-06

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee