BR9813373A - Composto, processo para a preparação do mesmo, composição farmacêutica, processo para a preparação da mesma, uso de um composto, e, processos para efetuar imunossupressão e para tratar ou reduzir o risco de uma doença das vias aérias obstrutiva reversìvel em um paciente - Google Patents
Composto, processo para a preparação do mesmo, composição farmacêutica, processo para a preparação da mesma, uso de um composto, e, processos para efetuar imunossupressão e para tratar ou reduzir o risco de uma doença das vias aérias obstrutiva reversìvel em um pacienteInfo
- Publication number
- BR9813373A BR9813373A BR9813373-0A BR9813373A BR9813373A BR 9813373 A BR9813373 A BR 9813373A BR 9813373 A BR9813373 A BR 9813373A BR 9813373 A BR9813373 A BR 9813373A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- preparing
- processes
- risk
- pharmaceutical composition
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 206010062016 Immunosuppression Diseases 0.000 title abstract 2
- 230000001506 immunosuppresive effect Effects 0.000 title abstract 2
- 230000000414 obstructive effect Effects 0.000 title 1
- 208000023504 respiratory system disease Diseases 0.000 title 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 1
- -1 thieno- Chemical compound 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"COMPOSTO, PROCESSO PARA A PREPARAçãO DO MESMO, COMPOSIçãO FARMACêUTICA, PROCESSO PARA PREPARAçãO DA MESMA, USO DE UM COMPOSTO, E, PROCESSOS PARA EFETUAR IMUNOSSUPRESSãO E PARA TRATAR OU REDUZIR O RISCO DE UMA DOENçA DAS VIAS AéREAS OBSTRUTIVA REVERSìVEL EM UM PACIENTE" A invenção provê certas pirrol-, tieno-, furano-, e pirazol - [3,4-d]-piridazinonas de fórmula geral (I): processos para a sua preparação, composições farmacêuticas contendo as mesmas, um processo para preparar as composições farmacêuticas, e processos de tratamento envolvendo o seu uso.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9704542A SE9704542D0 (sv) | 1997-12-05 | 1997-12-05 | Novel pyridazinone compounds |
SE9801989A SE9801989D0 (sv) | 1998-06-04 | 1998-06-04 | Novel compounds |
PCT/SE1998/002191 WO1999029695A1 (en) | 1997-12-05 | 1998-12-01 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9813373A true BR9813373A (pt) | 2000-10-03 |
Family
ID=26663151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9813373-0A BR9813373A (pt) | 1997-12-05 | 1998-12-01 | Composto, processo para a preparação do mesmo, composição farmacêutica, processo para a preparação da mesma, uso de um composto, e, processos para efetuar imunossupressão e para tratar ou reduzir o risco de uma doença das vias aérias obstrutiva reversìvel em um paciente |
Country Status (21)
Country | Link |
---|---|
US (2) | US6342601B1 (pt) |
EP (1) | EP1036076B1 (pt) |
JP (1) | JP2001525413A (pt) |
KR (1) | KR20010032769A (pt) |
CN (1) | CN1284079A (pt) |
AT (1) | ATE223413T1 (pt) |
AU (1) | AU1791699A (pt) |
BR (1) | BR9813373A (pt) |
CA (1) | CA2312419A1 (pt) |
DE (1) | DE69807741T2 (pt) |
EE (1) | EE200000318A (pt) |
HU (1) | HUP0100280A3 (pt) |
ID (1) | ID25628A (pt) |
IL (1) | IL136499A0 (pt) |
MX (1) | MXPA00005506A (pt) |
NO (1) | NO20002788L (pt) |
NZ (1) | NZ504452A (pt) |
PL (1) | PL340836A1 (pt) |
SK (1) | SK8402000A3 (pt) |
TR (1) | TR200001603T2 (pt) |
WO (1) | WO1999029695A1 (pt) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9801399D0 (sv) | 1998-04-21 | 1998-04-21 | Astra Pharma Prod | Method and apparatus for filling containers |
US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
EE05735B1 (et) * | 2001-02-24 | 2015-01-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ksantiini derivaadid, nende valmistamine ja kasutamine ravimina |
GB0117583D0 (en) | 2001-07-19 | 2001-09-12 | Astrazeneca Ab | Novel compounds |
GB0118479D0 (en) | 2001-07-28 | 2001-09-19 | Astrazeneca Ab | Novel compounds |
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US7495005B2 (en) | 2002-08-22 | 2009-02-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, their preparation and their use in pharmaceutical compositions |
US7569574B2 (en) | 2002-08-22 | 2009-08-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Purine derivatives, the preparation thereof and their use as pharmaceutical compositions |
US7482337B2 (en) | 2002-11-08 | 2009-01-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions |
DE10254304A1 (de) | 2002-11-21 | 2004-06-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel |
KR20050092761A (ko) | 2003-01-17 | 2005-09-22 | 아스트라제네카 아베 | 티에노피리다지논 및 그들의 자가면역 질환 조절 용도 |
SE0300120D0 (sv) * | 2003-01-17 | 2003-01-17 | Astrazeneca Ab | Novel compounds |
SE0300119D0 (sv) | 2003-01-17 | 2003-01-17 | Astrazeneca Ab | Novel compounds |
US7601718B2 (en) * | 2003-02-06 | 2009-10-13 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
DE10327439A1 (de) * | 2003-06-18 | 2005-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Imidazopyridazinon- und Imidazopyridonderivate, deren Herstellung und deren Verwendung als Arzneimittel |
US7566707B2 (en) | 2003-06-18 | 2009-07-28 | Boehringer Ingelheim International Gmbh | Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions |
WO2005054852A1 (en) * | 2003-11-21 | 2005-06-16 | Astrazeneca Ab | Screening method |
DE10355304A1 (de) * | 2003-11-27 | 2005-06-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 8-(Piperazin-1-yl)-und 8-([1,4]Diazepan-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
JPWO2005053695A1 (ja) * | 2003-12-04 | 2007-12-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 多発性硬化症予防剤または治療剤 |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004009039A1 (de) | 2004-02-23 | 2005-09-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und Verwendung als Arzneimittel |
US7393847B2 (en) | 2004-03-13 | 2008-07-01 | Boehringer Ingleheim International Gmbh | Imidazopyridazinediones, their preparation and their use as pharmaceutical compositions |
US7179809B2 (en) * | 2004-04-10 | 2007-02-20 | Boehringer Ingelheim International Gmbh | 2-Amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions |
US7439370B2 (en) * | 2004-05-10 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Imidazole derivatives, their preparation and their use as intermediates for the preparation of pharmaceutical compositions and pesticides |
EP2583678A3 (en) | 2004-06-24 | 2013-11-13 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
DE102004030502A1 (de) | 2004-06-24 | 2006-01-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel |
DE102004043944A1 (de) | 2004-09-11 | 2006-03-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 8-(3-Amino-piperidin-1-yl)-7-(but-2-inyl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
DE102004044221A1 (de) * | 2004-09-14 | 2006-03-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 3-Methyl-7-butinyl-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
KR101541791B1 (ko) | 2006-05-04 | 2015-08-04 | 베링거 인겔하임 인터내셔날 게엠베하 | 다형태 |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
EP2057160A1 (en) * | 2006-08-08 | 2009-05-13 | Boehringer Ingelheim International GmbH | Pyrrolo [3, 2 -d]pyrimidines as dpp-iv inhibitors for the treatment of diabetes mellitus |
AU2008290582B2 (en) * | 2007-08-17 | 2014-08-14 | Boehringer Ingelheim International Gmbh | Purin derivatives for use in the treatment of fab-related diseases |
PE20140960A1 (es) | 2008-04-03 | 2014-08-15 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
PE20100156A1 (es) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
EA031225B1 (ru) * | 2008-08-15 | 2018-12-28 | Бёрингер Ингельхайм Интернациональ Гмбх | Ингибиторы дпп-4 для заживления ран |
AU2009290911A1 (en) | 2008-09-10 | 2010-03-18 | Boehringer Ingelheim International Gmbh | Combination therapy for the treatment of diabetes and related conditions |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
NZ592924A (en) | 2008-12-23 | 2014-05-30 | Boehringer Ingelheim Int | Salt forms of a xanthine derivative |
TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
CA2782179C (en) | 2009-11-27 | 2020-06-23 | Boehringer Ingelheim International Gmbh | Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin |
NZ602921A (en) | 2010-05-05 | 2016-01-29 | Boehringer Ingelheim Int | Combination therapy comprising the administration of a glp-1 receptor agonist and a ddp-4 inhibitor |
JP5843855B2 (ja) | 2010-06-24 | 2016-01-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糖尿病療法 |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
ES2713566T3 (es) | 2011-07-15 | 2019-05-22 | Boehringer Ingelheim Int | Derivado de quinazolina dimérico sustituido, su preparación y su uso en composiciones farmacéuticas para el tratamiento de la diabetes de tipo I y II |
WO2013097052A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
EP3685839A1 (en) | 2012-05-14 | 2020-07-29 | Boehringer Ingelheim International GmbH | Linagliptin for use in the treatment of albuminuria and kidney related diseases |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
US9200005B2 (en) * | 2013-03-13 | 2015-12-01 | AbbVie Deutschland GmbH & Co. KG | Inhibitor compounds of phosphodiesterase type 10A |
ES2950384T3 (es) | 2014-02-28 | 2023-10-09 | Boehringer Ingelheim Int | Uso médico de un inhibidor de DPP-4 |
DK3442972T3 (da) | 2016-04-15 | 2020-04-27 | Abbvie Inc | Bromdomænehæmmere |
CN109310697A (zh) | 2016-06-10 | 2019-02-05 | 勃林格殷格翰国际有限公司 | 利格列汀和二甲双胍的组合 |
GB202106872D0 (en) | 2021-05-13 | 2021-06-30 | Addex Pharmaceuticals Sa | Novel compounds |
WO2023099648A1 (en) * | 2021-12-02 | 2023-06-08 | Astrazeneca Ab | Pyraolo- and triazolo-azinone compounds and their uses |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1453897A (fr) * | 1965-06-16 | 1966-07-22 | Dérivés du thiophène et de thiéno pyridazines | |
FR2478640A1 (fr) * | 1980-03-24 | 1981-09-25 | Sanofi Sa | Nouvelles thieno (2,3-d) pyridazinones-4 et thieno (2,3-d) pyridazinones-7, leur procede de preparation et leur therapeutique |
WO1991012251A1 (en) * | 1990-02-19 | 1991-08-22 | Chugai Seiyaku Kabushiki Kaisha | Novel fused heterocyclic compound and antiasthmatic agent prepared therefrom |
TW245719B (pt) * | 1990-09-10 | 1995-04-21 | Sterling Winthrop Inc | |
TW279162B (pt) * | 1991-09-26 | 1996-06-21 | Mitsubishi Chem Corp | |
US5753664A (en) * | 1995-03-16 | 1998-05-19 | Takeda Chemical Industries, Ltd. | Heterocyclic compounds, their production and use |
-
1998
- 1998-12-01 JP JP2000524288A patent/JP2001525413A/ja not_active Withdrawn
- 1998-12-01 WO PCT/SE1998/002191 patent/WO1999029695A1/en not_active Application Discontinuation
- 1998-12-01 ID IDW20001021D patent/ID25628A/id unknown
- 1998-12-01 PL PL98340836A patent/PL340836A1/xx not_active Application Discontinuation
- 1998-12-01 TR TR2000/01603T patent/TR200001603T2/xx unknown
- 1998-12-01 HU HU0100280A patent/HUP0100280A3/hu unknown
- 1998-12-01 EP EP98962754A patent/EP1036076B1/en not_active Expired - Lifetime
- 1998-12-01 DE DE69807741T patent/DE69807741T2/de not_active Expired - Fee Related
- 1998-12-01 SK SK840-2000A patent/SK8402000A3/sk unknown
- 1998-12-01 NZ NZ504452A patent/NZ504452A/en unknown
- 1998-12-01 CN CN98813493A patent/CN1284079A/zh active Pending
- 1998-12-01 AU AU17916/99A patent/AU1791699A/en not_active Abandoned
- 1998-12-01 IL IL13649998A patent/IL136499A0/xx unknown
- 1998-12-01 EE EEP200000318A patent/EE200000318A/xx unknown
- 1998-12-01 CA CA002312419A patent/CA2312419A1/en not_active Abandoned
- 1998-12-01 KR KR1020007006064A patent/KR20010032769A/ko not_active Application Discontinuation
- 1998-12-01 AT AT98962754T patent/ATE223413T1/de not_active IP Right Cessation
- 1998-12-01 BR BR9813373-0A patent/BR9813373A/pt not_active Application Discontinuation
- 1998-12-01 MX MXPA00005506A patent/MXPA00005506A/es not_active Application Discontinuation
-
1999
- 1999-01-12 US US09/214,755 patent/US6342601B1/en not_active Expired - Fee Related
-
2000
- 2000-05-31 NO NO20002788A patent/NO20002788L/no not_active Application Discontinuation
-
2001
- 2001-12-10 US US10/006,244 patent/US6770646B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO20002788L (no) | 2000-08-01 |
EP1036076B1 (en) | 2002-09-04 |
ID25628A (id) | 2000-10-19 |
US6770646B2 (en) | 2004-08-03 |
PL340836A1 (en) | 2001-02-26 |
KR20010032769A (ko) | 2001-04-25 |
EP1036076A1 (en) | 2000-09-20 |
AU1791699A (en) | 1999-06-28 |
ATE223413T1 (de) | 2002-09-15 |
MXPA00005506A (es) | 2008-09-11 |
HUP0100280A2 (hu) | 2001-10-28 |
CN1284079A (zh) | 2001-02-14 |
US6342601B1 (en) | 2002-01-29 |
EE200000318A (et) | 2001-08-15 |
WO1999029695A1 (en) | 1999-06-17 |
JP2001525413A (ja) | 2001-12-11 |
NO20002788D0 (no) | 2000-05-31 |
NZ504452A (en) | 2002-05-31 |
SK8402000A3 (en) | 2001-03-12 |
DE69807741D1 (de) | 2002-10-10 |
TR200001603T2 (tr) | 2000-10-23 |
CA2312419A1 (en) | 1999-06-17 |
IL136499A0 (en) | 2001-06-14 |
DE69807741T2 (de) | 2004-07-15 |
HUP0100280A3 (en) | 2003-03-28 |
US20020099055A1 (en) | 2002-07-25 |
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