ATE419273T1 - Translokationsvektoren abgeleitet von der antennapedia homeodomain helix 3 - Google Patents

Translokationsvektoren abgeleitet von der antennapedia homeodomain helix 3

Info

Publication number
ATE419273T1
ATE419273T1 AT99954212T AT99954212T ATE419273T1 AT E419273 T1 ATE419273 T1 AT E419273T1 AT 99954212 T AT99954212 T AT 99954212T AT 99954212 T AT99954212 T AT 99954212T AT E419273 T1 ATE419273 T1 AT E419273T1
Authority
AT
Austria
Prior art keywords
vectors derived
antennapedia homeodomain
translocation
helix
homeodomain helix
Prior art date
Application number
AT99954212T
Other languages
English (en)
Inventor
M Fischer
Nikolai Zhelev
Original Assignee
Cyclacel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9825000.4A external-priority patent/GB9825000D0/en
Priority claimed from GBGB9825001.2A external-priority patent/GB9825001D0/en
Priority claimed from GBGB9902525.6A external-priority patent/GB9902525D0/en
Priority claimed from GBGB9902522.3A external-priority patent/GB9902522D0/en
Priority claimed from GBGB9914578.1A external-priority patent/GB9914578D0/en
Application filed by Cyclacel Ltd filed Critical Cyclacel Ltd
Application granted granted Critical
Publication of ATE419273T1 publication Critical patent/ATE419273T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
    • C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Insects & Arthropods (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Surgical Instruments (AREA)
  • Structure Of Belt Conveyors (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Details Of Aerials (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Aerials With Secondary Devices (AREA)
AT99954212T 1998-11-13 1999-11-11 Translokationsvektoren abgeleitet von der antennapedia homeodomain helix 3 ATE419273T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9825000.4A GB9825000D0 (en) 1998-11-13 1998-11-13 A delivery vector
GBGB9825001.2A GB9825001D0 (en) 1998-11-13 1998-11-13 A delivery vector
GBGB9902525.6A GB9902525D0 (en) 1999-02-04 1999-02-04 Translocation vectors
GBGB9902522.3A GB9902522D0 (en) 1999-02-04 1999-02-04 Truncated vectors
GBGB9914578.1A GB9914578D0 (en) 1999-06-22 1999-06-22 Truncated vetors

Publications (1)

Publication Number Publication Date
ATE419273T1 true ATE419273T1 (de) 2009-01-15

Family

ID=27517480

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99954212T ATE419273T1 (de) 1998-11-13 1999-11-11 Translokationsvektoren abgeleitet von der antennapedia homeodomain helix 3

Country Status (13)

Country Link
US (2) US7153931B1 (de)
EP (2) EP1135410B1 (de)
JP (1) JP2002530059A (de)
AT (1) ATE419273T1 (de)
AU (1) AU766489B2 (de)
CA (1) CA2350919A1 (de)
CZ (1) CZ20011671A3 (de)
DE (1) DE69940215D1 (de)
ES (1) ES2318906T3 (de)
GB (1) GB2346616B (de)
HU (1) HUP0204199A3 (de)
IL (1) IL142869A0 (de)
WO (1) WO2000029427A2 (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2786397B1 (fr) * 1998-11-30 2003-01-10 Synt Em Vecteurs peptidiques de substances a travers la barriere hematoencephalique pour etre utilises dans le diagnostic ou la therapie d'une affection du snc
US6372494B1 (en) 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
US6864355B1 (en) 2000-05-02 2005-03-08 Yale University Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain
US8128922B2 (en) * 1999-10-20 2012-03-06 Johns Hopkins University Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen
US7049395B2 (en) 2000-05-02 2006-05-23 Yale University Anti-inflammatory compounds and uses thereof
GB0012528D0 (en) * 2000-05-23 2000-07-12 Univ Palackeho Triterpenoid derivatives
DE10027777A1 (de) * 2000-06-07 2001-12-13 Otogene Ag Transfektionsverfahren
FR2816845B1 (fr) 2000-11-20 2006-10-20 Centre Nat Rech Scient Vecteurs de transport a travers un epithelium a jonctions serrees
NZ530481A (en) * 2001-06-07 2007-11-30 Skinmedica Inc Compositions comprising cell culture medium conditioned by cells grown in three-dimensional culture
DE10128832A1 (de) * 2001-06-15 2003-02-06 Jochen Reis Vektor und dessen Verwendung in gentherapeutischen Verfahren
EP1432728A4 (de) * 2001-08-30 2007-10-24 Praecis Pharm Inc Verfahren und zusammensetzungen zur behandlung entzündlicher erkrankungen
WO2003064614A2 (en) * 2002-01-30 2003-08-07 Yale University Transport peptides and uses therefor
EP1495124A2 (de) * 2002-04-17 2005-01-12 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Smac-peptide zur verwendung als therapeutische mittel gegen krebs und autoimmunerkrankungen
EP1354953A1 (de) * 2002-04-17 2003-10-22 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Smac-Peptide zur Verwendung als therapeutische Mittel gegen Krebs und Autoimmunerkrankungen
EP1354952A1 (de) * 2002-04-17 2003-10-22 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Smac-Peptide zur Verwendung als therapeutische Mittel gegen Krebs und Autoimmunerkrankungen
US20060178297A1 (en) * 2003-01-28 2006-08-10 Troy Carol M Systems and methods for silencing expression of a gene in a cell and uses thereof
SI2441467T1 (sl) 2003-01-31 2015-10-30 The Mount Sinai School Of Medicine Of New York University Kombinirana terapija za zdravljenje motenj pomanjkanja proteina
WO2004076634A2 (en) 2003-02-24 2004-09-10 Ira Sanders Cell membrane translocation of regulated snare inhibitors , compositions therefor, and methods for treatment of disease
AU2004234076A1 (en) * 2003-04-30 2004-11-11 Laboratoires Serono Sa Beta-amyloid inhibitors and use thereof
US9701725B2 (en) 2003-05-05 2017-07-11 The Johns Hopkins University Anti-cancer DNA vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein
GB0311576D0 (en) * 2003-05-20 2003-06-25 Inst Of Ophthalomology Anti-inflammatory agents
WO2004112728A2 (en) 2003-06-19 2004-12-29 Mount Sinai School Of Medicine Of New York University Methods and agents for treating axonal damage, inhibition of neurotransmitter release and pain transmission, and blocking calcium influx in neurons
US7342114B2 (en) * 2003-07-01 2008-03-11 California Pacific Medical Center Podophyllotoxin derivatives
US8598146B2 (en) * 2003-09-16 2013-12-03 Garvan Institute Of Medical Research Methods for identifying modulators of protein kinase C-epsilon (PKCε) and method of treatment of aberrant glucose metabolism associated therewith
US20050148534A1 (en) * 2003-09-22 2005-07-07 Castellino Angelo J. Small molecule compositions and methods for increasing drug efficiency using compositions thereof
KR100897915B1 (ko) * 2004-11-03 2009-05-18 포휴먼텍(주) 경피전달을 위한 약제 조성물
GB0803352D0 (en) 2008-02-22 2008-04-02 Ntnu Technology Transfer As Oligopeptidic compounds and uses thereof
MX2010009148A (es) 2008-02-28 2010-12-06 Toray Industries Composicion farmaceutica para la administracion transnasal.
EP2283029A1 (de) * 2008-06-04 2011-02-16 Medical Research Council Peptide
EP2898900B1 (de) 2008-09-19 2017-11-15 Nektar Therapeutics Polymerkonjugate von Ziconotid
FR2941230B1 (fr) 2009-01-19 2011-03-18 Centre Nat Rech Scient Polypeptides d'adressage specifique a des cellules-cibles d'otx2
WO2010099401A1 (en) * 2009-02-26 2010-09-02 The Board Of Trustees Of The Leland Stanford Junior University Calcium signaling modulators involving stim and orai proteins
WO2010134537A1 (ja) * 2009-05-20 2010-11-25 東レ株式会社 細胞膜透過性ペプチド
EP2432501B1 (de) * 2009-05-22 2016-12-14 The Institute for Systems Biology Sekretionsbezogene bakterielle proteine zur nlrc4-stimulation
GB201001602D0 (en) 2010-02-01 2010-03-17 Cytovation As Oligopeptidic compounds and uses therof
JP5757497B2 (ja) * 2010-10-06 2015-07-29 公立大学法人大阪府立大学 シガトキシン類ｃｔｘ１ｂおよび５４−デオキシ−ｃｔｘ１ｂを認識するモノクローナル抗体およびそれを用いるシガトキシン類検出キット
JP2014512409A (ja) * 2011-04-28 2014-05-22 エスティーシー． ユーエヌエム 標的送達用の多孔性ナノ粒子に担持された脂質二重層（プロトセル）及びその使用方法
EP2751128B1 (de) 2011-08-30 2021-03-03 United Kingdom Research and Innovation Zellpenetrierende peptide mit einer zentralen hydrophoben domäne
GB201318954D0 (en) 2013-10-28 2013-12-11 Cupid Peptide Company Ltd Cell transport
GB201507722D0 (en) 2015-05-06 2015-06-17 Norwegian Univ Sci & Tech Ntnu Anti-bacterial agents and their use in therapy
US10087194B2 (en) 2015-10-27 2018-10-02 California Pacific Medical Center Podophyllotoxin derivatives and their use
US20190077813A1 (en) 2015-10-27 2019-03-14 California Pacific Medical Center Podophyllotoxin derivatives and their use
WO2017120504A1 (en) 2016-01-08 2017-07-13 Durfee Paul N Osteotropic nanoparticles for prevention or treatment of bone metastases
CA3069780A1 (en) 2016-08-09 2018-02-15 Aarhus Universitet Modulation of ifi16 and sting activity
WO2018045155A1 (en) * 2016-09-02 2018-03-08 The Board Of Trustees Of The University Of Illinois Kif13b-derived peptide and method of inhibiting angiogenesis
US11344629B2 (en) 2017-03-01 2022-05-31 Charles Jeffrey Brinker Active targeting of cells by monosized protocells
CN111201247A (zh) 2017-04-28 2020-05-26 奥克兰联合服务有限公司 治疗方法和新颖构建体
JP7489319B2 (ja) 2018-09-26 2024-05-23 株式会社カネカ 細胞膜透過性ペプチド
GB201915454D0 (en) 2019-10-24 2019-12-11 Norwegian Univ Sci & Tech Ntnu Antibacterial bone cement and uses thereof
GB202006699D0 (en) 2020-05-06 2020-06-17 Therapim Pty Ltd Dosage regimen
GB202008888D0 (en) 2020-06-11 2020-07-29 Norwegian Univ Of Science And Technology (Ntnu) Peptides for sepsis treatment

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847240A (en) 1978-01-16 1989-07-11 The Trustees Of Boston University Method of effecting cellular uptake of molecules
US5043329A (en) 1987-02-17 1991-08-27 Board Of Regents, University Of Texas System Methods and compositions employing unique mixtures of polar and neutral lipids for protecting the gastrointestinal tract
DE3836971C1 (de) 1988-10-31 1990-05-17 Weck, Wolfgang, Dr.Med., 6990 Bad Mergentheim, De
FR2662698A1 (fr) 1990-06-05 1991-12-06 Centre Nat Rech Scient Nouveaux facteurs de croissance neurotropes comprenant un peptide homeoboite.
US5888762A (en) 1990-06-05 1999-03-30 Centre National De La Recherche Scientifique (Cnrs) Neurotropic growth factors comprising a homeobox peptide
EP0481930B1 (de) 1990-10-15 1997-06-18 Tecnogen S.C.P.A. Nicht-lineare Peptide, die hydropatisch komplementär zu bekannten Aminosäuresequenzen sind, Verfahren zur Herstellung und Verwendung davon
WO1993022343A1 (en) 1992-05-01 1993-11-11 The Rockfeller University Multiple antigen peptide system having adjuvant properties and vaccines prepared therefrom
US5674977A (en) 1993-02-05 1997-10-07 The Ontario Cancer Institute Branched synthetic peptide conjugate
US5807746A (en) * 1994-06-13 1998-09-15 Vanderbilt University Method for importing biologically active molecules into cells
FR2739621B1 (fr) 1995-10-05 1997-12-05 Centre Nat Rech Scient Peptides utilisables comme vecteurs pour l'adressage intracellulaire de molecules actives
US5843903A (en) 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
US6344436B1 (en) * 1996-01-08 2002-02-05 Baylor College Of Medicine Lipophilic peptides for macromolecule delivery
US5877282A (en) * 1996-09-20 1999-03-02 Bristol-Myers Squibb Company Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof
CA2264227A1 (en) 1996-09-27 1998-04-02 Raymond A. Firestone Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells
WO1998020887A1 (en) * 1996-11-14 1998-05-22 Brigham And Women's Hospital, Inc. Polyphosphoinositide binding peptides for intracellular drug delivery
US5929042A (en) 1997-03-03 1999-07-27 The Trustees Of Columbia University In The City Of New York Antisense compounds which prevent cell death and uses thereof
IT1291649B1 (it) * 1997-04-24 1999-01-19 Intercos Italiana Polveri cosmetiche rivestite con ingredienti naturali
US6635623B1 (en) * 1997-06-13 2003-10-21 Baylor College Of Medicine Lipoproteins as nucleic acid vectors
CA2298067A1 (en) 1997-07-24 1999-02-04 Ulo Langel Conjugates of transporter peptides and nucleic acid analogs, and their use
WO1999010376A1 (en) * 1997-08-22 1999-03-04 Washington University Inducible regulatory system and use thereof
GB9718609D0 (en) * 1997-09-02 1997-11-05 Imp College Innovations Ltd Fusion protein
JP2002505341A (ja) * 1998-03-06 2002-02-19 オックスフォード バイオメディカ（ユーケイ）リミテッド プロドラッグの活性化の増強
EP1086126A1 (de) * 1998-06-10 2001-03-28 The Queen's University of Belfast Zell-durchlässige Peptide
GB9812675D0 (en) 1998-06-11 1998-08-12 Univ Edinburgh Peptides
GB9814527D0 (en) 1998-07-03 1998-09-02 Cyclacel Ltd Delivery system

Also Published As

Publication number Publication date
IL142869A0 (en) 2002-03-10
GB2346616A (en) 2000-08-16
DE69940215D1 (de) 2009-02-12
EP1135410B1 (de) 2008-12-31
CA2350919A1 (en) 2000-05-25
JP2002530059A (ja) 2002-09-17
US7153931B1 (en) 2006-12-26
EP1135410A2 (de) 2001-09-26
HUP0204199A2 (hu) 2003-03-28
EP1958961A3 (de) 2008-09-03
CZ20011671A3 (cs) 2001-10-17
HUP0204199A3 (en) 2005-09-28
ES2318906T3 (es) 2009-05-01
WO2000029427A2 (en) 2000-05-25
US7101967B2 (en) 2006-09-05
US20020098236A1 (en) 2002-07-25
WO2000029427A3 (en) 2000-10-05
EP1958961A2 (de) 2008-08-20
AU766489B2 (en) 2003-10-16
GB9926719D0 (en) 2000-01-12
AU1063000A (en) 2000-06-05
GB2346616B (en) 2004-04-21

Similar Documents

Publication Publication Date Title
ATE419273T1 (de) Translokationsvektoren abgeleitet von der antennapedia homeodomain helix 3
ATE460429T1 (de) Polypeptide enthaltend extrazellulären domäne von il-20ra und/oderr il-20rb
ATE368053T1 (de) Antimikrobielle peptide
NZ503007A (en) Conjugates that contain the homeodomain of antennapedia
BR0012759A (pt) Neurotoxinas recombinantes ativáveis
AU4162400A (en) Derivatives of the b or z domain from staphylococcal protein a (spa) interactingwith at least one domain of human factor viii
BR0210907A (pt) Vetores de flavivìrus quiméricos
IL113617A0 (en) Soluble polypeptide fraction
PT1346034E (pt) Polipéptido da protease de clivagem do factor de von willebrand (vwf), ácido nucleico que codifica o polipéptido e utilização do polipéptido
DE50112802D1 (de) Peptide, deren herstellung und verwendung zur bindung von immunglobulinen
GB9828628D0 (en) Novel ligand
ATE223481T1 (de) Peptid der löslichen form von acetylcholinesterase mit aktivität als calciumkanalmodulator
KR100295606B1 (de)
MXPA00002111A (es) Biomoleculas que contienen un peptido elastomerico.
ATE314474T1 (de) Klonering von dem gen für das t gondii protein gp 28.5 peptidfragmente aus diesem protein und ihre verwendungen.
ATE356140T1 (de) Gd3 mimetische peptide
BR9812435A (pt) Peptìdeo que tem afinidade por fator viii de coagulação
NO922421D0 (no) Collagenbindende protein, samt fremstilling derav
NO20002001L (no) Peptider i stand til Õ inhibere interaksjonen mellom preseniliner og <beta>-amyloidpeptidet eller dettes forløper
WO2000000506A3 (en) Human proteins having hydrophobic domains and dnas encoding these proteins
DE59109235D1 (de) Peptide des HIV-gag Proteins, ihre Herstellung und Verwendung
DE69534738D1 (de) Leukocyten-aktivierender Faktor
ATE393224T1 (de) Nukleinsäuresequenzen von hyperplasien und tumoren der schilddrüse
WO2000031264A3 (en) Testis-specific cystatin-like protein cystatin t
DE60008749D1 (de) Therapeutische peptide aus untersequenzen von bpi

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1135410

Country of ref document: EP

REN Ceased due to non-payment of the annual fee