AR089656A1 - Derivados de n-bicicloalquil- y n-tricicloalquil-(tio)-carboxamida fungicidas - Google Patents

Derivados de n-bicicloalquil- y n-tricicloalquil-(tio)-carboxamida fungicidas

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AR089656A1
AR089656A1 ARP120104492A ARP120104492A AR089656A1 AR 089656 A1 AR089656 A1 AR 089656A1 AR P120104492 A ARP120104492 A AR P120104492A AR P120104492 A ARP120104492 A AR P120104492A AR 089656 A1 AR089656 A1 AR 089656A1
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substituted
unsubstituted
alkyl
halogen atoms
halogen
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Bayer Intellectual Property GmbH
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N45/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring
    • A01N45/02—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring having three carbocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/38—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
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    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
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    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
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    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

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  • Dermatology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
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  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicación 1: Compuestos de N-bicicloalquil- y N-tricicloalquil-(tio)carboxamida, caracterizados por la formula (1), en la que T representa O ó S; n representa 0 ó 1; B representa un compuesto de fórmula (2) ó (3), en los que el enlace marcado con * está unido al resto de amida (CZ²Z³)ₙ-N; m representa 0 ó 1; p representa 0, 1, 2 ó 3; con la condición de que m + p es igual a de 1 a 3; t representa 1 ó 2; u representa 1, 2, 3 ó 4; Q¹ representa un enlace directo, CZ⁷Z⁸, O, S, SO, SO₂, NZ¹¹, -C(=V)-, -C(=NZ¹²), un alquilideno C₁₋₈ no sustituido o un alquilideno C₁₋₈ sustituido con hasta 10 átomos o grupos que pueden ser iguales o diferentes y que se pueden seleccionar de la lista que consiste en átomos de halógeno, ciano, alquilo C₁₋₈, halógenoalquilo C₁₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes, alcoxi C₁₋₈, halógenoalcoxi C₁₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes, alcoxi C₁₋₈-carbonilo, halógenoalcoxi C₁₋₈-carbonilo que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes, alquil C₁₋₈-aminocarbonilo y di-alquil C₁₋₈-aminocarbonilo; con la condición de que cuando Q¹ no es un enlace directo, entonces t + u es igual a de 2 a 4; o cuando Q¹ es un enlace directo, entonces u es igual a 3 ó 4; o cuando t es igual a 2, entonces [Q¹]₂ no es un grupo peróxido; Q² representa CZ⁹Z¹⁰ o -CH=CH-; V representa O ó S; Z¹ representa un átomo de hidrógeno; un grupo formilo; un alquilo C₁₋₈ sustituido o no sustituido; un alcoxi C₁₋₈ sustituido o no sustituido; un cicloalquilo C₃₋₇ no sustituido o un cicloalquilo C₃₋₇ sustituido con hasta 10 átomos o grupos que pueden ser iguales o diferentes y que se pueden seleccionar de la lista que consiste en átomos de halógeno, ciano, alquilo C₁₋₈, halógenoalquilo C₁₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes, alcoxi C₁₋₈, halógenoalcoxi C₁₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes, alcoxicarbonilo C₁₋₈, halógenoalcoxicarbonilo C₁₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes, alquilaminocarbonilo C₁₋₈ y di-alquilaminocarbonilo C₁₋₈; con la condición de que cuando Z¹ representa un átomo de hidrógeno, n representa 0, T representa O y B representa un grupo decahidronaftalenilo, grupo octahidro-1H-inden-4-ilo o grupo octahidro-1H-inden-5-ilo saturado o parcialmente insaturado, opcionalmente sustituido con monoalquilo, entonces R¹ y R³ no son simultáneamente un grupo metilo cuando R² es un átomo de flúor; Z² y Z³ representan independientemente un átomo de hidrógeno; un átomo de halógeno; ciano; alquilo C₁₋₈ sustituido o no sustituido; halógenoalquilo C₁₋₈ que tiene de 1 a 5 átomos de halógeno; alcoxi C₁₋₈ sustituido o no sustituido; alquil C₁₋₈-sulfanilo sustituido o no sustituido; o alcoxi C₁₋₈-carbonilo sustituido o no sustituido; o Z² y Z³ son un grupo alquileno C₂₋₅ que puede estar sustituido con hasta cuatro grupos alquilo C₁₋₈; Z⁴, Z⁵, Z⁶, Z⁷, Z⁸, Z⁹ o Z¹⁰ representan independientemente un átomo de hidrógeno; un átomo de halógeno; ciano; alquilo C₁₋₈ sustituido o no sustituido; halógenoalquilo C₁₋₈ que tiene de 1 a 5 átomos de halógeno; alcoxi C₁₋₈ sustituido o no sustituido; alquil C₁₋₈-sulfanilo sustituido o no sustituido; alcoxi C₁₋₈-carbonilo sustituido o no sustituido; o grupo bencilo; Z¹¹ representa un átomo de hidrógeno; un alquilo C₁₋₈ sustituido o no sustituido; un halógenoalquilo C₁₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes; alquenilo C₂₋₈ sustituido o no sustituido; halógenoalquenilo C₂₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes; alquinilo C₃₋₈ sustituido o no sustituido; halógenoalquinilo C₃₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes; cicloalquilo C₃₋₇ sustituido o no sustituido; halógenocicloalquilo C₃₋₇ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes; cicloalquil C₃₋₇-alquilo C₁₋₈ sustituido o no sustituido; formilo; alquil C₁₋₈-carbonilo sustituido o no sustituido; halógenoalquil C₁₋₈-carbonilo que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes; alcoxi C₁₋₈-carbonilo sustituido o no sustituido; halógenoalcoxi C₁₋₈-carbonilo que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes; alquil C₁₋₈-sulfonilo sustituido o no sustituido; halógenoalquil C₁₋₈-sulfonilo que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes; bencilo sustituido o no sustituido; o fenilsulfonilo sustituido o no sustituido; Z¹² representa un átomo de hidrógeno, un alquilo C₁₋₈ sustituido no sustituido; halógenoalquilo C₁₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes; alcoxi C₁₋₈ sustituido o no sustituido; halógenoalcoxi C₁₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes; cicloalquilo C₃₋₇ sustituido o no sustituido; halógenocicloalquilo C₃₋₇ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes; cicloalcoxi C₃₋₇ sustituido o no sustituido; halógenocicloalcoxi C₃₋₇ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes; bencilo sustituido o no sustituido; fenilo sustituido o no sustituido; benciloxi sustituido o no sustituido; o fenoxi sustituido o no sustituido; R¹, R² y R³ representan independientemente un átomo de halógeno; un átomo de halógeno; nitro; ciano; hidroxi; amino; sulfanilo; pentafluoro-l⁶-sulfanilo; alcoxiimino C₁₋₈-alquilo C₁₋₈ sustituido o no sustituido; benciloxiimino-alquilo C₁₋₈ sustituido o no sustituido; alquilo C₁₋₈ sustituido o no sustituido; halógenoalquilo C₁₋₈ que tiene de 1 a 9 átomos de halógeno; alquenilo C₂₋₈ sustituido o no sustituido; halógenoalquenilo C₂₋₈ que tiene de 1 a 9 átomos de halógeno; alquinilo C₂₋₈ sustituido o no sustituido; halógenoalquinilo C₂₋₈ que tiene de 1 a 9 átomos de halógeno; alcoxi C₁₋₈ sustituido o no sustituido; halógenoalcoxi C₁₋₈ que tiene de 1 a 9 átomos de halógeno; alquil C₁₋₈-sulfanilo sustituido o no sustituido; halógenoalquil C₁₋₈-sulfanilo que tiene de 1 a 9 átomos de halógeno; alquil C₁₋₈-sulfinilo sustituido o no sustituido; halógenoalquil C₁₋₈-sulfinilo que tiene de 1 a 9 átomos de halógeno; alquil C₁₋₈-sulfonilo sustituido o no sustituido; halógenoalquil C₁₋₈-sulfonilo que tiene de 1 a 9 átomos de halógeno; alquil C₁₋₈-amino sustituido o no sustituido; dialquil C₁₋₈-amino sustituido o no sustituido; alqueniloxi C₂₋₈ sustituido o no sustituido; alquiniloxi C₃₋₈ sustituido o no sustituido; cicloalquilo C₃₋₇ sustituido o no sustituido; halógenocicloalquilo C₃₋₇ que tiene de 1 a 9 átomos de halógeno; tri(alquil C₁₋₈)sililo sustituido o no sustituido; alquil C₁₋₈-carbonilo sustituido o no sustituido; halógenoalquil C₁₋₈-carbonilo que tiene de 1 a 9 átomos de halógeno; alcoxi C₁₋₈-carbonilo sustituido o no sustituido; halógenoalcoxi C₁₋₈-carbonilo que tiene de 1 a 9 átomos de halógeno; alquil C₁₋₈-carbamoilo sustituido o no sustituido; dialquil C₁₋₈-carbamoilo sustituido o no sustituido; fenoxi; fenilsulfanilo; fenilamino; benciloxi; bencilsulfanilo; o bencilamino; así como sus sales, N-óxidos, complejos metálicos, complejos metaloides e isómeros ópticamente activos.
ARP120104492A 2011-11-30 2012-11-29 Derivados de n-bicicloalquil- y n-tricicloalquil-(tio)-carboxamida fungicidas Pending AR089656A1 (es)

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US (1) US9725414B2 (es)
EP (1) EP2785698B1 (es)
JP (1) JP2015504442A (es)
KR (1) KR20140096391A (es)
CN (2) CN104066721B (es)
AR (1) AR089656A1 (es)
BR (1) BR112014013031A2 (es)
CA (1) CA2857438A1 (es)
CO (1) CO6990741A2 (es)
IL (1) IL232896A0 (es)
MX (1) MX2014006350A (es)
RU (1) RU2014126063A (es)
WO (1) WO2013079566A2 (es)

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CN107531676A (zh) * 2015-04-13 2018-01-02 拜耳作物科学股份公司 N‑环烷基‑n‑(双杂环基亚乙基)‑(硫代)羧酰胺衍生物

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