AR031529A1 - Proceso para la produccion de derivados del acido 5-alquilfenilacetico - Google Patents
Proceso para la produccion de derivados del acido 5-alquilfenilaceticoInfo
- Publication number
- AR031529A1 AR031529A1 ARP000105014A ARP000105014A AR031529A1 AR 031529 A1 AR031529 A1 AR 031529A1 AR P000105014 A ARP000105014 A AR P000105014A AR P000105014 A ARP000105014 A AR P000105014A AR 031529 A1 AR031529 A1 AR 031529A1
- Authority
- AR
- Argentina
- Prior art keywords
- fluorine
- formula
- acid
- salt
- chlorine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/52—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/54—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings
- C07C211/56—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
- C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
- C07C235/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Rheumatology (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Indole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Un proceso para la produccion de un derivado del ácido 5-alquilfenilacético de la formula 1 o una sal farmacéuticamente aceptable del mismo, o un éster de profármaco farmacéuticamente aceptable del mismo: en donde R es metilo o etilo; R1 es cloro o fluor; R2 es hidrogeno o fluor;R3 es hidrogeno, fluor, cloro, metilo, etilo, metoxilo, etoxilo, o hidroxilo; R4 es hidrogeno o fluor; y R5 es cloro, fluor, trifluorometilo, o metilo, en el entendido de que R1, R2, R3 y R4 no sean todos fluor cuando R sea etilo y R3 sea H; que comprende hidrolizar una lactama de la formula 2: en donde los símbolos son como se definen anteriormente, con una base; y en el proceso anterior, si se desea, proteger temporalmente cualesquiera grupos reactivos que interfieran, y luego aislar el compuesto resultante de la invencion; y si se desea, convertir el ácido carboxílico libre del compuesto de la formula 1 en un derivado de éster farmacéuticamente aceptable del mismo; y/o si se desea, convertir el ácido libre de la formula 1 en una sal, o una sal resultante en el ácido libre o en otra sal.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9922830.6A GB9922830D0 (en) | 1999-09-27 | 1999-09-27 | Processes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR031529A1 true AR031529A1 (es) | 2003-09-24 |
Family
ID=10861676
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000105014A AR031529A1 (es) | 1999-09-27 | 2000-09-25 | Proceso para la produccion de derivados del acido 5-alquilfenilacetico |
| ARP030100070A AR042404A2 (es) | 1999-09-27 | 2003-01-10 | Compuestos derivados de anilina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030100070A AR042404A2 (es) | 1999-09-27 | 2003-01-10 | Compuestos derivados de anilina |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US20080249318A1 (es) |
| EP (2) | EP1216226B1 (es) |
| JP (1) | JP2003510303A (es) |
| KR (1) | KR100745341B1 (es) |
| CN (1) | CN100412053C (es) |
| AR (2) | AR031529A1 (es) |
| AT (1) | ATE447547T1 (es) |
| AU (1) | AU775416B2 (es) |
| BR (1) | BR0014314A (es) |
| CA (1) | CA2379553C (es) |
| CO (1) | CO5210865A1 (es) |
| CY (1) | CY1110539T1 (es) |
| CZ (1) | CZ20021027A3 (es) |
| DE (1) | DE60043261D1 (es) |
| DK (1) | DK1216226T3 (es) |
| EC (2) | ECSP003680A (es) |
| ES (1) | ES2338209T3 (es) |
| GB (1) | GB9922830D0 (es) |
| HK (1) | HK1047739A1 (es) |
| HU (1) | HUP0202728A3 (es) |
| IL (2) | IL148330A0 (es) |
| MY (1) | MY125201A (es) |
| NO (1) | NO327912B1 (es) |
| NZ (1) | NZ517461A (es) |
| PE (1) | PE20010644A1 (es) |
| PL (1) | PL207777B1 (es) |
| PT (1) | PT1216226E (es) |
| RU (1) | RU2273628C2 (es) |
| SI (1) | SI1216226T1 (es) |
| SK (1) | SK287241B6 (es) |
| TR (1) | TR200200745T2 (es) |
| TW (1) | TWI270540B (es) |
| WO (1) | WO2001023346A2 (es) |
| ZA (1) | ZA200202367B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0209257D0 (en) * | 2002-04-23 | 2002-06-05 | Novartis Ag | Organic compounds |
| US7220749B2 (en) | 2002-06-11 | 2007-05-22 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| GB0224198D0 (en) * | 2002-10-17 | 2002-11-27 | Novartis Ag | Organic compounds |
| PE20040844A1 (es) | 2002-11-26 | 2004-12-30 | Novartis Ag | Acidos fenilaceticos y derivados como inhibidores de la cox-2 |
| US7161026B1 (en) | 2005-07-08 | 2007-01-09 | Property Development Corporation International, Ltd, Inc. | Method of preparation of methyl-benzyl-ketone |
| AR061623A1 (es) | 2006-06-26 | 2008-09-10 | Novartis Ag | Derivados de acido fenilacetico |
| WO2010056741A2 (en) | 2008-11-12 | 2010-05-20 | Auspex Pharmaceuticals, Inc. | Phenylacetic acid inhibitors of cyclooxygenase |
| CN102311355B (zh) * | 2011-09-26 | 2014-02-05 | 扬州天和药业有限公司 | 罗本考昔的一种制备方法 |
| CN107721901A (zh) * | 2017-11-12 | 2018-02-23 | 刘磊 | 一种2‑[2‑(2,3,5,6‑四氟苯胺基)苯基]乙酸的制备方法 |
| EP3830072A1 (en) | 2018-07-27 | 2021-06-09 | KRKA, d.d., Novo mesto | A process for the preparation of polymorphic form of robenacoxib |
| KR20210041579A (ko) * | 2018-08-03 | 2021-04-15 | 닛산 가가쿠 가부시키가이샤 | 불화 방향족 제2급 아민 화합물의 제조 방법 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3558690A (en) * | 1965-04-08 | 1971-01-26 | Gelgy Chemical Corp | Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation |
| IT1097265B (it) | 1978-06-23 | 1985-08-31 | Acraf | Nouva sintesi di un acido fenilacetico |
| JPS5677246A (en) * | 1980-11-27 | 1981-06-25 | Nissan Chem Ind Ltd | Production of substituted phenylacetic acid |
| DE3404401C2 (de) | 1984-02-08 | 1994-02-10 | Hoechst Ag | Verwendung von Aryloxy-Verbindungen als Antidots |
| FR2578836B1 (fr) | 1985-03-12 | 1987-04-17 | Rhone Poulenc Spec Chim | Procede de chloration selective de composes phenoliques |
| EP0380712B1 (de) * | 1989-01-27 | 1995-01-04 | HEUMANN PHARMA GMBH & CO | Verfahren zur Herstellung von 2,6-Dichlordiphenylaminessigsäurederivaten |
| IT1248032B (it) * | 1991-06-11 | 1995-01-05 | Laboratorio Chimico Int Spa | Procedimento per la preparazione della n- (2,6-diclorofenil) -n-fenil-n-(cloroacetil)-ammina. |
| CN1091420A (zh) * | 1993-02-25 | 1994-08-31 | 永信药品工业股份有限公司 | 二苯胺衍生物的制备方法 |
| JPH0789951A (ja) * | 1993-06-03 | 1995-04-04 | Sterling Winthrop Inc | インターロイキン−１β転換酵素阻害剤 |
| US5475139A (en) * | 1993-10-22 | 1995-12-12 | Yung Shin Pharm. Ind. Co., Ltd. | Method for the preparation of substituted derivatives of diphenyl amine |
| MX9605196A (es) | 1994-04-29 | 1997-12-31 | Sanofi Winthrop Inc | Halometilamidas como inhibidores de la proteasa il-1b. |
| US5576460A (en) * | 1994-07-27 | 1996-11-19 | Massachusetts Institute Of Technology | Preparation of arylamines |
| JPH0977664A (ja) * | 1995-09-13 | 1997-03-25 | Yakult Honsha Co Ltd | シクロオキシゲナーゼ−２特異的阻害剤及び抗炎症剤 |
| US6355680B1 (en) * | 1996-02-20 | 2002-03-12 | Exocell, Inc. | Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies |
| BR9600975A (pt) * | 1996-03-11 | 1997-12-30 | Fundacao Oswaldo Cruz | Derivados do ácido gem-difluorfenilacético e de gem-difluorfenilacetamida processo de sua preparação e suas aplicações farmacêuticas |
| US6034266A (en) * | 1996-03-11 | 2000-03-07 | Fundacao Oswaldo Cruz-Fiocruz | Gem-difluoro derivative of phenylacetamide and phenylacetic acid and their pharmaceutical uses |
| CA2208900C (en) | 1996-07-18 | 2006-08-01 | Lonza Ag | Process for preparing 2-pyrimidinecarboxylates |
| US5817877A (en) * | 1996-09-23 | 1998-10-06 | Yale University | Metal-catalyzed amination of organic sulfonates to organic amines |
| CO4960662A1 (es) | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
-
1999
- 1999-09-27 GB GBGB9922830.6A patent/GB9922830D0/en not_active Ceased
-
2000
- 2000-09-25 SK SK414-2002A patent/SK287241B6/sk not_active IP Right Cessation
- 2000-09-25 EP EP00969292A patent/EP1216226B1/en not_active Expired - Lifetime
- 2000-09-25 AR ARP000105014A patent/AR031529A1/es active IP Right Grant
- 2000-09-25 EP EP09171648A patent/EP2275403A1/en not_active Withdrawn
- 2000-09-25 DE DE60043261T patent/DE60043261D1/de not_active Expired - Lifetime
- 2000-09-25 EC EC2000003680A patent/ECSP003680A/es unknown
- 2000-09-25 WO PCT/EP2000/009346 patent/WO2001023346A2/en active IP Right Grant
- 2000-09-25 KR KR1020027003901A patent/KR100745341B1/ko not_active IP Right Cessation
- 2000-09-25 PE PE2000001007A patent/PE20010644A1/es not_active Application Discontinuation
- 2000-09-25 CN CNB008133972A patent/CN100412053C/zh not_active Expired - Fee Related
- 2000-09-25 HU HU0202728A patent/HUP0202728A3/hu unknown
- 2000-09-25 AT AT00969292T patent/ATE447547T1/de active
- 2000-09-25 DK DK00969292.2T patent/DK1216226T3/da active
- 2000-09-25 JP JP2001526501A patent/JP2003510303A/ja active Pending
- 2000-09-25 CZ CZ20021027A patent/CZ20021027A3/cs unknown
- 2000-09-25 TR TR2002/00745T patent/TR200200745T2/xx unknown
- 2000-09-25 BR BR0014314-6A patent/BR0014314A/pt not_active IP Right Cessation
- 2000-09-25 RU RU2002109239/04A patent/RU2273628C2/ru not_active IP Right Cessation
- 2000-09-25 CA CA2379553A patent/CA2379553C/en not_active Expired - Fee Related
- 2000-09-25 ES ES00969292T patent/ES2338209T3/es not_active Expired - Lifetime
- 2000-09-25 IL IL14833000A patent/IL148330A0/xx active IP Right Grant
- 2000-09-25 PL PL365994A patent/PL207777B1/pl unknown
- 2000-09-25 PT PT00969292T patent/PT1216226E/pt unknown
- 2000-09-25 SI SI200031050T patent/SI1216226T1/sl unknown
- 2000-09-25 NZ NZ517461A patent/NZ517461A/en not_active IP Right Cessation
- 2000-09-25 AU AU79067/00A patent/AU775416B2/en not_active Ceased
- 2000-09-26 MY MYPI20004481 patent/MY125201A/en unknown
- 2000-09-27 TW TWPROCESSFA patent/TWI270540B/zh not_active IP Right Cessation
- 2000-09-27 CO CO00073348A patent/CO5210865A1/es not_active Application Discontinuation
-
2002
- 2002-02-21 IL IL148330A patent/IL148330A/en not_active IP Right Cessation
- 2002-03-19 NO NO20021368A patent/NO327912B1/no not_active IP Right Cessation
- 2002-03-25 ZA ZA200202367A patent/ZA200202367B/en unknown
- 2002-12-23 HK HK02109296.0A patent/HK1047739A1/xx not_active IP Right Cessation
-
2003
- 2003-01-10 AR ARP030100070A patent/AR042404A2/es unknown
-
2007
- 2007-08-16 US US11/893,481 patent/US20080249318A1/en not_active Abandoned
-
2009
- 2009-01-13 EC EC2009003680A patent/ECSP093680A/es unknown
- 2009-05-07 US US12/436,991 patent/US7906677B2/en not_active Expired - Fee Related
-
2010
- 2010-02-03 CY CY20101100105T patent/CY1110539T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |