AR015170A1 - Bifenilsulfonilcianamidas, su empleo para la preparacion de un medicamento y medicamento que las contiene - Google Patents
Bifenilsulfonilcianamidas, su empleo para la preparacion de un medicamento y medicamento que las contieneInfo
- Publication number
- AR015170A1 AR015170A1 ARP980104685A ARP980104685A AR015170A1 AR 015170 A1 AR015170 A1 AR 015170A1 AR P980104685 A ARP980104685 A AR P980104685A AR P980104685 A ARP980104685 A AR P980104685A AR 015170 A1 AR015170 A1 AR 015170A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- phenyl
- substituents
- unsubstituted
- Prior art date
Links
- 229940126601 medicinal product Drugs 0.000 title 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 15
- 239000001257 hydrogen Substances 0.000 abstract 15
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 10
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 7
- 150000002431 hydrogen Chemical group 0.000 abstract 7
- -1 O-R10 Chemical group 0.000 abstract 6
- 125000001424 substituent group Chemical group 0.000 abstract 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- CBTRBYGUVACZIU-UHFFFAOYSA-N n-cyano-2-phenylbenzenesulfonamide Chemical class N#CNS(=O)(=O)C1=CC=CC=C1C1=CC=CC=C1 CBTRBYGUVACZIU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Bifenilsulfonilcianamidas que tienen extraordinarias propiedades antiarrítmicas de la formula (I), donde: R1 es hidrogeno, alquilo C1-8, 1-naftilo,2-naftilo, -CaH2a-cicloalquilo C3-7 o -CaH2a-fenilo, estando la parte de fenilo sin sustituir osustitu ida con 1-3 sustituyentes del grupo alquilo C1-8, F, Cl,Br, I, CF3, SOnR11, OR17, NR8R9, -C:::N, -NO2 o CO-R22; R11 alquilo C1-4 o NR20R21; R20 y R21 son, independientes entre sí, hidrogeno o alquilo C1-4; R17 eshidrogeno o alquilo C1-4; R8y R9 son, independientes entre sí, hidrogeno o alquilo C1-4; R22 es hidrogeno, alquilo C1-8 u OR30; R30 es hidrogeno o alquiloC1-8; a es 0, 1 o 2; n es 0, 1 o 2; o R1 y R3, junto con el átomo de C que los lleva, cicloalquilo C3-7 o fluorenilo; R2,R3, R4 y R5 son, independientes entresí, hidrogeno, F, CF3, O-R10, alquilo C1-8, cicloalquilo C3-7, CgH2g-fenilo, estando la parte de fenilo sin sustituir o sustituida con 1-3 sustituyentes delgrupo F, Cl, Br, I, CF3, metilo, metoxi, hidroxi oNr18R19; R18 y R1 9 son, independientes entre sí, hidrogeno o alquilo C1-4; g es 0, 1 o 2; R10 es hidrogeno,alquilo C1-8, fenilo, que está sin sustituir o sustituido con 1-3 sustituyentes del grupo F, Cl, Br, I, CF3, metilo, metoxi, hidroxi oNR12R13; R12 y R13 son,in dependientes entre sí, hidrogeno o alquilo C1-4; o R10 es heteroarilo C1-9, que está sin sustituir o sustituido con 1-3 sustituyentes del grupo F, Cl, BR, I,CF3, CH3, metoxi, hidroxi o NR14R15; R14 y R15 son, independientesentre sí, hidrogeno o alqu ilo C1-4; o R2 y R4, en comun, un segundo enlace entre los átomosde C que llevan los radicales R3 y R5, estando R1, R3 y R5 definidos como antes; R6 y R7 son, independientes entre sí, hidrogeno, F, Cl, Br, I, CF3,-C:::N,-NO2, SOp-R16, CO-R23 u O-R24 ; R23 es hidrogeno, alquilo C1-8 u OR25; R25 es hidrogeno o alquilo C1-8; R24 es hidrogeno, alquilo C1-8 o fenilo que está sinsustituir o p-sustituido con 1-3 sustituyentes del grupo F,Cl,Br,I,CF3, metilo, metoxio NR28R29; R28 y R29 son H o alquilo C1-4; R16 es alquilo C1-8,feniloque está sin sustituir o sustituido con 1-3 sustituyentes del grupo F, CL, BR, I, CF3, metilo, metoxi, hidroxi o NR26R27; R26 y R27 son iguales a H o alquilo
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19741635A DE19741635A1 (de) | 1997-09-22 | 1997-09-22 | Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR015170A1 true AR015170A1 (es) | 2001-04-18 |
Family
ID=7843124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980104685A AR015170A1 (es) | 1997-09-22 | 1998-09-18 | Bifenilsulfonilcianamidas, su empleo para la preparacion de un medicamento y medicamento que las contiene |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5968978A (es) |
| EP (1) | EP0903339B1 (es) |
| JP (1) | JP4272278B2 (es) |
| KR (1) | KR19990029983A (es) |
| CN (2) | CN1212255A (es) |
| AR (1) | AR015170A1 (es) |
| AT (1) | ATE210638T1 (es) |
| AU (1) | AU755553B2 (es) |
| BR (1) | BR9803968A (es) |
| CA (1) | CA2247749A1 (es) |
| CZ (1) | CZ300698A3 (es) |
| DE (2) | DE19741635A1 (es) |
| DK (1) | DK0903339T3 (es) |
| ES (1) | ES2169467T3 (es) |
| HK (1) | HK1040980A1 (es) |
| HU (1) | HUP9802132A3 (es) |
| PL (1) | PL328762A1 (es) |
| PT (1) | PT903339E (es) |
| TR (1) | TR199801871A3 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19737224A1 (de) * | 1997-08-27 | 1999-03-18 | Hoechst Marion Roussel De Gmbh | Pharmazeutisches Kombinationspräparat aus einem Inhibitor des Natrium-Wasserstoff-Austauschers und einem Arzneimittel zur Behandlung von Herz-Kreislauferkrankungen |
| DE19804251A1 (de) | 1998-02-04 | 1999-08-05 | Hoechst Marion Roussel De Gmbh | Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| ID25640A (id) * | 1998-03-04 | 2000-10-19 | Takeda Chemical Industries Ltd | Preparat pelepasan terus menerus untuk antagonistik aii, produksi dan penggunaannya |
| DE19820064A1 (de) * | 1998-05-06 | 1999-11-11 | Hoechst Marion Roussel De Gmbh | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| KR100634953B1 (ko) * | 1998-07-20 | 2006-10-17 | 스미스클라인 비참 코포레이션 | 에프로사르탄을 포함하는 생물학적으로 강화된 경구 고형투여 형태의 제제 |
| DE10018401A1 (de) * | 2000-04-13 | 2001-10-25 | Boehringer Ingelheim Pharma | Verwendung von Bradycardica bei der Behandlung von mit Hypertrophie einhergehenden Myocarderkrankungen und neue Arzneimittelkombinationen |
| US20070160645A1 (en) * | 2001-10-25 | 2007-07-12 | Jakob Vinten-Johansen | PostConditioning System And Method For The Reduction Of Ischemic-Reperfusion Injury In The Heart And Other Organs |
| ES2316618T3 (es) | 2001-10-25 | 2009-04-16 | Emory University | Cateter para perfusion modificada. |
| DE10206354A1 (de) * | 2002-02-14 | 2003-08-28 | Aventis Pharma Gmbh | Verwendung von Inhibitoren des Natrium-abhängigen Chlorid-Bicarbonat-Austauschers zur Behandlung von thrombotischen und inflammatorischer Erkrankungen |
| US20040138306A1 (en) * | 2002-07-25 | 2004-07-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of a specific cyclic amine derivative or the pharmaceutically acceptable salts thereof for the treatment or prevention of heart failure |
| US20060099230A1 (en) * | 2004-11-10 | 2006-05-11 | Chin-Chih Chiang | Novel formulations of eprosartan with enhanced bioavailability |
| AU2005319144A1 (en) * | 2004-12-22 | 2006-06-29 | Emory University | Therapeutic adjuncts to enhance the organ protective effects of postconditioning |
| EP1762179A1 (en) * | 2005-09-07 | 2007-03-14 | Boehringer Ingelheim Vetmedica Gmbh | Method for improving diagnostic quality in echocardiography |
| US7541492B2 (en) * | 2005-10-26 | 2009-06-02 | Toyota Jidosha Kabushiki Kaisha | Perfluoroalkanesulfonamide compounds |
| AU2012296925A1 (en) | 2011-08-12 | 2014-02-06 | Boehringer Ingelheim Vetmedica Gmbh | Taste masked pharmaceutical composition |
| WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
| CN113527152B (zh) * | 2021-08-09 | 2023-07-28 | 西北农林科技大学 | 一种联苯磺酰胺类化合物及其防治农作物害虫的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2533126A1 (de) * | 1975-07-24 | 1977-02-10 | Bayer Ag | Polytriazine und ein verfahren zu deren herstellung |
| DE2533127A1 (de) * | 1975-07-24 | 1977-02-10 | Bayer Ag | Polytriazine und ein verfahren zu deren herstellung |
| EP0503838A3 (en) * | 1991-03-08 | 1992-10-07 | Merck & Co. Inc. | Heterocyclic compounds bearing acidic functional groups as angiotensin ii antagonists |
| CA2062558A1 (en) * | 1991-03-08 | 1992-09-09 | Prasun K. Chakravarty | Heterocyclic compounds bearing acidic functional groups as angiotensin ii antagonists |
| CA2109524A1 (en) * | 1991-05-10 | 1992-11-11 | Prasun K. Chakravarty | Acidic aralkyl triazole derivatives active as angiotensin ii antagonists |
| EP0855392A3 (de) * | 1997-01-22 | 2000-01-05 | Hoechst Aktiengesellschaft | Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1997
- 1997-09-22 DE DE19741635A patent/DE19741635A1/de not_active Withdrawn
-
1998
- 1998-09-16 PT PT98117529T patent/PT903339E/pt unknown
- 1998-09-16 DE DE59802412T patent/DE59802412D1/de not_active Expired - Lifetime
- 1998-09-16 EP EP98117529A patent/EP0903339B1/de not_active Expired - Lifetime
- 1998-09-16 AT AT98117529T patent/ATE210638T1/de not_active IP Right Cessation
- 1998-09-16 DK DK98117529T patent/DK0903339T3/da active
- 1998-09-16 ES ES98117529T patent/ES2169467T3/es not_active Expired - Lifetime
- 1998-09-18 CZ CZ983006A patent/CZ300698A3/cs unknown
- 1998-09-18 AR ARP980104685A patent/AR015170A1/es unknown
- 1998-09-21 TR TR1998/01871A patent/TR199801871A3/tr unknown
- 1998-09-21 US US09/157,589 patent/US5968978A/en not_active Expired - Lifetime
- 1998-09-21 BR BR9803968-7A patent/BR9803968A/pt not_active IP Right Cessation
- 1998-09-21 AU AU86108/98A patent/AU755553B2/en not_active Ceased
- 1998-09-21 KR KR1019980038932A patent/KR19990029983A/ko not_active Application Discontinuation
- 1998-09-21 JP JP26685098A patent/JP4272278B2/ja not_active Expired - Fee Related
- 1998-09-21 CA CA002247749A patent/CA2247749A1/en not_active Abandoned
- 1998-09-22 HU HU9802132A patent/HUP9802132A3/hu unknown
- 1998-09-22 CN CN98119536A patent/CN1212255A/zh active Pending
- 1998-09-22 PL PL98328762A patent/PL328762A1/xx unknown
-
2000
- 2000-02-25 CN CN00102661A patent/CN1326928A/zh active Pending
-
2002
- 2002-04-03 HK HK02102461.4A patent/HK1040980A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL328762A1 (en) | 1999-03-29 |
| AU8610898A (en) | 1999-04-01 |
| HK1040980A1 (zh) | 2002-06-28 |
| DE59802412D1 (de) | 2002-01-24 |
| HU9802132D0 (en) | 1998-11-30 |
| BR9803968A (pt) | 2000-05-02 |
| CZ300698A3 (cs) | 1999-04-14 |
| PT903339E (pt) | 2002-06-28 |
| EP0903339A2 (de) | 1999-03-24 |
| EP0903339A3 (de) | 1999-03-31 |
| HUP9802132A3 (en) | 2000-04-28 |
| CN1212255A (zh) | 1999-03-31 |
| CA2247749A1 (en) | 1999-03-22 |
| AU755553B2 (en) | 2002-12-12 |
| JPH11189581A (ja) | 1999-07-13 |
| JP4272278B2 (ja) | 2009-06-03 |
| KR19990029983A (ko) | 1999-04-26 |
| TR199801871A2 (xx) | 1999-04-21 |
| DK0903339T3 (da) | 2002-04-08 |
| US5968978A (en) | 1999-10-19 |
| DE19741635A1 (de) | 1999-03-25 |
| HUP9802132A2 (hu) | 2000-02-28 |
| TR199801871A3 (tr) | 1999-04-21 |
| ES2169467T3 (es) | 2002-07-01 |
| EP0903339B1 (de) | 2001-12-12 |
| ATE210638T1 (de) | 2001-12-15 |
| CN1326928A (zh) | 2001-12-19 |
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