-
Notifications
You must be signed in to change notification settings - Fork 39
New issue
Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.
By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.
Already on GitHub? Sign in to your account
lipase activity edits #28339
Comments
Also:
|
id: GO:0102259 (7 annotations, 1 IDA) id: GO:0102258 (7 annotations, 1 IDA) |
+[Term] |
@sjm41 Can you give the reasons for merge? I assume GO:0102549 1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity is a specific substrate of GO:0102549? |
Hi @pgaudet |
Our lipase activity term and immediate child terms look like this:
After chatting with Lucila Aimo at RHEA and @pgaudet, there are several corrections to make:
id: GO:0016298
name: lipase activity
def: "Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds
id: GO:0047372
name: acylglycerol lipase activity
def: "Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol." [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN]
xref: EC:3.1.1.23
xref: MetaCyc:3.1.1.23-RXN
xref: RHEA:34019
is_a: GO:0016298 ! lipase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity
id: GO:0004806
name: triglyceride lipase activity
def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
xref: EC:3.1.1.3
xref: MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN
xref: RHEA:12044
is_a: GO:0016298 ! lipase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity
id: GO:0004465
name: lipoprotein lipase activity
def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein." [EC:3.1.1.34, GOC:bf]
xref: EC:3.1.1.34
is_a: GO:0004806 ! triglyceride lipase activity
EC:3.1.1.34 says:
Hydrolyzes triacylglycerols and diacylglycerol in chylomicrons and low-density lipoprotein particles (VLDL).
Human protein purified from post-heparin plasma (LPL) shows no activity against triglyceride in the absence of added lipoprotein.
The principal reaction sequence of that enzyme is triglyceride -> 1,2-diglyceride -> 2-monoglyceride.
The hepatic enzyme (LIPC) also hydrolyzes triglycerides and phospholipids present in circulating plasma lipoproteins.
name: diacylglycerol lipase activity
def: "Catalysis of the reaction: a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H+ [RHEA:32731]
xref: RHEA:32731
xref: MetaCyc:RXN-19279
is_a: GO:0016298 ! lipase activity
id: GO:0033878
name: hormone-sensitive lipase activity
def: "Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate." [EC:3.1.1.79]
xref: EC:3.1.1.79
xref: MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity
This is really a gene product that can catalyse hydrolysis of monoacylglycerols, diacylglycerols, and triacylglycerol - ie. three of the GO terms listed above.
id: GO:0004771
name: sterol esterase activity
def: "Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13]
xref: EC:3.1.1.13
xref: MetaCyc:STEROL-ESTERASE-RXN
xref: RHEA:10100
is_a: GO:0016298 ! lipase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity
id: GO:0047714
name: galactolipase activity
def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates." [EC:3.1.1.26, MetaCyc:GALACTOLIPASE-RXN]
xref: EC:3.1.1.26
xref: MetaCyc:GALACTOLIPASE-RXN
xref: RHEA:13189
is_a: GO:0016298 ! lipase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity
id: GO:0102549
name: 1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity
def: "Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + H2O = sn-1-lyso-2-16:0-monogalactosyldiacylglycerol + oleate + H+." [EC:3.1.1.26, GOC:pz]
xref: EC:3.1.1.26
xref: MetaCyc:RXN-14912
is_a: GO:0052689 ! carboxylic ester hydrolase activity
The text was updated successfully, but these errors were encountered: