NTR: beta-arrestin-dependent dopamine receptor signaling pathway

[pgaudet]

Following up on #26959

After discussion with @hattrill we agree that we should look into creating a new term under 'GO:0007166 cell surface signaling pathway', based on the paper @raymond91125 cited, PMID: 25671228, and also PMID:35688404.

One problem is that there are no general beta-arrestin or GSK3 signaling pathway terms in GO, so no 'module' we can reuse. Beta-arrestin a an adaptor that seem to activate may different proteins; can a a pathway in which the receptor binds beta-arrestin be defined unambiguously?

The mechanism of signaling is not clear: PMID: 25671228, mentions PP2, Akt and GSK3A, while

PMID:35688404 mentions Akt, PI3K, MAP kinases but not GSK3

Are these the same pathway?

The first step would be with it to review the direct annotations to GO:0007212 dopamine receptor signaling pathway (39 EXP) and see if they can be made more precise with existing terms, or if we already need a new term.

@raymond91105 can you please set up an annotation review?

Thanks, Pascale

[raymond91125]

@pgaudet For annotation review, is the proposal to make dopamine receptor signaling pathway do_not_annotate or obsolete or something else? Thanks.

[raymond91125]

The PMID:25671228 figure above is about D2R whereas PMID:35688404 D1R. As indicated in PMID:28328745, G-protein independent arrestin signaling is quite varied regarding both upstream (many different 7TM receptors) and downstream (kinase and non-kinase).

Perhaps we could do:
GO:0007166 cell surface signaling pathway
---GO:0007212 dopamine receptor signaling pathway (do_not_annotate)
------GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway (is_a G protein-coupled receptor signaling pathway)
------GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway (is_a G protein-coupled receptor signaling pathway)
------GO:0060158 phospholipase C-activating dopamine receptor signaling pathway (is_a G protein-coupled receptor signaling pathway)
------GO:nnnnnnn beta-arrestin-dependent dopamine receptor signaling pathway (LD = 'dopamine receptor signaling pathway'
and ('has part' some 'arrestin-family protein binding'))

[pgaudet]

This looks good to me. @hattrill ?

[RLovering]

Hi
I think I have found a review which confirms the beta-arrestin-dependent dopamine receptor signaling pathway. Is this term going to be created?

https://pubmed.ncbi.nlm.nih.gov/21711983/ - if so I will use it and maybe try to curate that experimental paper.

Or is there a beta-arrestin/AKT/GSK signaling pathway that I have missed and therefore could state that the DRs pos reg the beta-arrestin/AKT/GSK signaling pathway

Thanks
Ruth

[pgaudet]

@raymond91125 Can you please create that new term?

[raymond91125]

+[Term]
+id: GO:0160213
+name: beta-arrestin-dependent dopamine receptor signaling pathway
+namespace: biological_process
+def: "A beta-arrestin-dependent signaling pathway initiated by a dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [PMID:21711983, PMID:25671228]
+is_a: GO:0007166 ! cell surface receptor signaling pathway
+relationship: part_of GO:1903351 ! cellular response to dopamine
+property_value: term_tracker_item "#28005" xsd:anyURI
+created_by: rynl
+creation_date: 2024-09-12T19:51:02Z