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aldose reductase (NADPH) activity xrefs #27881

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sjm41 opened this issue May 9, 2024 · 1 comment
Closed

aldose reductase (NADPH) activity xrefs #27881

sjm41 opened this issue May 9, 2024 · 1 comment

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@sjm41
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sjm41 commented May 9, 2024

id: GO:0004032
name: aldose reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21]
synonym: "aldehyde reductase activity" RELATED [EC:1.1.1.21]
synonym: "alditol:NADP+ 1-oxidoreductase activity" EXACT []
synonym: "aldose reductase activity" RELATED [EC:1.1.1.21]
synonym: "polyol dehydrogenase (NADP(+)) activity" RELATED [EC:1.1.1.21]
xref: EC:1.1.1.21 {source="skos:broadMatch"}
xref: KEGG_REACTION:R02820
xref: MetaCyc:ALDEHYDE-REDUCTASE-RXN
xref: RHEA:12789
is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity
property_value: term_tracker_item "#27136" xsd:anyURI

Looking at the xrefs on this NADPH-specific term:
xref: EC:1.1.1.21 is for NAD(P)H, so 'broadMatch' is correct
xref: KEGG_REACTION:R02820 is for NADPH, so is correct
xref: MetaCyc:ALDEHYDE-REDUCTASE-RXN, is for NAD(P)H so should be changed to 'broadMatch'
xref: RHEA:12789 is for NADPH, so is correct

Alternatively, we could make a new parent GO term for the NAD(P)H reaction, and then move the EC and MetaCyc xrefs to that term as exact match xrefs.
If we did that, we would also make another term specific for the NADH reaction (= RHEA:12785)

What do you think @pgaudet ?

@sjm41
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sjm41 commented Jun 26, 2024

For now, I will just make the MetaCyc xref 'broadMatch'

@sjm41 sjm41 closed this as completed in ffe64d0 Jun 26, 2024
sjm41 added a commit that referenced this issue Jun 26, 2024
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