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Merge pull request #28402 from geneontology/enzyme_merges-2024-07-05
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Enzyme merges 2024 07 05
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pgaudet authored Jul 5, 2024
2 parents 5378363 + b0ab14d commit 0572a14
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85 changes: 50 additions & 35 deletions src/ontology/go-edit.obo
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Original file line number Diff line number Diff line change
Expand Up @@ -196587,7 +196587,6 @@ id: GO:0033782
name: 24-hydroxycholesterol 7alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (24S)-hydroxycholesterol + O2 + reduced [NADPH-hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H+ + H2O + oxidized [NADPH-hemoprotein reductase]." [PMID:10748047, PMID:11013305, RHEA:46124]
comment: Formerly EC:1.14.13.99.
synonym: "24-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" RELATED []
synonym: "24-hydroxycholesterol 7alpha-monooxygenase activity" RELATED [EC:1.14.14.26]
xref: EC:1.14.14.26
Expand Down Expand Up @@ -223328,13 +223327,14 @@ creation_date: 2012-05-22T01:54:09Z
id: GO:0036239
name: taxoid 7beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: taxusin + [reduced NADPH-hemoprotein reductase] + O2 = 7beta-hydroxytaxusin + [oxidized NADPH-hemoprotein reductase] + H2O and 2alpha-hydroxytaxusin + [reduced NADPH-hemoprotein reductase] + O2 = 2alpha,7beta-dihydroxytaxusin + [oxidized NADPH-hemoprotein reductase] + H2O." [PMID:15157877, PMID:15178487]
xref: EC:1.14.14.182
def: "Catalysis of the reaction: taxusin + [reduced NADPH-hemoprotein reductase] + O2 = 7beta-hydroxytaxusin + [oxidized NADPH-hemoprotein reductase] + H2O. Also converts 2alpha-hydroxytaxusin to 2alpha,7beta-dihydroxytaxusin." [EC:1.14.14.182, PMID:15157877, PMID:15178487]
xref: EC:1.14.14.182 {source="skos:exactMatch"}
xref: KEGG_REACTION:R09868
xref: MetaCyc:RXN-12885
xref: MetaCyc:RXN-12885 {source="skos:narrowMatch"}
xref: MetaCyc:RXN-13488 {source="skos:narrowMatch"}
xref: RHEA:31975 {source="skos:narrowMatch"}
xref: RHEA:71403 {source="skos:narrowMatch"}
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24049" xsd:anyURI
created_by: bf
creation_date: 2012-05-22T02:13:21Z
Expand Down Expand Up @@ -429513,9 +429513,10 @@ is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102097
name: (22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity
name: 22alpha-hydroxysteroid 23-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6-deoxoteasterone + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. Also converts 3-epi-6-deoxocathasterone to 6-deoxotyphasterol." [EC:1.14.14.147, GOC:pz]
def: "Catalysis of the reaction: (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6-deoxoteasterone + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. Also converts 3-epi-6-deoxocathasterone to 6-deoxotyphasterol." [EC:1.14.14.147]
synonym: "(22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity" EXACT []
xref: EC:1.14.14.147 {source="skos:exactMatch"}
xref: MetaCyc:RXN-11101
xref: RHEA:27321 {source="skos:narrowMatch"}
Expand Down Expand Up @@ -429815,25 +429816,25 @@ replaced_by: GO:0102097

[Term]
id: GO:0102137
name: 7-oxateasterone synthase activity
name: obsolete 7-oxateasterone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + teasterone = 7-oxateasterone + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:70015]
xref: EC:1.14.14.180 {source="skos:broadMatch"}
xref: MetaCyc:RXN-11537 {source="skos:exactMatch"}
xref: RHEA:70015 {source="skos:exactMatch"}
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
def: "OBSOLETE. Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + teasterone = 7-oxateasterone + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of brassinolide synthase activity ; GO:0102734.
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28199" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28224" xsd:anyURI
is_obsolete: true
replaced_by: GO:0102734

[Term]
id: GO:0102138
name: 7-oxatyphasterol synthase activity
name: obsolete 7-oxatyphasterol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + typhasterol = 7-oxatyphasterol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:70019]
xref: EC:1.14.14.180 {source="skos:broadMatch"}
xref: MetaCyc:RXN-11538 {source="skos:exactMatch"}
xref: RHEA:70019 {source="skos:exactMatch"}
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
def: "OBSOLETE. Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + typhasterol = 7-oxatyphasterol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of brassinolide synthase activity ; GO:0102734.
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28199" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28224" xsd:anyURI
is_obsolete: true
replaced_by: GO:0102734

[Term]
id: GO:0102139
Expand Down Expand Up @@ -431787,27 +431788,37 @@ is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102365
name: taxusin 2-alpha-hydroxylase activity
name: taxoid 2alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: taxusin + NADPH + O2 + H+ = 2-alpha-hydroxytaxusin + NADP + H2O." [GOC:pz, PMID:15178487]
def: "Catalysis of the reaction: taxusin + NADPH + O2 + H+ = 2-alpha-hydroxytaxusin + NADP + H2O. Also converts 7beta-hydroxytaxusin to 2alpha,7beta-dihydroxytaxusin." [EC:1.14.14.183, PMID:15178487]
synonym: "taxusin 2-alpha-hydroxylase activity" EXACT []
xref: EC:1.14.14.183 {source="skos:exactMatch"}
xref: MetaCyc:RXN-13486
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
xref: MetaCyc:RXN-13487
xref: RHEA:71399 {source="skos:narrowMatch"}
xref: RHEA:71407 {source="skos:narrowMatch"}
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28220" xsd:anyURI

[Term]
id: GO:0102366
name: 7-beta-hydroxytaxusin 2-alpha-hydroxylase activity
name: obsolete 7-beta-hydroxytaxusin 2-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-beta-hydroxytaxusin + NADPH + O2 + H+ = 2alpha, 7-beta-dihydroxytaxusin + NADP + H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-13487
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
def: "OBSOLETE. Catalysis of the reaction: 7-beta-hydroxytaxusin + NADPH + O2 + H+ = 2alpha, 7-beta-dihydroxytaxusin + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of taxoid 2alpha-hydroxylase activity ; GO:0102365.
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28220" xsd:anyURI
is_obsolete: true
replaced_by: GO:0102365

[Term]
id: GO:0102367
name: 2-alpha-hydroxytaxusin 7-beta-hydroxylase activity
name: obsolete 2-alpha-hydroxytaxusin 7-beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2alpha-hydroxytaxusin + NADPH + O2 + H+ = 2alpha, 7beta-dihydroxytaxusin + NADP + H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-13488
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
def: "OBSOLETE. Catalysis of the reaction: 2alpha-hydroxytaxusin + NADPH + O2 + H+ = 2alpha, 7beta-dihydroxytaxusin + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of taxoid 7beta-hydroxylase activity ; GO:0036239.
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28220" xsd:anyURI
is_obsolete: true
replaced_by: GO:0036239

[Term]
id: GO:0102368
Expand Down Expand Up @@ -435033,10 +435044,12 @@ is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorp
id: GO:0102734
name: brassinolide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: castasterone + O2 + reduced [NADPH--hemoprotein reductase] = brassinolide + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:69923]
def: "Catalysis of the reaction: castasterone + O2 + reduced [NADPH--hemoprotein reductase] = brassinolide + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. Broad specificity for several brassinosteroids, including castasterone, teasterone, and typhasterol." [RHEA:69923]
xref: EC:1.14.14.180 {source="skos:broadMatch"}
xref: MetaCyc:RXN-720 {source="skos:exactMatch"}
xref: RHEA:69923 {source="skos:exactMatch"}
xref: RHEA:70015 {source="skos:narrowMatch"}
xref: RHEA:70019 {source="skos:narrowMatch"}
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28199" xsd:anyURI

Expand Down Expand Up @@ -435278,11 +435291,13 @@ replaced_by: GO:0160191

[Term]
id: GO:0102760
name: 6-deoxocathasterone hydroxylase activity
name: obsolete 6-deoxocathasterone hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-deoxycathasterone + O2 + a reduced electron acceptor = 6-deoxoteasterone + H2O + an oxidized electron acceptor." [EC:1.14.-.-, GOC:pz]
xref: MetaCyc:RXN-774
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
def: "OBSOLETE. Catalysis of the reaction: 6-deoxycathasterone + O2 + a reduced electron acceptor = 6-deoxoteasterone + H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as 22alpha-hydroxysteroid 23-monooxygenase activity ; GO:0102097.
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28222" xsd:anyURI
is_obsolete: true
replaced_by: GO:0102097

[Term]
id: GO:0102761
Expand Down
92 changes: 3 additions & 89 deletions src/ontology/imports/go-catalytic-activities-participants.owl
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Original file line number Diff line number Diff line change
Expand Up @@ -161365,99 +161365,13 @@

<!-- https://purl.obolibrary.org/obo/GO_0102137 -->

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<!-- https://purl.obolibrary.org/obo/GO_0102138 -->

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Expand Down Expand Up @@ -183620,5 +183534,5 @@



<!-- Generated by the OWL API (version 4.5.26) https://github.com/owlcs/owlapi -->
<!-- Generated by the OWL API (version 4.5.25.2023-02-15T19:15:49Z) https://github.com/owlcs/owlapi -->

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