Multiple enzyme hicFindRestSites support?

[gtrichard]

Hi @joachimwolff and @LeilyR , best wishes for 2021.

I'm using Arima Genomics Hi-C kit which uses DpnII and HinfI enzymes. Currently, I need to perform two hicFindRestSites run (one for each enzyme) and concatenate the resulting .bed files to use in hicBuildMatrix for RF resolution matrices.

Do you plan multiple enzyme support for hicFindRestSites? I'm asking because I'm working on modifying the SnakePipes HiC pipeline to support the Arima kit. Before doing any changes to the pipeline, I would like to know if it is planned or not for HiCExplorer as it would solve the SnakePipes HiC issue of using multiple enzymes, as well as making hicFindRestSites easier to use for a kit that might become the norm for Hi-C in the future.

Thank you :)

[LeilyR]

I agree that it is going to be a good asset for hicexplorer. Shall we put it in todo list?

[joachimwolff]

We can add this, it is more or less one for-loop we have to add. However, it will be part of the next release which will be in maybe 2 - 4 weeks. I hope it is not too far in the future.

[LeilyR]

it may need downstream changes in QC too. Does that handle multi enzyme protocols?

[joachimwolff]

Implemented with PR #732