WNT
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2010/05/03 02:32 UTC 版)
WNT
- Microsoft Windows NT - マイクロソフトが開発したオペレーティングシステム(OS)。
- Windows NT系 - 上記OSのアーキテクチャを基に製作されたOS。
- Wntシグナル経路 - 胚発生とガンに関連するタンパク質のネットワーク。
- サッカーアメリカ合衆国女子代表(United States women's national soccer team) - アメリカ合衆国女子サッカーナショナルチーム。
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Wntシグナル経路
(Wnt から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/02/05 19:57 UTC 版)
Wntシグナル経路（ウィント-シグナルけいろ、英: Wnt signaling pathway）は、細胞表面受容体を介して細胞内へシグナルを伝達するタンパク質によって開始されるシグナル伝達経路の1つである。Wntという名称は、winglessとint-1という2つの遺伝子の名称に由来する「かばん語」である[1]。Wntシグナル経路は、近接する細胞間のコミュニケーション（傍分泌）または細胞自身に対するコミュニケーション（自己分泌）のいずれかを利用する。この経路は動物で進化的に高度に保存されており、ショウジョウバエからヒトまで類似した経路が存在する[2][3]。
- ^ a b “A new nomenclature for int-1 and related genes: the Wnt gene family”. Cell 64 (2): 231. (January 1991). doi:10.1016/0092-8674(91)90633-a. PMID 1846319.
- ^ a b “Wnt genes”. Cell 69 (7): 1073–87. (June 1992). doi:10.1016/0092-8674(92)90630-U. PMID 1617723.
- ^ a b c d “Wnt signaling in disease and in development”. Cell Research 15 (1): 28–32. (January 2005). doi:10.1038/sj.cr.7290260. PMID 15686623.
- ^ “Dishevelled-DEP domain interacting protein (DDIP) inhibits Wnt signaling by promoting TCF4 degradation and disrupting the TCF4/beta-catenin complex”. Cellular Signalling 22 (11): 1753–60. (November 2010). doi:10.1016/j.cellsig.2010.06.016. PMID 20603214.
- ^ a b c “Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration”. Cell 136 (6): 1136–47. (March 2009). doi:10.1016/j.cell.2009.01.015. PMC 2692708. PMID 19303855.
- ^ “The Wnt signaling pathway in development and disease”. Annual Review of Cell and Developmental Biology 20: 781–810. (2004). doi:10.1146/annurev.cellbio.20.010403.113126. PMID 15473860.
- ^ a b c d e f g h i j “Wnt signal transduction pathways”. Organogenesis 4 (2): 68–75. (April 2008). doi:10.4161/org.4.2.5851. PMC 2634250. PMID 19279717.
- ^ “Pharmacological interventions in the Wnt pathway: inhibition of Wnt secretion versus disrupting the protein-protein interfaces of nuclear factors”. British Journal of Pharmacology 174 (24): 4600–4610. (December 2017). doi:10.1111/bph.13864. PMC 5727313. PMID 28521071.
- ^ “Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15”. Nature 307 (5947): 131–6. (1984). Bibcode: 1984Natur.307..131N. doi:10.1038/307131a0. PMID 6318122.
- ^ van Amerongen, Renée (2020-04-30). “Celebrating Discoveries in Wnt Signaling: How One Man Gave Wings to an Entire Field”. Cell 181 (3): 487–491. doi:10.1016/j.cell.2020.03.033. ISSN 1097-4172. PMID 32234518.
- ^ “Wnt signalling and its impact on development and cancer”. Nature Reviews. Cancer 8 (5): 387–98. (May 2008). doi:10.1038/nrc2389. PMID 18432252.
- ^ “Wnt signaling: a common theme in animal development”. Genes & Development 11 (24): 3286–305. (December 1997). doi:10.1101/gad.11.24.3286. PMID 9407023.
- ^ “Synthetic protein lipidation”. Current Opinion in Chemical Biology 28: 39–46. (October 2015). doi:10.1016/j.cbpa.2015.05.025. PMID 26080277.
- ^ “WLS retrograde transport to the endoplasmic reticulum during Wnt secretion”. Developmental Cell 29 (3): 277–91. (May 2014). doi:10.1016/j.devcel.2014.03.016. PMID 24768165.
- ^ “Structural basis of Wnt recognition by Frizzled”. Science 337 (6090): 59–64. (July 2012). Bibcode: 2012Sci...337...59J. doi:10.1126/science.1222879. PMC 3577348. PMID 22653731.
- ^ “Wnt lipidation: Roles in trafficking, modulation, and function”. Journal of Cellular Physiology 234 (6): 8040–8054. (June 2019). doi:10.1002/jcp.27570. PMID 30341908.
- ^ “Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling”. The Biochemical Journal 402 (3): 515–23. (March 2007). doi:10.1042/BJ20061476. PMC 1863570. PMID 17117926.
- ^ Nusse, Roel. “The Wnt Homepage”. 2013年4月15日閲覧。
- ^ Sawa, Hitoshi; Korswagen, Hendrik C. (March 2013). “WNT signaling in C. Elegans”. WormBook: 1–30. doi:10.1895/wormbook.1.7.2. PMC 5402212. PMID 25263666.
- ^ a b c “An updated overview on Wnt signaling pathways: a prelude for more”. Circulation Research 106 (12): 1798–806. (June 2010). doi:10.1161/CIRCRESAHA.110.219840. PMID 20576942.
- ^ “The Frizzled family of unconventional G-protein-coupled receptors”. Trends in Pharmacological Sciences 28 (10): 518–25. (October 2007). doi:10.1016/j.tips.2007.09.001. PMID 17884187.
- ^ “Dishevelled and Wnt signaling: is the nucleus the final frontier?”. Journal of Biology 4 (1): 2. (February 2005). doi:10.1186/jbiol22. PMC 551522. PMID 15720723.
- ^ “Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?”. Molecular Cancer 10: 101. (August 2011). doi:10.1186/1476-4598-10-101. PMC 3170638. PMID 21859464.
- ^ Buckle, Ashley M, ed (2013). “Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations”. PLOS ONE 8 (10): e77257. Bibcode: 2013PLoSO...877257M. doi:10.1371/journal.pone.0077257. PMC 3793970. PMID 24130866.
- ^ a b c d “Wnt/beta-catenin signaling: components, mechanisms, and diseases”. Developmental Cell 17 (1): 9–26. (July 2009). doi:10.1016/j.devcel.2009.06.016. PMC 2861485. PMID 19619488.
- ^ “Tcf/Lef transcription factors during T-cell development: unique and overlapping functions”. The Hematology Journal 1 (1): 3–6. (February 2000). doi:10.1038/sj.thj.6200001. PMID 11920163.
- ^ “Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex”. Cell 109 (1): 47–60. (April 2002). doi:10.1016/s0092-8674(02)00679-7. PMID 11955446.
- ^ “Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo”. Cell 125 (2): 327–41. (April 2006). doi:10.1016/j.cell.2006.01.053. PMID 16630820.
- ^ “Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9”. eLife 6: e20882. (March 2017). doi:10.7554/elife.20882. PMC 5352222. PMID 28296634.
- ^ Söderholm, Simon; Cantù, Claudio (21 October 2020). “The WNT/β‐catenin dependent transcription: A tissue‐specific business”. WIREs Systems Biology and Medicine 13 (3): e1511. doi:10.1002/wsbm.1511. PMID 33085215.
- ^ “Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity”. Journal of Biological Chemistry 282 (15): 11221–9. (April 2007). doi:10.1074/jbc.M611871200. PMC 1850976. PMID 17287208.
- ^ “The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription”. Development 140 (11): 2377–86. (June 2013). doi:10.1242/dev.093591. PMID 23637336.
- ^ “Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development”. Genes & Development 28 (17): 1879–84. (September 2014). doi:10.1101/gad.246140.114. PMC 4197948. PMID 25184676.
- ^ “A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation”. Science Signaling 10 (465): eaah4598. (February 2017). doi:10.1126/scisignal.aah4598. PMID 28174279.
- ^ “Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors”. The Journal of Biological Chemistry 281 (32): 22429–33. (August 2006). doi:10.1074/jbc.R600015200. PMID 16793760.
- ^ “Noncanonical Wnt signaling in vertebrate development, stem cells, and diseases”. Birth Defects Research. Part C, Embryo Today 90 (4): 243–56. (December 2010). doi:10.1002/bdrc.20195. PMID 21181886.
- ^ a b c “Towards an integrated view of Wnt signaling in development”. Development 136 (19): 3205–14. (October 2009). doi:10.1242/dev.033910. PMID 19736321.
- ^ “Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development”. Developmental Biology 369 (1): 101–14. (September 2012). doi:10.1016/j.ydbio.2012.06.020. PMC 3435145. PMID 22771246.
- ^ “Activation of intracellular calcium by multiple Wnt ligands and translocation of β-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/β-catenin pathways”. The Journal of Biological Chemistry 288 (50): 35651–9. (December 2013). doi:10.1074/jbc.M112.437913. PMC 3861617. PMID 24158438.
- ^ “TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth”. Cell 126 (5): 955–68. (September 2006). doi:10.1016/j.cell.2006.06.055. PMID 16959574.
- ^ “Canonical Wnt signaling induces BMP-4 to specify slow myofibrogenesis of fetal myoblasts”. Skeletal Muscle 3 (1): 5. (March 2013). doi:10.1186/2044-5040-3-5. PMC 3602004. PMID 23497616.
- ^ “Extracellular modulators of Wnt signalling”. Current Opinion in Structural Biology 29: 77–84. (December 2014). doi:10.1016/j.sbi.2014.10.003. PMID 25460271.
- ^ “Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy”. Hepatology 60 (2): 576–87. (August 2014). doi:10.1002/hep.26996. PMC 4083010. PMID 24492943.
- ^ “Epitope mapping by a Wnt-blocking antibody: evidence of the Wnt binding domain in heparan sulfate”. Scientific Reports 6: 26245. (May 2016). Bibcode: 2016NatSR...626245G. doi:10.1038/srep26245. PMC 4869111. PMID 27185050.
- ^ “Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signalling and protein synthesis”. Nature Communications 6: 6536. (March 2015). Bibcode: 2015NatCo...6.6536G. doi:10.1038/ncomms7536. PMC 4357278. PMID 25758784.
- ^ a b c “A Frizzled-Like Cysteine-Rich Domain in Glypican-3 Mediates Wnt Binding and Regulates Hepatocellular Carcinoma Tumor Growth in Mice”. Hepatology 70 (4): 1231–1245. (April 2019). doi:10.1002/hep.30646. PMC 6783318. PMID 30963603.
- ^ “Glypican-3: a new target for cancer immunotherapy”. European Journal of Cancer 47 (3): 333–8. (February 2011). doi:10.1016/j.ejca.2010.10.024. PMC 3031711. PMID 21112773.
- ^ “Glypicans as Cancer Therapeutic Targets”. Trends in Cancer 4 (11): 741–754. (November 2018). doi:10.1016/j.trecan.2018.09.004. PMC 6209326. PMID 30352677.
- ^ Gao, Wei; Xu, Yongmei; Liu, Jian; Ho, Mitchell (May 17, 2016). “Epitope mapping by a Wnt-blocking antibody: evidence of the Wnt binding domain in heparan sulfate”. Scientific Reports 6: 26245. Bibcode: 2016NatSR...626245G. doi:10.1038/srep26245. ISSN 2045-2322. PMC 4869111. PMID 27185050.
- ^ “The Role of Glypican-3 in Regulating Wnt, YAP, and Hedgehog in Liver Cancer”. Frontiers in Oncology 9: 708. (2019-08-02). doi:10.3389/fonc.2019.00708. PMC 6688162. PMID 31428581.
- ^ “Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1”. Nature Structural & Molecular Biology 18 (8): 886–93. (July 2011). doi:10.1038/nsmb.2081. PMC 3430870. PMID 21743455.
- ^ “Docking of fatty acids into the WIF domain of the human Wnt inhibitory factor-1”. Lipids 43 (3): 227–30. (March 2008). doi:10.1007/s11745-007-3144-3. PMID 18256869.
- ^ a b “Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations”. PLOS ONE 8 (10): e77257. (2013). Bibcode: 2013PLoSO...877257M. doi:10.1371/journal.pone.0077257. PMC 3793970. PMID 24130866.
- ^ a b c d Gilbert, Scott F. (2010). Developmental biology (9th ed.). Sunderland, Mass.: Sinauer Associates. ISBN 9780878933846
- ^ “Modeling gastrulation in the chick embryo: formation of the primitive streak”. PLOS ONE 5 (5): e10571. (May 2010). Bibcode: 2010PLoSO...510571V. doi:10.1371/journal.pone.0010571. PMC 2868022. PMID 20485500.
- ^ “Early Development in Birds”. Developmental Biology (10th ed.). Sunderland (MA): Sinauer Associates. (2014)
- ^ “Wnt won the war: antagonistic role of Wnt over Shh controls dorso-ventral patterning of the vertebrate neural tube”. Developmental Dynamics 239 (1): 69–76. (January 2010). doi:10.1002/dvdy.22058. PMID 19681160.
- ^ “Wnt signaling in axon guidance”. Trends in Neurosciences 27 (9): 528–32. (September 2004). doi:10.1016/j.tins.2004.06.015. PMID 15331234.
- ^ “The organelle of differentiation in embryos: the cell state splitter”. Theoretical Biology & Medical Modelling 13: 11. (March 2016). doi:10.1186/s12976-016-0037-2. PMC 4785624. PMID 26965444.
- ^ Embryogenesis Explained. Singapore: World Scientific Publishing. (2016). pp. 580–591. doi:10.1142/8152. ISBN 978-981-4740-69-2
- ^ a b “Wnt signaling and stem cell control”. Cell Research 18 (5): 523–7. (May 2008). doi:10.1038/cr.2008.47. PMID 18392048.
- ^ “Generation of multipotential mesendodermal progenitors from mouse embryonic stem cells via sustained Wnt pathway activation”. The Journal of Biological Chemistry 282 (43): 31703–12. (October 2007). doi:10.1074/jbc.M704287200. PMID 17711862.
- ^ “Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells”. Blood 111 (1): 122–31. (January 2008). doi:10.1182/blood-2007-04-084186. PMC 2200802. PMID 17875805.
- ^ “Wnt antagonism initiates cardiogenesis in Xenopus laevis”. Genes & Development 15 (3): 304–15. (February 2001). doi:10.1101/gad.855601. PMC 312618. PMID 11159911.
- ^ “Inhibition of Wnt activity induces heart formation from posterior mesoderm”. Genes & Development 15 (3): 316–27. (February 2001). doi:10.1101/gad.855501. PMC 312622. PMID 11159912.
- ^ “Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells”. Proceedings of the National Academy of Sciences of the United States of America 104 (23): 9685–90. (June 2007). Bibcode: 2007PNAS..104.9685U. doi:10.1073/pnas.0702859104. PMC 1876428. PMID 17522258.
- ^ “Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm”. Circulation Research 109 (4): 360–4. (August 2011). doi:10.1161/CIRCRESAHA.111.249540. PMC 3327303. PMID 21737789.
- ^ “Chemically defined generation of human cardiomyocytes”. Nature Methods 11 (8): 855–60. (August 2014). doi:10.1038/nmeth.2999. PMC 4169698. PMID 24930130.
- ^ “Wnt signaling in mitosis”. Developmental Cell 17 (6): 749–50. (December 2009). doi:10.1016/j.devcel.2009.12.001. PMID 20059944.
- ^ “Wnt signaling: is the party in the nucleus?”. Genes & Development 20 (11): 1394–404. (June 2006). doi:10.1101/gad.1424006. PMID 16751178.
- ^ Hodge, Russ (2016年1月25日). “Hacking the programs of cancer stem cells”. medicalxpress.com. Medical Express. 2016年2月12日閲覧。
- ^ Schambony, A; Wedlich, D. (2013). Wnt Signaling and Cell Migration. Landes Bioscience 2013年5月7日閲覧。
- ^ “Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression”. Journal of Mammary Gland Biology and Neoplasia 15 (2): 117–34. (June 2010). doi:10.1007/s10911-010-9178-9. PMC 2886089. PMID 20490631.
- ^ “Activation of Wnt/beta-catenin signaling increases insulin sensitivity through a reciprocal regulation of Wnt10b and SREBP-1c in skeletal muscle cells”. PLOS ONE 4 (12): e8509. (December 2009). Bibcode: 2009PLoSO...4.8509A. doi:10.1371/journal.pone.0008509. PMC 2794543. PMID 20041157.
- ^ Milosevic, Vladan; Kopecka, Joanna; Salaroglio, Iris C.; Libener, Roberta; Napoli, Francesca; Izzo, Stefania; Orecchia, Sara; Ananthanarayanan, Preeta et al. (2020-01-01). “Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5”. International Journal of Cancer 146 (1): 192–207. doi:10.1002/ijc.32419. ISSN 1097-0215. PMID 31107974.
- ^ “Wnt signaling and breast cancer”. Cancer Biology & Therapy 3 (1): 36–41. (January 2004). doi:10.4161/cbt.3.1.561. PMID 14739782.
- ^ “Shutting down Wnt signal-activated cancer”. Nature Genetics 36 (4): 320–2. (April 2004). doi:10.1038/ng0404-320. PMID 15054482.
- ^ “A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer”. Cancer Research 69 (13): 5364–73. (July 2009). doi:10.1158/0008-5472.CAN-08-4135. PMC 2782448. PMID 19549913.
- ^ “WNT signalling pathways as therapeutic targets in cancer”. Nature Reviews. Cancer 13 (1): 11–26. (January 2013). doi:10.1038/nrc3419. PMID 23258168.
- ^ Malladi, Srinivas; Macalinao, Danilo G.; Jin, Xin; He, Lan; Basnet, Harihar; Zou, Yilong; de Stanchina, Elisa; Massagué, Joan (2016-03-24). “Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT”. Cell 165 (1): 45–60. doi:10.1016/j.cell.2016.02.025. ISSN 1097-4172. PMC 4808520. PMID 27015306.
- ^ Esposito, Mark; Fang, Cao; Cook, Katelyn C.; Park, Nana; Wei, Yong; Spadazzi, Chiara; Bracha, Dan; Gunaratna, Ramesh T. et al. (March 2021). “TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis” (英語). Nature Cell Biology 23 (3): 257–267. doi:10.1038/s41556-021-00641-w. ISSN 1476-4679. PMC 7970447.
- ^ Esposito, Mark; Mondal, Nandini; Greco, Todd M.; Wei, Yong; Spadazzi, Chiara; Lin, Song-Chang; Zheng, Hanqiu; Cheung, Corey et al. (May 2019). “Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis” (英語). Nature Cell Biology 21 (5): 627–639. doi:10.1038/s41556-019-0309-2. ISSN 1476-4679. PMC 6556210.
- ^ “Wnt signaling: relevance to beta-cell biology and diabetes”. Trends in Endocrinology and Metabolism 19 (10): 349–55. (December 2008). doi:10.1016/j.tem.2008.08.004. PMID 18926717.
- ^ “Wnt signaling regulates mitochondrial physiology and insulin sensitivity”. Genes & Development 24 (14): 1507–18. (July 2010). doi:10.1101/gad.1924910. PMC 2904941. PMID 20634317.
- ^ “Role of reactive oxygen species in injury-induced insulin resistance”. Molecular Endocrinology 25 (3): 492–502. (March 2011). doi:10.1210/me.2010-0224. PMC 3045736. PMID 21239612.
- ^ “Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes”. Nature Genetics 38 (3): 320–3. (March 2006). doi:10.1038/ng1732. PMID 16415884.
[続きの解説]
「Wntシグナル経路」の続きの解説一覧
- 1 Wntシグナル経路とは
- 2 Wntシグナル経路の概要
- 3 機構
- 4 誘導される細胞応答
- 5 臨床との関係
- 6 関連文献
- 7 外部リンク
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