KEGG   PATHWAY: leri00280
Entry
leri00280                   Pathway                                
Name
Valine, leucine and isoleucine degradation - Leucoraja erinaceus (little skate)
Class
Metabolism; Amino acid metabolism
Pathway map
leri00280  Valine, leucine and isoleucine degradation
leri00280

Module
leri_M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:leri00280]
leri_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:leri00280]
Other DBs
GO: 0006550 0006552 0006574
Organism
Leucoraja erinaceus (little skate) [GN:leri]
Gene
129713842  branched-chain-amino-acid aminotransferase, cytosolic-like [KO:K00826] [EC:2.6.1.42]
129707667  bcat1; branched-chain-amino-acid aminotransferase, cytosolic [KO:K00826] [EC:2.6.1.42]
129714177  bckdha; 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial [KO:K00166] [EC:1.2.4.4]
129697469  bckdhb; 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial [KO:K00167] [EC:1.2.4.4]
129701239  dbt; lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial [KO:K09699] [EC:2.3.1.168]
129707622  dldh; dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]
129709137  acads; short-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00248] [EC:1.3.8.1]
129694048  acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
129700475  ivd; isovaleryl-CoA dehydrogenase, mitochondrial [KO:K00253] [EC:1.3.8.4]
129703993  acadsb; short/branched chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K09478] [EC:1.3.8.5]
129712474  acad8; isobutyryl-CoA dehydrogenase, mitochondrial [KO:K11538] [EC:1.3.99.-]
129697175  trifunctional enzyme subunit alpha, mitochondrial-like isoform X1 [KO:K07515] [EC:4.2.1.17 1.1.1.211]
129712872  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
129701011  hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
129711954  acaa2; 3-ketoacyl-CoA thiolase, mitochondrial [KO:K07508] [EC:2.3.1.16]
129697176  hadhb; trifunctional enzyme subunit beta, mitochondrial [KO:K07509] [EC:2.3.1.16]
129697920  pcca; propionyl-CoA carboxylase alpha chain, mitochondrial [KO:K01965] [EC:6.4.1.3]
129703589  pccb; propionyl-CoA carboxylase beta chain, mitochondrial isoform X1 [KO:K01966] [EC:6.4.1.3 2.1.3.15]
129708601  mcee; methylmalonyl-CoA epimerase, mitochondrial [KO:K05606] [EC:5.1.99.1]
129697216  mmut; methylmalonyl-CoA mutase, mitochondrial [KO:K01847] [EC:5.4.99.2]
129698638  hibch; 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X1 [KO:K05605] [EC:3.1.2.4]
129711896  hibadhb; 3-hydroxyisobutyrate dehydrogenase b [KO:K00020] [EC:1.1.1.31]
129700013  aldh6a1; methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial [KO:K00140] [EC:1.2.1.18 1.2.1.27]
129709155  aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
129713971  aldehyde dehydrogenase family 16 member A1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
129710558  aldehyde dehydrogenase family 3 member A2-like [KO:K00128] [EC:1.2.1.3]
129710561  aldehyde dehydrogenase family 3 member A2-like [KO:K00128] [EC:1.2.1.3]
129695789  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
129701198  aldh9a1a.1; 4-trimethylaminobutyraldehyde dehydrogenase A [KO:K00149] [EC:1.2.1.47 1.2.1.3]
129715058  acsf3; malonate--CoA ligase ACSF3, mitochondrial [KO:K18660] [EC:6.2.1.76 6.2.1.-]
129706627  abat; 4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
129715313  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
129703193  mccc1; methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial [KO:K01968] [EC:6.4.1.4]
129695332  mccc2; methylcrotonoyl-CoA carboxylase beta chain, mitochondrial [KO:K01969] [EC:6.4.1.4]
129701009  si:ch211-198n5.11; methylcrotonoyl-coenzyme A carboxylase 2 isoform X1 [KO:K01969] [EC:6.4.1.4]
129695687  auh; methylglutaconyl-CoA hydratase, mitochondrial [KO:K05607] [EC:4.2.1.18]
129709707  hydroxymethylglutaryl-CoA lyase, mitochondrial-like [KO:K01640] [EC:4.1.3.4]
129697027  hmgcll1; 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic [KO:K01640] [EC:4.1.3.4]
129695267  oxct1a; 3-oxoacid CoA transferase 1a [KO:K01027] [EC:2.8.3.5]
129709361  aacs; acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
129698132  acat1; acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
129699588  acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
129695286  hmgcs1; hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1 [KO:K01641] [EC:2.3.3.10]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
Related
pathway
leri00020  Citrate cycle (TCA cycle)
leri00240  Pyrimidine metabolism
leri00290  Valine, leucine and isoleucine biosynthesis
leri00640  Propanoate metabolism
leri00900  Terpenoid backbone biosynthesis
KO pathway
ko00280   
LinkDB

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