Homo sapiens (human): 6531
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Entry
6531 CDS
T01001
Symbol
SLC6A3, DAT, DAT1, PKDYS, PKDYS1
Name
(RefSeq) solute carrier family 6 member 3
KO
K05036
solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
Organism
hsa
Homo sapiens (human)
Pathway
hsa04721
Synaptic vesicle cycle
hsa04728
Dopaminergic synapse
hsa05012
Parkinson disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05030
Cocaine addiction
hsa05031
Amphetamine addiction
hsa05034
Alcoholism
Network
nt06028
Dopamine and serotonin metabolism
Element
N01790
Transport of dopamine into the neuron
Disease
H02676
Infantile-onset parkinsonism-dystonia
Drug target
Amfepramone (
DG00104
):
D03801
<US>
D07444
Amfetamine (
DG00966
):
D02074
<US>
D07445
<US>
Amfonelic acid:
D02897
Amitifadine (
DG01386
):
D10088
D10089
Amphetamine aspartate monohydrate:
D11622
Armodafinil:
D03215
<US>
Benzfetamine (
DG01755
):
D07514
D07515
<US>
Brasofensine maleate:
D03153
Bupropion (
DG00957
):
D00817
<US>
D07591
D07938
<US>
Centanafadine (
DG01858
):
D10697
D10698
Cocaine (
DG00808
):
D00110
D02182
<US>
Dasotraline (
DG01989
):
D10700
D10870
Dexamfetamine (
DG00967
):
D02078
<US>
D03740
<US>
Dexmethylphenidate (
DG00972
):
D03721
<US>
D07806
Dextroamphetamine saccharate:
D11623
Iodine ioflupane (123I):
D10014
<JP/US>
Lisdexamfetamine (
DG00973
):
D04747
<JP/US>
D08130
Mazindol:
D00367
<JP>
Mesocarb:
D12716
Metamfetamine (
DG00968
):
D02242
<JP/US>
D08187
Methylphenidate (
DG00969
):
D01296
<JP/US>
D04999
<US>
Midomafetamine (
DG03316
):
D11172
D12937
Napamezole hydrochloride:
D05119
Phenmetrazine hydrochloride:
D05454
Phentermine (
DG00102
):
D05458
D05459
<US>
Pyrovalerone hydrochloride:
D05663
Radafaxine hydrochloride:
D05692
Sibutramine (
DG00108
):
D02571
D08513
Solriamfetol (
DG02989
):
D11315
D11328
<US>
Tenamfetamine:
D12715
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09156 Nervous system
04728 Dopaminergic synapse
6531 (SLC6A3)
04721 Synaptic vesicle cycle
6531 (SLC6A3)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
6531 (SLC6A3)
05022 Pathways of neurodegeneration - multiple diseases
6531 (SLC6A3)
09165 Substance dependence
05030 Cocaine addiction
6531 (SLC6A3)
05031 Amphetamine addiction
6531 (SLC6A3)
05034 Alcoholism
6531 (SLC6A3)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
02000 Transporters [BR:
hsa02000
]
6531 (SLC6A3)
Transporters [BR:
hsa02000
]
Solute carrier family (SLC)
SLC6: Sodium- and chloride-dependent neurotransmitter transporter
6531 (SLC6A3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
SNF
Motif
Other DBs
NCBI-GeneID:
6531
NCBI-ProteinID:
NP_001035
OMIM:
126455
HGNC:
11049
Ensembl:
ENSG00000142319
UniProt:
Q01959
Structure
PDB
PDBj
LinkDB
All DBs
Position
5:complement(1392794..1445440)
Genome browser
AA seq
620 aa
AA seq
DB search
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
NT seq
1863 nt
NT seq
+upstream
nt +downstream
nt
atgagtaagagcaaatgctccgtgggactcatgtcttccgtggtggccccggctaaggag
cccaatgccgtgggcccgaaggaggtggagctcatccttgtcaaggagcagaacggagtg
cagctcaccagctccaccctcaccaacccgcggcagagccccgtggaggcccaggatcgg
gagacctggggcaagaagatcgactttctcctgtccgtcattggctttgctgtggacctg
gccaacgtctggcggttcccctacctgtgctacaaaaatggtggcggtgccttcctggtc
ccctacctgctcttcatggtcattgctgggatgccacttttctacatggagctggccctc
ggccagttcaacagggaaggggccgctggtgtctggaagatctgccccatactgaaaggt
gtgggcttcacggtcatcctcatctcactgtatgtcggcttcttctacaacgtcatcatc
gcctgggcgctgcactatctcttctcctccttcaccacggagctcccctggatccactgc
aacaactcctggaacagccccaactgctcggatgcccatcctggtgactccagtggagac
agctcgggcctcaacgacacttttgggaccacacctgctgccgagtactttgaacgtggc
gtgctgcacctccaccagagccatggcatcgacgacctggggcctccgcggtggcagctc
acagcctgcctggtgctggtcatcgtgctgctctacttcagcctctggaagggcgtgaag
acctcagggaaggtggtatggatcacagccaccatgccatacgtggtcctcactgccctg
ctcctgcgtggggtcaccctccctggagccatagacggcatcagagcatacctgagcgtt
gacttctaccggctctgcgaggcgtctgtttggattgacgcggccacccaggtgtgcttc
tccctgggcgtggggttcggggtgctgatcgccttctccagctacaacaagttcaccaac
aactgctacagggacgcgattgtcaccacctccatcaactccctgacgagcttctcctcc
ggcttcgtcgtcttctccttcctggggtacatggcacagaagcacagtgtgcccatcggg
gacgtggccaaggacgggccagggctgatcttcatcatctacccggaagccatcgccacg
ctccctctgtcctcagcctgggccgtggtcttcttcatcatgctgctcaccctgggtatc
gacagcgccatgggtggtatggagtcagtgatcaccgggctcatcgatgagttccagctg
ctgcacagacaccgtgagctcttcacgctcttcatcgtcctggcgaccttcctcctgtcc
ctgttctgcgtcaccaacggtggcatctacgtcttcacgctcctggaccattttgcagcc
ggcacgtccatcctctttggagtgctcatcgaagccatcggagtggcctggttctatggt
gttgggcagttcagcgacgacatccagcagatgaccgggcagcggcccagcctgtactgg
cggctgtgctggaagctggtcagcccctgctttctcctgttcgtggtcgtggtcagcatt
gtgaccttcagacccccccactacggagcctacatcttccccgactgggccaacgcgctg
ggctgggtcatcgccacatcctccatggccatggtgcccatctatgcggcctacaagttc
tgcagcctgcctgggtcctttcgagagaaactggcctacgccattgcacccgagaaggac
cgtgagctggtggacagaggggaggtgcgccagttcacgctccgccactggctcaaggtg
tag
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