Viewpoint Series

JCI's 100th anniversary

On October 1, 1924, the American Society of Clinical Investigation published the first issue of the JCI. Over the last 100 years, JCI’s mission has been to provide a forum for research exploring mechanisms underlying human health and disease. To celebrate this century of scientific discovery, JCI is featuring a special collection of articles that highlight major innovations in medicine, with a spotlight on the key mechanistic studies that contributed to these advances. Additionally, this collection also explores outstanding questions to be tackled in the next century. Look for 100th anniversary viewpoint articles throughout 2024 from esteemed leaders in biomedical research, including Jeff Flier and Rex Ahima, Daniel Drucker, Barbara Salvodo, Michael Brown and Joseph Goldstein, Susan Quaggin, Robert Lefkowitz and Howard Rockman, and many more.

Related articles:

The convergence of genomic medicine and translational omics in transforming breast cancer patient care
Sulin Wu, … , Yonglan Zheng, Olufunmilayo I. Olopade
Sulin Wu, … , Yonglan Zheng, Olufunmilayo I. Olopade
Published November 1, 2024
Citation Information: J Clin Invest. 2024;134(21):e187520. https://doi.org/10.1172/JCI187520.
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Toward a better understanding of chronic hepatitis B virus infection
Barbara Rehermann
Barbara Rehermann
Published October 1, 2024
Citation Information: J Clin Invest. 2024;134(19):e185568. https://doi.org/10.1172/JCI185568.
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The arc of discovery, from the description of cystic fibrosis to effective treatments
Michael J. Welsh
Michael J. Welsh
Published October 1, 2024
Citation Information: J Clin Invest. 2024;134(19):e186231. https://doi.org/10.1172/JCI186231.
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Intertwining clonality and resistance: Staphylococcus aureus in the antibiotic era
Henry F. Chambers, Vance G. Fowler Jr
Henry F. Chambers, Vance G. Fowler Jr
Published October 1, 2024
Citation Information: J Clin Invest. 2024;134(19):e185824. https://doi.org/10.1172/JCI185824.
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The expanding application of antisense oligonucleotides to neurodegenerative diseases
Charlotte J. Sumner, Timothy M. Miller
Charlotte J. Sumner, Timothy M. Miller
Published October 1, 2024
Citation Information: J Clin Invest. 2024;134(19):e186116. https://doi.org/10.1172/JCI186116.
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Checkpoint therapy in cancer treatment: progress, challenges, and future directions
Mesude Bicak, … , Cansu Cimen Bozkus, Nina Bhardwaj
Mesude Bicak, … , Cansu Cimen Bozkus, Nina Bhardwaj
Published September 17, 2024
Citation Information: J Clin Invest. 2024;134(18):e184846. https://doi.org/10.1172/JCI184846.
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Checkpoint therapy in cancer treatment: progress, challenges, and future directions

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Authors

Mesude Bicak, Cansu Cimen Bozkus, Nina Bhardwaj

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Is it time to rethink the relationship between adipose inflammation and insulin resistance?
Evan D. Rosen, Shingo Kajimura
Evan D. Rosen, Shingo Kajimura
Published September 3, 2024
Citation Information: J Clin Invest. 2024;134(17):e184663. https://doi.org/10.1172/JCI184663.
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The forgotten pandemic: how understanding cholera illuminated mechanisms of chloride channels in multiple diseases
Qais Al-Awqati
Qais Al-Awqati
Published August 15, 2024
Citation Information: J Clin Invest. 2024;134(16):e184297. https://doi.org/10.1172/JCI184297.
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Two decades of advances in preeclampsia research: molecular mechanisms and translational studies
S. Ananth Karumanchi
S. Ananth Karumanchi
Published August 1, 2024
Citation Information: J Clin Invest. 2024;134(15):e184052. https://doi.org/10.1172/JCI184052.
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A half-century of VEGFA: from theory to practice
Susan E. Quaggin
Susan E. Quaggin
Published August 1, 2024
Citation Information: J Clin Invest. 2024;134(15):e184205. https://doi.org/10.1172/JCI184205.
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A half-century of VEGFA: from theory to practice

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Authors

Susan E. Quaggin

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The other pandemic: lessons from 40 years of HIV research
Mary E. Klotman, Barton F. Haynes
Mary E. Klotman, Barton F. Haynes
Published July 1, 2024
Citation Information: J Clin Invest. 2024;134(13):e183039. https://doi.org/10.1172/JCI183039.
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The other pandemic: lessons from 40 years of HIV research

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Authors

Mary E. Klotman, Barton F. Haynes

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Defining and targeting mechanisms of eosinophilic inflammation in a new era of severe asthma treatment
Joshua A. Boyce, Stephanie C. Eisenbarth
Joshua A. Boyce, Stephanie C. Eisenbarth
Published June 17, 2024
Citation Information: J Clin Invest. 2024;134(12):e182410. https://doi.org/10.1172/JCI182410.
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Navigating an enigma: the continuing journey of autoimmunity discoveries
Mariana J. Kaplan
Mariana J. Kaplan
Published June 3, 2024
Citation Information: J Clin Invest. 2024;134(11):e182287. https://doi.org/10.1172/JCI182287.
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Advancing chemokine research: the molecular function of CXCL8
Yiran Hou, Anna Huttenlocher
Yiran Hou, Anna Huttenlocher
Published May 15, 2024
Citation Information: J Clin Invest. 2024;134(10):e180984. https://doi.org/10.1172/JCI180984.
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Advancing chemokine research: the molecular function of CXCL8

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Authors

Yiran Hou, Anna Huttenlocher

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Life-saving effect of pulmonary surfactant in premature babies
J. Usha Raj, … , Marlene Rabinovitch, Michael A. Matthay
J. Usha Raj, … , Marlene Rabinovitch, Michael A. Matthay
Published May 1, 2024
Citation Information: J Clin Invest. 2024;134(9):e179948. https://doi.org/10.1172/JCI179948.
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Life-saving effect of pulmonary surfactant in premature babies

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Authors

J. Usha Raj, Richard D. Bland, Jahar Bhattacharya, Marlene Rabinovitch, Michael A. Matthay

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Major breakthroughs in hematopoietic stem cell transplantation and future challenges in clinical implementation
Leslie S. Kean, Bruce R. Blazar
Leslie S. Kean, Bruce R. Blazar
Published April 15, 2024
Citation Information: J Clin Invest. 2024;134(8):e179944. https://doi.org/10.1172/JCI179944.
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Pandemics past, present, and future: progress and persistent risks
Arturo Casadevall
Arturo Casadevall
Published April 1, 2024
Citation Information: J Clin Invest. 2024;134(7):e179519. https://doi.org/10.1172/JCI179519.
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Bisphosphonates for osteoporosis: from bench to clinic
Teresita Bellido
Teresita Bellido
Published March 15, 2024
Citation Information: J Clin Invest. 2024;134(6):e179942. https://doi.org/10.1172/JCI179942.
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SGLT2 inhibitors: cardiorenal metabolic drugs for the ages
Ralph A. DeFronzo
Ralph A. DeFronzo
Published March 1, 2024
Citation Information: J Clin Invest. 2024;134(5):e177625. https://doi.org/10.1172/JCI177625.
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G protein–coupled receptors: from radioligand binding to cellular signaling
Howard A. Rockman, Robert J. Lefkowitz
Howard A. Rockman, Robert J. Lefkowitz
Published March 1, 2024
Citation Information: J Clin Invest. 2024;134(5):e178109. https://doi.org/10.1172/JCI178109.
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G protein–coupled receptors: from radioligand binding to cellular signaling

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Authors

Howard A. Rockman, Robert J. Lefkowitz

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Nitric oxide in vascular biology: elegance in complexity
Joseph Loscalzo
Joseph Loscalzo
Published February 15, 2024
Citation Information: J Clin Invest. 2024;134(4):e176747. https://doi.org/10.1172/JCI176747.
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How the JCI’s most-cited paper sparked the field of lipoprotein research
Michael S. Brown, Joseph L. Goldstein
Michael S. Brown, Joseph L. Goldstein
Published February 15, 2024
Citation Information: J Clin Invest. 2024;134(4):e177475. https://doi.org/10.1172/JCI177475.
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How the JCI’s most-cited paper sparked the field of lipoprotein research

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Authors

Michael S. Brown, Joseph L. Goldstein

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Clinical investigation of hypoxia-inducible factors: getting there
Gregg L. Semenza
Gregg L. Semenza
Published February 1, 2024
Citation Information: J Clin Invest. 2024;134(3):e176253. https://doi.org/10.1172/JCI176253.
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Pancreatic β cell function versus insulin resistance: application of the hyperbolic law of glucose tolerance
Richard N. Bergman
Richard N. Bergman
Published February 1, 2024
Citation Information: J Clin Invest. 2024;134(3):e176738. https://doi.org/10.1172/JCI176738.
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CAR T cells for hematological malignancies
Barbara Savoldo, … , Natalie Grover, Gianpietro Dotti
Barbara Savoldo, … , Natalie Grover, Gianpietro Dotti
Published January 16, 2024
Citation Information: J Clin Invest. 2024;134(2):e177160. https://doi.org/10.1172/JCI177160.
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CAR T cells for hematological malignancies

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Authors

Barbara Savoldo, Natalie Grover, Gianpietro Dotti

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The GLP-1 journey: from discovery science to therapeutic impact
Daniel J. Drucker
Daniel J. Drucker
Published January 16, 2024
Citation Information: J Clin Invest. 2024;134(2):e175634. https://doi.org/10.1172/JCI175634.
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Leptin physiology and pathophysiology: knowns and unknowns 30 years after its discovery
Jeffrey S. Flier, Rexford S. Ahima
Jeffrey S. Flier, Rexford S. Ahima
Published January 2, 2024
Citation Information: J Clin Invest. 2024;134(1):e174595. https://doi.org/10.1172/JCI174595.
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Solid organ transplantation: solid but not yet spectacular
Laurence A. Turka
Laurence A. Turka
Published January 2, 2024
Citation Information: J Clin Invest. 2024;134(1):e176856. https://doi.org/10.1172/JCI176856.
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