ORTHOLOGY: K00222 Help
Entry
Symbol
TM7SF2, ERG24
Name
Pathway
map01110 Biosynthesis of secondary metabolites
Module
M00101 Cholesterol biosynthesis, FPP => cholesterol
M00102 Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol
M00917 Phytosterol biosynthesis, squalene 2,3-epoxide => campesterol/sitosterol
Reaction
R05639 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09103 Lipid metabolism
00100 Steroid biosynthesis
K00222 TM7SF2, ERG24; Delta14-sterol reductase
Enzymes [BR:ko01000 ]
1. Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.1 With NAD+ or NADP+ as acceptor
1.3.1.70 Delta14-sterol reductase
K00222 TM7SF2, ERG24; Delta14-sterol reductase
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Taxonomy UniProt
Reference
Authors
Paik YK, Trzaskos JM, Shafiee A, Gaylor JL
Title
Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent delta 8,14-steroid 14-reductase.
Journal
J Biol Chem 259:13413-23 (1984)
Reference
Authors
Schrick K, Mayer U, Horrichs A, Kuhnt C, Bellini C, Dangl J, Schmidt J, Jurgens G
Title
FACKEL is a sterol C-14 reductase required for organized cell division and expansion in Arabidopsis embryogenesis.
Journal
Sequence