JNCI Journal of the National Cancer Institute, 2009
Compared with treatment options for early-stage breast cancer, few data exist regarding the optim... more Compared with treatment options for early-stage breast cancer, few data exist regarding the optimal use of chemotherapy for metastatic breast cancer (MBC). The choice of using a combination of cytotoxic chemotherapies vs sequential single agents is controversial. At the 6th European Breast Cancer Conference, the European School of Oncology Metastatic Breast Cancer Task Force convened an open debate on the relative benefits of combination vs sequential therapy. Based on the available data, the Task Force recommends sequential monotherapy as the preferred choice in advanced disease, in the absence of rapid clinical progression, life-threatening visceral metastases, or the need for rapid symptom and/or disease control. Patient-and diseaserelated factors should be used to choose between combination and sequential single-agent chemotherapy for MBC. Additional research is needed to determine the impact of therapy on patient-rated quality of life and to identify predictive factors that can be used to guide therapy. JNCI | Commentary 1175 * A = doxorubicin; A + Doc* = doxorubicin 50 mg/m 2 and docetaxel 75 mg/m 2 ; A + Doc † = doxorubicin 60 mg/m 2 and docetaxel 60 mg/m 2 ; Doc = docetaxel; E = epirubicin; G = gemcitabine; MF = methotrexate-5-fluorouracil; NR = not reported; Pac = paclitaxel; X = capecitabine. † Infection including febrile neutropenia. by guest on June 1, 2015
JNCI Journal of the National Cancer Institute, 2009
Compared with treatment options for early-stage breast cancer, few data exist regarding the optim... more Compared with treatment options for early-stage breast cancer, few data exist regarding the optimal use of chemotherapy for metastatic breast cancer (MBC). The choice of using a combination of cytotoxic chemotherapies vs sequential single agents is controversial. At the 6th European Breast Cancer Conference, the European School of Oncology Metastatic Breast Cancer Task Force convened an open debate on the relative benefits of combination vs sequential therapy. Based on the available data, the Task Force recommends sequential monotherapy as the preferred choice in advanced disease, in the absence of rapid clinical progression, life-threatening visceral metastases, or the need for rapid symptom and/or disease control. Patient-and diseaserelated factors should be used to choose between combination and sequential single-agent chemotherapy for MBC. Additional research is needed to determine the impact of therapy on patient-rated quality of life and to identify predictive factors that can be used to guide therapy. JNCI | Commentary 1175 * A = doxorubicin; A + Doc* = doxorubicin 50 mg/m 2 and docetaxel 75 mg/m 2 ; A + Doc † = doxorubicin 60 mg/m 2 and docetaxel 60 mg/m 2 ; Doc = docetaxel; E = epirubicin; G = gemcitabine; MF = methotrexate-5-fluorouracil; NR = not reported; Pac = paclitaxel; X = capecitabine. † Infection including febrile neutropenia. by guest on June 1, 2015
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