Papers by Georgette Danczyk
Neuro-oncology, 2017
NEURO-ONCOLOGY • NOVEMBER 2017 for community control vs. 0.48 [0.25-0.91], p=.02 for MRI control)... more NEURO-ONCOLOGY • NOVEMBER 2017 for community control vs. 0.48 [0.25-0.91], p=.02 for MRI control). As a measure of health care access, cases and MRI controls had similar flu vaccine rates, but dissimilar rates with community controls. CONCLUSION: Epidemiologic assessment of glioma risks requires specific attention to case ascertainment and control selection. Different control groups draw different conclusions. Community controls appear susceptible to detection bias. Using a more stringent control group, our study findings uphold prior reports of inverse association between asthma and the risk of glioma.
Engineering in Medicine, 2019
The potential for developing gene therapy technologies is evident from the recent surge in resear... more The potential for developing gene therapy technologies is evident from the recent surge in research activity. The use of these emerging technologies, along with blastocyst complementation, could greatly enhance our ability to produce exogenic organs and cells in a relatively short period of time. Furthermore, the generation of human–animal organ chimeras, together with their associated vasculature, could be developed to overcome the global problem of organ shortage for transplantation, as well as complications associated with immune rejection. It will be imperative that we understand the underlying conditions for stem cell growth in a developmental environment, to determine if cross-species chimeras can be therapeutically developed. Importantly, the combination of gene editing and blastocyst complementation has created an entirely new and exciting field of medicine, one that we envision will have a critical role for precision medicine.
Cell Transplantation
Blastocyst complementation combined with gene editing is an emerging approach in the field of reg... more Blastocyst complementation combined with gene editing is an emerging approach in the field of regenerative medicine that could potentially solve the worldwide problem of organ shortages for transplantation. In theory, blastocyst complementation can generate fully functional human organs or tissues, grown within genetically engineered livestock animals. Targeted deletion of a specific gene(s) using gene editing to cause deficiencies in organ development can open a niche for human stem cells to occupy, thus generating human tissues. Within this review, we will focus on the pancreas, liver, heart, kidney, lung, and skeletal muscle, as well as cells of the immune and nervous systems. Within each of these organ systems, we identify and discuss (i) the common causes of organ failure; (ii) the current state of regenerative therapies; and (iii) the candidate genes to knockout and enable specific exogenous organ development via the use of blastocyst complementation. We also highlight some of...
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Papers by Georgette Danczyk