Neuromedin S
| Neuromedin S | |
|---|---|
| Identifikatori | |
| Simbol | NMS |
| Entrez | 129521 |
| HUGO | 32203 |
| Drugi podaci | |
| Lokus | Hromozom 2 q11.2 |
Neuromedin S je neuropeptid sa 36 aminokiselina nađen u mozgu ljudi i drugih sisara. On nastaje u suprahiazmatičnom jezgru hipotalamusa, i srodan je sa neuromedinom U. Smatra se da on učestvuje u regulaciji cirkadijalnog ritma i da deluje kao supresant apetita,[1][2][3][4][5] kao i regulator oslobađanja nekoliko drugih peptidnih hormona među kojima su vazopresin,[6] Luteinizirajući hormon,[7] i oksitocin.[8]
- ↑ Mori K, Miyazato M, Ida T, Murakami N, Serino R, Ueta Y, Kojima M, Kangawa K (January 2005). „Identification of neuromedin S and its possible role in the mammalian circadian oscillator system”. The EMBO Journal 24 (2): 325–35. DOI:10.1038/sj.emboj.7600526. PMC 545815. PMID 15635449.
- ↑ Mori K, Miyazato M, Kangawa K (2008). „Neuromedin S: discovery and functions”. Results and Problems in Cell Differentiation 46: 201–12. DOI:10.1007/400_2007_054. PMID 18214396.
- ↑ Novak CM (July 2009). „Neuromedin S and U”. Endocrinology 150 (7): 2985–7. DOI:10.1210/en.2009-0448. PMC 2703548. PMID 19549882.
- ↑ Peier A, Kosinski J, Cox-York K, Qian Y, Desai K, Feng Y, Trivedi P, Hastings N, Marsh DJ (July 2009). „The antiobesity effects of centrally administered neuromedin U and neuromedin S are mediated predominantly by the neuromedin U receptor 2 (NMUR2)”. Endocrinology 150 (7): 3101–9. DOI:10.1210/en.2008-1772. PMC 2703546. PMID 19324999.
- ↑ Mitchell J, Maguire J, Davenport A (June 2009). „Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S”. British Journal of Pharmacology 158 (1): 87–103. DOI:10.1111/j.1476-5381.2009.00252.x. PMC 2795236. PMID 19519756.
- ↑ Sakamoto T, Mori K, Nakahara K, Miyazato M, Kangawa K, Sameshima H, Murakami N (September 2007). „Neuromedin S exerts an antidiuretic action in rats”. Biochemical and Biophysical Research Communications 361 (2): 457–61. DOI:10.1016/j.bbrc.2007.07.036. PMID 17645872.
- ↑ Vigo E, Roa J, López M, Castellano JM, Fernandez-Fernandez R, Navarro VM, Pineda R, Aguilar E, Diéguez C, Pinilla L, Tena-Sempere M (February 2007). „Neuromedin s as novel putative regulator of luteinizing hormone secretion”. Endocrinology 148 (2): 813–23. DOI:10.1210/en.2006-0636. PMID 17110433.
- ↑ Sakamoto T, Mori K, Miyazato M, Kangawa K, Sameshima H, Nakahara K, Murakami N (October 2008). „Involvement of neuromedin S in the oxytocin release response to suckling stimulus”. Biochemical and Biophysical Research Communications 375 (1): 49–53. DOI:10.1016/j.bbrc.2008.07.124. PMID 18675786.