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Timothy Lane [23]Timothy Joseph Lane [18]Timothy J. Lane [6]
  1. Toward an explanatory framework for mental ownership.Timothy Lane - 2012 - Phenomenology and the Cognitive Sciences 11 (2):251-286.
    Philosophical and scientific investigations of the proprietary aspects of self—mineness or mental ownership—often presuppose that searching for unique constituents is a productive strategy. But there seem not to be any unique constituents. Here, it is argued that the “self-specificity” paradigm, which emphasizes subjective perspective, fails. Previously, it was argued that mode of access also fails to explain mineness. Fortunately, these failures, when leavened by other findings (those that exhibit varieties and vagaries of mineness), intimate an approach better suited to searching (...)
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  2. Self-Consciousness and Immunity.Timothy Lane & Caleb Liang - 2011 - Journal of Philosophy 108 (2):78-99.
    Sydney Shoemaker, developing an idea of Wittgenstein’s, argues that we are immune to error through misidentification relative to the first-person pronoun. Although we might be liable to error when “I” (or its cognates) is used as an object, we are immune to error when “I” is used as a subject (as when one says, “I have a toothache”). Shoemaker claims that the relationship between “I” as-subject and the mental states of which it is introspectively aware is tautological: when, say, we (...)
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  3. Self, belonging, and conscious experience: A critique of subjectivity theories of consciousness.Timothy Lane - 2015 - In Rocco J. Gennaro (ed.), Disturbed Consciousness: New Essays on Psychopathology and Theories of Consciousness. MIT Press. pp. 103-140.
    Subjectivity theories of consciousness take self-reference, somehow construed, as essential to having conscious experience. These theories differ with respect to how many levels they posit and to whether self-reference is conscious or not. But all treat self-referencing as a process that transpires at the personal level, rather than at the subpersonal level, the level of mechanism. -/- Working with conceptual resources afforded by pre-existing theories of consciousness that take self-reference to be essential, several attempts have been made to explain seemingly (...)
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  4. The minimal self hypothesis.Timothy Lane - 2020 - Consciousness and Cognition 85:103029.
    For millennia self has been conjectured to be necessary for consciousness. But scant empirical evidence has been adduced to support this hypothesis. Inconsistent explications of “self” and failure to design apt experiments have impeded progress. Advocates of phenomenological psychiatry, however, have helped explicate “self,” and employed it to explain some psychopathological symptoms. In those studies, “self” is understood in a minimalist sense, sheer “for-me-ness.” Unfortunately, explication of the “minimal self” (MS) has relied on conceptual analysis, and applications to psychopathology have (...)
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  5. Breathing is coupled with voluntary initiation of mental imagery.Timothy J. Lane - 2022 - NeuroImage 264.
    Previous research has suggested that bodily signals from internal organs are associated with diverse cortical and subcortical processes involved in sensory-motor functions, beyond homeostatic reflexes. For instance, a recent study demonstrated that the preparation and execution of voluntary actions, as well as its underlying neural activity, are coupled with the breathing cycle. In the current study, we investigated whether such breathing-action coupling is limited to voluntary motor action or whether it is also present for mental actions not involving any overt (...)
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  6. Higher-order thought and pathological self: The case of somatoparaphrenia.Caleb Liang & Timothy Lane - 2009 - Analysis 69 (4):661-668.
    According to Rosenthal’s Higher-Order Thought (HOT) theory of consciousness, first-order mental states become conscious only when they are targeted by HOTs that necessarily represent the states as belonging to self. On this view a state represented as belonging to someone distinct from self could not be a conscious state. Rosenthal develops this view in terms of what he calls the ‘thin immunity principle’ (TIP). According to TIP, when I experience a conscious state, I cannot be wrong about whether it is (...)
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  7. Mental Ownership and Higher Order Thought.Timothy Lane & Caleb Liang - 2010 - Analysis 70 (3):496-501.
    Mental ownership concerns who experiences a mental state. According to David Rosenthal (2005: 342), the proper way to characterize mental ownership is: ‘being conscious of a state as present is being conscious of it as belonging to somebody. And being conscious of a state as belonging to somebody other than oneself would plainly not make it a conscious state’. In other words, if a mental state is consciously present to a subject in virtue of a higher-order thought (HOT), then the (...)
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  8. The trajectory of self.Timothy Lane, Niall W. Duncan, Tony Cheng & Georg Northoff - 2016 - Trends in Cognitive Sciences 20 (7):481-482.
    In a recent Opinion article, Sui and Humphreys [1] argue that experimental findings suggest self is ‘special’, in that self-reference serves a binding function within human cognitive economy. Contrasting their view with other functionalist positions, chiefly Dennett's [2], they deny that self is a convenient fiction and adduce findings to show that a ‘core self representation’ serves as an ‘integrative glue’ helping to bind distinct types of information as well as distinct stages of psycho- logical processing. In other words, where (...)
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  9. Resting state glutamate predicts elevated pre-stimulus alpha during self-relatedness: A combined EEG-MRS study on 'rest-self' overlap.Yu Bai, Timothy Lane, Georg Northoff & et al - 2015 - Social Neuroscience:DOI:10.1080/17470919.2015.107258.
    Recent studies have demonstrated neural overlap between resting state activity and self-referential processing. This “rest-self” overlap occurs especially in anterior cortical midline structures like the perigenual anterior cingulate cortex (PACC). However, the exact neurotemporal and biochemical mechanisms remain to be identified. Therefore, we conducted a combined electroencephalography (EEG)-magnetic resonance spectroscopy (MRS) study. EEG focused on pre-stimulus (e.g., prior to stimulus presentation or perception) power changes to assess the degree to which those changes can predict subjects’ perception (and judgment) of subsequent (...)
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  10. Higher Order Thought and the Problem of Radical Confabulation.Timothy Lane & Caleb Liang - 2008 - Southern Journal of Philosophy 46 (1):69-98.
    Currently, one of the most influential theories of consciousness is Rosenthal's version of higher-order-thought (HOT). We argue that the HOT theory allows for two distinct interpretations: a one-component and a two-component view. We further argue that the two-component view is more consistent with his effort to promote HOT as an explanatory theory suitable for application to the empirical sciences. Unfortunately, the two-component view seems incapable of handling a group of counterexamples that we refer to as cases of radical confabulation. We (...)
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  11. What Subjective Experiences Determine the Perception of Falling Asleep During the Sleep Onset Period?C. M. Yang & Timothy Lane - 2010 - Consciousness and Cognition 19 (4):1084-1092.
    Sleep onset is associated with marked changes in behavioral, physiological, and subjective phenomena. In daily life though subjective experience is the main criterion in terms of which we identify it. But very few studies have focused on these experiences. This study seeks to identify the subjective variables that reflect sleep onset. Twenty young subjects took an afternoon nap in the laboratory while polysomnographic recordings were made. They were awakened four times in order to assess subjective experiences that correlate with the (...)
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  12. Neuroexistentialism, Eudaimonics, and Positive Illusions.Timothy Lane & Owen Flanagan - forthcoming - In Byron Kaldis (ed.), Mind and Society: Cognitive Science Meets the Philosophy of the Social Sciences. SYNTHESE Philosophy Library Studies in Epistemology, Logic, Methodology, & Philosophy of Science. Springer Science+Business.
    There is a distinctive form of existential anxiety, neuroexistential anxiety, which derives from the way in which contemporary neuroscience provides copious amounts of evidence to underscore the Darwinian message—we are animals, nothing more. One response to this 21st century existentialism is to promote Eudaimonics, a version of ethical naturalism that is committed to promoting fruitful interaction between ethical inquiry and science, most notably psychology and neuroscience. We argue that philosophical reflection on human nature and social life reveals that while working (...)
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  13. (1 other version)Rationality and its contexts.Timothy Lane - 2016 - In Timothy Joseph Lane & Tzu-Wei Hung (eds.), Rationality: Constraints and Contexts. London, U.K.: Elsevier Academic Press. pp. 3-13.
    A cursory glance at the list of Nobel Laureates for Economics is sufficient to confirm Stanovich’s description of the project to evaluate human rationality as seminal. Herbert Simon, Reinhard Selten, John Nash, Daniel Kahneman, and others, were awarded their prizes less for their work in economics, per se, than for their work on rationality, as such. Although philosophical works have for millennia attempted to describe, explicate and evaluate individual and collective aspects of rationality, new impetus was brought to this endeavor (...)
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  14. Switching to the rubber hand.S. L. Yeh & Timothy Joseph Lane - 2017 - Frontiers in Psychology 8.
    Inducing the rubber hand illusion (RHI) requires that participants look at an imitation hand while it is stroked in synchrony with their occluded biological hand. Previous explanations of the RHI have emphasized multisensory integration, and excluded higher cognitive functions. We investigated the relationship between the RHI and higher cognitive functions by experimentally testing task switch (as measured by switch cost) and mind wandering (as measured by SART score); we also included a questionnaire for attentional control that comprises two subscales, attention-shift (...)
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  15. Is depressive rumination rational?Timothy Lane & Georg Northoff - 2016 - In Timothy Joseph Lane & Tzu-Wei Hung (eds.), Rationality: Constraints and Contexts. London, U.K.: Elsevier Academic Press. pp. 121-145.
    Most mental disorders affect only a small segment of the population. On the reasonable assumption that minds or brains are prone to occasional malfunction, these disorders do not seem to pose distinctive explanatory problems. Depression, however, because it is so prevalent and costly, poses a conundrum that some try to explain by characterizing it as an adaptation—a trait that exists because it performed fitness-enhancing functions in ancestral populations. Heretofore, proposed evolutionary explanations of depression did not focus on thought processes; instead, (...)
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  16. The Ethics of False Belief.Timothy Lane - 2010 - EurAmerica 40 (3):591-633.
    According to Allen Wood’s “procedural principle” we should believe only that which can be justified by evidence, and nothing more. He argues that holding beliefs which are not justified by evidence diminishes our self-respect and corrupts us, both individually and collectively. Wood’s normative and descriptive views as regards belief are of a piece with the received view which holds that beliefs aim at the truth. This view I refer to as the Truth-Tracking View (TTV). I first present a modest version (...)
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  17. Spontaneous activity in default-mode network predicts ascriptions of self-relatedness to stimuli.Pengmin Qin, Georg Northoff, Timothy Lane & et al - 2016 - Social Cognitive and Affective Neuroscience:xx-yy.
    Spontaneous activity levels prior to stimulus presentation can determine how that stimulus will be perceived. It has also been proposed that such spontaneous activity, particularly in the default-mode network (DMN), is involved in self-related processing. We therefore hypothesised that pre-stimulus activity levels in the DMN predict whether a stimulus is judged as self-related or not. Method: Participants were presented in the MRI scanner with a white noise stimulus that they were instructed contained their name or another. They then had to (...)
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  18. Vascular-metabolic and GABAergic Inhibitory Correlates of Neural Variability Modulation. A Combined fMRI and PET Study.Timothy J. Lane - 2018 - Neuroscience 379:142-151.
    Neural activity varies continually from moment to moment. Such temporal variability (TV) has been highlighted as a functionally specific brain property playing a fundamental role in cognition. We sought to investigate the mechanisms involved in TV changes between two basic behavioral states, namely having the eyes open (EO) or eyes closed (EC) in vivo in humans. To these ends we acquired BOLD fMRI, ASL, and [18F]-fluoro-deoxyglucose PET in a group of healthy participants (n = 15), along with BOLD fMRI and (...)
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  19. GABAA Receptor Deficits Predict Recovery in Patients With Disorders of Consciousness: A Preliminary Multimodal [11C]Flumazenil PET and fMRI Study.Pengmin Qin, Georg Northoff, Timothy Lane & et al - 2015 - Human Brain Mapping:DOI: 10.1002/hbm.22883.
    Disorders of consciousness (DoC)—that is, unresponsive wakefulness syndrome/vegetative state and minimally conscious state—are debilitating conditions for which no reliable markers of consciousness recovery have yet been identified. Evidence points to the GABAergic system being altered in DoC, making it a potential target as such a marker.
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  20. Indication of dynamic neurovascular coupling from inconsistency between EEG and fMRI indices across sleep–wake states.Timothy J. Lane - 2019 - Sleep and Biological Rhythms 17:423-431.
    Neurovascular coupling (NVC), the transient regional hyperemia following the evoked neuronal responses, is the basis of blood oxygenation level-dependent techniques and is generally adopted across physiological conditions, including the intrinsic resting state. However, the possibility of neurovascular dissociations across physiological alterations is indicated in the literature. To examine the NVC stability across sleep–wake states, we used electroencephalography (EEG) as the index of neural activity and functional magnetic resonance imaging (fMRI) as the measure of cerebrovascular response. Eight healthy adults were recruited (...)
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  21. Abnormal Functional Relationship of Sensorimotor Network With Neurotransmitter-Related Nuclei via Subcortical-Cortical Loops in Manic and Depressive Phases of Bipolar Disorder.Timothy J. Lane - 2020 - Schizophrenia Bulletin 46 (1):163–174.
    Objective Manic and depressive phases of bipolar disorder (BD) show opposite psychomotor symptoms. Neuronally, these may depend on altered relationships between sensorimotor network (SMN) and subcortical structures. The study aimed to investigate the functional relationships of SMN with substantia nigra (SN) and raphe nuclei (RN) via subcortical-cortical loops, and their alteration in bipolar mania and depression, as characterized by psychomotor excitation and inhibition. -/- Method In this resting-state functional magnetic resonance imaging (fMRI) study on healthy (n = 67) and BD (...)
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  22. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.Timothy J. Lane - 2021 - Psychiatry Research: Neuroimaging 308.
    The neurotransmitters GABA and glutamate have been suggested to play a role in Major Depressive Disorder (MDD) through an imbalance between cortical inhibition and excitation. This effect has been highlighted in higher brain areas, such as the prefrontal cortex, but has also been posited in basic sensory cortices. Based on this, magnetic resonance spectroscopy (MRS) was used to investigate potential changes to GABA+ and glutamate+glutamine (Glx) concentrations within the occipital cortex in MDD patients (n = 25) and healthy controls (n (...)
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  23. Depressive rumination is correlated with brain responses during self-related processing.Tzu-Yu Hsu & Timothy J. Lane - 2021 - Journal of Psychiatry and Neuroscience 46:E518-E527.
    Background: Rumination, a tendency to focus on negative self-related thoughts, is a central symptom of depression. Studying the self-related aspect of such symptoms is challenging because of the need to distinguish self effects from the emotional content of task stimuli. This study employed an emotionally neutral self-related paradigm to investigate possible altered self-processing in depression and its link to rumination. Methods: People with major depressive disorder (n = 25) and controls (n = 25) underwent task-based electro-encephalogram recording. We studied late (...)
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  24. Too fast or too slow? Time and neuronal variability in bipolar disorder—A combined theoretical and empirical investigation.Timothy Lane & Georg Northoff - 2018 - Schizophrenia Bulletin 44 (1):54-64.
    Time is an essential feature in bipolar disorder (BP). Manic and depressed BP patients perceive the speed of time as either too fast or too slow. The present article combines theoretical and empirical approaches to integrate phenomenological, psychological, and neuroscientific accounts of abnormal time perception in BP. Phenomenology distinguishes between perception of inner time, ie, self-time, and outer time, ie, world-time, that desynchronize or dissociate from each other in BP: inner time speed is abnormally slow (as in depression) or fast (...)
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  25. The Threshold of Wakefulness, the Experience of Control, and Theory Development.Timothy Lane & Chien-Ming Yang - 2010 - Consciousness and Cognition 19 (4):1095-1096.
    Reinterpretation of our data concerning sleep onset, motivated by the desire to pay close attention to “intra-individual regularities,” suggests that the experience of control might be a key factor in determining the subjective sense that sleep has begun. This loss of control seems akin to what Frith and others have described as “passivity experiences,” which also occur in schizophrenia. Although clearly sleep onset is not a schizophrenic episode, this similarity might help to explain other features of sleep onset. We further (...)
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  26. Attention and memory-driven effects in action studies.Philip Tseng, Timothy Lane & Bruce Bridgeman - 2016 - Behavioral and Brain Sciences 39:48-49.
    We provide empirical examples to conceptually clarify some items on Firestone & Scholl’s (F&S’s) checklist, and to explain perceptual effects from an attentional and memory perspective. We also note that action and embodied cognition studies seem to be most susceptible to misattributing attentional and memory effects as perceptual, and identify four characteristics unique to action studies and possibly responsible for misattributions.
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  27. Cerebral blood flow autoregulation is impaired in schizophrenia.Hsiao-Lun Ku, Timothy Lane & et al - 2017 - Schizophrenia Research:xx-yy.
    Patients with schizophrenia have a higher risk of cardiovascular diseases and higher mortality from them than does the general population; however, the underlying mechanism remains unclear. Impaired cerebral autoregulation is associated with cerebrovascular diseases and their mortality. Increased or decreased cerebral blood flow in different brain regions has been reported in patients with schizophrenia, which implies impaired cerebral autoregulation. This study investigated the cerebral autoregulation in 21 patients with schizophrenia and 23 age- and sex-matched healthy controls. None of the participants (...)
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  28. Issues at the intersection of ethics, evolution and neuroscience.Timothy Lane - 2010 - EurAmerica 40 (3):519-527.
    It is becoming increasingly difficult for those who engage in ethical analysis to ignore evolution and neuroscience. The kind of creature that we are and that we have evolved to be matters when determining how we ought to live. There is still a need to aim for a reflective equilibrium that includes reflection over not straightforwardly empirical issues. It would, for example, be inaccurate to say that "good" just means "highly evolved." But it does turn out to be the case (...)
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  29. 意識測量儀初登場.Timothy Joseph Lane - 2018 - Scientific American 193:38-42.
    意識是如此不可捉摸又抽象的概念,「測量」意識簡直就像科幻小說情節。科學家近年來在這方面已大有進展,藉由各項腦造影技術和實驗手法,能夠分析不同意識狀態下的大腦活動型態。.
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  30.  82
    Arterial spin labeling as a promising alternative to FDG-PET for clinical diagnosis of patients with disorders of consciousness.Timothy Joseph Lane - manuscript
    Objective: To evaluate the potential of arterial spin labeling (ASL) as an alternative to FDG-PET in the diagnosis of disorders of consciousness (DOC), we conducted a comparative study of the two modalities. Methods: A total of 36 DOC patients (11 female; mean age = 49.67 ± 14.54 years) and 17 healthy control (HC) participants (9 female; mean age = 31.9 ± 9.6 years) underwent both FDG-PET scans that measure metabolism via glucose uptake and ASL scans that measure cerebral blood flow (...)
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  31. (1 other version)When actions feel alien: An explanatory model.Timothy Lane - 2014 - In Tzu-Wei Hung (ed.), Communicative Action. Singapore: Springer Science+Business. pp. 53-74.
    It is not necessarily the case that we ever have experiences of self, but human beings do regularly report instances for which self is experienced as absent. That is there are times when body parts, mental states, or actions are felt to be alien. Here I sketch an explanatory framework for explaining these alienation experiences, a framework that also attempts to explain the “mental glue” whereby self is bound to body, mind, or action. The framework is a multi-dimensional model that (...)
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  32. Functional blindsight and its diagnosis.Timothy Joseph Lane - 2024 - Frontiers in Neurology 15.
    Even when brain scans fail to detect a striate lesion, functional evidence for blindsight can be adduced. In the aftermath of an automobile accident, JK became blind. Results of ophthalmic exams indicated that the blindness must be cortical. Nevertheless, multiple MRI scans failed to detect structural damage to the striate cortex. Prior to the accident JK had been an athlete; after the accident he retained some athletic abilities, arousing suspicions that he might be engaged in fraud. His residual athletic abilities—e.g., (...)
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  33. Somebody is home.Timothy Joseph Lane - 2020 - Cognitive Neuropsychology 37 (3-4):193-196.
    Invited Commentary On: Graziano, M. S. A., Guterstam, A., Bio, B. J., Wilterson, A. I. (2019). Toward a standard model of consciousness: Reconciling the attention schema, global workspace, higher order thought, and illusionist theories. Cognitive Neuropsychology.
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  34. Eyes-Open and Eyes-Closed Resting State Network Connectivity Differences.Junrong Han & Timothy Joseph Lane - 2023 - Brain Sciences 13.
    Resting state networks comprise several brain regions that exhibit complex patterns of interaction. Switching from eyes closed (EC) to eyes open (EO) during the resting state modifies these patterns of connectivity, but precisely how these change remains unclear. Here we use functional magnetic resonance imaging to scan healthy participants in two resting conditions (viz., EC and EO). Seven resting state networks were chosen for this study: salience network (SN), default mode network (DMN), central executive network (CEN), dorsal attention network (DAN), (...)
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  35. The neurophysiological basis of the discrepancy between objective and subjective sleep during the sleep onset period: an EEG-fMRI study.Timothy Joseph Lane - 2018 - Sleep 41 (6):1-10.
    Subjective perception of sleep is not necessarily consistent with electroencephalography (EEG) indications of sleep. The mismatch between subjective reports and objective measures is often referred to as “sleep state misperception.” Previous studies evince that this mismatch is found in both patients with insomnia and in normal sleepers, but the neurophysiological mechanism remains unclear. The aim of the study is to explore the neurophysiological basis of this mechanism, from the perspective of both EEG power and functional magnetic resonance imaging (fMRI) fluctuations. (...)
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  36. Reactivity of intrinsic activity temporal structure to a behavioural state change is correlated with depressive symptoms.Timothy Joseph Lane - 2020 - European Journal of Neuroscience 52.
    The brain’s intrinsic activity plays a fundamental role in its function. In normal conditions this activity is responsive to behavioural context, changing as an individual switches between directed tasks and task‐free conditions. A key feature of such changes is the movement of the brain between corresponding critical and sub‐critical states, with these dynamics supporting efficient cognitive processing. Breakdowns in processing efficiency can occur, however, in brain disorders such as depression. It was therefore hypothesised that depressive symptoms would be related to (...)
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  37. Instability of brain connectivity during nonrapid eye movement sleep reflects altered properties of information integration.Timothy Joseph Lane - 2019 - Human Brain Mapping 40:3192–3202.
    Nonrapid eye movement (NREM) sleep is associated with fading consciousness in humans. Recent neuroimaging studies have demonstrated the spatiotemporal alterations of the brain functional connectivity (FC) in NREM sleep, suggesting the changes of information integration in the sleeping brain. However, the common stationarity assumption in FC does not satisfactorily explain the dynamic process of information integration during sleep. The dynamic FC (dFC) across brain networks is speculated to better reflect the time-varying information propagation during sleep. Accordingly, we conducted simultaneous EEG-fMRI (...)
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  38. Spontaneous thought-related network connectivity predicts sertraline effects on major depressive disorder.Timothy Joseph Lane - 2021 - Brain Imaging and Behavior 15 (4):1705-1717.
    Sertraline is one of the most commonly prescribed antidepressants. Major depressive disorder (MDD) is characterized by spontaneous thoughts that are laden with negative affect-a "malignant sadness". Prior neuroimaging studies have identified abnormal resting-state functional connectivity (rsFC) in the spontaneous brain networks of MDD patients. But how antidepressant medication acts to relieve the experience of depression as well as adjust its associated spontaneous networks and mood-regulation circuits remains an open question. In this study, we recruited 22 drug-naïve MDD patients along with (...)
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  39. From local to global and back: An exploratory study on cross-scale desynchronization in schizophrenia and its relation to thought disorders.Timothy Joseph Lane - 2021 - Schizophrenia Research 231:10-12.
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  40. Pain without power.Timothy Joseph Lane - 2008 - National Chengchi University Philosophical Journal 20:123-182.
    Some theories of consciousness emphasize its relationship to language, its emergent quality, and its causal role. Prominent among these theories is the one that Dennett has been developing for nearly four decades. According to Dennett’s most recent version, consciousness is a kind of cerebral clout. But consideration of examples of pain—arguably the best candidate on offer for a paradigm of consciousness—reveals that clout is neither necessary nor sufficient for consciousness. Moreover, pain doesn’t necessarily have the aftermath that is predicted by (...)
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  41. Strong Circadian Rhythms in the Choroid Plexus: Implications for Sleep-Independent Brain Metabolite Clearance.Timothy Joseph Lane - 2018 - Journal of Experimental Neuroscience 12.
    Cerebrospinal fluid (CSF) is a fluidic part of the brain’s microenvironment that isolates the brain from the rest of the body. CSF dilutes metabolites from neuronal activities and removes them from the brain. Its production and resorption are regulated dynamically and are central to maintaining brain homeostasis. We discovered that the major CSF source, the choroid plexus (CP), harbors the brain’s strongest circadian clock. Here, we consider some implications of the CP circadian clock for metabolite clearance in the brain. If (...)
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  42. Temporal Preparation, Impulsivity and Short-Term Memory in Depression.Timothy Joseph Lane - 2019 - Frontiers in Behavioral Neuroscience 13.
    Patient suffering of major depressive disorder (MDD) often complain that subjective time seems to “drag” with respect to physical time. This may point toward a generalized dysfunction of temporal processing in MDD. In the present study, we investigated temporal preparation in MDD. “Temporal preparation” refers to an increased readiness to act before an expected event; consequently, reaction time should be reduced. MDD patients and age-matched controls were required to make a saccadic eye movement between a central and an eccentric visual (...)
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  43. intrinsic neural activity predisposes susceptibility to a body illusion.Timothy Joseph Lane - 2022 - Cerebral Cortex 1 (3):1-12.
    Susceptibility to the rubber hand illusion (RHI) varies. To date, however, there is no consensus explanation of this variability. Previous studies, focused on the role of multisensory integration, have searched for neural correlates of the illusion. But those studies have failed to identify a sufficient set of functionally specific neural correlates. Because some evidence suggests that frontal α power is one means of tracking neural instantiations of self, we hypothesized that the higher the frontal α power during the eyes-closed resting (...)
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  44. Intrinsic brain activity of subcortical-cortical sensorimotor system and psychomotor alterations in schizophrenia and bipolar disorder.Timothy Joseph Lane - 2020 - Schizophrenia Research 215.
    Objective: Alterations in psychomotor dimension cut across different psychiatric disorders, such as schizophrenia (SCZ) and bipolar disorder (BD). This preliminary study aimed to investigate the organization of intrinsic brain activity in the subcortical-cortical sensorimotor system in SCZ (and BD) as characterized according to psychomotor dimension. -/- Method: In this resting-state functional magnetic resonance imaging (fMRI) study, functional connectivity (FC) between thalamus and sensorimotor network (SMN), along with FC from substantia nigra (SN) and raphe nuclei (RN) to basal ganglia (BG) and (...)
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