Cloutier et al., 2022 - Google Patents

Preventing erosion of X-chromosome inactivation in human embryonic stem cells

Cloutier et al., 2022

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Document ID
8112079165331255832
Author
Cloutier M
Kumar S
Buttigieg E
Keller L
Lee B
Williams A
Mojica-Perez S
Erliandri I
Rocha A
Cadigan K
Smith G
Kalantry S
Publication year
Publication venue
Nature communications

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X-chromosome inactivation is a paradigm of epigenetic transcriptional regulation. Female human embryonic stem cells (hESCs) often undergo erosion of X-inactivation upon prolonged culture. Here, we investigate the sources of X-inactivation instability by deriving …
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