Habuchi et al., 1998 - Google Patents

Biosynthesis of heparan sulfate and heparin how are the multifunctional glycosaminoglycans built up?

Habuchi et al., 1998

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Document ID
7409025639777770387
Author
Habuchi H
Habuchi O
Kimata K
Publication year
Publication venue
Trends in Glycoscience and Glycotechnology

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A. Introduction Heparan sulfate proteoglycans (HSPG) are ubiquitously present on cell surface and in extracellular matrix including basement membrane (1, 2). Heparan sulfate chains are known to interact with a variety of proteins such as heparin-binding growth …
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    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
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    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

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