Brandel et al., 2016 - Google Patents

Structural aspects of solid solutions of enantiomers

Brandel et al., 2016

Document ID
6489689729555081721
Author
Brandel C
Petit S
Cartigny Y
Coquerel G
Publication year
Publication venue
Current Pharmaceutical Design

External Links

Snippet

A mixture of two enantiomers can crystallize according to three types of heterogeneous equilibria: a racemic compound (a 1: 1 stoichiometric compound), a conglomerate (a physical mixture of particles with opposite chirality) or, more rarely, as a solid solution (a …
Continue reading at www.ingentaconnect.com (other versions)

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings

Similar Documents

Publication Publication Date Title
Brandel et al. Structural aspects of solid solutions of enantiomers
Berry et al. Applying hot-stage microscopy to co-crystal screening: A study of nicotinamide with seven active pharmaceutical ingredients
Sheikh et al. Scalable solution cocrystallization: case of carbamazepine-nicotinamide I
Brandel et al. Impact of molecular flexibility on double polymorphism, solid solutions and chiral discrimination during crystallization of diprophylline enantiomers
TWI379681B (en) Polymorphs of eltrombopag and eltrombopag salts and processes for preparation thereof
Kato et al. Kinetic study of the transformation of mefenamic acid polymorphs in various solvents and under high humidity conditions
Grzesiak et al. New form discovery for the analgesics flurbiprofen and sulindac facilitated by polymer‐induced heteronucleation
Wang et al. Crystallization‐based separation of enantiomers
Zeidan et al. Polymorphism of dehydro-aripiprazole, the active metabolite of the antipsychotic drug aripiprazole (abilify)
Oketani et al. Deracemization in a Complex Quaternary System with a Second‐Order Asymmetric Transformation by Using Phase Diagram Studies
Harfouche et al. Enabling direct preferential crystallization in a stable racemic compound system
de Diego et al. Formation of solid solutions between racemic and enantiomeric citalopram oxalate
P Otto et al. Solid state concerns during drug discovery and development: thermodynamic and kinetic aspects of crystal polymorphism and the special cases of concomitant polymorphs, co-crystals and glasses
JP7303821B2 (en) Polymorphs and Solid Forms of Pyrimidinylamino-Pyrazole Compounds and Methods of Making
Davey et al. The isolation of a metastable conglomerate using a combined computational and controlled crystallization approach
Le Minh et al. Enantiomeric 3‐chloromandelic acid system: Binary melting point phase diagram, ternary solubility phase diagrams and polymorphism
Lerdwiriyanupap et al. Combining diastereomeric resolution and Viedma ripening by using a racemic resolving agent
Li et al. Solid tryptophan as a pseudoracemate: physicochemical and crystallographic characterization
Lee et al. Stabilization of metastable flufenamic acid by inclusion of mefenamic acid: solid solution or epilayer?
Iwata et al. Cocrystallization enhanced TAK-441 aqueous solubility and suppressed high solvatomorphism
Choobdari et al. Anion effect on the binary and ternary phase diagrams of chiral medetomidine salts and conglomerate crystal formation
Nordstrom et al. Concomitant Precipitation of Solid-State Miscible Product-Impurity Phases in Solution Crystallization–Part 2: Industrial Case Studies
KR20220143897A (en) Optically resolved Trolox intermediate and method for preparing the same
EP3927692A1 (en) Solidification or crystallisation method
Heffernan An investigation into the effect of impurities on the crystallization of curcumin