Verpoort et al., 2007 - Google Patents

Fine-specificity of the antibodies against citrullinated protein response is influenced by shared epitope alleles

Verpoort et al., 2007

View PDF
Document ID
5073496308941889185
Author
Verpoort K
Cheung K
Ioan-Facsinay A
van der Helm-van Mil A
de Vries R
Breedveld F
Huizinga T
Pruijn G
Toes R
Publication year
Publication venue
Arthritis Research & Therapy

External Links

Snippet

Objective In classic studies on the genetic background of antibody production, MHC has been shown to act as the most prominent immune-response gene that controls the magnitude and the specificity of antibody production. The strongest genetic risk factor for …
Continue reading at link.springer.com (PDF) (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans

Similar Documents

Publication Publication Date Title
Nakayama et al. Lymphotoxin-beta receptor blockade induces inflammation and fibrosis in tolerized cardiac allografts
Griesenauer et al. ST2/MyD88 deficiency protects mice against acute graft-versus-host disease and spares regulatory T cells
JP2016506411A (en) TSPAN33, a candidate for antibody-targeted therapy for the treatment of B-cell Hodgkin lymphoma
Afif et al. Peroxisome proliferator-activated receptor gamma 1 expression is diminished in human osteoarthritis cartilage and is downregulated by IL-1β in articular chondrocytes
Morand et al. Evidence for the role of CD74 in innate immunity, arthritis, and the action of migration inhibitory factor
Chaturvedi Safety and diagnostic value of medical arthroscopy: retrospective analysis of 100 medical arthroscopies performed by a rheumatologist
Reich et al. Tumor necrosis factor polymorphisms in psoriatic arthritis: association with the promoter polymorphism TNF-857 independent of the PSORS1 risk allele
Nagy et al. Histidine deficiency does not protect against aggrecan-induced arthritis
Sayers et al. Generation of dexamethasone and vitamin D3-treated human monocyte-derived dendritic cells with tolerogenic properties
Verpoort et al. Fine-specificity of the antibodies against citrullinated protein response is influenced by shared epitope alleles
Nagy et al. Nitric oxide differentially regulates T-cell function in rheumatoid arthritis and systemic lupus erythematosus
Alexiou et al. Diagnostic value of anticyclic citrullinated peptide antibodies in Greek patients with rheumatoid arthritis: association with extra-articular manifestations
Palmer et al. IL-33: a novel cytokine with proinflammatory properties
Möller et al. Class switched memory B cells are enriched in the synovium after rituximab treatment
Korb et al. Tumour necrosis factor-dependent inflammatory cartilage destruction
Lee et al. Cadherin-11 regulates synovial fibroblast behavior in health and disease
Longo et al. Characterization of immunoglobulin mutations in humans with activation-induced cytidine deaminase deficiency
Shao et al. Disrupting Mer receptor tyrosine kinase expression prevents autoimmune chronic graft-versus-host disease
Lajeunesse et al. Altered expression and production of leptin is responsible for abnormal cell markers in subchondral osteoblasts from osteoarthritic patients
Zhang et al. Differential Toll-like receptor-dependent collagenase expression in chondrocytes
Chouchourel et al. Abnormal collagen type 1 production in subchondral osteoarthritic osteoblasts is responsible in part for altered mineralization in these cells
Warstat et al. Activation of synovial fibroblasts by laminin-1 and transforming growth factor beta induces expression of stromelysins independently of TNFα, IL-1β or NF-κB
Echtermeyer et al. Matrix remodeling during enchondral ossification and aggrecan cleavage in osteoarthritic cartilage depends on syndecan-4
Kowal-Bielecka et al. Regulation of eicosanoid production in peripheral blood mononuclear cells from patients with systemic sclerosis
Ibrahim An integrative genomics strategy for the identification of collagen-induced arthritis susceptibility genes