Wu et al., 2024 - Google Patents

A Biomimetic Synthetic Strategy Can Provide Keratan Sulfate I and II Oligosaccharides with Diverse Fucosylation and Sulfation Patterns

Wu et al., 2024

View HTML
Document ID
4743919054149742878
Author
Wu Y
Bosman G
Chapla D
Huang C
Moremen K
de Vries R
Boons G
Publication year
Publication venue
Journal of the American Chemical Society

External Links

Snippet

Keratan sulfate (KS) is a proteoglycan that is widely expressed in the extracellular matrix of various tissue types, where it performs multiple biological functions. KS is the least understood proteoglycan, which in part is due to a lack of panels of well-defined KS …
Continue reading at pubs.acs.org (HTML) (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures

Similar Documents

Publication Publication Date Title
Krasnova et al. Oligosaccharide synthesis and translational innovation
Gagarinov et al. Chemoenzymatic approach for the preparation of asymmetric bi-, tri-, and tetra-antennary N-glycans from a common precursor
Panza et al. Automated chemical oligosaccharide synthesis: novel approach to traditional challenges
Li et al. Chemoenzymatic methods for the synthesis of glycoproteins
Wen et al. Toward automated enzymatic synthesis of oligosaccharides
Le Mai Hoang et al. Traceless photolabile linker expedites the chemical synthesis of complex oligosaccharides by automated glycan assembly
Cheng et al. Programmable one-pot synthesis of oligosaccharides
Sugiarto et al. A sialyltransferase mutant with decreased donor hydrolysis and reduced sialidase activities for directly sialylating LewisX
Blixt et al. Solid-phase enzymatic synthesis of a sialyl Lewis X tetrasaccharide on a sepharose matrix
Lo et al. Synthesis of sialidase-resistant oligosaccharide and antibody glycoform containing α2, 6-linked 3Fax-Neu5Ac
Blixt et al. Efficient chemoenzymatic synthesis of O-linked sialyl oligosaccharides
Brzezicka et al. Synthesis and microarray-assisted binding studies of core xylose and fucose containing N-glycans
Bojarová et al. Enzymatic glycosylation of multivalent scaffolds
Lu et al. Redox-controlled site-specific α2–6-sialylation
Wang et al. Chemoenzymatic modular assembly of O-GalNAc glycans for functional glycomics
Gao et al. Chemoenzymatic synthesis of O-mannose glycans containing sulfated or nonsulfated HNK-1 epitope
Wu et al. A Biomimetic Synthetic Strategy Can Provide Keratan Sulfate I and II Oligosaccharides with Diverse Fucosylation and Sulfation Patterns
Huang et al. Substrate characterization of Bacteroides fragilis α1, 3/4-fucosyltransferase enabling access to programmable one-pot enzymatic synthesis of KH-1 antigen
Shivatare et al. Synthetic carbohydrate chemistry and translational medicine
Santra et al. Regioselective one-pot multienzyme (OPME) chemoenzymatic strategies for systematic synthesis of sialyl core 2 glycans
Bergfeld et al. Metabolism of vertebrate amino sugars with N-glycolyl groups: incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine
Xu et al. Successfully engineering a bacterial sialyltransferase for regioselective α2, 6-sialylation
Na et al. Engineer P. multocida heparosan synthase 2 (PmHS2) for size-controlled synthesis of longer heparosan oligosaccharides
Huang et al. Sulfo-Fluorous tagging strategy for site-selective enzymatic glycosylation of Para-human milk oligosaccharides
Kumar HV et al. A new approach for the synthesis of hyperbranched N-glycan core structures from locust bean gum