Wolf et al., 1995 - Google Patents

The N-Methyl-d-Aspartate Antagonist Dextrorphan Acts Like Ketamine by Selectively Increasing Tail Flick Lactencies in Spinally Transected But Not Intact Rats

Wolf et al., 1995

Document ID
4391428554235779975
Author
Wolf E
Advokat C
Publication year
Publication venue
Analgesia

External Links

Snippet

Background: Antagonists of the NMDA receptor subtype of the excitatory amino acids (EAAs) selectively reduce hyperalgesia in experimental models of neuropathic pain. As yet, however, assessments of their possible therapeutic benefit are limited. Among the clinically …
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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