Barfod et al., 1989 - Google Patents

The conserved UG pair in the 5′ splice site duplex of a group I intron is required in the first but not the second step of self-splicing

Barfod et al., 1989

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Document ID
3847422099490855583
Author
Barfod E
Cech T
Publication year
Publication venue
Molecular and cellular biology

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Group I self-splicing introns have a 5′ splice site duplex (P1) that contains a single conserved base pair (UG). The U is the last nucleotide of the 5′ exon, and the G is part of the internal guide sequence within the intron. Using site-specific mutagenesis and analysis …
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