Plumb et al., 1990 - Google Patents

The activity of verapamil as a resistance modifier in vitro in drug resistant human tumour cell lines is not stereospecific

Plumb et al., 1990

Document ID
3561470834764425385
Author
Plumb J
Milroyf R
Kaye S
Publication year
Publication venue
Biochemical pharmacology

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Snippet

The l-isomer of verapamil is a more potent calcium antagonist than the d-isomer. We have examined the two stereoisomers of verapamil for their ability to increase the chemosensitivity in vitro of three drug resistant cell lines (2780AD, MCF7/Adr r and H6 …
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/47—Quinolines; Isoquinolines
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