Wharton et al., 2022 - Google Patents

[213Bi] Bi3+/[111In] In3+-neunpa-cycMSH: Theranostic Radiopharmaceutical Targeting Melanoma─ Structural, Radiochemical, and Biological Evaluation

Wharton et al., 2022

Document ID
295627368796746150
Author
Wharton L
Zhang C
Yang H
Zeisler J
Radchenko V
Rodríguez-Rodríguez C
Osooly M
Patrick B
Lin K
Bénard F
Schaffer P
Orvig C
Publication year
Publication venue
Bioconjugate Chemistry

External Links

Snippet

With the emergence of [225Ac] Ac3+ as a therapeutic radionuclide for targeted α therapy (TAT), access to clinical quantities of the potent, short-lived α-emitter [213Bi] Bi3+ (t 1/2= 45.6 min) will increase over the next decade. With this in mind, the nonadentate chelator …
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    • A61K51/1003—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody not used, see subgroups
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody not used, see subgroups against animal or human tumor cells or tumor cell determinants
    • A61K51/1069—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody not used, see subgroups against animal or human tumor cells or tumor cell determinants the tumor cell being from blood cells, e.g. the cancer being a myeloma
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    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody conjugates with carriers being antibodies
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    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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