Yamanaka et al., 2014 - Google Patents

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

Yamanaka et al., 2014

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Document ID
14488871931104765956
Author
Yamanaka K
Reynolds K
Kersten R
Ryan K
Gonzalez D
Nizet V
Dorrestein P
Moore B
Publication year
Publication venue
Proceedings of the National Academy of Sciences

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Recent developments in next-generation sequencing technologies have brought recognition of microbial genomes as a rich resource for novel natural product discovery. However, owing to the scarcity of efficient procedures to connect genes to molecules, only a small …
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