Dunckley et al., 1998 - Google Patents

Modification of splicing in the dystrophin gene in cultured Mdx muscle cells by antisense oligoribonucleotides

Dunckley et al., 1998

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Document ID
14180216829992640192
Author
Dunckley M
Manoharan M
Villiet P
Eperon I
Dickson G
Publication year
Publication venue
Human molecular genetics

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Deletions and point mutations in the gene encoding the cytoskeletal protein dystrophin and its isoforms cause either the severe progressive myopathy Duchenne muscular dystrophy (DMD) or the milder Becker muscular dystrophy (BMD), largely depending on whether the …
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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