Boylan et al., 1973 - Google Patents

Molecular-scale drug entrapment as a precise method of controlled drug release IV: Entrapment of anionic drugs by polymeric gelation

Boylan et al., 1973

Document ID
12786122970526800980
Author
Boylan J
Banker G
Publication year
Publication venue
Journal of Pharmaceutical Sciences

External Links

Snippet

A physicochemical approach to the preparation of drug-containing matrix systems is described in which a soluble anionic drug may be entrapped on a molecular scale in coagulated (gelled) polymer emulsion systems. The resultant dried product (or drug-xerogel …
Continue reading at www.sciencedirect.com (other versions)

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases; Films; Fibres of the matrix type containing drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells

Similar Documents

Publication Publication Date Title
US3629392A (en) Entrapment compositions and processes
AU565354B2 (en) Bioadhesive compositions and methods of treatment therewith
US3608063A (en) Molecular drug entrapment process and compositions
US4795436A (en) Bioadhesive composition and method of treatment therewith
US3499960A (en) Palatable coated particles of an anion exchange resin
HOU et al. Sustained release of indomethacin from chitosan granules
JP2662253B2 (en) Polymer blends with reversed-phase morphology for controlled release of bioactive agents
US4221778A (en) Prolonged release pharmaceutical preparations
US5183829A (en) Oral liquid compositions of non-steroidal anti-inflammatory drugs
Motycka et al. Preparation and evaluation of microencapsulated ion-exchange resin beads
Bloedow et al. Effects of lipids on bioavailability of sulfisoxazole acetyl, dicumarol, and griseofulvin in rats
Sheth et al. Use of powdered solutions to improve the dissolution rate of polythiazide tablets
Boylan et al. Molecular-scale drug entrapment as a precise method of controlled drug release IV: Entrapment of anionic drugs by polymeric gelation
Goodman et al. Molecular-scale drug entrapment as a precise method of controlled drug release I: Entrapment of cationic drugs by Polymeric flocculation
US5087455A (en) Hollow granular medicine and its preparation
Boggiano et al. Gastric acid inactivation of erythromycin stearate in solid dosage forms
CN110146500B (en) Method for determining free bismuth in colloidal bismuth pectin or colloidal bismuth pectin-containing preparation
AU663695B2 (en) Polyamine drug-resin complexes
Bondesen et al. 5-Aminosalicylic acid enemas in patients with active ulcerative colitis: influence of acidity on the kinetic pattern
USRE28316E (en) Entrapment compositions and processes
DE69319064T2 (en) Biologically active reagent made from polymer containing aldehyde groups, test equipment, analytical element and application methods
Pongpaibul et al. Effect of process variables on drug release from microparticles containing a drug-resin complex
Szejtli Enhancement of drug bioavailability by cyclodextrins
Jambhekar et al. pH‐and flow‐rate‐independent release of drug from uncoated slow‐release tablets
Capan et al. Formulation and in vitro-in vivo evaluations on sustained release acetylsalicylic acid tablets