Canova-Davis et al., 1980 - Google Patents

Specific activation of the arginine carboxyl group of the B-chain of bovine des-octapeptide-(B23–30)-insulin

Canova-Davis et al., 1980

Document ID
11959319473536002482
Author
Canova-Davis E
Carpenter F
Publication year
Publication venue
Insulin. Chemistry, Structure and Function of Insulin and Related Hormones

External Links

Snippet

The biological activity of insulin is known to be closely related to the C-terminal octapeptide fragment of its B-chain. The desoctapeptide hormone obtained from tryptic digests of insulin retains less than 1% of insulin activity (1, 2). Due to this low activity it has been proposed that …
Continue reading at www.degruyter.com (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Similar Documents

Publication Publication Date Title
Robey et al. Automated synthesis of N-bromoacetyl-modified peptides for the preparation of synthetic peptide polymers, peptide-protein conjugates, and cyclic peptides
Bodanszky et al. Synthesis of secretin. II. Stepwise approach
KR100537842B1 (en) How to Obtain Insulin Precursor with Correctly Bound Cystine Bridges
Fischer et al. A shortened insulin with full in vitro potency
Blake et al. New segment-coupling method for peptide synthesis in aqueous solution: application to synthesis of human [Gly17]-beta-endorphin.
JP3863579B2 (en) Method for obtaining insulin with correctly linked cystine bridges
Atherton et al. Peptide synthesis. Part 7. Solid-phase synthesis of conotoxin G1
JPH0236197A (en) Solid phase method for synthesis of thymosin alpha 1
CA1162868A (en) Process for preparing insulin esters
Kato et al. Purification of synthetic ribonuclease S-peptide derivatives by specific complex formation on columns of ribonuclease S-protein bound to agarose
EP0045187A1 (en) A process for enzymatic replacement of the B-30 amino acid in insulins
US4430266A (en) Process for producing an insulin precursor
FI79860B (en) FOERFARANDE FOER FRAMSTAELLNING AV HUMANINSULIN DES-PHEB1-HUMANINSULIN ELLER DERIVAT DAERAV UR SVININSULIN, DES-PHEB1-SVININSULIN ELLER DERIVAT DAERAV.
Schwartz et al. A highly potent insulin: des-(B26-B30)-[AspB10, TyrB25-NH2] insulin (human).
JPH10152500A (en) Synthesis of peptide in solid phase
EP0037255B1 (en) Process for producing an insulin precursor
Atherton et al. Peptide synthesis. Part 6. Protection of the sulphydryl group of cysteine in solid-phase synthesis using N α-fluorenylmethoxycarbonylamino acids. Linear oxytocin derivatives
Canova-Davis et al. Specific activation of the arginine carboxyl group of the B-chain of bovine des-octapeptide-(B23–30)-insulin
DE3151738A1 (en) PEPTID FOR ANALYSIS OF THE HUMAN HORMONE OF THE PARALIDAL GLANCE
Markussen et al. Duck insulin: isolation, crystallization and amino acid sequence
Canova-Davis et al. Semisynthesis of insulin: specific activation of the arginine carboxyl group of the B chain of desoctapeptide-(B23-30)-insulin (bovine)
JP2777193B2 (en) Method for producing peptide
NAITHANI et al. Semisynthesis of human proinsulin, I. Preparation of arginyl-A-chain cyclic bis-disulfide
KR100351389B1 (en) Hirudin derivatives and process for their preparation
Visser et al. Studies on polypeptides. Part X: Synthesis of 1‐13 [10‐Homoarginine, 13‐Leucine] bovine pancreatic ribonuclease by combined solid‐phase and classical methods