Smith et al., 1998 - Google Patents

Structural requirements for α9β1-mediated adhesion and migration to thrombin-cleaved osteopontin

Smith et al., 1998

Document ID
10993775750235202799
Author
Smith L
Giachelli C
Publication year
Publication venue
Experimental cell research

External Links

Snippet

Osteopontin is an RGD-containing glycoprotein that mediates adhesion and migration of a variety of different cell types. We recently showed that a recombinant osteopontin fragment that was expected to be formed following thrombin cleavage was not only biologically active …
Continue reading at www.sciencedirect.com (other versions)

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Similar Documents

Publication Publication Date Title
Smith et al. Structural requirements for α9β1-mediated adhesion and migration to thrombin-cleaved osteopontin
Pierschbacher et al. Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule
ES2303362T3 (en) MODIFIED VITAMIN K DEPENDENT POLYPEPTIDES.
Aota et al. Characterization of regions of fibronectin besides the arginine-glycine-aspartic acid sequence required for adhesive function of the cell-binding domain using site-directed mutagenesis
Hopf et al. Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan
Carnemolla et al. Localization of the cellular‐fibronectin‐specific epitope recognized by the monoclonal antibody IST‐9 using fusion proteins expressed in E. coli
Xuan et al. Site‐directed mutagenesis of the arginine‐glycine‐aspartic acid sequence in osteopontin destroys cell adhesion and migration functions
Sun et al. Disulfides modulate RGD-inhibitable cell adhesive activity of thrombospondin.
Sidenius et al. Domain 1 of the urokinase receptor (uPAR) is required for uPAR-mediated cell binding to vitronectin
KR101175687B1 (en) Growth factor complexes and modulation of cell migration and growth
JPH11509187A (en) Regulation of endothelial cell proliferation
Chen et al. Properties of recombinant mouse thrombospondin 2 expressed in Spodoptera cells.
Kuratomi et al. Identification of metastasis-promoting sequences in the mouse laminin α1 chain
JP2001509516A (en) Semaphorin receptor
Horiuchi et al. Site-directed mutagenesis of the region around Cys-241 of complement component C2. Evidence for a C4b binding site.
US20030044899A1 (en) Isolated laminin 10
WO2000055206A1 (en) Endothelial cell stimulation by a complex of fibronectin and vascular endothelial growth factor
Delpech et al. The origin of hyaluronectin in human tumors
KR100852415B1 (en) - Polypeptide and derivatives thereof containing novel heparin-binding site derived from human tenacin C
AU719909B2 (en) Protein tyrosine phosphatases of hematopoietic cells
WO1997035019A9 (en) Protein tyrosine phosphatases of hematopoietic cells
US6030795A (en) Recombinant TGF-β type I receptor variants having differentially diminished capacity to signal for matrix protein production
US20080280833A1 (en) Therapeutic Peptides Derived from Urokinase Plasminogen Activator Receptor
KR20000047835A (en) DNA constructs of blood clotting factors and P-Selectin
AU2004208856B2 (en) Growth factor complexes and modulation of cell migration and growth