Guo et al., 1997 - Google Patents

Enhanced discrimination of single nucleotide polymorphisms by artificial mismatch hybridization

Guo et al., 1997

Document ID
10987595994035258837
Author
Guo Z
Liu Q
Smith L
Publication year
Publication venue
Nature biotechnology

External Links

Snippet

In order to increase the discrimination of single nucleotide polymorphisms in DNA hybridization, artificial mismatches are inserted into probe oligonucleotides using the base analog 3-nitropyrrole. Differences in thermal stability (ΔTm) between hybrids formed with …
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