Zhao et al., 2022 - Google Patents

Approaches and vectors for efficient cochlear gene transfer in adult mouse models

Zhao et al., 2022

View HTML
Document ID
10278143511353166413
Author
Zhao Y
Zhang L
Wang D
Chen B
Shu Y
Publication year
Publication venue
Biomolecules

External Links

Snippet

Inner ear gene therapy using adeno-associated viral vectors (AAVs) in neonatal mice can alleviate hearing loss in mouse models of deafness. However, efficient and safe transgene delivery to the adult mouse cochlea is critical for the effectiveness of AAV-mediated therapy …
Continue reading at www.mdpi.com (HTML) (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof

Similar Documents

Publication Publication Date Title
Mélik Parsadaniantz et al. Glaucoma: a degenerative optic neuropathy related to neuroinflammation?
Zhao et al. Approaches and vectors for efficient cochlear gene transfer in adult mouse models
Shin et al. Acoustic trauma modulates cochlear blood flow and vasoactive factors in a rodent model of noise-induced hearing loss
Lyu et al. Mitochondrial damage and necroptosis in aging cochlea
Kanzaki et al. Application of mesenchymal stem cell therapy and inner ear regeneration for hearing loss: a review
Youn et al. Age-related hearing loss in C57BL/6J mice is associated with mitophagy impairment in the central auditory system
Park et al. Induced short-term hearing loss due to stimulation of age-related factors by intermittent hypoxia, high-fat diet, and galactose injection
Lahlou et al. Towards the clinical application of gene therapy for genetic inner ear diseases
Wolfberg et al. Hearing loss in mucopolysaccharidoses: current knowledge and future directions
Kanzaki Gene delivery into the inner ear and its clinical implications for hearing and balance
Marcovich et al. Optimized AAV vectors for TMC1 gene therapy in a humanized mouse model of DFNB7/11
Blanc et al. rAAV-mediated cochlear gene therapy: prospects and challenges for clinical application
Patil et al. A novel mouse model of TGFβ2-induced ocular hypertension using lentiviral gene delivery
Häussler et al. Challenges of cochlear implantation in intralabyrinthine schwannoma patients: surgical procedures and auditory outcome
Park et al. Changes in microRNA expression in the cochlear nucleus and inferior colliculus after acute noise-induced hearing loss
Iannacone et al. How cochlear implant rehabilitation impacts the therapeutic strategy for vestibular schwannoma
Fang et al. Hedgehog signaling in CNS remyelination
Hahn et al. Gene therapy for inherited hearing loss: updates and remaining challenges
Lee-Gosselin et al. TREM2-Deficient microglia attenuate tau spreading in vivo
Blebea et al. The effect of pluronic-coated gold nanoparticles in hearing preservation following cochlear implantation-pilot study
van Beelen et al. Efficient viral transduction in fetal and adult human inner ear explants with AAV9-PHP. B vectors
Amat et al. Long-term effects of repetitive transcranial magnetic stimulation on tinnitus in a guinea pig model
Maiborodin et al. Some special aspects of liver repair after resection and administration of multipotent stromal cells in experiment
Verdoodt et al. Cochlin deficiency protects aged mice from noise-induced hearing loss
Okuda et al. Striatal-Inoculation of α-Synuclein Preformed Fibrils Aggravated the Phenotypes of REM Sleep without Atonia in A53T BAC-SNCA Transgenic Mice